ID   HXT13_YEAST             Reviewed;         564 AA.
AC   P39924; D3DLI2;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   27-MAR-2024, entry version 172.
DE   RecName: Full=Hexose transporter HXT13;
GN   Name=HXT13; Synonyms=HXT8; OrderedLocusNames=YEL069C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC   -!- FUNCTION: Probable glucose transporter.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; U18795; AAB65018.1; -; Genomic_DNA.
DR   EMBL; AY723801; AAU09718.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07586.1; -; Genomic_DNA.
DR   PIR; S50520; S50520.
DR   RefSeq; NP_010845.1; NM_001178884.1.
DR   AlphaFoldDB; P39924; -.
DR   SMR; P39924; -.
DR   BioGRID; 36662; 61.
DR   DIP; DIP-3943N; -.
DR   IntAct; P39924; 1.
DR   STRING; 4932.YEL069C; -.
DR   TCDB; 2.A.1.1.110; the major facilitator superfamily (mfs).
DR   PaxDb; 4932-YEL069C; -.
DR   PeptideAtlas; P39924; -.
DR   DNASU; 856640; -.
DR   EnsemblFungi; YEL069C_mRNA; YEL069C; YEL069C.
DR   GeneID; 856640; -.
DR   KEGG; sce:YEL069C; -.
DR   AGR; SGD:S000000795; -.
DR   SGD; S000000795; HXT13.
DR   VEuPathDB; FungiDB:YEL069C; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   GeneTree; ENSGT00940000176280; -.
DR   HOGENOM; CLU_001265_30_1_1; -.
DR   InParanoid; P39924; -.
DR   OMA; TGVMNIE; -.
DR   OrthoDB; 2020602at2759; -.
DR   BioCyc; YEAST:G3O-30184-MONOMER; -.
DR   BioGRID-ORCS; 856640; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P39924; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P39924; Protein.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0005353; F:fructose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0015578; F:mannose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR   GO; GO:0015797; P:mannitol transmembrane transport; IGI:SGD.
DR   GO; GO:0015795; P:sorbitol transmembrane transport; IGI:SGD.
DR   CDD; cd17356; MFS_HXT; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   NCBIfam; TIGR00879; SP; 1.
DR   PANTHER; PTHR48022:SF75; GALACTOSE TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR48022; PLASTIDIC GLUCOSE TRANSPORTER 4; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Repeat; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..564
FT                   /note="Hexose transporter HXT13"
FT                   /id="PRO_0000050402"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..167
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        189..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..229
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..350
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        351..356
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..374
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        375..381
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        403..424
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        446..462
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        484
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        506..564
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          530..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  62734 MW;  AEFFFF691718AB44 CRC64;
     MSSAQSSIDS DGDVRDADIH VAPPVEKEWS DGFDDNEVIN GDNVEPPKRG LIGYLVIYLL
     CYPISFGGFL PGWDSGITAG FINMDNFKMN FGSYKHSTGE YYLSNVRMGL LVAMFSIGCA
     IGGLIFARLA DTLGRRLAIV IVVLVYMVGA IIQISSNHKW YQYFVGKIIY GLGAGGCSVL
     CPMLLSEIAP TDLRGGLVSL YQLNMTFGIF LGYCSVYGTR KYDNTAQWRV PLGLCFLWAL
     IIIIGMLLVP ESPRYLIECE RHEEARASIA KINKVSPEDP WVLKQADEIN AGVLAQRELG
     EASWKELFSV KTKVLQRLIT GILVQTFLQL TGENYFFFYG TTIFKSVGLT DGFETSIVLG
     TVNFFSTIIA VMVVDKIGRR KCLLFGAAGM MACMVIFASI GVKCLYPHGQ DGPSSKGAGN
     AMIVFTCFYI FCFATTWAPV AYIVVAESFP SKVKSRAMSI STACNWLWQF LIGFFTPFIT
     GSIHFYYGYV FVGCLVAMFL YVFFFLPETI GLSLEEIQLL YEEGIKPWKS ASWVPPSRRG
     ISSEESKTEK KDWKKFLKFS KNSD
//