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P39964

- CEF1_SCHPO

UniProt

P39964 - CEF1_SCHPO

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Protein

Pre-mRNA-splicing factor cdc5

Gene

cdc5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and cell cycle control.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi29 – 5224H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi80 – 10223H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA binding Source: PomBase

GO - Biological processi

  1. mRNA cis splicing, via spliceosome Source: PomBase
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cdc5
Alternative name(s):
Cell division control protein 5
Gene namesi
Name:cdc5
ORF Names:SPAC644.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC644.12.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
  3. Prp19 complex Source: PomBase
  4. spliceosomal complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Pre-mRNA-splicing factor cdc5PRO_0000197104Add
BLAST

Proteomic databases

MaxQBiP39964.
PRIDEiP39964.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
cwf10O943165EBI-538771,EBI-538866
cwf11O945083EBI-538771,EBI-539118
cwf12O743703EBI-538771,EBI-538882
cwf17O946203EBI-538771,EBI-539124
cwf2P871265EBI-538771,EBI-538799
cwf3Q9P7R97EBI-538771,EBI-538809
cwf4P873127EBI-538771,EBI-538818
cwf5O598004EBI-538771,EBI-538826
cwf7Q9USV34EBI-538771,EBI-538841
prp45Q098823EBI-538771,EBI-457758
prp5O136157EBI-538771,EBI-538787

Protein-protein interaction databases

BioGridi279998. 81 interactions.
DIPiDIP-34817N.
IntActiP39964. 50 interactions.
MINTiMINT-4689419.
STRINGi4896.SPAC644.12-1.

Structurei

3D structure databases

ProteinModelPortaliP39964.
SMRiP39964. Positions 9-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5656HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 10650HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CEF1 family.Curated
Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5147.
HOGENOMiHOG000182446.
InParanoidiP39964.
KOiK12860.
OMAiTIDMDED.
OrthoDBiEOG78SQWR.
PhylomeDBiP39964.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR021786. DUF3351.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF11831. Myb_Cef. 1 hit.
PF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39964-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVLKGGAWK NTEDEILKAA VSKYGKNQWA RISSLLVRKT PKQCKARWYE
60 70 80 90 100
WIDPSIKKTE WSREEDEKLL HLAKLLPTQW RTIAPIVGRT ATQCLERYQK
110 120 130 140 150
LLDDLEAKEN EQLGLISGEG AEAAAPVNDP NSRLRFGEAE PNLETLPALP
160 170 180 190 200
DAIDMDEDEK EMLSEARARL ANTQGKKAKR KDREKQLELT RRLSHLQKRR
210 220 230 240 250
ELKAAGINIK LFRRKKNEMD YNASIPFEKK PAIGFYDTSE EDRQNFREKR
260 270 280 290 300
EADQKIIENG IRNNEMESEG RKFGHFEKPK PIDRVKKPNK DAQEEKMRRL
310 320 330 340 350
AEAEQMSKRR KLNLPSPTVS QDELDKVVKL GFAGDRARAM TDTTPDANYS
360 370 380 390 400
TNLLGKYTQI ERATPLRTPI SGELEGREDS VTIEVRNQLM RNREQSSLLG
410 420 430 440 450
QESIPLQPGG TGYTGVTPSH AANGSALAAP QATPFRTPRD TFSINAAAER
460 470 480 490 500
AGRLASEREN KIRLKALREL LAKLPKPKND YELMEPRFAD ETDVEATVGV
510 520 530 540 550
LEEDATDRER RIQERIAEKE RLAKARRSQV IQRDLIRPSV TQPEKWKRSL
560 570 580 590 600
ENEDPTANVL LKEMIALISS DAINYPFGNS KVKGTANKVP DLSNEEIERC
610 620 630 640 650
RLLLKKEIGQ LESDDYIQFE KEFLETYSAL HNTSSLLPGL VIYEEDDEDV
660 670 680 690 700
EAAEKFYTND IQRDLAKKAL ECNKLENRVY DLVRSSYEQR NFLIKKISHA
710 720 730 740 750
WKALQTERKN LTCYEFLYNQ ERLALPNRLE AAEIELSKMQ QIEAYAQQDY

ARVTGQN
Length:757
Mass (Da):86,844
Last modified:February 1, 1995 - v1
Checksum:i9FCA639A2F9A9E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19525 mRNA. Translation: AAA17515.1.
CU329670 Genomic DNA. Translation: CAB90139.1.
PIRiS41712.
RefSeqiNP_593880.1. NM_001019310.2.

Genome annotation databases

EnsemblFungiiSPAC644.12.1; SPAC644.12.1:pep; SPAC644.12.
GeneIDi2543583.
KEGGispo:SPAC644.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19525 mRNA. Translation: AAA17515.1 .
CU329670 Genomic DNA. Translation: CAB90139.1 .
PIRi S41712.
RefSeqi NP_593880.1. NM_001019310.2.

3D structure databases

ProteinModelPortali P39964.
SMRi P39964. Positions 9-110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279998. 81 interactions.
DIPi DIP-34817N.
IntActi P39964. 50 interactions.
MINTi MINT-4689419.
STRINGi 4896.SPAC644.12-1.

Proteomic databases

MaxQBi P39964.
PRIDEi P39964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC644.12.1 ; SPAC644.12.1:pep ; SPAC644.12 .
GeneIDi 2543583.
KEGGi spo:SPAC644.12.

Organism-specific databases

PomBasei SPAC644.12.

Phylogenomic databases

eggNOGi COG5147.
HOGENOMi HOG000182446.
InParanoidi P39964.
KOi K12860.
OMAi TIDMDED.
OrthoDBi EOG78SQWR.
PhylomeDBi P39964.

Miscellaneous databases

NextBioi 20804590.
PROi P39964.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR021786. DUF3351.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view ]
Pfami PF11831. Myb_Cef. 1 hit.
PF00249. Myb_DNA-binding. 2 hits.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51294. HTH_MYB. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb."
    Ohi R., McCollum D., Hirani B., den Haese G.J., Zhang X., Burke J.D., Turner K., Gould K.L.
    EMBO J. 13:471-483(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing."
    McDonald W.H., Ohi R., Smelkova N., Frendewey D., Gould K.L.
    Mol. Cell. Biol. 19:5352-5362(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE 40S CDC5-ASSOCIATED COMPLEX.
  4. "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
    Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
    Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCEF1_SCHPO
AccessioniPrimary (citable) accession number: P39964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3