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P39955

- SAP1_YEAST

UniProt

P39955 - SAP1_YEAST

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Protein

Protein SAP1

Gene

SAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi645 – 6528ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: SGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SAP1
Alternative name(s):
SIN1-associated protein
Gene namesi
Name:SAP1
Ordered Locus Names:YER047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER047c.
SGDiS000000849. SAP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Protein SAP1PRO_0000084761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei536 – 5361Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39955.
PaxDbiP39955.

Expressioni

Gene expression databases

GenevestigatoriP39955.

Interactioni

Subunit structurei

Interacts with SPT2/SIN1.

Binary interactionsi

WithEntry#Exp.IntActNotes
HOF1Q050804EBI-16463,EBI-5412
MYO3P360063EBI-16463,EBI-11670
MYO5Q044394EBI-16463,EBI-11687

Protein-protein interaction databases

BioGridi36784. 33 interactions.
DIPiDIP-1550N.
IntActiP39955. 15 interactions.
MINTiMINT-407680.
STRINGi4932.YER047C.

Structurei

3D structure databases

ProteinModelPortaliP39955.
SMRiP39955. Positions 559-889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000216613.
InParanoidiP39955.
OMAiHGDEVHW.
OrthoDBiEOG72JWRT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39955-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSQRSHHIL TRLTKIRRRP QQPLTDFTEL YSRIANETIY YLNLEEKKRY
60 70 80 90 100
KEALQGWKAL TTDVLFKQTL IEHNYPNTQS YTKDEVSLQN GIRELYHKSV
110 120 130 140 150
MHLKRVKKLV REEPAPRNDM PSSKTYTNHS SSFTRSTEPP PVFQMVPGRM
160 170 180 190 200
MKTLRNRNAC GYKTAYSNPS LSSYGNSTSI KRGEDAENIR VNFVPSKPLS
210 220 230 240 250
NNASRQHKNP IEHNDPPLKK ETELYSDKYI SEPILIDLTN DEDDHDVGIL
260 270 280 290 300
KGHNVFDEEE SDGFEFDVSD YYDNFSEVDV EEEEEEKEER RRIKTLEAIQ
310 320 330 340 350
QQMSDLSVTS STSSNKSVSS SENVPGSCIQ SLPTTAPALP SLPPPPLLNV
360 370 380 390 400
DRASSTGALK PHSLETSTTM DSSKIRNPQI SKLMKNNHVP YLKGTKSTPT
410 420 430 440 450
LITKSTPTFI TRSKSNTKPI IKSNASSPTS SLTVPNSVIQ KPKTAAMAAK
460 470 480 490 500
RVLNSKKVAS NPALNTTKKS HPILKSKTAK VPNSSSKKTS SHPSRPVSNS
510 520 530 540 550
KPYSHGASQN KKPSKNQTTS MSKTNRKIPA QKKIGSPKIE DVGTEDATEH
560 570 580 590 600
ATSLNEQREE PEIDKKVLRE ILEDEIIDSL QGVDRQAAKQ IFAEIVVHGD
610 620 630 640 650
EVHWDDIAGL ESAKYSLKEA VVYPFLRPDL FRGLREPVRG MLLFGPPGTG
660 670 680 690 700
KTMLARAVAT ESHSTFFSIS ASSLTSKYLG ESEKLVRALF AIAKKLSPSI
710 720 730 740 750
IFVDEIDSIM GSRNNENENE SSRRIKNEFL VQWSSLSSAA AGSNKSNTNN
760 770 780 790 800
SDTNGDEDDT RVLVLAATNL PWSIDEAARR RFVRRQYIPL PEDQTRHVQF
810 820 830 840 850
KKLLSHQKHT LTESDFDELV KITEGYSGSD ITSLAKDAAM GPLRDLGDKL
860 870 880 890
LETEREMIRP IGLVDFKNSL VYIKPSVSQD GLVKYEKWAS QFGSSGS
Length:897
Mass (Da):100,332
Last modified:February 1, 1995 - v1
Checksum:iE9780B269700144C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64582.1.
BK006939 Genomic DNA. Translation: DAA07702.1.
PIRiS50550.
RefSeqiNP_010966.1. NM_001178938.1.

Genome annotation databases

EnsemblFungiiYER047C; YER047C; YER047C.
GeneIDi856771.
KEGGisce:YER047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64582.1 .
BK006939 Genomic DNA. Translation: DAA07702.1 .
PIRi S50550.
RefSeqi NP_010966.1. NM_001178938.1.

3D structure databases

ProteinModelPortali P39955.
SMRi P39955. Positions 559-889.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36784. 33 interactions.
DIPi DIP-1550N.
IntActi P39955. 15 interactions.
MINTi MINT-407680.
STRINGi 4932.YER047C.

Proteomic databases

MaxQBi P39955.
PaxDbi P39955.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER047C ; YER047C ; YER047C .
GeneIDi 856771.
KEGGi sce:YER047C.

Organism-specific databases

CYGDi YER047c.
SGDi S000000849. SAP1.

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00570000078874.
HOGENOMi HOG000216613.
InParanoidi P39955.
OMAi HGDEVHW.
OrthoDBi EOG72JWRT.

Enzyme and pathway databases

BioCyci YEAST:G3O-30226-MONOMER.

Miscellaneous databases

NextBioi 982962.

Gene expression databases

Genevestigatori P39955.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Association of yeast SAP1, a novel member of the 'AAA' ATPase family of proteins, with the chromatin protein SIN1."
    Liberzon A., Shpungin S., Bangio H., Yona E., Katcoff D.J.
    FEBS Lett. 388:5-10(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSAP1_YEAST
AccessioniPrimary (citable) accession number: P39955
Secondary accession number(s): D3DLU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3