Skip Header

Contribute Send feedback
Read comments (?) or add your own

P39915 (AROA2_BURPS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
OrganismBurkholderia pseudomallei (Pseudomonas pseudomallei)
Taxonomic identifier28450 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Sequence caution

The sequence CAA54317.1 differs from that shown. Reason: Frameshift at position 308.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4634633-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000088239

Sequences

Sequence LengthMass (Da)Tools
P39915 [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: C164DE1812F5B89B

FASTA46349,536
        10         20         30         40         50         60 
MAFQWPRFPL QPWRHVTGHL RLPGDKSISN RSLLLGALAE GVTEVTGLLD SDDARAMLNA 

        70         80         90        100        110        120 
LRDLGVVIEG PHQGRCTVHG VGLHGLKAPP GPLFLGNAGT AMRPLSAALA LQPFDTTLTG 

       130        140        150        160        170        180 
DPRMSERPIN RLVDALREMG AVIEYLAQEG YPPLTIRGGG SVSSQFLTAL LMTAPMASAQ 

       190        200        210        220        230        240 
IKSGLLLSKP YIDITLNVMP FGVPTRDHTE RIFAVSAIRY PSPAVLRLEG DATSASYFLA 

       250        260        270        280        290        300 
AAGIKGVPVT GIGRHSMQGD SWFPRALRRM GARSCGSSMI VCPRGELRAA VRSDSNSIPD 

       310        320        330        340        350        360 
AAMTLATXXA LARGGRRPRT IFAWRVKETD RLYAMSTELG AAGARVVPGA GLRGCPLRGR 

       370        380        390        400        410        420 
SYYVARCRRD SRMAMCFSLP AHGGRAVRHP GSRLHRQDAE LSSKVVRSVP EVWGMAITAL 

       430        440        450        460 
RCPSGGALRA MARFESMTGQ RGDVVSQLPL LGAARRHAGT FGG

« Hide

References

[1]"Cloning and sequencing of the aroA gene from Pseudomonas pseudomallei."
Penaloza-Vazquez A., Bailey A.M.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X77019 Genomic DNA. Translation: CAA54317.1. Frameshift.

3D structure databases

ProteinModelPortalP39915.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_00210. EPSP_synth. Divergent sequence.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA2_BURPS
AccessionPrimary (citable) accession number: P39915
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 31, 2002
Last modified: June 28, 2011
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents