Reviewed, UniProtKB/Swiss-Prot P39912 (AROG_BACSU)

Names and origin

Protein names

Recommended name:
    Protein aroA(G)
Including the following 2 domains:
    1- Recommended name:
            Phospho-2-dehydro-3-deoxyheptonate aldolase
              EC=2.5.1.54
        Alternative name(s):
            Phospho-2-keto-3-deoxyheptonate aldolase
            3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
            DAHP synthetase
    2- Recommended name:
            Chorismate mutase
              EC=5.4.99.5

Gene names

Name:	aroA
Ordered Locus Names:	BSU29750

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. Chorismate = prephenate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 1/7. Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Sequence similarities	Belongs to the class-I DAHP synthetase family. Contains 1 chorismate mutase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Isomerase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC aldehyde-lyase activity Inferred from electronic annotation. Source: InterPro chorismate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Protein aroA(G)		PRO_0000140827
Regions
	Domain	1 – 90	90	Chorismate mutase
Amino acid modifications
	Modified residue	2	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P39912-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 95D217477A2DE5AC	FASTA	358	39,539
	10 20 30 40 50 60 MSNTELELLR QKADELNLQI LKLINERGNV VKEIGKAKEA QGVNRFDPVR ERTMLNNIIE 70 80 90 100 110 120 NNDGPFENST IQHIFKEIFK AGLELQEEDH SKALLVSRKK KPEDTIVDIK GEKIGDGQQR 130 140 150 160 170 180 FIVGPCAVES YEQVAEVAAA AKKQGIKILR GGAFKPRTSP YDFQGLGVEG LQILKRVADE 190 200 210 220 230 240 FDLAVISEIV TPAHIEEALD YIDVIQIGAR NMQNFELLKA AGAVKKPVLL KRGLAATISE 250 260 270 280 290 300 FINAAEYIMS QGNDQIILCE RGIRTYETAT RNTLDISAVP ILKQETHLPV FVDVTHSTGR 310 320 330 340 350 RDLLLPTAKA ALAIGADGVM AEVHPDPSVA LSDSAQQMAI PEFEKWLNEL KPMVKVNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identical amino acid sequence of the aroA(G) gene products of Bacillus subtilis 168 and B. subtilis Marburg strain." Bolotin A.P., Khazak V.E., Stoynova N., Ratmanova K., Yomantas Y., Kozlov Y. Microbiology 141:2219-2222(1995) [PubMed: 7496534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region." Lapidus A., Galleron N., Sorokin A., Ehrlich S.D. Microbiology 143:3431-3441(1997) [PubMed: 9387221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis." Macek B., Mijakovic I., Olsen J.V., Gnad F., Kumar C., Jensen P.R., Mann M. Mol. Cell. Proteomics 6:697-707(2007) [PubMed: 17218307] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65945 Genomic DNA. Translation: CAA46760.1. AF008220 Genomic DNA. Translation: AAC00298.1. AL009126 Genomic DNA. Translation: CAB14953.1.
PIR	S21418.
RefSeq	NP_390853.1.
3D structure databases
HSSP	HSSP built from PDB template 1LRQ based on UniProtKB O66496.
ModBase	Search...
PTM databases
PhosSite	P39912.
Genome annotation databases
GeneID	937853.
GenomeReviews	Gene locus BSU29750 in contig AL009126_GR.
KEGG	bsu:BSU29750.
NMPDR	fig|224308.1.peg.2978.
Organism-specific databases
SubtiList	BG10375. aroA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P39912.
OMA	P39912. TQVILCE.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU2971-MON.
BRENDA	2.5.1.54. 150. 5.4.99.5. 150.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR002701. Chorismate_mut. IPR010954. CM_A. IPR006218. DAHP1/KDSA. IPR006268. DAHP_syn_2. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF1. DAHP_syn_2. 1 hit.
Pfam	PF01817. CM_2. 1 hit. PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01801. CM_A. 1 hit. TIGR01361. DAHP_synth_Bsub. 1 hit.
PROSITE	PS51168. CHORISMATE_MUT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROG_BACSU

Accession

Primary (citable) accession number: P39912

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)