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Protein

Transcription factor IIIA

Gene

PZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 7426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri80 – 10223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri108 – 13023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15926C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18624C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21926C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38925C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34309-MONOMER.
ReactomeiR-SCE-73780. RNA Polymerase III Chain Elongation.
R-SCE-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-SCE-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-SCE-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-SCE-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Alternative name(s):
Putative zinc finger protein 1
Gene namesi
Name:PZF1
Synonyms:TFC2, TFIIIA
Ordered Locus Names:YPR186C
ORF Names:P9677.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR186C.
SGDiS000006390. PZF1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Transcription factor IIIAPRO_0000047086Add
BLAST

Proteomic databases

MaxQBiP39933.

PTM databases

iPTMnetiP39933.

Interactioni

GO - Molecular functioni

  • TFIIIC-class transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi36358. 22 interactions.
MINTiMINT-2781143.

Structurei

3D structure databases

ProteinModelPortaliP39933.
SMRiP39933. Positions 47-272, 354-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4320Ser-richAdd
BLAST
Compositional biasi321 – 3277Arg/Lys-rich (basic)

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 7426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri80 – 10223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri108 – 13023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15926C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18624C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21926C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27725C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38925C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00750000117653.
HOGENOMiHOG000248089.
InParanoidiP39933.
OMAiKGVTTRQ.
OrthoDBiEOG092C5UG7.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEVLNNEG MPLAELKQET IPISRSESSE SLNSLTSTRS SSSNRPKTYF
60 70 80 90 100
CDYDGCDKAF TRPSILTEHQ LSVHQGLRAF QCDKCAKSFV KKSHLERHLY
110 120 130 140 150
THSDTKPFQC SYCGKGVTTR QQLKRHEVTH TKSFICPEEG CNLRFYKHPQ
160 170 180 190 200
LRAHILSVHL HKLTCPHCNK SFQRPYRLRN HISKHHDPEV ENPYQCTFAG
210 220 230 240 250
CCKEFRIWSQ LQSHIKNDHP KLKCPICSKP CVGENGLQMH MIIHDDSLVT
260 270 280 290 300
KNWKCHICPD MSFSRKHDLL THYGSIHTEE DIPLELKYKI SDIQQLVQDH
310 320 330 340 350
GVQLGNSKHS NEQDEEKISN RLRKRRKLTE NNNVEFLQNE VDLEKRLESG
360 370 380 390 400
ENGLNLLLNT VGRKYRCFYN NCSRTFKTKE KYEKHIDKHK VHELKLKILQ
410 420
EKEENKTLVD QNHKEPFIIQ KETQSAGDK
Length:429
Mass (Da):50,027
Last modified:February 1, 1995 - v1
Checksum:i209B1EDEA20422D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80611 Genomic DNA. Translation: AAB08014.1.
M90638 Genomic DNA. No translation available.
U25841 Genomic DNA. Translation: AAB64615.1.
BK006949 Genomic DNA. Translation: DAA11602.1.
PIRiS20050.
RefSeqiNP_015512.1. NM_001184283.1.

Genome annotation databases

EnsemblFungiiYPR186C; YPR186C; YPR186C.
GeneIDi856316.
KEGGisce:YPR186C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80611 Genomic DNA. Translation: AAB08014.1.
M90638 Genomic DNA. No translation available.
U25841 Genomic DNA. Translation: AAB64615.1.
BK006949 Genomic DNA. Translation: DAA11602.1.
PIRiS20050.
RefSeqiNP_015512.1. NM_001184283.1.

3D structure databases

ProteinModelPortaliP39933.
SMRiP39933. Positions 47-272, 354-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36358. 22 interactions.
MINTiMINT-2781143.

PTM databases

iPTMnetiP39933.

Proteomic databases

MaxQBiP39933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR186C; YPR186C; YPR186C.
GeneIDi856316.
KEGGisce:YPR186C.

Organism-specific databases

EuPathDBiFungiDB:YPR186C.
SGDiS000006390. PZF1.

Phylogenomic databases

GeneTreeiENSGT00750000117653.
HOGENOMiHOG000248089.
InParanoidiP39933.
OMAiKGVTTRQ.
OrthoDBiEOG092C5UG7.

Enzyme and pathway databases

BioCyciYEAST:G3O-34309-MONOMER.
ReactomeiR-SCE-73780. RNA Polymerase III Chain Elongation.
R-SCE-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-SCE-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-SCE-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-SCE-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

PROiP39933.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3A_YEAST
AccessioniPrimary (citable) accession number: P39933
Secondary accession number(s): D6W4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.