Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sugar transporter STL1

Gene

STL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • solute:proton symporter activity Source: SGD

GO - Biological processi

  • glycerol transport Source: SGD
  • proton transport Source: GOC
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30046-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.38. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter STL1
Gene namesi
Name:STL1
Ordered Locus Names:YDR536W
ORF Names:D9719.39
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

CYGDiYDR536w.
EuPathDBiFungiDB:YDR536W.
SGDiS000002944. STL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 7929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 1077CytoplasmicSequence Analysis
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 1291ExtracellularSequence Analysis
Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini151 – 16818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini190 – 20314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini225 – 29167CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini313 – 33018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei331 – 35121Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini352 – 3587CytoplasmicSequence Analysis
Transmembranei359 – 37921Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini380 – 38910ExtracellularSequence Analysis
Transmembranei390 – 41021Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini411 – 42616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei427 – 44721Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini448 – 4536ExtracellularSequence Analysis
Transmembranei454 – 47421Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini475 – 56995CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Sugar transporter STL1PRO_0000050461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi32584. 29 interactions.
DIPiDIP-5275N.
IntActiP39932. 1 interaction.
MINTiMINT-551224.

Structurei

3D structure databases

ProteinModelPortaliP39932.
SMRiP39932. Positions 29-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000167080.
InParanoidiP39932.
OMAiVITEVAM.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLKLSNFK GKFISRTSHW GLTGKKLRYF ITIASMTGFS LFGYDQGLMA
60 70 80 90 100
SLITGKQFNY EFPATKENGD HDRHATVVQG ATTSCYELGC FAGSLFVMFC
110 120 130 140 150
GERIGRKPLI LMGSVITIIG AVISTCAFRG YWALGQFIIG RVVTGVGTGL
160 170 180 190 200
NTSTIPVWQS EMSKAENRGL LVNLEGSTIA FGTMIAYWID FGLSYTNSSV
210 220 230 240 250
QWRFPVSMQI VFALFLLAFM IKLPESPRWL ISQSRTEEAR YLVGTLDDAD
260 270 280 290 300
PNDEEVITEV AMLHDAVNRT KHEKHSLSSL FSRGRSQNLQ RALIAASTQF
310 320 330 340 350
FQQFTGCNAA IYYSTVLFNK TIKLDYRLSM IIGGVFATIY ALSTIGSFFL
360 370 380 390 400
IEKLGRRKLF LLGATGQAVS FTITFACLVK ENKENARGAA VGLFLFITFF
410 420 430 440 450
GLSLLSLPWI YPPEIASMKV RASTNAFSTC TNWLCNFAVV MFTPIFIGQS
460 470 480 490 500
GWGCYLFFAV MNYLYIPVIF FFYPETAGRS LEEIDIIFAK AYEDGTQPWR
510 520 530 540 550
VANHLPKLSL QEVEDHANAL GSYDDEMEKE DFGEDRVEDT YNQINGDNSS
560
SSSNIKNEDT VNDKANFEG
Length:569
Mass (Da):63,532
Last modified:October 1, 1996 - v2
Checksum:i053F3C546F84F056
GO

Sequence cautioni

The sequence AAA57229.1 differs from that shown. Reason: Frameshift at position 537. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371E → G in AAU09713 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
U33057 Genomic DNA. Translation: AAB64975.1.
AY723796 Genomic DNA. Translation: AAU09713.1.
BK006938 Genomic DNA. Translation: DAA12366.1.
PIRiS69591.
RefSeqiNP_010825.3. NM_001180844.3.

Genome annotation databases

EnsemblFungiiYDR536W; YDR536W; YDR536W.
GeneIDi852149.
KEGGisce:YDR536W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
U33057 Genomic DNA. Translation: AAB64975.1.
AY723796 Genomic DNA. Translation: AAU09713.1.
BK006938 Genomic DNA. Translation: DAA12366.1.
PIRiS69591.
RefSeqiNP_010825.3. NM_001180844.3.

3D structure databases

ProteinModelPortaliP39932.
SMRiP39932. Positions 29-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32584. 29 interactions.
DIPiDIP-5275N.
IntActiP39932. 1 interaction.
MINTiMINT-551224.

Protein family/group databases

TCDBi2.A.1.1.38. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR536W; YDR536W; YDR536W.
GeneIDi852149.
KEGGisce:YDR536W.

Organism-specific databases

CYGDiYDR536w.
EuPathDBiFungiDB:YDR536W.
SGDiS000002944. STL1.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000167080.
InParanoidiP39932.
OMAiVITEVAM.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-30046-MONOMER.

Miscellaneous databases

NextBioi970573.
PROiP39932.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein."
    Zhao S., Douglas N.W., Heine M.J., Williams G.M., Winther-Larsen H.C., Meaden P.G.
    Gene 146:215-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiSTL1_YEAST
AccessioniPrimary (citable) accession number: P39932
Secondary accession number(s): D6VTF6, E9P950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.