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Protein

Ubiquitin carboxyl-terminal hydrolase 5

Gene

UBP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei455NucleophilePROSITE-ProRule annotation1
Active sitei761Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  • protein deubiquitination Source: SGD
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-30305-MONOMER
ReactomeiR-SCE-1358803 Downregulation of ERBB2:ERBB3 signaling
R-SCE-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.006

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 5 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 5
Ubiquitin thioesterase 5
Ubiquitin-specific-processing protease 5
Gene namesi
Name:UBP5
Ordered Locus Names:YER144C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER144C
SGDiS000000946 UBP5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805901 – 805Ubiquitin carboxyl-terminal hydrolase 5Add BLAST805

Proteomic databases

MaxQBiP39944
PaxDbiP39944
PRIDEiP39944

Interactioni

Protein-protein interaction databases

BioGridi36893, 80 interactors
DIPiDIP-1716N
IntActiP39944, 7 interactors
MINTiP39944
STRINGi4932.YER144C

Structurei

3D structure databases

ProteinModelPortaliP39944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 283RhodanesePROSITE-ProRule annotationAdd BLAST125
Domaini446 – 804USPAdd BLAST359

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

GeneTreeiENSGT00860000133682
HOGENOMiHOG000248489
InParanoidiP39944
KOiK11839
OMAiQYLRASE
OrthoDBiEOG092C5R71

Family and domain databases

Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P39944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEQALSEV VESAKERFGR LRHLVQKFLD DDDVPQECLP LLQECAEIWS
60 70 80 90 100
SYVDACQDIT MQAPKEDANR LSKGFLRLNE TAFLYYMIVY TLLEDTLPRL
110 120 130 140 150
KEFSSNKDQN VRNLYGERIQ LLHNDPNIER IRNVIENYPK FIQLQTIEPG
160 170 180 190 200
KLSSMLHFHG DALLLIDVRP RSEFVRAHIK CKNIICIDPA SFKDSFTDQQ
210 220 230 240 250
IESVSLITSP HSDITFFSNR DKFKFIILYT DTQLHNNFQQ RQTRILAKIL
260 270 280 290 300
SQNSVIKPLS GTKILILENG FSNWVKLGGA YQSSVSETAH LTSSSSTPAF
310 320 330 340 350
GSPQVPTGLF NQKSLSPNKD KSMPMVSMNT QPLLTTVQRP QLPLYYSDLP
360 370 380 390 400
IIPQPSPNRN SPTVQKFSPH PPTTLSKLNT PSTIQNKANT VERISPDIRA
410 420 430 440 450
AQAHAYLPPA SNVFSPRIPP LPQQNLSSSR QTILNNSQVL DLDLIVGLEN
460 470 480 490 500
IGNCCYMNCI LQCLVGTHDL VRMFLDNTYL NFINFDSSRG SKGLLAKNFA
510 520 530 540 550
ILVNNMHRHG AFTPPNVRTI PVQTIQFKKI CGHINPMYSD SMQQDCQEFC
560 570 580 590 600
QFLLDGLHED LNQNGSKKHL KQLSDEEERM REKMSIRKAS ALEWERFLLT
610 620 630 640 650
DFSAIIDLFQ GQYASRLQCQ VCEHTSTTYQ TFSVLSVPVP RVKTCNILDC
660 670 680 690 700
FREFTKCERL GVDEQWSCPK CLKKQPSTKQ LKITRLPKKL IINLKRFDNQ
710 720 730 740 750
MNKNNVFVQY PYSLDLTPYW ARDFNHEAIV NEDIPTRGQV PPFRYRLYGV
760 770 780 790 800
ACHSGSLYGG HYTSYVYKGP KKGWYFFDDS LYRPITFSTE FITPSAYVLF

YERIF
Length:805
Mass (Da):92,261
Last modified:February 1, 1995 - v1
Checksum:i884054A66370DFF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10082 Genomic DNA Translation: AAC48928.1
U18917 Genomic DNA Translation: AAB64671.1
BK006939 Genomic DNA Translation: DAA07805.1
PIRiS50277
RefSeqiNP_011071.3, NM_001179034.3

Genome annotation databases

EnsemblFungiiYER144C; YER144C; YER144C
GeneIDi856887
KEGGisce:YER144C

Similar proteinsi

Entry informationi

Entry nameiUBP5_YEAST
AccessioniPrimary (citable) accession number: P39944
Secondary accession number(s): D3DM51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Keywords (XML)
    Controlled vocabulary of keywords (XML)
  2. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites

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