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Protein

Cyclin-G1

Gene

Ccng1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cell division Source: UniProtKB-KW
  • cell growth Source: RGD
  • mitotic G2 DNA damage checkpoint Source: RGD
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: RGD
  • response to organonitrogen compound Source: RGD
  • syncytium formation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-6804757. Regulation of TP53 Degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:Ccng1
Synonyms:Ccng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2295. Ccng1.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: RGD
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cyclin-G1PRO_0000080468Add
BLAST

Proteomic databases

PaxDbiP39950.
PRIDEiP39950.

Expressioni

Developmental stagei

Induced within 3 hours after growth stimulation, remains elevated with no apparent cell cycle dependency.

Inductioni

By doxorubicin (DOX).

Gene expression databases

ExpressionAtlasiP39950. baseline and differential.
GenevisibleiP39950. RN.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi247440. 2 interactions.
STRINGi10116.ENSRNOP00000063905.

Structurei

3D structure databases

ProteinModelPortaliP39950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP39950.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP39950.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 2 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

P39950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL
60 70 80 90 100
RDFEVKDLLS LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC
110 120 130 140 150
FYLAVKSIEE ERNVPLATDL IRISQYRFTV SDLMRMEKIV LEKVCWKVKA
160 170 180 190 200
TTAFQFLQLY YSLIRETLPF ERRNDLNFER LEAQLKACHC RIIFSKAKPS
210 220 230 240 250
VLALAIIALE IQALKYVELT EGVECIQKHS KISGRDLTFW QELVSKCLTE
260 270 280 290
YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETMG
Length:294
Mass (Da):33,934
Last modified:November 1, 1997 - v2
Checksum:i229A5588E66F0DBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70871 mRNA. Translation: CAA50219.1.
BC081852 mRNA. Translation: AAH81852.1.
PIRiS37693.
RefSeqiNP_037055.1. NM_012923.2.
UniGeneiRn.5834.

Genome annotation databases

EnsembliENSRNOT00000065633; ENSRNOP00000063905; ENSRNOG00000003256.
GeneIDi25405.
KEGGirno:25405.
UCSCiRGD:2295. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70871 mRNA. Translation: CAA50219.1.
BC081852 mRNA. Translation: AAH81852.1.
PIRiS37693.
RefSeqiNP_037055.1. NM_012923.2.
UniGeneiRn.5834.

3D structure databases

ProteinModelPortaliP39950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247440. 2 interactions.
STRINGi10116.ENSRNOP00000063905.

Proteomic databases

PaxDbiP39950.
PRIDEiP39950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065633; ENSRNOP00000063905; ENSRNOG00000003256.
GeneIDi25405.
KEGGirno:25405.
UCSCiRGD:2295. rat.

Organism-specific databases

CTDi900.
RGDi2295. Ccng1.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP39950.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP39950.
TreeFamiTF101007.

Enzyme and pathway databases

ReactomeiR-RNO-6804757. Regulation of TP53 Degradation.

Miscellaneous databases

PROiP39950.

Gene expression databases

ExpressionAtlasiP39950. baseline and differential.
GenevisibleiP39950. RN.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 2 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1."
    Tamura K., Kanaoka Y., Jinno S., Nagata A., Ogiso Y., Shimizu K., Hayakawa T., Nojima H., Okayama H.
    Oncogene 8:2113-2118(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Structure and chromosomal assignment of the human cyclin G gene."
    Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.
    Genomics 38:92-95(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  3. "Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites."
    Zauberman A., Lupo A., Oren M.
    Oncogene 10:2361-2366(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Embryonic fibroblast.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  5. "CyclinG contributes to G2/M arrest of cells in response to DNA damage."
    Shimizu A., Nishida J., Ueoka Y., Kato K., Hachiya T., Kuriaki Y., Wake N.
    Biochem. Biophys. Res. Commun. 242:529-533(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCCNG1_RAT
AccessioniPrimary (citable) accession number: P39950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.