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P39964 (CEF1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-mRNA-splicing factor cdc5
Alternative name(s):
Cell division control protein 5
Gene names
Name:cdc5
ORF Names:SPAC644.12
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mRNA splicing and cell cycle control. Ref.1 Ref.3

Subunit structure

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2. Ref.3 Ref.4

Subcellular location

Nucleus Ref.3.

Sequence similarities

Belongs to the CEF1 family.

Contains 2 HTH myb-type DNA-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Pre-mRNA-splicing factor cdc5
PRO_0000197104

Regions

Domain1 – 5656HTH myb-type 1
Domain57 – 10650HTH myb-type 2
DNA binding29 – 5224H-T-H motif By similarity
DNA binding80 – 10223H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
P39964 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9FCA639A2F9A9E84

FASTA75786,844
        10         20         30         40         50         60 
MVVLKGGAWK NTEDEILKAA VSKYGKNQWA RISSLLVRKT PKQCKARWYE WIDPSIKKTE 

        70         80         90        100        110        120 
WSREEDEKLL HLAKLLPTQW RTIAPIVGRT ATQCLERYQK LLDDLEAKEN EQLGLISGEG 

       130        140        150        160        170        180 
AEAAAPVNDP NSRLRFGEAE PNLETLPALP DAIDMDEDEK EMLSEARARL ANTQGKKAKR 

       190        200        210        220        230        240 
KDREKQLELT RRLSHLQKRR ELKAAGINIK LFRRKKNEMD YNASIPFEKK PAIGFYDTSE 

       250        260        270        280        290        300 
EDRQNFREKR EADQKIIENG IRNNEMESEG RKFGHFEKPK PIDRVKKPNK DAQEEKMRRL 

       310        320        330        340        350        360 
AEAEQMSKRR KLNLPSPTVS QDELDKVVKL GFAGDRARAM TDTTPDANYS TNLLGKYTQI 

       370        380        390        400        410        420 
ERATPLRTPI SGELEGREDS VTIEVRNQLM RNREQSSLLG QESIPLQPGG TGYTGVTPSH 

       430        440        450        460        470        480 
AANGSALAAP QATPFRTPRD TFSINAAAER AGRLASEREN KIRLKALREL LAKLPKPKND 

       490        500        510        520        530        540 
YELMEPRFAD ETDVEATVGV LEEDATDRER RIQERIAEKE RLAKARRSQV IQRDLIRPSV 

       550        560        570        580        590        600 
TQPEKWKRSL ENEDPTANVL LKEMIALISS DAINYPFGNS KVKGTANKVP DLSNEEIERC 

       610        620        630        640        650        660 
RLLLKKEIGQ LESDDYIQFE KEFLETYSAL HNTSSLLPGL VIYEEDDEDV EAAEKFYTND 

       670        680        690        700        710        720 
IQRDLAKKAL ECNKLENRVY DLVRSSYEQR NFLIKKISHA WKALQTERKN LTCYEFLYNQ 

       730        740        750 
ERLALPNRLE AAEIELSKMQ QIEAYAQQDY ARVTGQN 

« Hide

References

« Hide 'large scale' references
[1]"The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb."
Ohi R., McCollum D., Hirani B., den Haese G.J., Zhang X., Burke J.D., Turner K., Gould K.L.
EMBO J. 13:471-483(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing."
McDonald W.H., Ohi R., Smelkova N., Frendewey D., Gould K.L.
Mol. Cell. Biol. 19:5352-5362(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE 40S CDC5-ASSOCIATED COMPLEX.
[4]"Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19525 mRNA. Translation: AAA17515.1.
CU329670 Genomic DNA. Translation: CAB90139.1.
PIRS41712.
RefSeqNP_593880.1. NM_001019310.2.

3D structure databases

ProteinModelPortalP39964.
SMRP39964. Positions 9-110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279998. 78 interactions.
DIPDIP-34817N.
IntActP39964. 50 interactions.
MINTMINT-4689419.
STRING4896.SPAC644.12-1.

Proteomic databases

MaxQBP39964.
PRIDEP39964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC644.12.1; SPAC644.12.1:pep; SPAC644.12.
GeneID2543583.
KEGGspo:SPAC644.12.

Organism-specific databases

PomBaseSPAC644.12.

Phylogenomic databases

eggNOGCOG5147.
HOGENOMHOG000182446.
KOK12860.
OMATIDMDED.
OrthoDBEOG78SQWR.
PhylomeDBP39964.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR021786. DUF3351.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamPF11831. Myb_Cef. 1 hit.
PF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51294. HTH_MYB. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804590.
PROP39964.

Entry information

Entry nameCEF1_SCHPO
AccessionPrimary (citable) accession number: P39964
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names