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P39932 (STL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sugar transporter STL1
Gene names
Name:STL1
Ordered Locus Names:YDR536W
ORF Names:D9719.39
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence caution

The sequence AAA57229.1 differs from that shown. Reason: Frameshift at position 537.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Sugar transporter STL1
PRO_0000050461

Regions

Topological domain1 – 2929Cytoplasmic Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 7929Extracellular Potential
Transmembrane80 – 10021Helical; Name=2; Potential
Topological domain101 – 1077Cytoplasmic Potential
Transmembrane108 – 12821Helical; Name=3; Potential
Topological domain1291Extracellular Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 16818Cytoplasmic Potential
Transmembrane169 – 18921Helical; Name=5; Potential
Topological domain190 – 20314Extracellular Potential
Transmembrane204 – 22421Helical; Name=6; Potential
Topological domain225 – 29167Cytoplasmic Potential
Transmembrane292 – 31221Helical; Name=7; Potential
Topological domain313 – 33018Extracellular Potential
Transmembrane331 – 35121Helical; Name=8; Potential
Topological domain352 – 3587Cytoplasmic Potential
Transmembrane359 – 37921Helical; Name=9; Potential
Topological domain380 – 38910Extracellular Potential
Transmembrane390 – 41021Helical; Name=10; Potential
Topological domain411 – 42616Cytoplasmic Potential
Transmembrane427 – 44721Helical; Name=11; Potential
Topological domain448 – 4536Extracellular Potential
Transmembrane454 – 47421Helical; Name=12; Potential
Topological domain475 – 56995Cytoplasmic Potential

Amino acid modifications

Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation3191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2371E → G in AAU09713. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P39932 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 053F3C546F84F056

FASTA56963,532
        10         20         30         40         50         60 
MKDLKLSNFK GKFISRTSHW GLTGKKLRYF ITIASMTGFS LFGYDQGLMA SLITGKQFNY 

        70         80         90        100        110        120 
EFPATKENGD HDRHATVVQG ATTSCYELGC FAGSLFVMFC GERIGRKPLI LMGSVITIIG 

       130        140        150        160        170        180 
AVISTCAFRG YWALGQFIIG RVVTGVGTGL NTSTIPVWQS EMSKAENRGL LVNLEGSTIA 

       190        200        210        220        230        240 
FGTMIAYWID FGLSYTNSSV QWRFPVSMQI VFALFLLAFM IKLPESPRWL ISQSRTEEAR 

       250        260        270        280        290        300 
YLVGTLDDAD PNDEEVITEV AMLHDAVNRT KHEKHSLSSL FSRGRSQNLQ RALIAASTQF 

       310        320        330        340        350        360 
FQQFTGCNAA IYYSTVLFNK TIKLDYRLSM IIGGVFATIY ALSTIGSFFL IEKLGRRKLF 

       370        380        390        400        410        420 
LLGATGQAVS FTITFACLVK ENKENARGAA VGLFLFITFF GLSLLSLPWI YPPEIASMKV 

       430        440        450        460        470        480 
RASTNAFSTC TNWLCNFAVV MFTPIFIGQS GWGCYLFFAV MNYLYIPVIF FFYPETAGRS 

       490        500        510        520        530        540 
LEEIDIIFAK AYEDGTQPWR VANHLPKLSL QEVEDHANAL GSYDDEMEKE DFGEDRVEDT 

       550        560 
YNQINGDNSS SSSNIKNEDT VNDKANFEG

« Hide

References

« Hide 'large scale' references
[1]"The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein."
Zhao S., Douglas N.W., Heine M.J., Williams G.M., Winther-Larsen H.C., Meaden P.G.
Gene 146:215-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
U33057 Genomic DNA. Translation: AAB64975.1.
AY723796 Genomic DNA. Translation: AAU09713.1.
BK006938 Genomic DNA. Translation: DAA12366.1.
PIRS69591.
RefSeqNP_010825.3. NM_001180844.3.

3D structure databases

ProteinModelPortalP39932.
SMRP39932. Positions 29-488.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5275N.
IntActP39932. 1 interaction.
MINTMINT-551224.
STRING4932.YDR536W.

Protein family/group databases

TCDB2.A.1.1.38. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR536W; YDR536W; YDR536W.
GeneID852149.
KEGGsce:YDR536W.

Organism-specific databases

CYGDYDR536w.
SGDS000002944. STL1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00680000100735.
HOGENOMHOG000167080.
OMAGWGCYLF.
OrthoDBEOG4K9FMG.

Enzyme and pathway databases

BioCycYEAST:G3O-30046-MONOMER.

Gene expression databases

GenevestigatorP39932.
GermOnlineYDR536W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio970573.

Entry information

Entry nameSTL1_YEAST
AccessionPrimary (citable) accession number: P39932
Secondary accession number(s): D6VTF6, E9P950
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 29, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents