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Protein

Transcription corepressor MIG3

Gene

MIG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding transcriptional repressor involved in response to toxic agents such as ribonucleotide reductase inhibitor, hydroxyurea (HU).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri45 – 69C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • cellular response to UV Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: SGD
  • regulation of transcription from RNA polymerase II promoter by glucose Source: SGD
  • response to ethanol Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30209-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription corepressor MIG3
Alternative name(s):
Multicopy inhibitor of growth protein 3
Gene namesi
Name:MIG3
Ordered Locus Names:YER028C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER028C
SGDiS000000830 MIG3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468861 – 394Transcription corepressor MIG3Add BLAST394

Post-translational modificationi

Phosphorylated during genotoxic stress. DNA damage induces phosphorylation by SNF1 or the MEC1 pathway and leads to its inactivation, which allows induction of damage response genes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39943
PaxDbiP39943
PRIDEiP39943

Expressioni

Inductioni

Down-regulated at low calcium levels.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi36763, 35 interactors
DIPiDIP-2545N
IntActiP39943, 4 interactors
MINTiP39943
STRINGi4932.YER028C

Structurei

3D structure databases

ProteinModelPortaliP39943
SMRiP39943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 296Ser-richAdd BLAST134

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri45 – 69C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00550000074455
InParanoidiP39943
KOiK09467
OrthoDBiEOG092C5XWP

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

P39943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYLRDRFPP DNDQRPFRCE ICSRGFHRLE HKKRHGRTHT GEKPHKCTVQ
60 70 80 90 100
GCPKSFSRSD ELKRHLRTHT KGVQRRRIKS KGSRKTVVNT ATAAPTTFNE
110 120 130 140 150
NTGVSLTGIG QSKVPPILIS VAQNCDDVNI RNTGNNNGIV ETQAPAILVP
160 170 180 190 200
VINIPNDPHP IPSSLSTTSI TSIASVYPST SPFQYLKSGF PEDPASTPYV
210 220 230 240 250
HSSGSSLALG ELSSNSSIFS KSRRNLAAMS GPDSLSSSKN QSSASLLSQT
260 270 280 290 300
SHPSKSFSRP PTDLSPLRRI MPSVNTGDME ISRTVSVSSS SSSLTSVTYD
310 320 330 340 350
DTAAKDMGMG IFFDRPPVTQ KACRSNHKYK VNAVSRGRQH ERAQFHISGD
360 370 380 390
DEDSNVHRQE SRASNTSPNV SLPPIKSILR QIDNFNSAPS YFSK
Length:394
Mass (Da):43,119
Last modified:February 1, 1995 - v1
Checksum:i5218D1A0F117BEBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18778 Genomic DNA Translation: AAB64561.1
BK006939 Genomic DNA Translation: DAA07681.1
PIRiS50486
RefSeqiNP_010945.1, NM_001178919.1

Genome annotation databases

EnsemblFungiiYER028C; YER028C; YER028C
GeneIDi856750
KEGGisce:YER028C

Similar proteinsi

Entry informationi

Entry nameiMIG3_YEAST
AccessioniPrimary (citable) accession number: P39943
Secondary accession number(s): D3DLS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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