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Protein

Pre-mRNA-splicing factor cdc5

Gene

cdc5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and cell cycle control.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi80 – 102H-T-H motifPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • mRNA cis splicing, via spliceosome Source: PomBase
  • regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cdc5
Alternative name(s):
Cell division control protein 5
Gene namesi
Name:cdc5
ORF Names:SPAC644.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC644.12
PomBaseiSPAC644.12 cdc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971041 – 757Pre-mRNA-splicing factor cdc5Add BLAST757

Proteomic databases

MaxQBiP39964
PaxDbiP39964
PRIDEiP39964

PTM databases

iPTMnetiP39964

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi279998, 84 interactors
DIPiDIP-34817N
IntActiP39964, 51 interactors
STRINGi4896.SPAC644.12.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60W1-236[»]
W652-757[»]
ProteinModelPortaliP39964
SMRiP39964
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56HTH myb-type 1PROSITE-ProRule annotationAdd BLAST56
Domaini57 – 106HTH myb-type 2PROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Belongs to the CEF1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000182446
InParanoidiP39964
KOiK12860
OMAiYKNYQKQ
OrthoDBiEOG092C1DPM
PhylomeDBiP39964

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR021786 Cdc5p/Cef1
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF11831 Myb_Cef, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 2 hits

Sequencei

Sequence statusi: Complete.

P39964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVLKGGAWK NTEDEILKAA VSKYGKNQWA RISSLLVRKT PKQCKARWYE
60 70 80 90 100
WIDPSIKKTE WSREEDEKLL HLAKLLPTQW RTIAPIVGRT ATQCLERYQK
110 120 130 140 150
LLDDLEAKEN EQLGLISGEG AEAAAPVNDP NSRLRFGEAE PNLETLPALP
160 170 180 190 200
DAIDMDEDEK EMLSEARARL ANTQGKKAKR KDREKQLELT RRLSHLQKRR
210 220 230 240 250
ELKAAGINIK LFRRKKNEMD YNASIPFEKK PAIGFYDTSE EDRQNFREKR
260 270 280 290 300
EADQKIIENG IRNNEMESEG RKFGHFEKPK PIDRVKKPNK DAQEEKMRRL
310 320 330 340 350
AEAEQMSKRR KLNLPSPTVS QDELDKVVKL GFAGDRARAM TDTTPDANYS
360 370 380 390 400
TNLLGKYTQI ERATPLRTPI SGELEGREDS VTIEVRNQLM RNREQSSLLG
410 420 430 440 450
QESIPLQPGG TGYTGVTPSH AANGSALAAP QATPFRTPRD TFSINAAAER
460 470 480 490 500
AGRLASEREN KIRLKALREL LAKLPKPKND YELMEPRFAD ETDVEATVGV
510 520 530 540 550
LEEDATDRER RIQERIAEKE RLAKARRSQV IQRDLIRPSV TQPEKWKRSL
560 570 580 590 600
ENEDPTANVL LKEMIALISS DAINYPFGNS KVKGTANKVP DLSNEEIERC
610 620 630 640 650
RLLLKKEIGQ LESDDYIQFE KEFLETYSAL HNTSSLLPGL VIYEEDDEDV
660 670 680 690 700
EAAEKFYTND IQRDLAKKAL ECNKLENRVY DLVRSSYEQR NFLIKKISHA
710 720 730 740 750
WKALQTERKN LTCYEFLYNQ ERLALPNRLE AAEIELSKMQ QIEAYAQQDY

ARVTGQN
Length:757
Mass (Da):86,844
Last modified:February 1, 1995 - v1
Checksum:i9FCA639A2F9A9E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19525 mRNA Translation: AAA17515.1
CU329670 Genomic DNA Translation: CAB90139.1
PIRiS41712
RefSeqiNP_593880.1, NM_001019310.2

Genome annotation databases

EnsemblFungiiSPAC644.12.1; SPAC644.12.1:pep; SPAC644.12
GeneIDi2543583
KEGGispo:SPAC644.12

Similar proteinsi

Entry informationi

Entry nameiCEF1_SCHPO
AccessioniPrimary (citable) accession number: P39964
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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