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P39920

- FTSK_COXBU

UniProt

P39920 - FTSK_COXBU

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Protein
DNA translocase FtsK
Gene
ftsK, spoIIIE, CBU_1191
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi439 – 4446ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Synonyms:spoIIIE
Ordered Locus Names:CBU_1191
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cell inner membrane; Multi-pass membrane protein By similarity
Note: Located at the septum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 778586Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 778778DNA translocase FtsK
PRO_0000098256Add
BLAST

Proteomic databases

PRIDEiP39920.

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA By similarity.

Protein-protein interaction databases

STRINGi227377.CBU_1191.

Structurei

3D structure databases

ProteinModelPortaliP39920.
SMRiP39920. Positions 284-689, 711-776.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini419 – 629211FtsK
Add
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.
Contains 1 FtsK domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiGFMSVFD.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39920-1 [UniParc]FASTAAdd to Basket

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MGRRKGKKSA KETGVLLRRH LRYRLREGCF ILALAFSAFL FIALLSYHRS    50
DPGWSHSIVV KHVANLTGEA GAWLSDFTLY MVGYLAYIFP LMVAFAAWVF 100
FRNRHEEQDI PTKWPLLILR AVGFLLILLA GSALAAIHLG TLDANLPYNG 150
GGIIGVVMAK SLFPIFNTAG TSLILIAFLL IGITLFTGLS WFQFLELLGK 200
NAIKFTKFCA IRLGAISWKD LFLSLLPSQD KREAVTVPKI KRVEPDLVPD 250
ALDMISTPKI AERPKLEIID HEFKTPRFKG SAILPELSLL DKPSQDHTLS 300
YSEEELQQKS REVELRLADF GIQAKVVAVH PGPVVTRFEL QLAAGTKASR 350
VTNLAKDLAR SLSVISVRIV EVIPGKSVIG LELPNKNREV VTIYEVLATK 400
QYQNARSSLT LALGKDIGGH PVIVDLAKMP HLLVAGTTGS GKSVSLNAML 450
LSLLYKSTPQ QLRLILIDPK MLELSVYEGI PHLLTPVVTD MKDAAAALRW 500
CVVEMERRYR LMASLGVRNI LGYNAKVKEA IEAGAPLLDP LQAAAEGKPP 550
ELQELPQLVV IADEFADMMV VVGKKVETLI VRLAQKARAA GIHLIFATQR 600
PSVDVITGLI KANIPTRVAF QVSSKIDSRT ILDQQGAEQL LGHGDLLYLA 650
PGSGVPVRVH GPYVKDEEVH RVAEYLRESS EPNYVEGILD EMGAQDLSGF 700
VEAALGGGSE EGGESDPLYD EAVEAVIRSR RVSVSSIQRR FKIGYNRAAR 750
IVEAMEAAGV VSPMENNGAR EVLAPSKE 778
Length:778
Mass (Da):85,251
Last modified:May 9, 2003 - v2
Checksum:i54B9D88081D73F7D
GO

Sequence cautioni

The sequence AAO90700.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641A → P in CAA53289. 1 Publication
Sequence conflicti79 – 802LY → KN in CAA53289. 1 Publication
Sequence conflicti87 – 871Y → N in CAA53289. 1 Publication
Sequence conflicti102 – 1021R → P in CAA53289. 1 Publication
Sequence conflicti121 – 1211A → P in CAA53289. 1 Publication
Sequence conflicti159 – 1591A → P in CAA53289. 1 Publication
Sequence conflicti168 – 1681T → A in CAA53289. 1 Publication
Sequence conflicti192 – 1921F → C in CAA53289. 1 Publication
Sequence conflicti200 – 2001K → R in CAA53289. 1 Publication
Sequence conflicti236 – 2361T → A in CAA53289. 1 Publication
Sequence conflicti245 – 2451P → R in CAA53289. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75627 Genomic DNA. Translation: CAA53289.1.
AE016828 Genomic DNA. Translation: AAO90700.2. Different initiation.
PIRiS43132.
RefSeqiNP_820186.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90700; AAO90700; CBU_1191.
GeneIDi1209095.
KEGGicbu:CBU_1191.
PATRICi17931127. VBICoxBur82552_1189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75627 Genomic DNA. Translation: CAA53289.1 .
AE016828 Genomic DNA. Translation: AAO90700.2 . Different initiation.
PIRi S43132.
RefSeqi NP_820186.2. NC_002971.3.

3D structure databases

ProteinModelPortali P39920.
SMRi P39920. Positions 284-689, 711-776.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1191.

Proteomic databases

PRIDEi P39920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90700 ; AAO90700 ; CBU_1191 .
GeneIDi 1209095.
KEGGi cbu:CBU_1191.
PATRICi 17931127. VBICoxBur82552_1189.

Phylogenomic databases

eggNOGi COG1674.
HOGENOMi HOG000010003.
KOi K03466.
OMAi GFMSVFD.
OrthoDBi EOG6S52GD.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1180-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50901. FTSK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A sporulation gene in Coxiella burnetii?"
    Oswald W., Thiele D.
    J. Vet. Med. B 40:366-370(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile phase I / Bratislava.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiFTSK_COXBU
AccessioniPrimary (citable) accession number: P39920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 9, 2003
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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