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Protein

Protein SAP1

Gene

SAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi645 – 652ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • microtubule-severing ATPase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SAP1
Alternative name(s):
SIN1-associated protein
Gene namesi
Name:SAP1
Ordered Locus Names:YER047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER047C.
SGDiS000000849. SAP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847611 – 897Protein SAP1Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei536PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39955.
PRIDEiP39955.
TopDownProteomicsiP39955.

PTM databases

iPTMnetiP39955.

Interactioni

Subunit structurei

Interacts with SPT2/SIN1.

Binary interactionsi

WithEntry#Exp.IntActNotes
HOF1Q050804EBI-16463,EBI-5412
MYO3P360063EBI-16463,EBI-11670
MYO5Q044394EBI-16463,EBI-11687

Protein-protein interaction databases

BioGridi36784. 33 interactors.
DIPiDIP-1550N.
IntActiP39955. 16 interactors.
MINTiMINT-407680.

Structurei

3D structure databases

ProteinModelPortaliP39955.
SMRiP39955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

GeneTreeiENSGT00570000078874.
HOGENOMiHOG000216613.
InParanoidiP39955.
OMAiEREMIRP.
OrthoDBiEOG092C2QJ3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQRSHHIL TRLTKIRRRP QQPLTDFTEL YSRIANETIY YLNLEEKKRY
60 70 80 90 100
KEALQGWKAL TTDVLFKQTL IEHNYPNTQS YTKDEVSLQN GIRELYHKSV
110 120 130 140 150
MHLKRVKKLV REEPAPRNDM PSSKTYTNHS SSFTRSTEPP PVFQMVPGRM
160 170 180 190 200
MKTLRNRNAC GYKTAYSNPS LSSYGNSTSI KRGEDAENIR VNFVPSKPLS
210 220 230 240 250
NNASRQHKNP IEHNDPPLKK ETELYSDKYI SEPILIDLTN DEDDHDVGIL
260 270 280 290 300
KGHNVFDEEE SDGFEFDVSD YYDNFSEVDV EEEEEEKEER RRIKTLEAIQ
310 320 330 340 350
QQMSDLSVTS STSSNKSVSS SENVPGSCIQ SLPTTAPALP SLPPPPLLNV
360 370 380 390 400
DRASSTGALK PHSLETSTTM DSSKIRNPQI SKLMKNNHVP YLKGTKSTPT
410 420 430 440 450
LITKSTPTFI TRSKSNTKPI IKSNASSPTS SLTVPNSVIQ KPKTAAMAAK
460 470 480 490 500
RVLNSKKVAS NPALNTTKKS HPILKSKTAK VPNSSSKKTS SHPSRPVSNS
510 520 530 540 550
KPYSHGASQN KKPSKNQTTS MSKTNRKIPA QKKIGSPKIE DVGTEDATEH
560 570 580 590 600
ATSLNEQREE PEIDKKVLRE ILEDEIIDSL QGVDRQAAKQ IFAEIVVHGD
610 620 630 640 650
EVHWDDIAGL ESAKYSLKEA VVYPFLRPDL FRGLREPVRG MLLFGPPGTG
660 670 680 690 700
KTMLARAVAT ESHSTFFSIS ASSLTSKYLG ESEKLVRALF AIAKKLSPSI
710 720 730 740 750
IFVDEIDSIM GSRNNENENE SSRRIKNEFL VQWSSLSSAA AGSNKSNTNN
760 770 780 790 800
SDTNGDEDDT RVLVLAATNL PWSIDEAARR RFVRRQYIPL PEDQTRHVQF
810 820 830 840 850
KKLLSHQKHT LTESDFDELV KITEGYSGSD ITSLAKDAAM GPLRDLGDKL
860 870 880 890
LETEREMIRP IGLVDFKNSL VYIKPSVSQD GLVKYEKWAS QFGSSGS
Length:897
Mass (Da):100,332
Last modified:February 1, 1995 - v1
Checksum:iE9780B269700144C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64582.1.
BK006939 Genomic DNA. Translation: DAA07702.1.
PIRiS50550.
RefSeqiNP_010966.1. NM_001178938.1.

Genome annotation databases

EnsemblFungiiYER047C; YER047C; YER047C.
GeneIDi856771.
KEGGisce:YER047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64582.1.
BK006939 Genomic DNA. Translation: DAA07702.1.
PIRiS50550.
RefSeqiNP_010966.1. NM_001178938.1.

3D structure databases

ProteinModelPortaliP39955.
SMRiP39955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36784. 33 interactors.
DIPiDIP-1550N.
IntActiP39955. 16 interactors.
MINTiMINT-407680.

PTM databases

iPTMnetiP39955.

Proteomic databases

MaxQBiP39955.
PRIDEiP39955.
TopDownProteomicsiP39955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER047C; YER047C; YER047C.
GeneIDi856771.
KEGGisce:YER047C.

Organism-specific databases

EuPathDBiFungiDB:YER047C.
SGDiS000000849. SAP1.

Phylogenomic databases

GeneTreeiENSGT00570000078874.
HOGENOMiHOG000216613.
InParanoidiP39955.
OMAiEREMIRP.
OrthoDBiEOG092C2QJ3.

Enzyme and pathway databases

BioCyciYEAST:G3O-30226-MONOMER.

Miscellaneous databases

PROiP39955.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAP1_YEAST
AccessioniPrimary (citable) accession number: P39955
Secondary accession number(s): D3DLU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.