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Protein

Mitochondrial nicotinamide adenine dinucleotide transporter 2

Gene

YEA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.2 Publications

GO - Molecular functioni

  1. NAD transporter activity Source: SGD
  2. transporter activity Source: SGD

GO - Biological processi

  1. NAD transmembrane transport Source: SGD
  2. transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30135-MONOMER.

Protein family/group databases

TCDBi2.A.29.10.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Alternative name(s):
Mitochondrial NAD(+) transporter 2
Gene namesi
Name:YEA6
Synonyms:NDT2
Ordered Locus Names:YEL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYEL006w.
EuPathDBiFungiDB:YEL006W.
SGDiS000000732. YEA6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Mitochondrial nicotinamide adenine dinucleotide transporter 2PRO_0000090694Add
BLAST

Proteomic databases

MaxQBiP39953.
PaxDbiP39953.

Expressioni

Gene expression databases

GenevestigatoriP39953.

Interactioni

Protein-protein interaction databases

BioGridi36725. 23 interactions.
DIPiDIP-4659N.
MINTiMINT-502454.
STRINGi4932.YEL006W.

Structurei

3D structure databases

ProteinModelPortaliP39953.
SMRiP39953. Positions 43-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 12893Solcar 1Add
BLAST
Repeati136 – 22590Solcar 2Add
BLAST
Repeati241 – 32989Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314559.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000188210.
InParanoidiP39953.
KOiK15115.
OMAiPTHNSAT.
OrthoDBiEOG73Z352.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA
60 70 80 90 100
LSAMLVCPFD VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL
110 120 130 140 150
YKGLQPTVLG YIPTLMIYFS VYDFCRKYSV DIFPHSPFLS NASSAITAGA
160 170 180 190 200
ISTVATNPIW VVKTRLMLQT GIGKYSTHYK GTIDTFRKII QQEGAKALYA
210 220 230 240 250
GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS SNFQKLILAS
260 270 280 290 300
MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG
310 320 330
FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ
Length:335
Mass (Da):36,961
Last modified:February 1, 1995 - v1
Checksum:i91555A2CE81286AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64483.1.
BK006939 Genomic DNA. Translation: DAA07645.1.
PIRiS50453.
RefSeqiNP_010910.1. NM_001178821.1.

Genome annotation databases

EnsemblFungiiYEL006W; YEL006W; YEL006W.
GeneIDi856712.
KEGGisce:YEL006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64483.1.
BK006939 Genomic DNA. Translation: DAA07645.1.
PIRiS50453.
RefSeqiNP_010910.1. NM_001178821.1.

3D structure databases

ProteinModelPortaliP39953.
SMRiP39953. Positions 43-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36725. 23 interactions.
DIPiDIP-4659N.
MINTiMINT-502454.
STRINGi4932.YEL006W.

Protein family/group databases

TCDBi2.A.29.10.8. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP39953.
PaxDbiP39953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL006W; YEL006W; YEL006W.
GeneIDi856712.
KEGGisce:YEL006W.

Organism-specific databases

CYGDiYEL006w.
EuPathDBiFungiDB:YEL006W.
SGDiS000000732. YEA6.

Phylogenomic databases

eggNOGiNOG314559.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000188210.
InParanoidiP39953.
KOiK15115.
OMAiPTHNSAT.
OrthoDBiEOG73Z352.

Enzyme and pathway databases

BioCyciYEAST:G3O-30135-MONOMER.

Miscellaneous databases

NextBioi982787.
PROiP39953.

Gene expression databases

GenevestigatoriP39953.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae."
    el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.
    Yeast 13:573-581(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae."
    Todisco S., Agrimi G., Castegna A., Palmieri F.
    J. Biol. Chem. 281:1524-1531(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiYEA6_YEAST
AccessioniPrimary (citable) accession number: P39953
Secondary accession number(s): D3DLP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.