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P39949

- CCNE1_RAT

UniProt

P39949 - CCNE1_RAT

Protein

G1/S-specific cyclin-E1

Gene

Ccne1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G1/S (start) transition.

    GO - Molecular functioni

    1. protein complex binding Source: RGD
    2. protein kinase binding Source: RGD

    GO - Biological processi

    1. antral ovarian follicle growth Source: RGD
    2. cell division Source: UniProtKB-KW
    3. cellular response to nutrient Source: RGD
    4. G1/S transition of mitotic cell cycle Source: InterPro
    5. liver development Source: RGD
    6. organ regeneration Source: RGD
    7. positive regulation of cell differentiation Source: RGD
    8. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    9. response to corticosterone Source: RGD
    10. response to cytokine Source: RGD
    11. response to drug Source: RGD
    12. response to estradiol Source: RGD
    13. response to ethanol Source: RGD
    14. response to methylmercury Source: RGD
    15. response to organic cyclic compound Source: RGD
    16. response to organonitrogen compound Source: RGD
    17. response to progesterone Source: RGD
    18. response to purine-containing compound Source: RGD
    19. response to steroid hormone Source: RGD
    20. response to vitamin E Source: RGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin-E1
    Gene namesi
    Name:Ccne1
    Synonyms:Ccne
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2294. Ccne1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: RGD
    2. cytoplasm Source: RGD
    3. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411G1/S-specific cyclin-E1PRO_0000080451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771PhosphothreonineBy similarity
    Modified residuei104 – 1041PhosphoserineBy similarity
    Modified residuei388 – 3881PhosphoserineBy similarity
    Modified residuei396 – 3961PhosphothreonineBy similarity
    Modified residuei400 – 4001PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation of both Thr-396 by GSK3 and Ser-400 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7 By similarity.By similarity
    Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP39949.
    PRIDEiP39949.

    Expressioni

    Gene expression databases

    GenevestigatoriP39949.

    Interactioni

    Subunit structurei

    Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-29865N.

    Structurei

    3D structure databases

    ProteinModelPortaliP39949.
    SMRiP39949. Positions 104-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin E subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000231743.
    HOVERGENiHBG050834.
    InParanoidiP39949.
    PhylomeDBiP39949.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR028858. Cyclin_E.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39949-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRERKERDS KDHTKMKEEG GSDLSVRSRK RKPNVPVFLQ DPDEEIAKID    50
    KTVKSQDSSQ PWDDDSACVD PCSFIPTPNK EEDNELEYPK TAFQPRKIRP 100
    PRASPLPVLN WANREEVWRI MLNKEKTYLR DEHFLQRHPL LQARMRAVLL 150
    DWLMEVCEVY KLHRETFYLA QDFFDRYMAS QQNIIKTLLQ LIGISALFIA 200
    SKLEEIYPPK LHQFAYVTDG ACSGDEILTM ELMMMKALKW RLSPLTIVSW 250
    LNVYVQVAYV NDTGEVLMPQ YPQQVFVQIA ELLDLCVLDV GCLEFPYGVL 300
    AASALYHFSS LELMQKVSGY QWCDIEKCVK WMVPFAMVIR EMGSSKLKHF 350
    RGVPMEDSHN IQTHTNSLDL LDKAQAKKAI LSEQNRISPP PSGVLTPPHS 400
    SKKQSSEQET E 411
    Length:411
    Mass (Da):47,482
    Last modified:November 13, 2007 - v2
    Checksum:i24CA81652056C036
    GO

    Sequence cautioni

    The sequence BAA03116.1 differs from that shown. Reason: Frameshift at position 15.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2211A → T in BAA09640. (PubMed:8673024)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14015 mRNA. Translation: BAA03116.1. Frameshift.
    D63164 mRNA. Translation: BAA09640.1.
    UniGeneiRn.15455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14015 mRNA. Translation: BAA03116.1 . Frameshift.
    D63164 mRNA. Translation: BAA09640.1 .
    UniGenei Rn.15455.

    3D structure databases

    ProteinModelPortali P39949.
    SMRi P39949. Positions 104-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29865N.

    Proteomic databases

    PaxDbi P39949.
    PRIDEi P39949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2294. Ccne1.

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000231743.
    HOVERGENi HBG050834.
    InParanoidi P39949.
    PhylomeDBi P39949.

    Miscellaneous databases

    PROi P39949.

    Gene expression databases

    Genevestigatori P39949.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR028858. Cyclin_E.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF71. PTHR10177:SF71. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1."
      Tamura K., Kanaoka Y., Jinno S., Nagata A., Ogiso Y., Shimizu K., Hayakawa T., Nojima H., Okayama H.
      Oncogene 8:2113-2118(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells."
      Hosokawa Y., Yang M., Kaneko S., Tanaka M., Nakashima K.
      Biochem. Mol. Biol. Int. 37:393-399(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-222.

    Entry informationi

    Entry nameiCCNE1_RAT
    AccessioniPrimary (citable) accession number: P39949
    Secondary accession number(s): O09138
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3