Reviewed, UniProtKB/Swiss-Prot P39941 (DSF1_YEAST)

Names and origin

Protein names

Recommended name:
    Mannitol dehydrogenase DSF1
    EC=1.1.1.-
Alternative name(s):
    Deletion suppressor of MPT5 mutation protein 1

Gene names

Name:	DSF1
Ordered Locus Names:	YEL070W
AND
Ordered Locus Names:	YNR073C
ORF Names:	N3810

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Disruption phenotype	Rescues temperature-sensitivity of MPT5 deletion. Ref.5
Miscellaneous	Present with 125 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Mannitol dehydrogenase DSF1		PRO_0000170751

Sequences

	Sequence		Length	Mass (Da)
	P39941-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: A7E0CC01AADC1B2A	FASTA	502	56,470
	10 20 30 40 50 60 MTKSDETTAT SLNAKTLKSF ESTLPIPTYP REGVKQGIVH LGVGAFHRSH LAVFMHRLMQ 70 80 90 100 110 120 EHHLKDWSIC GVGLMKADAL MRDAMKAQDC LYTLVERGIK DTNAYIVGSI TAYMYAPDDP 130 140 150 160 170 180 RAVIEKMANP DTHIVSLTVT ENGYYHSEAT NSLMTDAPEI INDLNHPEKP DTLYGYLYEA 190 200 210 220 230 240 LLLRYKRGLT PFTIMSCDNM PQNGVTVKTM LVAFAKLKKD EKFAAWIEDK VTSPNSMVDR 250 260 270 280 290 300 VTPRCTDKER KYVADTWGIK DQCPVVAEPF IQWVLEDNFS DGRPPWELVG VQVVKDVDSY 310 320 330 340 350 360 ELMKLRLLNG GHSAMGYLGY LAGYTYIHEV VNDPTINKYI RVLMREEVIP LLPKVPGVDF 370 380 390 400 410 420 EEYTASVLER FSNPAIQDTV ARICLMGSGK MPKYVLPSIY EQLRKPDGKY KLLAVCVAGW 430 440 450 460 470 480 FRYLTGVDMN GKPFEIEDPM APTLKAAAVK GGKDPHELLN IEVLFSPEIR DNKEFVAQLT 490 500 HSLETVYDKG PIAAIKEILD QV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (YEL070W). Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (YNR073C). Strain: ATCC 204508 / S288c.
[3]	"Sequencing of a 9.2 kb telomeric fragment from the right arm of Saccharomyces cerevisiae chromosome XIV." Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C. Yeast 12:289-295(1996) [PubMed: 8904342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-439 (YNR073C). Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Suppressor analysis of the mpt5/htr1/uth4/puf5 deletion in Saccharomyces cerevisiae." Ohkuni K., Kikuchi Y., Hara K., Taneda T., Hayashi N., Kikuchi A. Mol. Genet. Genomics 275:81-88(2006) [PubMed: 16328373] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18795 Genomic DNA. Translation: AAB65017.1. Z71688 Genomic DNA. Translation: CAA96356.1. Z71689 Genomic DNA. Translation: CAA96358.1. X86790 Genomic DNA. Translation: CAA60486.1.
PIR	S50519.
RefSeq	NP_010844.1. NP_014471.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5120N.
IntAct	P39941. 4 interactions.
Genome annotation databases
Ensembl	YEL070W; YEL070W; YEL070W; Saccharomyces cerevisiae. [Genome view] YNR073C; YNR073C; YNR073C; Saccharomyces cerevisiae. [Genome view]
GeneID	855810. 856639.
KEGG	sce:YEL070W. sce:YNR073C.
Organism-specific databases
CYGD	YEL070w. YNR073c.
SGD	S000000796. DSF1. S000005356. YNR073C.
Phylogenomic databases
HOGENOM	P39941.
OMA	FIENTEV
OrthoDB	EOG90032G
Gene expression databases
Genevestigator	P39941.
GermOnline	YEL070W. Saccharomyces cerevisiae. YNR073C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	980336.

Entry information

Entry name

DSF1_YEAST

Accession

Primary (citable) accession number: P39941

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)