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Protein

Cyclin-C

Gene

Ccnc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Cyclin, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:Ccnc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70905. Ccnc.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804221 – 278Cyclin-CAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP39947.
PRIDEiP39947.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011442.

Structurei

3D structure databases

ProteinModelPortaliP39947.
SMRiP39947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 139Cyclin N-terminalAdd BLAST99

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG0794. Eukaryota.
COG5333. LUCA.
HOGENOMiHOG000008007.
HOVERGENiHBG050836.
InParanoidiP39947.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR028367. CyclinC/Ssn8.
PANTHERiPTHR10026:SF86. PTHR10026:SF86. 1 hit.
PfamiView protein in Pfam
PF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

P39947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNFWQSSH YLQWILDKER QKDLKFLSEE EYWKLQIFFT NVIQALGEHL
60 70 80 90 100
KLRQQVIATA TVYFKRFYAR YSLKSIDPVL MAPTCVFLAS KVEEFGVVSN
110 120 130 140 150
TSLIAATTSV LKTRFSYASP KEFPYRMNHI LECEFYLLEL MDCCLIVYHP
160 170 180 190 200
YRPLLQYVQD MGQEDVLLPL AWRIVNDTYR TDLCLLYPPF MIALACLHVA
210 220 230 240 250
CVVQQKDARQ WFAELSVDME KILEIIRVIL KLYEQWKNFD ERKEMATILS
260 270
KMPKPKPPPN SEGEQGPNGS QNSSYSQS
Length:278
Mass (Da):32,514
Last modified:January 15, 2008 - v2
Checksum:iA8A0EDC18E7FCBE4
GO

Sequence cautioni

The sequence BAA03114 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14013 mRNA. Translation: BAA03114.1. Different initiation.
UniGeneiRn.106758.

Genome annotation databases

UCSCiRGD:70905. rat.

Similar proteinsi

Entry informationi

Entry nameiCCNC_RAT
AccessioniPrimary (citable) accession number: P39947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 15, 2008
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families