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P39955

- SAP1_YEAST

UniProt

P39955 - SAP1_YEAST

Protein

Protein SAP1

Gene

SAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi645 – 6528ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30226-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SAP1
    Alternative name(s):
    SIN1-associated protein
    Gene namesi
    Name:SAP1
    Ordered Locus Names:YER047C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER047c.
    SGDiS000000849. SAP1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 897897Protein SAP1PRO_0000084761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei536 – 5361Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP39955.
    PaxDbiP39955.

    Expressioni

    Gene expression databases

    GenevestigatoriP39955.

    Interactioni

    Subunit structurei

    Interacts with SPT2/SIN1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HOF1Q050804EBI-16463,EBI-5412
    MYO3P360063EBI-16463,EBI-11670
    MYO5Q044394EBI-16463,EBI-11687

    Protein-protein interaction databases

    BioGridi36784. 33 interactions.
    DIPiDIP-1550N.
    IntActiP39955. 15 interactions.
    MINTiMINT-407680.
    STRINGi4932.YER047C.

    Structurei

    3D structure databases

    ProteinModelPortaliP39955.
    SMRiP39955. Positions 559-889.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00570000078874.
    HOGENOMiHOG000216613.
    OMAiHGDEVHW.
    OrthoDBiEOG72JWRT.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSQRSHHIL TRLTKIRRRP QQPLTDFTEL YSRIANETIY YLNLEEKKRY    50
    KEALQGWKAL TTDVLFKQTL IEHNYPNTQS YTKDEVSLQN GIRELYHKSV 100
    MHLKRVKKLV REEPAPRNDM PSSKTYTNHS SSFTRSTEPP PVFQMVPGRM 150
    MKTLRNRNAC GYKTAYSNPS LSSYGNSTSI KRGEDAENIR VNFVPSKPLS 200
    NNASRQHKNP IEHNDPPLKK ETELYSDKYI SEPILIDLTN DEDDHDVGIL 250
    KGHNVFDEEE SDGFEFDVSD YYDNFSEVDV EEEEEEKEER RRIKTLEAIQ 300
    QQMSDLSVTS STSSNKSVSS SENVPGSCIQ SLPTTAPALP SLPPPPLLNV 350
    DRASSTGALK PHSLETSTTM DSSKIRNPQI SKLMKNNHVP YLKGTKSTPT 400
    LITKSTPTFI TRSKSNTKPI IKSNASSPTS SLTVPNSVIQ KPKTAAMAAK 450
    RVLNSKKVAS NPALNTTKKS HPILKSKTAK VPNSSSKKTS SHPSRPVSNS 500
    KPYSHGASQN KKPSKNQTTS MSKTNRKIPA QKKIGSPKIE DVGTEDATEH 550
    ATSLNEQREE PEIDKKVLRE ILEDEIIDSL QGVDRQAAKQ IFAEIVVHGD 600
    EVHWDDIAGL ESAKYSLKEA VVYPFLRPDL FRGLREPVRG MLLFGPPGTG 650
    KTMLARAVAT ESHSTFFSIS ASSLTSKYLG ESEKLVRALF AIAKKLSPSI 700
    IFVDEIDSIM GSRNNENENE SSRRIKNEFL VQWSSLSSAA AGSNKSNTNN 750
    SDTNGDEDDT RVLVLAATNL PWSIDEAARR RFVRRQYIPL PEDQTRHVQF 800
    KKLLSHQKHT LTESDFDELV KITEGYSGSD ITSLAKDAAM GPLRDLGDKL 850
    LETEREMIRP IGLVDFKNSL VYIKPSVSQD GLVKYEKWAS QFGSSGS 897
    Length:897
    Mass (Da):100,332
    Last modified:February 1, 1995 - v1
    Checksum:iE9780B269700144C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64582.1.
    BK006939 Genomic DNA. Translation: DAA07702.1.
    PIRiS50550.
    RefSeqiNP_010966.1. NM_001178938.1.

    Genome annotation databases

    EnsemblFungiiYER047C; YER047C; YER047C.
    GeneIDi856771.
    KEGGisce:YER047C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64582.1 .
    BK006939 Genomic DNA. Translation: DAA07702.1 .
    PIRi S50550.
    RefSeqi NP_010966.1. NM_001178938.1.

    3D structure databases

    ProteinModelPortali P39955.
    SMRi P39955. Positions 559-889.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36784. 33 interactions.
    DIPi DIP-1550N.
    IntActi P39955. 15 interactions.
    MINTi MINT-407680.
    STRINGi 4932.YER047C.

    Proteomic databases

    MaxQBi P39955.
    PaxDbi P39955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER047C ; YER047C ; YER047C .
    GeneIDi 856771.
    KEGGi sce:YER047C.

    Organism-specific databases

    CYGDi YER047c.
    SGDi S000000849. SAP1.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00570000078874.
    HOGENOMi HOG000216613.
    OMAi HGDEVHW.
    OrthoDBi EOG72JWRT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30226-MONOMER.

    Miscellaneous databases

    NextBioi 982962.

    Gene expression databases

    Genevestigatori P39955.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Association of yeast SAP1, a novel member of the 'AAA' ATPase family of proteins, with the chromatin protein SIN1."
      Liberzon A., Shpungin S., Bangio H., Yona E., Katcoff D.J.
      FEBS Lett. 388:5-10(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSAP1_YEAST
    AccessioniPrimary (citable) accession number: P39955
    Secondary accession number(s): D3DLU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3