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Protein

Sugar transporter STL1

Gene

STL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • glycerol transport Source: SGD
  • hexose transmembrane transport Source: GO_Central
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30046-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.38. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter STL1
Gene namesi
Name:STL1
Ordered Locus Names:YDR536W
ORF Names:D9719.39
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR536W.
SGDiS000002944. STL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 79ExtracellularSequence analysisAdd BLAST29
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini101 – 107CytoplasmicSequence analysis7
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129ExtracellularSequence analysis1
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 168CytoplasmicSequence analysisAdd BLAST18
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 203ExtracellularSequence analysisAdd BLAST14
Transmembranei204 – 224Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini225 – 291CytoplasmicSequence analysisAdd BLAST67
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 330ExtracellularSequence analysisAdd BLAST18
Transmembranei331 – 351Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini352 – 358CytoplasmicSequence analysis7
Transmembranei359 – 379Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini380 – 389ExtracellularSequence analysis10
Transmembranei390 – 410Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini411 – 426CytoplasmicSequence analysisAdd BLAST16
Transmembranei427 – 447Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini448 – 453ExtracellularSequence analysis6
Transmembranei454 – 474Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini475 – 569CytoplasmicSequence analysisAdd BLAST95

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504611 – 569Sugar transporter STL1Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi32584. 29 interactors.
DIPiDIP-5275N.
IntActiP39932. 1 interactor.
MINTiMINT-551224.

Structurei

3D structure databases

ProteinModelPortaliP39932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000132021.
HOGENOMiHOG000167080.
InParanoidiP39932.
OMAiVITEVAM.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLKLSNFK GKFISRTSHW GLTGKKLRYF ITIASMTGFS LFGYDQGLMA
60 70 80 90 100
SLITGKQFNY EFPATKENGD HDRHATVVQG ATTSCYELGC FAGSLFVMFC
110 120 130 140 150
GERIGRKPLI LMGSVITIIG AVISTCAFRG YWALGQFIIG RVVTGVGTGL
160 170 180 190 200
NTSTIPVWQS EMSKAENRGL LVNLEGSTIA FGTMIAYWID FGLSYTNSSV
210 220 230 240 250
QWRFPVSMQI VFALFLLAFM IKLPESPRWL ISQSRTEEAR YLVGTLDDAD
260 270 280 290 300
PNDEEVITEV AMLHDAVNRT KHEKHSLSSL FSRGRSQNLQ RALIAASTQF
310 320 330 340 350
FQQFTGCNAA IYYSTVLFNK TIKLDYRLSM IIGGVFATIY ALSTIGSFFL
360 370 380 390 400
IEKLGRRKLF LLGATGQAVS FTITFACLVK ENKENARGAA VGLFLFITFF
410 420 430 440 450
GLSLLSLPWI YPPEIASMKV RASTNAFSTC TNWLCNFAVV MFTPIFIGQS
460 470 480 490 500
GWGCYLFFAV MNYLYIPVIF FFYPETAGRS LEEIDIIFAK AYEDGTQPWR
510 520 530 540 550
VANHLPKLSL QEVEDHANAL GSYDDEMEKE DFGEDRVEDT YNQINGDNSS
560
SSSNIKNEDT VNDKANFEG
Length:569
Mass (Da):63,532
Last modified:October 1, 1996 - v2
Checksum:i053F3C546F84F056
GO

Sequence cautioni

The sequence AAA57229 differs from that shown. Reason: Frameshift at position 537.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237E → G in AAU09713 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
U33057 Genomic DNA. Translation: AAB64975.1.
AY723796 Genomic DNA. Translation: AAU09713.1.
BK006938 Genomic DNA. Translation: DAA12366.1.
PIRiS69591.
RefSeqiNP_010825.3. NM_001180844.3.

Genome annotation databases

EnsemblFungiiYDR536W; YDR536W; YDR536W.
GeneIDi852149.
KEGGisce:YDR536W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
U33057 Genomic DNA. Translation: AAB64975.1.
AY723796 Genomic DNA. Translation: AAU09713.1.
BK006938 Genomic DNA. Translation: DAA12366.1.
PIRiS69591.
RefSeqiNP_010825.3. NM_001180844.3.

3D structure databases

ProteinModelPortaliP39932.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32584. 29 interactors.
DIPiDIP-5275N.
IntActiP39932. 1 interactor.
MINTiMINT-551224.

Protein family/group databases

TCDBi2.A.1.1.38. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR536W; YDR536W; YDR536W.
GeneIDi852149.
KEGGisce:YDR536W.

Organism-specific databases

EuPathDBiFungiDB:YDR536W.
SGDiS000002944. STL1.

Phylogenomic databases

GeneTreeiENSGT00840000132021.
HOGENOMiHOG000167080.
InParanoidiP39932.
OMAiVITEVAM.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-30046-MONOMER.

Miscellaneous databases

PROiP39932.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTL1_YEAST
AccessioniPrimary (citable) accession number: P39932
Secondary accession number(s): D6VTF6, E9P950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.