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Protein

Protein PAC2

Gene

PAC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for viability in the absence of the kinesin-related CIN8 mitotic motor. Seems to be involved in the assembly of alpha-tubulin.

GO - Molecular functioni

  • alpha-tubulin binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30194-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PAC2
Gene namesi
Name:PAC2
Ordered Locus Names:YER007W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER007W.
SGDiS000000809. PAC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Protein PAC2PRO_0000083526Add
BLAST

Proteomic databases

MaxQBiP39937.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi36737. 56 interactions.
DIPiDIP-2342N.
MINTiMINT-475566.

Structurei

3D structure databases

ProteinModelPortaliP39937.
SMRiP39937. Positions 92-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 6745CAP-GlyPROSITE-ProRule annotationAdd
BLAST
Repeati153 – 17422LRR 1Add
BLAST
Repeati179 – 20123LRR 2Add
BLAST
Repeati204 – 22724LRR 3Add
BLAST
Repeati229 – 25224LRR 4Add
BLAST
Repeati255 – 27622LRR 5Add
BLAST
Repeati277 – 29822LRR 6Add
BLAST
Repeati299 – 31921LRR 7Add
BLAST
Repeati324 – 34522LRR 8Add
BLAST

Sequence similaritiesi

Contains 1 CAP-Gly domain.PROSITE-ProRule annotation
Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063405.
InParanoidiP39937.
OMAiNNERETR.
OrthoDBiEOG76DV2B.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF13516. LRR_6. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYEIGDRLK IGGYFCTIKF IGVIKPWPSV KAYGVEWDDH SRGKHSGTID
60 70 80 90 100
DIHYFDVQIP NSGSFLKESK IKSPGVRRIT FYEALSEKYG GSSNNINDLS
110 120 130 140 150
IGNKRVEGLG FDELNARNKN YKKLRKIALR DSDVAILFQN QDELNRVIQN
160 170 180 190 200
CVNVKDLDLS LNLFTNINSL CEFIEPLKNL ESLNISQNKL LSGWDNLKEY
210 220 230 240 250
DLSHIKTLRL SSCGLSYKHI GKLLKSFRTL KMLDLSYNNL TSAGIQNFEN
260 270 280 290 300
EIPCTLEELN ISGNNLISFP LFPKNLTLKG LNVSNNQISR APSIAIYSVE
310 320 330 340 350
SLDITDNKFK ERSLIDDLNK TFPSLKNIHL SGNEFNYNGN YINVEEQATF
360 370 380 390 400
YEVLARFDRV MVLNGSICDV KTRREAEMFF VSKVMNNELS YDTNLPRWSS
410 420 430 440 450
LIKSYEIDMS KLSFNNERET RQSLVLKIKI RAGKKPSSDL DYWVLPSFTV
460 470 480 490 500
RYVKSVICRK LNFDILNVKL FHENSEGMIN EIKYNFRPIS DFNVVNGDII
510
HVSSPVNNKS IQKVNSPS
Length:518
Mass (Da):59,258
Last modified:February 1, 1995 - v1
Checksum:i3997C60547D04A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16814 Genomic DNA. Translation: AAB00683.1.
U18778 Genomic DNA. Translation: AAB64540.1.
BK006939 Genomic DNA. Translation: DAA07657.1.
PIRiS50465.
RefSeqiNP_010922.1. NM_001178898.1.

Genome annotation databases

EnsemblFungiiYER007W; YER007W; YER007W.
GeneIDi856724.
KEGGisce:YER007W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16814 Genomic DNA. Translation: AAB00683.1.
U18778 Genomic DNA. Translation: AAB64540.1.
BK006939 Genomic DNA. Translation: DAA07657.1.
PIRiS50465.
RefSeqiNP_010922.1. NM_001178898.1.

3D structure databases

ProteinModelPortaliP39937.
SMRiP39937. Positions 92-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36737. 56 interactions.
DIPiDIP-2342N.
MINTiMINT-475566.

Proteomic databases

MaxQBiP39937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER007W; YER007W; YER007W.
GeneIDi856724.
KEGGisce:YER007W.

Organism-specific databases

EuPathDBiFungiDB:YER007W.
SGDiS000000809. PAC2.

Phylogenomic databases

GeneTreeiENSGT00530000063405.
InParanoidiP39937.
OMAiNNERETR.
OrthoDBiEOG76DV2B.

Enzyme and pathway databases

BioCyciYEAST:G3O-30194-MONOMER.

Miscellaneous databases

PROiP39937.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF13516. LRR_6. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability."
    Hoyt M.A., Macke J.P., Roberts B.T., Geiser J.R.
    Genetics 146:849-857(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPAC2_YEAST
AccessioniPrimary (citable) accession number: P39937
Secondary accession number(s): D3DLQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2140 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.