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P39953

- YEA6_YEAST

UniProt

P39953 - YEA6_YEAST

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Protein
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Gene
YEA6, NDT2, YEL006W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.2 Publications

GO - Molecular functioni

  1. NAD transporter activity Source: SGD
  2. transporter activity Source: SGD

GO - Biological processi

  1. NAD transmembrane transport Source: SGD
  2. transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30135-MONOMER.

Protein family/group databases

TCDBi2.A.29.10.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Alternative name(s):
Mitochondrial NAD(+) transporter 2
Gene namesi
Name:YEA6
Synonyms:NDT2
Ordered Locus Names:YEL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL006w.
SGDiS000000732. YEA6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Mitochondrial nicotinamide adenine dinucleotide transporter 2
PRO_0000090694Add
BLAST

Proteomic databases

MaxQBiP39953.
PaxDbiP39953.

Expressioni

Gene expression databases

GenevestigatoriP39953.

Interactioni

Protein-protein interaction databases

BioGridi36725. 23 interactions.
DIPiDIP-4659N.
MINTiMINT-502454.
STRINGi4932.YEL006W.

Structurei

3D structure databases

ProteinModelPortaliP39953.
SMRiP39953. Positions 43-318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 12893Solcar 1
Add
BLAST
Repeati136 – 22590Solcar 2
Add
BLAST
Repeati241 – 32989Solcar 3
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314559.
GeneTreeiENSGT00600000084419.
HOGENOMiHOG000188210.
KOiK15115.
OMAiPLIKITY.
OrthoDBiEOG73Z352.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39953-1 [UniParc]FASTAAdd to Basket

« Hide

MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA    50
LSAMLVCPFD VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL 100
YKGLQPTVLG YIPTLMIYFS VYDFCRKYSV DIFPHSPFLS NASSAITAGA 150
ISTVATNPIW VVKTRLMLQT GIGKYSTHYK GTIDTFRKII QQEGAKALYA 200
GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS SNFQKLILAS 250
MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG 300
FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ 335
Length:335
Mass (Da):36,961
Last modified:February 1, 1995 - v1
Checksum:i91555A2CE81286AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18530 Genomic DNA. Translation: AAB64483.1.
BK006939 Genomic DNA. Translation: DAA07645.1.
PIRiS50453.
RefSeqiNP_010910.1. NM_001178821.1.

Genome annotation databases

EnsemblFungiiYEL006W; YEL006W; YEL006W.
GeneIDi856712.
KEGGisce:YEL006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18530 Genomic DNA. Translation: AAB64483.1 .
BK006939 Genomic DNA. Translation: DAA07645.1 .
PIRi S50453.
RefSeqi NP_010910.1. NM_001178821.1.

3D structure databases

ProteinModelPortali P39953.
SMRi P39953. Positions 43-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36725. 23 interactions.
DIPi DIP-4659N.
MINTi MINT-502454.
STRINGi 4932.YEL006W.

Protein family/group databases

TCDBi 2.A.29.10.8. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBi P39953.
PaxDbi P39953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL006W ; YEL006W ; YEL006W .
GeneIDi 856712.
KEGGi sce:YEL006W.

Organism-specific databases

CYGDi YEL006w.
SGDi S000000732. YEA6.

Phylogenomic databases

eggNOGi NOG314559.
GeneTreei ENSGT00600000084419.
HOGENOMi HOG000188210.
KOi K15115.
OMAi PLIKITY.
OrthoDBi EOG73Z352.

Enzyme and pathway databases

BioCyci YEAST:G3O-30135-MONOMER.

Miscellaneous databases

NextBioi 982787.

Gene expression databases

Genevestigatori P39953.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae."
    el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.
    Yeast 13:573-581(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae."
    Todisco S., Agrimi G., Castegna A., Palmieri F.
    J. Biol. Chem. 281:1524-1531(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiYEA6_YEAST
AccessioniPrimary (citable) accession number: P39953
Secondary accession number(s): D3DLP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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