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P39920

- FTSK_COXBU

UniProt

P39920 - FTSK_COXBU

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (09 May 2003)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi439 – 4446ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1180-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Synonyms:spoIIIE
    Ordered Locus Names:CBU_1191
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 778778DNA translocase FtsKPRO_0000098256Add
    BLAST

    Proteomic databases

    PRIDEiP39920.

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi227377.CBU_1191.

    Structurei

    3D structure databases

    ProteinModelPortaliP39920.
    SMRiP39920. Positions 284-689, 711-776.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini193 – 778586CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini419 – 629211FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1674.
    HOGENOMiHOG000010003.
    KOiK03466.
    OMAiGFMSVFD.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRRKGKKSA KETGVLLRRH LRYRLREGCF ILALAFSAFL FIALLSYHRS    50
    DPGWSHSIVV KHVANLTGEA GAWLSDFTLY MVGYLAYIFP LMVAFAAWVF 100
    FRNRHEEQDI PTKWPLLILR AVGFLLILLA GSALAAIHLG TLDANLPYNG 150
    GGIIGVVMAK SLFPIFNTAG TSLILIAFLL IGITLFTGLS WFQFLELLGK 200
    NAIKFTKFCA IRLGAISWKD LFLSLLPSQD KREAVTVPKI KRVEPDLVPD 250
    ALDMISTPKI AERPKLEIID HEFKTPRFKG SAILPELSLL DKPSQDHTLS 300
    YSEEELQQKS REVELRLADF GIQAKVVAVH PGPVVTRFEL QLAAGTKASR 350
    VTNLAKDLAR SLSVISVRIV EVIPGKSVIG LELPNKNREV VTIYEVLATK 400
    QYQNARSSLT LALGKDIGGH PVIVDLAKMP HLLVAGTTGS GKSVSLNAML 450
    LSLLYKSTPQ QLRLILIDPK MLELSVYEGI PHLLTPVVTD MKDAAAALRW 500
    CVVEMERRYR LMASLGVRNI LGYNAKVKEA IEAGAPLLDP LQAAAEGKPP 550
    ELQELPQLVV IADEFADMMV VVGKKVETLI VRLAQKARAA GIHLIFATQR 600
    PSVDVITGLI KANIPTRVAF QVSSKIDSRT ILDQQGAEQL LGHGDLLYLA 650
    PGSGVPVRVH GPYVKDEEVH RVAEYLRESS EPNYVEGILD EMGAQDLSGF 700
    VEAALGGGSE EGGESDPLYD EAVEAVIRSR RVSVSSIQRR FKIGYNRAAR 750
    IVEAMEAAGV VSPMENNGAR EVLAPSKE 778
    Length:778
    Mass (Da):85,251
    Last modified:May 9, 2003 - v2
    Checksum:i54B9D88081D73F7D
    GO

    Sequence cautioni

    The sequence AAO90700.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641A → P in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti79 – 802LY → KN in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti87 – 871Y → N in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti102 – 1021R → P in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti121 – 1211A → P in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti159 – 1591A → P in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti168 – 1681T → A in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti192 – 1921F → C in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti200 – 2001K → R in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti236 – 2361T → A in CAA53289. (PubMed:8237209)Curated
    Sequence conflicti245 – 2451P → R in CAA53289. (PubMed:8237209)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75627 Genomic DNA. Translation: CAA53289.1.
    AE016828 Genomic DNA. Translation: AAO90700.2. Different initiation.
    PIRiS43132.
    RefSeqiNP_820186.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90700; AAO90700; CBU_1191.
    GeneIDi1209095.
    KEGGicbu:CBU_1191.
    PATRICi17931127. VBICoxBur82552_1189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75627 Genomic DNA. Translation: CAA53289.1 .
    AE016828 Genomic DNA. Translation: AAO90700.2 . Different initiation.
    PIRi S43132.
    RefSeqi NP_820186.2. NC_002971.3.

    3D structure databases

    ProteinModelPortali P39920.
    SMRi P39920. Positions 284-689, 711-776.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1191.

    Proteomic databases

    PRIDEi P39920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90700 ; AAO90700 ; CBU_1191 .
    GeneIDi 1209095.
    KEGGi cbu:CBU_1191.
    PATRICi 17931127. VBICoxBur82552_1189.

    Phylogenomic databases

    eggNOGi COG1674.
    HOGENOMi HOG000010003.
    KOi K03466.
    OMAi GFMSVFD.
    OrthoDBi EOG6S52GD.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1180-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A sporulation gene in Coxiella burnetii?"
      Oswald W., Thiele D.
      J. Vet. Med. B 40:366-370(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Nine Mile phase I / Bratislava.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiFTSK_COXBU
    AccessioniPrimary (citable) accession number: P39920
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: May 9, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3