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P39953

- YEA6_YEAST

UniProt

P39953 - YEA6_YEAST

Protein

Mitochondrial nicotinamide adenine dinucleotide transporter 2

Gene

YEA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.2 Publications

    GO - Molecular functioni

    1. NAD transporter activity Source: SGD
    2. transporter activity Source: SGD

    GO - Biological processi

    1. NAD transmembrane transport Source: SGD
    2. transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30135-MONOMER.

    Protein family/group databases

    TCDBi2.A.29.10.8. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial nicotinamide adenine dinucleotide transporter 2
    Alternative name(s):
    Mitochondrial NAD(+) transporter 2
    Gene namesi
    Name:YEA6
    Synonyms:NDT2
    Ordered Locus Names:YEL006W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL006w.
    SGDiS000000732. YEA6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Mitochondrial nicotinamide adenine dinucleotide transporter 2PRO_0000090694Add
    BLAST

    Proteomic databases

    MaxQBiP39953.
    PaxDbiP39953.

    Expressioni

    Gene expression databases

    GenevestigatoriP39953.

    Interactioni

    Protein-protein interaction databases

    BioGridi36725. 23 interactions.
    DIPiDIP-4659N.
    MINTiMINT-502454.
    STRINGi4932.YEL006W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39953.
    SMRiP39953. Positions 43-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati36 – 12893Solcar 1Add
    BLAST
    Repeati136 – 22590Solcar 2Add
    BLAST
    Repeati241 – 32989Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314559.
    GeneTreeiENSGT00600000084419.
    HOGENOMiHOG000188210.
    KOiK15115.
    OMAiPLIKITY.
    OrthoDBiEOG73Z352.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39953-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA    50
    LSAMLVCPFD VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL 100
    YKGLQPTVLG YIPTLMIYFS VYDFCRKYSV DIFPHSPFLS NASSAITAGA 150
    ISTVATNPIW VVKTRLMLQT GIGKYSTHYK GTIDTFRKII QQEGAKALYA 200
    GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS SNFQKLILAS 250
    MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG 300
    FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ 335
    Length:335
    Mass (Da):36,961
    Last modified:February 1, 1995 - v1
    Checksum:i91555A2CE81286AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18530 Genomic DNA. Translation: AAB64483.1.
    BK006939 Genomic DNA. Translation: DAA07645.1.
    PIRiS50453.
    RefSeqiNP_010910.1. NM_001178821.1.

    Genome annotation databases

    EnsemblFungiiYEL006W; YEL006W; YEL006W.
    GeneIDi856712.
    KEGGisce:YEL006W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18530 Genomic DNA. Translation: AAB64483.1 .
    BK006939 Genomic DNA. Translation: DAA07645.1 .
    PIRi S50453.
    RefSeqi NP_010910.1. NM_001178821.1.

    3D structure databases

    ProteinModelPortali P39953.
    SMRi P39953. Positions 43-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36725. 23 interactions.
    DIPi DIP-4659N.
    MINTi MINT-502454.
    STRINGi 4932.YEL006W.

    Protein family/group databases

    TCDBi 2.A.29.10.8. the mitochondrial carrier (mc) family.

    Proteomic databases

    MaxQBi P39953.
    PaxDbi P39953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL006W ; YEL006W ; YEL006W .
    GeneIDi 856712.
    KEGGi sce:YEL006W.

    Organism-specific databases

    CYGDi YEL006w.
    SGDi S000000732. YEA6.

    Phylogenomic databases

    eggNOGi NOG314559.
    GeneTreei ENSGT00600000084419.
    HOGENOMi HOG000188210.
    KOi K15115.
    OMAi PLIKITY.
    OrthoDBi EOG73Z352.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30135-MONOMER.

    Miscellaneous databases

    NextBioi 982787.

    Gene expression databases

    Genevestigatori P39953.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae."
      el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.
      Yeast 13:573-581(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae."
      Todisco S., Agrimi G., Castegna A., Palmieri F.
      J. Biol. Chem. 281:1524-1531(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiYEA6_YEAST
    AccessioniPrimary (citable) accession number: P39953
    Secondary accession number(s): D3DLP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1630 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3