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Protein

Cyclin-G1

Gene

Ccng1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cell division Source: UniProtKB-KW
  • cell growth Source: RGD
  • mitotic G2 DNA damage checkpoint Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • response to organonitrogen compound Source: RGD
  • syncytium formation Source: RGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-6804757. Regulation of TP53 Degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:Ccng1
Synonyms:Ccng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2295. Ccng1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804681 – 294Cyclin-G1Add BLAST294

Proteomic databases

PaxDbiP39950.
PRIDEiP39950.

Expressioni

Developmental stagei

Induced within 3 hours after growth stimulation, remains elevated with no apparent cell cycle dependency.

Inductioni

By doxorubicin (DOX).

Gene expression databases

BgeeiENSRNOG00000003256.
ExpressionAtlasiP39950. baseline and differential.
GenevisibleiP39950. RN.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi247440. 2 interactors.
STRINGi10116.ENSRNOP00000063905.

Structurei

3D structure databases

ProteinModelPortaliP39950.
SMRiP39950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP39950.
KOiK10145.
PhylomeDBiP39950.
TreeFamiTF101007.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF268. PTHR10177:SF268. 1 hit.
PfamiView protein in Pfam
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

P39950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL
60 70 80 90 100
RDFEVKDLLS LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC
110 120 130 140 150
FYLAVKSIEE ERNVPLATDL IRISQYRFTV SDLMRMEKIV LEKVCWKVKA
160 170 180 190 200
TTAFQFLQLY YSLIRETLPF ERRNDLNFER LEAQLKACHC RIIFSKAKPS
210 220 230 240 250
VLALAIIALE IQALKYVELT EGVECIQKHS KISGRDLTFW QELVSKCLTE
260 270 280 290
YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETMG
Length:294
Mass (Da):33,934
Last modified:November 1, 1997 - v2
Checksum:i229A5588E66F0DBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70871 mRNA. Translation: CAA50219.1.
BC081852 mRNA. Translation: AAH81852.1.
PIRiS37693.
RefSeqiNP_037055.1. NM_012923.2.
UniGeneiRn.5834.

Genome annotation databases

EnsembliENSRNOT00000065633; ENSRNOP00000063905; ENSRNOG00000003256.
GeneIDi25405.
KEGGirno:25405.
UCSCiRGD:2295. rat.

Similar proteinsi

Entry informationi

Entry nameiCCNG1_RAT
AccessioniPrimary (citable) accession number: P39950
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families