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P39953 (YEA6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Alternative name(s):
Mitochondrial NAD(+) transporter 2
Gene names
Name:YEA6
Synonyms:NDT2
Ordered Locus Names:YEL006W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP. Ref.3 Ref.5

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Mitochondrial nicotinamide adenine dinucleotide transporter 2
PRO_0000090694

Regions

Transmembrane42 – 6221Helical; Name=1; Potential
Transmembrane104 – 12421Helical; Name=2; Potential
Transmembrane142 – 16221Helical; Name=3; Potential
Transmembrane198 – 21821Helical; Name=4; Potential
Transmembrane247 – 26721Helical; Name=5; Potential
Transmembrane298 – 31821Helical; Name=6; Potential
Repeat36 – 12893Solcar 1
Repeat136 – 22590Solcar 2
Repeat241 – 32989Solcar 3

Sequences

Sequence LengthMass (Da)Tools
P39953 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 91555A2CE81286AC

FASTA33536,961
        10         20         30         40         50         60 
MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA LSAMLVCPFD 

        70         80         90        100        110        120 
VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL YKGLQPTVLG YIPTLMIYFS 

       130        140        150        160        170        180 
VYDFCRKYSV DIFPHSPFLS NASSAITAGA ISTVATNPIW VVKTRLMLQT GIGKYSTHYK 

       190        200        210        220        230        240 
GTIDTFRKII QQEGAKALYA GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS 

       250        260        270        280        290        300 
SNFQKLILAS MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG 

       310        320        330 
FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae."
el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.
Yeast 13:573-581(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae."
Todisco S., Agrimi G., Castegna A., Palmieri F.
J. Biol. Chem. 281:1524-1531(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18530 Genomic DNA. Translation: AAB64483.1.
BK006939 Genomic DNA. Translation: DAA07645.1.
PIRS50453.
RefSeqNP_010910.1. NM_001178821.1.

3D structure databases

ProteinModelPortalP39953.
SMRP39953. Positions 40-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36725. 23 interactions.
DIPDIP-4659N.
MINTMINT-502454.
STRING4932.YEL006W.

Protein family/group databases

TCDB2.A.29.10.8. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbP39953.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL006W; YEL006W; YEL006W.
GeneID856712.
KEGGsce:YEL006W.

Organism-specific databases

CYGDYEL006w.
SGDS000000732. YEA6.

Phylogenomic databases

eggNOGNOG314559.
GeneTreeENSGT00600000084419.
HOGENOMHOG000188210.
KOK15115.
OMANLETHAL.
OrthoDBEOG73Z352.

Enzyme and pathway databases

BioCycYEAST:G3O-30135-MONOMER.

Gene expression databases

GenevestigatorP39953.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio982787.

Entry information

Entry nameYEA6_YEAST
AccessionPrimary (citable) accession number: P39953
Secondary accession number(s): D3DLP1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families