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P39924 (HXT13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexose transporter HXT13
Gene names
Name:HXT13
Synonyms:HXT8
Ordered Locus Names:YEL069C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Hexose transporter HXT13
PRO_0000050402

Regions

Topological domain1 – 5252Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=1; Potential
Topological domain74 – 10936Extracellular Potential
Transmembrane110 – 13021Helical; Name=2; Potential
Topological domain131 – 1366Cytoplasmic Potential
Transmembrane137 – 15721Helical; Name=3; Potential
Topological domain158 – 16710Extracellular Potential
Transmembrane168 – 18821Helical; Name=4; Potential
Topological domain189 – 1946Cytoplasmic Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 22914Extracellular Potential
Transmembrane230 – 25021Helical; Name=6; Potential
Topological domain251 – 33383Cytoplasmic Potential
Transmembrane334 – 35017Helical; Name=7; Potential
Topological domain351 – 3566Extracellular Potential
Transmembrane357 – 37418Helical; Name=8; Potential
Topological domain375 – 3817Cytoplasmic Potential
Transmembrane382 – 40221Helical; Name=9; Potential
Topological domain403 – 42422Extracellular Potential
Transmembrane425 – 44521Helical; Name=10; Potential
Topological domain446 – 46217Cytoplasmic Potential
Transmembrane463 – 48321Helical; Name=11; Potential
Topological domain4841Extracellular Potential
Transmembrane485 – 50521Helical; Name=12; Potential
Topological domain506 – 56459Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P39924 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: AEFFFF691718AB44

FASTA56462,734
        10         20         30         40         50         60 
MSSAQSSIDS DGDVRDADIH VAPPVEKEWS DGFDDNEVIN GDNVEPPKRG LIGYLVIYLL 

        70         80         90        100        110        120 
CYPISFGGFL PGWDSGITAG FINMDNFKMN FGSYKHSTGE YYLSNVRMGL LVAMFSIGCA 

       130        140        150        160        170        180 
IGGLIFARLA DTLGRRLAIV IVVLVYMVGA IIQISSNHKW YQYFVGKIIY GLGAGGCSVL 

       190        200        210        220        230        240 
CPMLLSEIAP TDLRGGLVSL YQLNMTFGIF LGYCSVYGTR KYDNTAQWRV PLGLCFLWAL 

       250        260        270        280        290        300 
IIIIGMLLVP ESPRYLIECE RHEEARASIA KINKVSPEDP WVLKQADEIN AGVLAQRELG 

       310        320        330        340        350        360 
EASWKELFSV KTKVLQRLIT GILVQTFLQL TGENYFFFYG TTIFKSVGLT DGFETSIVLG 

       370        380        390        400        410        420 
TVNFFSTIIA VMVVDKIGRR KCLLFGAAGM MACMVIFASI GVKCLYPHGQ DGPSSKGAGN 

       430        440        450        460        470        480 
AMIVFTCFYI FCFATTWAPV AYIVVAESFP SKVKSRAMSI STACNWLWQF LIGFFTPFIT 

       490        500        510        520        530        540 
GSIHFYYGYV FVGCLVAMFL YVFFFLPETI GLSLEEIQLL YEEGIKPWKS ASWVPPSRRG 

       550        560 
ISSEESKTEK KDWKKFLKFS KNSD 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18795 Genomic DNA. Translation: AAB65018.1.
AY723801 Genomic DNA. Translation: AAU09718.1.
BK006939 Genomic DNA. Translation: DAA07586.1.
PIRS50520.
RefSeqNP_010845.1. NM_001178884.1.

3D structure databases

ProteinModelPortalP39924.
SMRP39924. Positions 57-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3943N.
MINTMINT-530973.
STRING4932.YEL069C.

Protein family/group databases

TCDB2.A.1.1.110. the major facilitator superfamily (mfs).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL069C; YEL069C; YEL069C.
GeneID856640.
KEGGsce:YEL069C.

Organism-specific databases

CYGDYEL069c.
SGDS000000795. HXT13.

Phylogenomic databases

GeneTreeENSGT00720000108754.
HOGENOMHOG000202870.
KOK08139.
OrthoDBEOG73JM4H.

Enzyme and pathway databases

BioCycYEAST:G3O-30184-MONOMER.

Gene expression databases

GenevestigatorP39924.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982601.

Entry information

Entry nameHXT13_YEAST
AccessionPrimary (citable) accession number: P39924
Secondary accession number(s): D3DLI2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families