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Protein

40S ribosomal protein S26-A

Gene

RPS26A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 16300 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS26 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosome assembly Source: SGD
  • rRNA export from nucleus Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30672-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26-A1 Publication
Alternative name(s):
Small ribosomal subunit protein eS26-A1 Publication
Gene namesi
Name:RPS26A1 Publication
Synonyms:RPS26
Ordered Locus Names:YGL189C
ORF Names:G1355
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL189C.
SGDiS000003157. RPS26A.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045281 – 11940S ribosomal protein S26-AAdd BLAST119

Proteomic databases

MaxQBiP39938.
PRIDEiP39938.

PTM databases

iPTMnetiP39938.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).1 Publication3 Publications

Protein-protein interaction databases

BioGridi33067. 59 interactors.
DIPiDIP-1396N.
IntActiP39938. 8 interactors.
MINTiMINT-383624.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Beta strandi20 – 22Combined sources3
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Helixi32 – 34Combined sources3
Beta strandi37 – 42Combined sources6
Turni47 – 49Combined sources3
Helixi50 – 55Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi67 – 72Combined sources6
Helixi76 – 80Combined sources5
Turni89 – 92Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10261-119[»]
3J6Yelectron microscopy6.10261-119[»]
3J77electron microscopy6.20261-119[»]
3J78electron microscopy6.30261-119[»]
3V88X-ray3.00a1-119[»]
4V88X-ray3.00Aa/Ca1-119[»]
4V8Yelectron microscopy4.30A01-119[»]
4V8Zelectron microscopy6.60A01-119[»]
4V92electron microscopy3.70a2-98[»]
5DGEX-ray3.45D6/d62-98[»]
5FCIX-ray3.40D6/d62-98[»]
5JUOelectron microscopy4.00XB1-119[»]
5JUPelectron microscopy3.50XB1-119[»]
5JUSelectron microscopy4.20XB1-119[»]
5JUTelectron microscopy4.00XB1-119[»]
5JUUelectron microscopy4.00XB1-119[»]
5MC6electron microscopy3.80e1-119[»]
ProteinModelPortaliP39938.
SMRiP39938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000108824.
InParanoidiP39938.
KOiK02976.
OMAiVRCLNCA.
OrthoDBiEOG092C5TXE.

Family and domain databases

InterProiView protein in InterPro
IPR000892. Ribosomal_S26e.
PANTHERiPTHR12538. PTHR12538. 1 hit.
PfamiView protein in Pfam
PF01283. Ribosomal_S26e. 1 hit.
PROSITEiView protein in PROSITE
PS00733. RIBOSOMAL_S26E. 1 hit.

Sequencei

Sequence statusi: Complete.

P39938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKRASNGR NKKGRGHVKP VRCVNCSKSI PKDKAIKRMA IRNIVEAAAV
60 70 80 90 100
RDLSEASVYP EYALPKTYNK LHYCVSCAIH ARIVRVRSRE DRKNRAPPQR
110
PRFNRENKVS PADAAKKAL
Length:119
Mass (Da):13,505
Last modified:February 1, 1995 - v1
Checksum:i2BB61CF9B233E3FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10563 Genomic DNA. Translation: AAA66066.1.
X91489 Genomic DNA. Translation: CAA62786.1.
Z72711 Genomic DNA. Translation: CAA96901.1.
EF123138 mRNA. Translation: ABM97482.1.
BK006941 Genomic DNA. Translation: DAA07926.1.
PIRiS47942.
RefSeqiNP_011326.1. NM_001181054.1.

Genome annotation databases

EnsemblFungiiYGL189C; YGL189C; YGL189C.
GeneIDi852686.
KEGGisce:YGL189C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10563 Genomic DNA. Translation: AAA66066.1.
X91489 Genomic DNA. Translation: CAA62786.1.
Z72711 Genomic DNA. Translation: CAA96901.1.
EF123138 mRNA. Translation: ABM97482.1.
BK006941 Genomic DNA. Translation: DAA07926.1.
PIRiS47942.
RefSeqiNP_011326.1. NM_001181054.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10261-119[»]
3J6Yelectron microscopy6.10261-119[»]
3J77electron microscopy6.20261-119[»]
3J78electron microscopy6.30261-119[»]
3V88X-ray3.00a1-119[»]
4V88X-ray3.00Aa/Ca1-119[»]
4V8Yelectron microscopy4.30A01-119[»]
4V8Zelectron microscopy6.60A01-119[»]
4V92electron microscopy3.70a2-98[»]
5DGEX-ray3.45D6/d62-98[»]
5FCIX-ray3.40D6/d62-98[»]
5JUOelectron microscopy4.00XB1-119[»]
5JUPelectron microscopy3.50XB1-119[»]
5JUSelectron microscopy4.20XB1-119[»]
5JUTelectron microscopy4.00XB1-119[»]
5JUUelectron microscopy4.00XB1-119[»]
5MC6electron microscopy3.80e1-119[»]
ProteinModelPortaliP39938.
SMRiP39938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33067. 59 interactors.
DIPiDIP-1396N.
IntActiP39938. 8 interactors.
MINTiMINT-383624.

PTM databases

iPTMnetiP39938.

Proteomic databases

MaxQBiP39938.
PRIDEiP39938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL189C; YGL189C; YGL189C.
GeneIDi852686.
KEGGisce:YGL189C.

Organism-specific databases

EuPathDBiFungiDB:YGL189C.
SGDiS000003157. RPS26A.

Phylogenomic databases

HOGENOMiHOG000108824.
InParanoidiP39938.
KOiK02976.
OMAiVRCLNCA.
OrthoDBiEOG092C5TXE.

Enzyme and pathway databases

BioCyciYEAST:G3O-30672-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiPR:P39938.

Family and domain databases

InterProiView protein in InterPro
IPR000892. Ribosomal_S26e.
PANTHERiPTHR12538. PTHR12538. 1 hit.
PfamiView protein in Pfam
PF01283. Ribosomal_S26e. 1 hit.
PROSITEiView protein in PROSITE
PS00733. RIBOSOMAL_S26E. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRS26A_YEAST
AccessioniPrimary (citable) accession number: P39938
Secondary accession number(s): A2TBN5, D6VTW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 10, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.