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P39944 (UBP5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 5

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 5
Ubiquitin thioesterase 5
Ubiquitin-specific-processing protease 5
Gene names
Name:UBP5
Ordered Locus Names:YER144C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length805 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 rhodanese domain.

Contains 1 USP domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HOF1Q050803EBI-19847,EBI-5412

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 805805Ubiquitin carboxyl-terminal hydrolase 5
PRO_0000080590

Regions

Domain159 – 283125Rhodanese
Domain446 – 804359USP

Sites

Active site4551Nucleophile By similarity
Active site7611Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P39944 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 884054A66370DFF7

FASTA80592,261
        10         20         30         40         50         60 
MGSEQALSEV VESAKERFGR LRHLVQKFLD DDDVPQECLP LLQECAEIWS SYVDACQDIT 

        70         80         90        100        110        120 
MQAPKEDANR LSKGFLRLNE TAFLYYMIVY TLLEDTLPRL KEFSSNKDQN VRNLYGERIQ 

       130        140        150        160        170        180 
LLHNDPNIER IRNVIENYPK FIQLQTIEPG KLSSMLHFHG DALLLIDVRP RSEFVRAHIK 

       190        200        210        220        230        240 
CKNIICIDPA SFKDSFTDQQ IESVSLITSP HSDITFFSNR DKFKFIILYT DTQLHNNFQQ 

       250        260        270        280        290        300 
RQTRILAKIL SQNSVIKPLS GTKILILENG FSNWVKLGGA YQSSVSETAH LTSSSSTPAF 

       310        320        330        340        350        360 
GSPQVPTGLF NQKSLSPNKD KSMPMVSMNT QPLLTTVQRP QLPLYYSDLP IIPQPSPNRN 

       370        380        390        400        410        420 
SPTVQKFSPH PPTTLSKLNT PSTIQNKANT VERISPDIRA AQAHAYLPPA SNVFSPRIPP 

       430        440        450        460        470        480 
LPQQNLSSSR QTILNNSQVL DLDLIVGLEN IGNCCYMNCI LQCLVGTHDL VRMFLDNTYL 

       490        500        510        520        530        540 
NFINFDSSRG SKGLLAKNFA ILVNNMHRHG AFTPPNVRTI PVQTIQFKKI CGHINPMYSD 

       550        560        570        580        590        600 
SMQQDCQEFC QFLLDGLHED LNQNGSKKHL KQLSDEEERM REKMSIRKAS ALEWERFLLT 

       610        620        630        640        650        660 
DFSAIIDLFQ GQYASRLQCQ VCEHTSTTYQ TFSVLSVPVP RVKTCNILDC FREFTKCERL 

       670        680        690        700        710        720 
GVDEQWSCPK CLKKQPSTKQ LKITRLPKKL IINLKRFDNQ MNKNNVFVQY PYSLDLTPYW 

       730        740        750        760        770        780 
ARDFNHEAIV NEDIPTRGQV PPFRYRLYGV ACHSGSLYGG HYTSYVYKGP KKGWYFFDDS 

       790        800 
LYRPITFSTE FITPSAYVLF YERIF 

« Hide

References

« Hide 'large scale' references
[1]"UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product."
Xiao W., Fontanie T., Tang M.
Yeast 10:1497-1502(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10082 Genomic DNA. Translation: AAC48928.1.
U18917 Genomic DNA. Translation: AAB64671.1.
BK006939 Genomic DNA. Translation: DAA07805.1.
PIRS50277.
RefSeqNP_011071.3. NM_001179034.3.

3D structure databases

ProteinModelPortalP39944.
SMRP39944. Positions 445-803.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36893. 29 interactions.
DIPDIP-1716N.
IntActP39944. 7 interactions.
MINTMINT-409937.
STRING4932.YER144C.

Protein family/group databases

MEROPSC19.006.

Proteomic databases

MaxQBP39944.
PaxDbP39944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER144C; YER144C; YER144C.
GeneID856887.
KEGGsce:YER144C.

Organism-specific databases

CYGDYER144c.
SGDS000000946. UBP5.

Phylogenomic databases

eggNOGCOG5533.
GeneTreeENSGT00750000117363.
HOGENOMHOG000248489.
KOK11839.
OMAKGISANE.
OrthoDBEOG7R2BSX.

Enzyme and pathway databases

BioCycYEAST:G3O-30305-MONOMER.

Gene expression databases

GenevestigatorP39944.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR001763. Rhodanese-like_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983284.

Entry information

Entry nameUBP5_YEAST
AccessionPrimary (citable) accession number: P39944
Secondary accession number(s): D3DM51
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries