Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase I homolog 3

Gene

YCK3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60ATPPROSITE-ProRule annotation1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: GO_Central
  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YER123W-MONOMER.
BRENDAi2.7.11.1. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 3 (EC:2.7.11.1)
Gene namesi
Name:YCK3
Synonyms:CKI3
Ordered Locus Names:YER123W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER123W.
SGDiS000000925. YCK3.

Subcellular locationi

GO - Cellular componenti

  • fungal-type vacuole Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • nuclear membrane Source: UniProtKB-SubCell
  • nucleus Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi444Y → H: Impaired vacuolar targeting. 1 Publication1
Mutagenesisi446S → P: Impaired vacuolar targeting. 1 Publication1
Mutagenesisi447I → N: Impaired vacuolar targeting. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928581 – 524Casein kinase I homolog 3Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi517S-palmitoyl cysteine1 Publication1
Lipidationi518S-palmitoyl cysteine1 Publication1
Lipidationi519S-palmitoyl cysteine1 Publication1
Lipidationi520S-palmitoyl cysteine1 Publication1
Lipidationi522S-palmitoyl cysteine1 Publication1
Lipidationi523S-palmitoyl cysteine1 Publication1
Lipidationi524S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP39962.
PRIDEiP39962.
TopDownProteomicsiP39962.

PTM databases

iPTMnetiP39962.
SwissPalmiP39962.

Interactioni

Protein-protein interaction databases

BioGridi36867. 104 interactors.
DIPiDIP-6331N.
IntActiP39962. 4 interactors.
MINTiMINT-4484355.

Structurei

3D structure databases

ProteinModelPortaliP39962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST306

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi444 – 447YXXZ targeting signal4

Domaini

The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00850000132311.
HOGENOMiHOG000182055.
InParanoidiP39962.
KOiK19830.
OMAiHAYYFGQ.
OrthoDBiEOG092C30PR.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRSSQHIV GIHYAVGPKI GEGSFGVIFE GENILHSCQA QTGSKRDSSI
60 70 80 90 100
IMANEPVAIK FEPRHSDAPQ LRDEFRAYRI LNGCVGIPHA YYFGQEGMHN
110 120 130 140 150
ILIIDLLGPS LEDLFEWCGR KFSVKTTCMV AKQMIDRVRA IHDHDLIYRD
160 170 180 190 200
IKPDNFLISQ YQRISPEGKV IKSCASSSNN DPNLIYMVDF GMAKQYRDPR
210 220 230 240 250
TKQHIPYRER KSLSGTARYM SINTHFGREQ SRRDDLESLG HVFFYFLRGS
260 270 280 290 300
LPWQGLKAPN NKLKYEKIGM TKQKLNPDDL LLNNAIPYQF ATYLKYARSL
310 320 330 340 350
KFDEDPDYDY LISLMDDALR LNDLKDDGHY DWMDLNGGKG WNIKINRRAN
360 370 380 390 400
LHGYGNPNPR VNGNTARNNV NTNSKTRNTT PVATPKQQAQ NSYNKDNSKS
410 420 430 440 450
RISSNPQSFT KQQHVLKKIE PNSKYIPETH SNLQRPIKSQ SQTYDSISHT
460 470 480 490 500
QNSPFVPYSS SKANPKRSNN EHNLPNHYTN LANKNINYQS QRNYEQENDA
510 520
YSDDENDTFC SKIYKYCCCC FCCC
Length:524
Mass (Da):60,261
Last modified:November 1, 1995 - v2
Checksum:iFD4BBA311D0CD805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87108 Genomic DNA. Translation: CAA60589.1.
U18916 Genomic DNA. Translation: AAC03221.2.
BK006939 Genomic DNA. Translation: DAA07783.1.
PIRiS50626.
RefSeqiNP_011049.2. NM_001179013.1.

Genome annotation databases

EnsemblFungiiYER123W; YER123W; YER123W.
GeneIDi856860.
KEGGisce:YER123W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87108 Genomic DNA. Translation: CAA60589.1.
U18916 Genomic DNA. Translation: AAC03221.2.
BK006939 Genomic DNA. Translation: DAA07783.1.
PIRiS50626.
RefSeqiNP_011049.2. NM_001179013.1.

3D structure databases

ProteinModelPortaliP39962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36867. 104 interactors.
DIPiDIP-6331N.
IntActiP39962. 4 interactors.
MINTiMINT-4484355.

PTM databases

iPTMnetiP39962.
SwissPalmiP39962.

Proteomic databases

MaxQBiP39962.
PRIDEiP39962.
TopDownProteomicsiP39962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER123W; YER123W; YER123W.
GeneIDi856860.
KEGGisce:YER123W.

Organism-specific databases

EuPathDBiFungiDB:YER123W.
SGDiS000000925. YCK3.

Phylogenomic databases

GeneTreeiENSGT00850000132311.
HOGENOMiHOG000182055.
InParanoidiP39962.
KOiK19830.
OMAiHAYYFGQ.
OrthoDBiEOG092C30PR.

Enzyme and pathway databases

BioCyciYEAST:YER123W-MONOMER.
BRENDAi2.7.11.1. 984.

Miscellaneous databases

PROiP39962.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKC13_YEAST
AccessioniPrimary (citable) accession number: P39962
Secondary accession number(s): D3DM29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.