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Protein

40S ribosomal protein S26-B

Gene

RPS26B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 503000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS26 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosome assembly Source: SGD
  • rRNA export from nucleus Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30294-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26-B1 Publication
Alternative name(s):
Small ribosomal subunit protein eS26-B1 Publication
Gene namesi
Name:RPS26B1 Publication
Ordered Locus Names:YER131W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER131W.
SGDiS000000933. RPS26B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045291 – 11940S ribosomal protein S26-BAdd BLAST119

Proteomic databases

PRIDEiP39939.

PTM databases

iPTMnetiP39939.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).1 Publication3 Publications

Protein-protein interaction databases

BioGridi36875. 142 interactors.
DIPiDIP-1395N.
IntActiP39939. 8 interactors.
MINTiMINT-383586.
STRINGi4932.YER131W.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi20 – 22Combined sources3
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Turni32 – 34Combined sources3
Beta strandi37 – 45Combined sources9
Helixi49 – 55Combined sources7
Beta strandi58 – 61Combined sources4
Beta strandi66 – 72Combined sources7
Helixi76 – 80Combined sources5
Beta strandi81 – 83Combined sources3
Helixi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U3MX-ray3.00D6/d62-98[»]
4U3NX-ray3.20D6/d62-98[»]
4U3UX-ray2.90D6/d62-98[»]
4U4NX-ray3.10D6/d62-98[»]
4U4OX-ray3.60D6/d62-98[»]
4U4QX-ray3.00D6/d62-98[»]
4U4RX-ray2.80D6/d62-98[»]
4U4UX-ray3.00D6/d62-98[»]
4U4YX-ray3.20D6/d62-98[»]
4U4ZX-ray3.10D6/d62-98[»]
4U50X-ray3.20D6/d62-98[»]
4U51X-ray3.20D6/d62-98[»]
4U52X-ray3.00D6/d62-98[»]
4U53X-ray3.30D6/d62-98[»]
4U55X-ray3.20D6/d62-98[»]
4U56X-ray3.45D6/d62-98[»]
4U6FX-ray3.10D6/d62-98[»]
5DATX-ray3.15D6/d62-98[»]
5DC3X-ray3.25D6/d62-98[»]
5DGFX-ray3.30D6/d62-98[»]
5DGVX-ray3.10D6/d62-98[»]
5FCJX-ray3.10D6/d62-98[»]
5I4LX-ray3.10D6/d62-98[»]
5LYBX-ray3.25D6/d62-98[»]
5M1Jelectron microscopy3.30a22-99[»]
5TGAX-ray3.30D6/d62-98[»]
5TGMX-ray3.50D6/d62-98[»]
ProteinModelPortaliP39939.
SMRiP39939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000002517.
HOGENOMiHOG000108824.
InParanoidiP39939.
KOiK02976.
OMAiDKAICVT.
OrthoDBiEOG092C5TXE.

Family and domain databases

InterProiView protein in InterPro
IPR000892. Ribosomal_S26e.
PANTHERiPTHR12538. PTHR12538. 1 hit.
PfamiView protein in Pfam
PF01283. Ribosomal_S26e. 1 hit.
PROSITEiView protein in PROSITE
PS00733. RIBOSOMAL_S26E. 1 hit.

Sequencei

Sequence statusi: Complete.

P39939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKRASNGR NKKGRGHVKP VRCVNCSKSI PKDKAIKRMA IRNIVEAAAV
60 70 80 90 100
RDLSEASVYP EYALPKTYNK LHYCVSCAIH ARIVRVRSRE DRKNRAPPQR
110
PRFNRDNKVS PAAAAKKAL
Length:119
Mass (Da):13,447
Last modified:February 1, 1995 - v1
Checksum:i2BB61CF9B232A18E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → P in AAT92801 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03229.1.
AY692782 Genomic DNA. Translation: AAT92801.1.
EF123142 mRNA. Translation: ABM97486.1.
BK006939 Genomic DNA. Translation: DAA07791.1.
PIRiS50634.
RefSeqiNP_011057.1. NM_001179021.1.

Genome annotation databases

EnsemblFungiiYER131W; YER131W; YER131W.
GeneIDi856868.
KEGGisce:YER131W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRS26B_YEAST
AccessioniPrimary (citable) accession number: P39939
Secondary accession number(s): A2TBN5, D3DM37, Q6B2E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names