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Protein

40S ribosomal protein S26-B

Gene

RPS26B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 503000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS26 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosome assembly Source: SGD
  • rRNA export from nucleus Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30294-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SCE-72702 Ribosomal scanning and start codon recognition
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26-B1 Publication
Alternative name(s):
Small ribosomal subunit protein eS26-B1 Publication
Gene namesi
Name:RPS26B1 Publication
Ordered Locus Names:YER131W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER131W
SGDiS000000933 RPS26B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045291 – 11940S ribosomal protein S26-BAdd BLAST119

Proteomic databases

PaxDbiP39939
PRIDEiP39939

PTM databases

CarbonylDBiP39939
iPTMnetiP39939

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).1 Publication3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36875, 145 interactors
DIPiDIP-1395N
IntActiP39939, 23 interactors
MINTiP39939
STRINGi4932.YER131W

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi20 – 22Combined sources3
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Turni32 – 34Combined sources3
Beta strandi37 – 45Combined sources9
Helixi49 – 55Combined sources7
Beta strandi58 – 61Combined sources4
Beta strandi66 – 72Combined sources7
Helixi76 – 80Combined sources5
Beta strandi81 – 83Combined sources3
Helixi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U3MX-ray3.00D6/d62-98[»]
4U3NX-ray3.20D6/d62-98[»]
4U3UX-ray2.90D6/d62-98[»]
4U4NX-ray3.10D6/d62-98[»]
4U4OX-ray3.60D6/d62-98[»]
4U4QX-ray3.00D6/d62-98[»]
4U4RX-ray2.80D6/d62-98[»]
4U4UX-ray3.00D6/d62-98[»]
4U4YX-ray3.20D6/d62-98[»]
4U4ZX-ray3.10D6/d62-98[»]
4U50X-ray3.20D6/d62-98[»]
4U51X-ray3.20D6/d62-98[»]
4U52X-ray3.00D6/d62-98[»]
4U53X-ray3.30D6/d62-98[»]
4U55X-ray3.20D6/d62-98[»]
4U56X-ray3.45D6/d62-98[»]
4U6FX-ray3.10D6/d62-98[»]
5DATX-ray3.15D6/d62-98[»]
5DC3X-ray3.25D6/d62-98[»]
5DGFX-ray3.30D6/d62-98[»]
5DGVX-ray3.10D6/d62-98[»]
5FCJX-ray3.10D6/d62-98[»]
5I4LX-ray3.10D6/d62-98[»]
5LYBX-ray3.25D6/d62-98[»]
5M1Jelectron microscopy3.30a22-99[»]
5MEIX-ray3.50b/d62-98[»]
5NDGX-ray3.70D6/d62-98[»]
5NDVX-ray3.30D6/d62-98[»]
5NDWX-ray3.70D6/d62-98[»]
5OBMX-ray3.40D6/d62-98[»]
5ON6X-ray3.10b/d62-98[»]
5TBWX-ray3.00b/d62-98[»]
5TGAX-ray3.30D6/d62-98[»]
5TGMX-ray3.50D6/d62-98[»]
ProteinModelPortaliP39939
SMRiP39939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000108824
InParanoidiP39939
KOiK02976
OMAiDKAICVT
OrthoDBiEOG092C5TXE

Family and domain databases

Gene3Di3.30.1740.20, 1 hit
InterProiView protein in InterPro
IPR000892 Ribosomal_S26e
IPR038551 Ribosomal_S26e_sf
PANTHERiPTHR12538 PTHR12538, 1 hit
PfamiView protein in Pfam
PF01283 Ribosomal_S26e, 1 hit
PROSITEiView protein in PROSITE
PS00733 RIBOSOMAL_S26E, 1 hit

Sequencei

Sequence statusi: Complete.

P39939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKRASNGR NKKGRGHVKP VRCVNCSKSI PKDKAIKRMA IRNIVEAAAV
60 70 80 90 100
RDLSEASVYP EYALPKTYNK LHYCVSCAIH ARIVRVRSRE DRKNRAPPQR
110
PRFNRDNKVS PAAAAKKAL
Length:119
Mass (Da):13,447
Last modified:February 1, 1995 - v1
Checksum:i2BB61CF9B232A18E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → P in AAT92801 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA Translation: AAC03229.1
AY692782 Genomic DNA Translation: AAT92801.1
EF123142 mRNA Translation: ABM97486.1
BK006939 Genomic DNA Translation: DAA07791.1
PIRiS50634
RefSeqiNP_011057.1, NM_001179021.1

Genome annotation databases

EnsemblFungiiYER131W; YER131W; YER131W
GeneIDi856868
KEGGisce:YER131W

Similar proteinsi

Entry informationi

Entry nameiRS26B_YEAST
AccessioniPrimary (citable) accession number: P39939
Secondary accession number(s): A2TBN5, D3DM37, Q6B2E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health