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Protein

G1/S-specific cyclin-E1

Gene

Ccne1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Biological processi

  • animal organ regeneration Source: RGD
  • antral ovarian follicle growth Source: RGD
  • cell division Source: UniProtKB-KW
  • cellular response to nutrient Source: RGD
  • G1/S transition of mitotic cell cycle Source: InterPro
  • liver development Source: RGD
  • positive regulation of cell differentiation Source: RGD
  • regulation of cell cycle Source: InterPro
  • response to corticosterone Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to methylmercury Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to progesterone Source: RGD
  • response to purine-containing compound Source: RGD
  • response to steroid hormone Source: RGD
  • response to vitamin E Source: RGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E1
Gene namesi
Name:Ccne1
Synonyms:Ccne
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2294 Ccne1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804511 – 411G1/S-specific cyclin-E1Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphothreonineBy similarity1
Modified residuei104PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei396PhosphothreonineBy similarity1
Modified residuei400PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of both Thr-396 by GSK3 and Ser-400 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7 (By similarity).By similarity
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP39949
PRIDEiP39949

PTM databases

PhosphoSitePlusiP39949

Interactioni

Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Skp1Q6PEC42EBI-847441,EBI-919194

Protein-protein interaction databases

DIPiDIP-29865N
IntActiP39949, 1 interactor
STRINGi10116.ENSRNOP00000020014

Structurei

3D structure databases

ProteinModelPortaliP39949
SMRiP39949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiP39949
PhylomeDBiP39949

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF71 PTHR10177:SF71, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P39949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRERKERDS KDHTKMKEEG GSDLSVRSRK RKPNVPVFLQ DPDEEIAKID
60 70 80 90 100
KTVKSQDSSQ PWDDDSACVD PCSFIPTPNK EEDNELEYPK TAFQPRKIRP
110 120 130 140 150
PRASPLPVLN WANREEVWRI MLNKEKTYLR DEHFLQRHPL LQARMRAVLL
160 170 180 190 200
DWLMEVCEVY KLHRETFYLA QDFFDRYMAS QQNIIKTLLQ LIGISALFIA
210 220 230 240 250
SKLEEIYPPK LHQFAYVTDG ACSGDEILTM ELMMMKALKW RLSPLTIVSW
260 270 280 290 300
LNVYVQVAYV NDTGEVLMPQ YPQQVFVQIA ELLDLCVLDV GCLEFPYGVL
310 320 330 340 350
AASALYHFSS LELMQKVSGY QWCDIEKCVK WMVPFAMVIR EMGSSKLKHF
360 370 380 390 400
RGVPMEDSHN IQTHTNSLDL LDKAQAKKAI LSEQNRISPP PSGVLTPPHS
410
SKKQSSEQET E
Length:411
Mass (Da):47,482
Last modified:November 13, 2007 - v2
Checksum:i24CA81652056C036
GO

Sequence cautioni

The sequence BAA03116 differs from that shown. Reason: Frameshift at position 15.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221A → T in BAA09640 (PubMed:8673024).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14015 mRNA Translation: BAA03116.1 Frameshift.
D63164 mRNA Translation: BAA09640.1
UniGeneiRn.15455

Similar proteinsi

Entry informationi

Entry nameiCCNE1_RAT
AccessioniPrimary (citable) accession number: P39949
Secondary accession number(s): O09138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health