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Protein

Protein PAC2

Gene

PAC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for viability in the absence of the kinesin-related CIN8 mitotic motor. Seems to be involved in the assembly of alpha-tubulin.

Miscellaneous

Present with 2140 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • tubulin complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30194-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PAC2
Gene namesi
Name:PAC2
Ordered Locus Names:YER007W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER007W.
SGDiS000000809. PAC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835261 – 518Protein PAC2Add BLAST518

Proteomic databases

MaxQBiP39937.
PRIDEiP39937.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi36737. 104 interactors.
DIPiDIP-2342N.
IntActiP39937. 9 interactors.
MINTiMINT-475566.
STRINGi4932.YER007W.

Structurei

3D structure databases

ProteinModelPortaliP39937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 67CAP-GlyPROSITE-ProRule annotationAdd BLAST45
Repeati153 – 174LRR 1Add BLAST22
Repeati179 – 201LRR 2Add BLAST23
Repeati204 – 227LRR 3Add BLAST24
Repeati229 – 252LRR 4Add BLAST24
Repeati255 – 276LRR 5Add BLAST22
Repeati277 – 298LRR 6Add BLAST22
Repeati299 – 319LRR 7Add BLAST21
Repeati324 – 345LRR 8Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063405.
InParanoidiP39937.
KOiK21768.
OMAiRMITVQT.
OrthoDBiEOG092C1EBM.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR029071. Ubiquitin-rel_dom.
PfamiView protein in Pfam
PF01302. CAP_GLY. 1 hit.
PF13516. LRR_6. 2 hits.
SMARTiView protein in SMART
SM01052. CAP_GLY. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiView protein in PROSITE
PS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P39937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYEIGDRLK IGGYFCTIKF IGVIKPWPSV KAYGVEWDDH SRGKHSGTID
60 70 80 90 100
DIHYFDVQIP NSGSFLKESK IKSPGVRRIT FYEALSEKYG GSSNNINDLS
110 120 130 140 150
IGNKRVEGLG FDELNARNKN YKKLRKIALR DSDVAILFQN QDELNRVIQN
160 170 180 190 200
CVNVKDLDLS LNLFTNINSL CEFIEPLKNL ESLNISQNKL LSGWDNLKEY
210 220 230 240 250
DLSHIKTLRL SSCGLSYKHI GKLLKSFRTL KMLDLSYNNL TSAGIQNFEN
260 270 280 290 300
EIPCTLEELN ISGNNLISFP LFPKNLTLKG LNVSNNQISR APSIAIYSVE
310 320 330 340 350
SLDITDNKFK ERSLIDDLNK TFPSLKNIHL SGNEFNYNGN YINVEEQATF
360 370 380 390 400
YEVLARFDRV MVLNGSICDV KTRREAEMFF VSKVMNNELS YDTNLPRWSS
410 420 430 440 450
LIKSYEIDMS KLSFNNERET RQSLVLKIKI RAGKKPSSDL DYWVLPSFTV
460 470 480 490 500
RYVKSVICRK LNFDILNVKL FHENSEGMIN EIKYNFRPIS DFNVVNGDII
510
HVSSPVNNKS IQKVNSPS
Length:518
Mass (Da):59,258
Last modified:February 1, 1995 - v1
Checksum:i3997C60547D04A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16814 Genomic DNA. Translation: AAB00683.1.
U18778 Genomic DNA. Translation: AAB64540.1.
BK006939 Genomic DNA. Translation: DAA07657.1.
PIRiS50465.
RefSeqiNP_010922.1. NM_001178898.1.

Genome annotation databases

EnsemblFungiiYER007W; YER007W; YER007W.
GeneIDi856724.
KEGGisce:YER007W.

Similar proteinsi

Entry informationi

Entry nameiPAC2_YEAST
AccessioniPrimary (citable) accession number: P39937
Secondary accession number(s): D3DLQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names