Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S26-A

Gene

RPS26A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 16300 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS26 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosome assembly Source: SGD
  • rRNA export from nucleus Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30672-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26-A1 Publication
Alternative name(s):
Small ribosomal subunit protein eS26-A1 Publication
Gene namesi
Name:RPS26A1 Publication
Synonyms:RPS26
Ordered Locus Names:YGL189C
ORF Names:G1355
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL189C
SGDiS000003157 RPS26A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045281 – 11940S ribosomal protein S26-AAdd BLAST119

Proteomic databases

MaxQBiP39938
PaxDbiP39938
PRIDEiP39938

PTM databases

iPTMnetiP39938

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).1 Publication3 Publications

Protein-protein interaction databases

BioGridi33067, 63 interactors
DIPiDIP-1396N
IntActiP39938, 7 interactors
MINTiP39938
STRINGi4932.YGL189C

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Turni47 – 49Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10261-119[»]
3J6Yelectron microscopy6.10261-119[»]
3J77electron microscopy6.20261-119[»]
3J78electron microscopy6.30261-119[»]
4V88X-ray3.00Aa/Ca1-119[»]
4V8Yelectron microscopy4.30A01-119[»]
4V8Zelectron microscopy6.60A01-119[»]
4V92electron microscopy3.70a2-98[»]
5DGEX-ray3.45D6/d62-98[»]
5FCIX-ray3.40D6/d62-98[»]
5JUOelectron microscopy4.00XB1-119[»]
5JUPelectron microscopy3.50XB1-119[»]
5JUSelectron microscopy4.20XB1-119[»]
5JUTelectron microscopy4.00XB1-119[»]
5JUUelectron microscopy4.00XB1-119[»]
5LL6electron microscopy3.90e1-119[»]
5MC6electron microscopy3.80e1-119[»]
ProteinModelPortaliP39938
SMRiP39938
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000002517
HOGENOMiHOG000108824
InParanoidiP39938
KOiK02976
OMAiDIKENCI
OrthoDBiEOG092C5TXE

Family and domain databases

Gene3Di3.30.1740.20, 1 hit
InterProiView protein in InterPro
IPR000892 Ribosomal_S26e
IPR038551 Ribosomal_S26e_sf
PANTHERiPTHR12538 PTHR12538, 1 hit
PfamiView protein in Pfam
PF01283 Ribosomal_S26e, 1 hit
PROSITEiView protein in PROSITE
PS00733 RIBOSOMAL_S26E, 1 hit

Sequencei

Sequence statusi: Complete.

P39938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKRASNGR NKKGRGHVKP VRCVNCSKSI PKDKAIKRMA IRNIVEAAAV
60 70 80 90 100
RDLSEASVYP EYALPKTYNK LHYCVSCAIH ARIVRVRSRE DRKNRAPPQR
110
PRFNRENKVS PADAAKKAL
Length:119
Mass (Da):13,505
Last modified:February 1, 1995 - v1
Checksum:i2BB61CF9B233E3FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10563 Genomic DNA Translation: AAA66066.1
X91489 Genomic DNA Translation: CAA62786.1
Z72711 Genomic DNA Translation: CAA96901.1
EF123138 mRNA Translation: ABM97482.1
BK006941 Genomic DNA Translation: DAA07926.1
PIRiS47942
RefSeqiNP_011326.1, NM_001181054.1

Genome annotation databases

EnsemblFungiiYGL189C; YGL189C; YGL189C
GeneIDi852686
KEGGisce:YGL189C

Similar proteinsi

Entry informationi

Entry nameiRS26A_YEAST
AccessioniPrimary (citable) accession number: P39938
Secondary accession number(s): A2TBN5, D6VTW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health