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P39937 (PAC2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PAC2
Gene names
Name:PAC2
Ordered Locus Names:YER007W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for viability in the absence of the kinesin-related CIN8 mitotic motor. Seems to be involved in the assembly of alpha-tubulin.

Subcellular location

Cytoplasmcytoskeleton Probable.

Miscellaneous

Present with 2140 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 CAP-Gly domain.

Contains 8 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Protein PAC2
PRO_0000083526

Regions

Domain23 – 6745CAP-Gly
Repeat153 – 17422LRR 1
Repeat179 – 20123LRR 2
Repeat204 – 22724LRR 3
Repeat229 – 25224LRR 4
Repeat255 – 27622LRR 5
Repeat277 – 29822LRR 6
Repeat299 – 31921LRR 7
Repeat324 – 34522LRR 8

Sequences

Sequence LengthMass (Da)Tools
P39937 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 3997C60547D04A4A

FASTA51859,258
        10         20         30         40         50         60 
MTYEIGDRLK IGGYFCTIKF IGVIKPWPSV KAYGVEWDDH SRGKHSGTID DIHYFDVQIP 

        70         80         90        100        110        120 
NSGSFLKESK IKSPGVRRIT FYEALSEKYG GSSNNINDLS IGNKRVEGLG FDELNARNKN 

       130        140        150        160        170        180 
YKKLRKIALR DSDVAILFQN QDELNRVIQN CVNVKDLDLS LNLFTNINSL CEFIEPLKNL 

       190        200        210        220        230        240 
ESLNISQNKL LSGWDNLKEY DLSHIKTLRL SSCGLSYKHI GKLLKSFRTL KMLDLSYNNL 

       250        260        270        280        290        300 
TSAGIQNFEN EIPCTLEELN ISGNNLISFP LFPKNLTLKG LNVSNNQISR APSIAIYSVE 

       310        320        330        340        350        360 
SLDITDNKFK ERSLIDDLNK TFPSLKNIHL SGNEFNYNGN YINVEEQATF YEVLARFDRV 

       370        380        390        400        410        420 
MVLNGSICDV KTRREAEMFF VSKVMNNELS YDTNLPRWSS LIKSYEIDMS KLSFNNERET 

       430        440        450        460        470        480 
RQSLVLKIKI RAGKKPSSDL DYWVLPSFTV RYVKSVICRK LNFDILNVKL FHENSEGMIN 

       490        500        510 
EIKYNFRPIS DFNVVNGDII HVSSPVNNKS IQKVNSPS 

« Hide

References

« Hide 'large scale' references
[1]"Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability."
Hoyt M.A., Macke J.P., Roberts B.T., Geiser J.R.
Genetics 146:849-857(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U16814 Genomic DNA. Translation: AAB00683.1.
U18778 Genomic DNA. Translation: AAB64540.1.
BK006939 Genomic DNA. Translation: DAA07657.1.
PIRS50465.
RefSeqNP_010922.1. NM_001178898.1.

3D structure databases

ProteinModelPortalP39937.
SMRP39937. Positions 2-74, 118-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36737. 53 interactions.
DIPDIP-2342N.
MINTMINT-475566.
STRING4932.YER007W.

Proteomic databases

PaxDbP39937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER007W; YER007W; YER007W.
GeneID856724.
KEGGsce:YER007W.

Organism-specific databases

CYGDYER007w.
SGDS000000809. PAC2.

Phylogenomic databases

eggNOGNOG245706.
GeneTreeENSGT00530000063405.
OMARGKNNGE.
OrthoDBEOG76DV2B.

Enzyme and pathway databases

BioCycYEAST:G3O-30194-MONOMER.

Gene expression databases

GenevestigatorP39937.

Family and domain databases

Gene3D2.30.30.190. 1 hit.
InterProIPR000938. CAP-Gly_domain.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamPF01302. CAP_GLY. 1 hit.
PF00560. LRR_1. 1 hit.
[Graphical view]
SMARTSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMSSF74924. SSF74924. 1 hit.
PROSITEPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982823.
PROP39937.

Entry information

Entry namePAC2_YEAST
AccessionPrimary (citable) accession number: P39937
Secondary accession number(s): D3DLQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families