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P39932

- STL1_YEAST

UniProt

P39932 - STL1_YEAST

Protein

Sugar transporter STL1

Gene

STL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. solute:proton symporter activity Source: SGD

    GO - Biological processi

    1. glycerol transport Source: SGD
    2. proton transport Source: GOC
    3. transmembrane transport Source: SGD

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30046-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.1.38. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transporter STL1
    Gene namesi
    Name:STL1
    Ordered Locus Names:YDR536W
    ORF Names:D9719.39
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR536w.
    SGDiS000002944. STL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Sugar transporter STL1PRO_0000050461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP39932.

    Interactioni

    Protein-protein interaction databases

    BioGridi32584. 28 interactions.
    DIPiDIP-5275N.
    IntActiP39932. 1 interaction.
    MINTiMINT-551224.
    STRINGi4932.YDR536W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39932.
    SMRiP39932. Positions 29-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 7929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1077CytoplasmicSequence Analysis
    Topological domaini129 – 1291ExtracellularSequence Analysis
    Topological domaini151 – 16818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini190 – 20314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 29167CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 33018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini352 – 3587CytoplasmicSequence Analysis
    Topological domaini380 – 38910ExtracellularSequence Analysis
    Topological domaini411 – 42616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini448 – 4536ExtracellularSequence Analysis
    Topological domaini475 – 56995CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00720000108754.
    HOGENOMiHOG000167080.
    OMAiVITEVAM.
    OrthoDBiEOG73JM4H.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39932-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDLKLSNFK GKFISRTSHW GLTGKKLRYF ITIASMTGFS LFGYDQGLMA    50
    SLITGKQFNY EFPATKENGD HDRHATVVQG ATTSCYELGC FAGSLFVMFC 100
    GERIGRKPLI LMGSVITIIG AVISTCAFRG YWALGQFIIG RVVTGVGTGL 150
    NTSTIPVWQS EMSKAENRGL LVNLEGSTIA FGTMIAYWID FGLSYTNSSV 200
    QWRFPVSMQI VFALFLLAFM IKLPESPRWL ISQSRTEEAR YLVGTLDDAD 250
    PNDEEVITEV AMLHDAVNRT KHEKHSLSSL FSRGRSQNLQ RALIAASTQF 300
    FQQFTGCNAA IYYSTVLFNK TIKLDYRLSM IIGGVFATIY ALSTIGSFFL 350
    IEKLGRRKLF LLGATGQAVS FTITFACLVK ENKENARGAA VGLFLFITFF 400
    GLSLLSLPWI YPPEIASMKV RASTNAFSTC TNWLCNFAVV MFTPIFIGQS 450
    GWGCYLFFAV MNYLYIPVIF FFYPETAGRS LEEIDIIFAK AYEDGTQPWR 500
    VANHLPKLSL QEVEDHANAL GSYDDEMEKE DFGEDRVEDT YNQINGDNSS 550
    SSSNIKNEDT VNDKANFEG 569
    Length:569
    Mass (Da):63,532
    Last modified:October 1, 1996 - v2
    Checksum:i053F3C546F84F056
    GO

    Sequence cautioni

    The sequence AAA57229.1 differs from that shown. Reason: Frameshift at position 537.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371E → G in AAU09713. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07492 Genomic DNA. Translation: AAA57229.1. Frameshift.
    U33057 Genomic DNA. Translation: AAB64975.1.
    AY723796 Genomic DNA. Translation: AAU09713.1.
    BK006938 Genomic DNA. Translation: DAA12366.1.
    PIRiS69591.
    RefSeqiNP_010825.3. NM_001180844.3.

    Genome annotation databases

    EnsemblFungiiYDR536W; YDR536W; YDR536W.
    GeneIDi852149.
    KEGGisce:YDR536W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07492 Genomic DNA. Translation: AAA57229.1 . Frameshift.
    U33057 Genomic DNA. Translation: AAB64975.1 .
    AY723796 Genomic DNA. Translation: AAU09713.1 .
    BK006938 Genomic DNA. Translation: DAA12366.1 .
    PIRi S69591.
    RefSeqi NP_010825.3. NM_001180844.3.

    3D structure databases

    ProteinModelPortali P39932.
    SMRi P39932. Positions 29-488.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32584. 28 interactions.
    DIPi DIP-5275N.
    IntActi P39932. 1 interaction.
    MINTi MINT-551224.
    STRINGi 4932.YDR536W.

    Protein family/group databases

    TCDBi 2.A.1.1.38. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR536W ; YDR536W ; YDR536W .
    GeneIDi 852149.
    KEGGi sce:YDR536W.

    Organism-specific databases

    CYGDi YDR536w.
    SGDi S000002944. STL1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00720000108754.
    HOGENOMi HOG000167080.
    OMAi VITEVAM.
    OrthoDBi EOG73JM4H.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30046-MONOMER.

    Miscellaneous databases

    NextBioi 970573.

    Gene expression databases

    Genevestigatori P39932.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein."
      Zhao S., Douglas N.W., Heine M.J., Williams G.M., Winther-Larsen H.C., Meaden P.G.
      Gene 146:215-219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiSTL1_YEAST
    AccessioniPrimary (citable) accession number: P39932
    Secondary accession number(s): D6VTF6, E9P950
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3