true1995-02-012024-03-27153CCNE1_RATCyclin G: a new mammalian cyclin with homology to fission yeast Cig1.Tamura K.Kanaoka Y.Jinno S.Nagata A.Ogiso Y.Shimizu K.Hayakawa T.Nojima H.Okayama H.1993Oncogene82113-2118NUCLEOTIDE SEQUENCE [MRNA]KidneySynergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells.Hosokawa Y.Yang M.Kaneko S.Tanaka M.Nakashima K.1995Biochem. Mol. Biol. Int.37393-399NUCLEOTIDE SEQUENCE [MRNA] OF 152-222Frameshift.Cyclin E1-CDK2 complex1Ccne1EukaryotaG0 and Early G1SCF(Skp2)-mediated degradation of p27/p21DNA Damage/Telomere Stress Induced SenescenceTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestCDK-mediated phosphorylation and removal of Cdc6Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesCyclin E associated events during G1/S transitionCyclin D associated events in G1p53-Dependent G1 DNA Damage ResponsePTK6 Regulates Cell CycleRHOBTB3 ATPase cycleCYCLIN_CCNE1_rpt2Cyclin-likeCyclinCyclin-like_domCyclin-like_sfCyclin_C-domCyclin_NCyclins_cyclin-boxCYCLINSG1_S-SPECIFIC CYCLIN-E1Cyclin_CCyclin_NCYCLINCyclin_CCyclin-likeCYCLINSG1/S-specific cyclin-E1Ccne1CcneEssential for the control of the cell cycle at the G1/S (start) transition.Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. Interacts with INCA1 (By similarity).Phosphorylation of both Thr-396 by GSK3 and Ser-400 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7 (By similarity).Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.Belongs to the cyclin family. Cyclin E subfamily.G1/S-specific cyclin-E1474821411Disordered44Disordered381Phosphothreonine77Phosphoserine104Phosphoserine388Phosphothreonine396Phosphoserine400T221false2Skp12007-11-1324748288bb4450524036349a7cd75340180fd6MPRERKERDSKDHTKMKEEGGSDLSVRSRKRKPNVPVFLQDPDEEIAKIDKTVKSQDSSQPWDDDSACVDPCSFIPTPNKEEDNELEYPKTAFQPRKIRPPRASPLPVLNWANREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWCDIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMEDSHNIQTHTNSLDLLDKAQAKKAILSEQNRISPPPSGVLTPPHSSKKQSSEQETEtruetruetruetruetruetruetruetrue