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Protein

Hexose transporter HXT13

Gene

HXT13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • mannitol transport Source: SGD
  • sorbitol transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30184-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.110. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT13
Gene namesi
Name:HXT13
Synonyms:HXT8
Ordered Locus Names:YEL069C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL069C.
SGDiS000000795. HXT13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini74 – 109ExtracellularSequence analysisAdd BLAST36
Transmembranei110 – 130Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini131 – 136CytoplasmicSequence analysis6
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 167ExtracellularSequence analysis10
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 194CytoplasmicSequence analysis6
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 229ExtracellularSequence analysisAdd BLAST14
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 333CytoplasmicSequence analysisAdd BLAST83
Transmembranei334 – 350Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini351 – 356ExtracellularSequence analysis6
Transmembranei357 – 374Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini375 – 381CytoplasmicSequence analysis7
Transmembranei382 – 402Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini403 – 424ExtracellularSequence analysisAdd BLAST22
Transmembranei425 – 445Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini446 – 462CytoplasmicSequence analysisAdd BLAST17
Transmembranei463 – 483Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini484ExtracellularSequence analysis1
Transmembranei485 – 505Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini506 – 564CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504021 – 564Hexose transporter HXT13Add BLAST564

Proteomic databases

PRIDEiP39924.

Interactioni

Protein-protein interaction databases

BioGridi36662. 60 interactors.
DIPiDIP-3943N.
MINTiMINT-530973.
STRINGi4932.YEL069C.

Structurei

3D structure databases

ProteinModelPortaliP39924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00880000137949.
HOGENOMiHOG000202870.
InParanoidiP39924.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P39924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAQSSIDS DGDVRDADIH VAPPVEKEWS DGFDDNEVIN GDNVEPPKRG
60 70 80 90 100
LIGYLVIYLL CYPISFGGFL PGWDSGITAG FINMDNFKMN FGSYKHSTGE
110 120 130 140 150
YYLSNVRMGL LVAMFSIGCA IGGLIFARLA DTLGRRLAIV IVVLVYMVGA
160 170 180 190 200
IIQISSNHKW YQYFVGKIIY GLGAGGCSVL CPMLLSEIAP TDLRGGLVSL
210 220 230 240 250
YQLNMTFGIF LGYCSVYGTR KYDNTAQWRV PLGLCFLWAL IIIIGMLLVP
260 270 280 290 300
ESPRYLIECE RHEEARASIA KINKVSPEDP WVLKQADEIN AGVLAQRELG
310 320 330 340 350
EASWKELFSV KTKVLQRLIT GILVQTFLQL TGENYFFFYG TTIFKSVGLT
360 370 380 390 400
DGFETSIVLG TVNFFSTIIA VMVVDKIGRR KCLLFGAAGM MACMVIFASI
410 420 430 440 450
GVKCLYPHGQ DGPSSKGAGN AMIVFTCFYI FCFATTWAPV AYIVVAESFP
460 470 480 490 500
SKVKSRAMSI STACNWLWQF LIGFFTPFIT GSIHFYYGYV FVGCLVAMFL
510 520 530 540 550
YVFFFLPETI GLSLEEIQLL YEEGIKPWKS ASWVPPSRRG ISSEESKTEK
560
KDWKKFLKFS KNSD
Length:564
Mass (Da):62,734
Last modified:February 1, 1995 - v1
Checksum:iAEFFFF691718AB44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA. Translation: AAB65018.1.
AY723801 Genomic DNA. Translation: AAU09718.1.
BK006939 Genomic DNA. Translation: DAA07586.1.
PIRiS50520.
RefSeqiNP_010845.1. NM_001178884.1.

Genome annotation databases

EnsemblFungiiYEL069C; YEL069C; YEL069C.
GeneIDi856640.
KEGGisce:YEL069C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHXT13_YEAST
AccessioniPrimary (citable) accession number: P39924
Secondary accession number(s): D3DLI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names