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Protein

Casein kinase I homolog 3

Gene

YCK3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60ATPPROSITE-ProRule annotation1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: GO_Central
  • vesicle-mediated transport Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YER123W-MONOMER
BRENDAi2.7.11.1 984

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 3 (EC:2.7.11.1)
Gene namesi
Name:YCK3
Synonyms:CKI3
Ordered Locus Names:YER123W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER123W
SGDiS000000925 YCK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi444Y → H: Impaired vacuolar targeting. 1 Publication1
Mutagenesisi446S → P: Impaired vacuolar targeting. 1 Publication1
Mutagenesisi447I → N: Impaired vacuolar targeting. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928581 – 524Casein kinase I homolog 3Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi517S-palmitoyl cysteine1 Publication1
Lipidationi518S-palmitoyl cysteine1 Publication1
Lipidationi519S-palmitoyl cysteine1 Publication1
Lipidationi520S-palmitoyl cysteine1 Publication1
Lipidationi522S-palmitoyl cysteine1 Publication1
Lipidationi523S-palmitoyl cysteine1 Publication1
Lipidationi524S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP39962
PaxDbiP39962
PRIDEiP39962
TopDownProteomicsiP39962

PTM databases

iPTMnetiP39962
SwissPalmiP39962

Interactioni

Protein-protein interaction databases

BioGridi36867, 163 interactors
DIPiDIP-6331N
IntActiP39962, 5 interactors
MINTiP39962
STRINGi4932.YER123W

Structurei

3D structure databases

ProteinModelPortaliP39962
SMRiP39962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST306

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi444 – 447YXXZ targeting signal4

Domaini

The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000144761
HOGENOMiHOG000182055
InParanoidiP39962
KOiK19830
OMAiHAYYFGQ
OrthoDBiEOG092C30PR

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P39962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRSSQHIV GIHYAVGPKI GEGSFGVIFE GENILHSCQA QTGSKRDSSI
60 70 80 90 100
IMANEPVAIK FEPRHSDAPQ LRDEFRAYRI LNGCVGIPHA YYFGQEGMHN
110 120 130 140 150
ILIIDLLGPS LEDLFEWCGR KFSVKTTCMV AKQMIDRVRA IHDHDLIYRD
160 170 180 190 200
IKPDNFLISQ YQRISPEGKV IKSCASSSNN DPNLIYMVDF GMAKQYRDPR
210 220 230 240 250
TKQHIPYRER KSLSGTARYM SINTHFGREQ SRRDDLESLG HVFFYFLRGS
260 270 280 290 300
LPWQGLKAPN NKLKYEKIGM TKQKLNPDDL LLNNAIPYQF ATYLKYARSL
310 320 330 340 350
KFDEDPDYDY LISLMDDALR LNDLKDDGHY DWMDLNGGKG WNIKINRRAN
360 370 380 390 400
LHGYGNPNPR VNGNTARNNV NTNSKTRNTT PVATPKQQAQ NSYNKDNSKS
410 420 430 440 450
RISSNPQSFT KQQHVLKKIE PNSKYIPETH SNLQRPIKSQ SQTYDSISHT
460 470 480 490 500
QNSPFVPYSS SKANPKRSNN EHNLPNHYTN LANKNINYQS QRNYEQENDA
510 520
YSDDENDTFC SKIYKYCCCC FCCC
Length:524
Mass (Da):60,261
Last modified:November 1, 1995 - v2
Checksum:iFD4BBA311D0CD805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87108 Genomic DNA Translation: CAA60589.1
U18916 Genomic DNA Translation: AAC03221.2
BK006939 Genomic DNA Translation: DAA07783.1
PIRiS50626
RefSeqiNP_011049.2, NM_001179013.1

Genome annotation databases

EnsemblFungiiYER123W; YER123W; YER123W
GeneIDi856860
KEGGisce:YER123W

Similar proteinsi

Entry informationi

Entry nameiKC13_YEAST
AccessioniPrimary (citable) accession number: P39962
Secondary accession number(s): D3DM29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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