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Protein

Protein AroA(G)

Gene

aroA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Chorismate = prephenate.

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Protein AroA(G) (aroA)
  2. 3-dehydroquinate synthase (aroB), 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (yqhS), 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroF), Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Chorismate mutase AroH (aroH), Chorismate mutase AroH (aroH), Protein AroA(G) (aroA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU29750-MONOMER
UniPathwayiUPA00053; UER00084
UPA00120; UER00203

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AroA(G)
Including the following 2 domains:
Phospho-2-dehydro-3-deoxyheptonate aldolase (EC:2.5.1.54)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Chorismate mutase (EC:5.4.99.5)
Gene namesi
Name:aroA
Ordered Locus Names:BSU29750
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001408271 – 358Protein AroA(G)Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP39912
PRIDEiP39912

PTM databases

iPTMnetiP39912

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100016231

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 37Combined sources33
Helixi48 – 60Combined sources13
Beta strandi64 – 66Combined sources3
Helixi68 – 87Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GMUX-ray1.80A/B1-90[»]
5GO2X-ray1.91A/B/C/D1-90[»]
ProteinModelPortaliP39912
SMRiP39912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90Chorismate mutasePROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105CXR Bacteria
COG1605 LUCA
COG2876 LUCA
HOGENOMiHOG000023020
InParanoidiP39912
KOiK13853
OMAiFRGIPTM
PhylomeDBiP39912

Family and domain databases

Gene3Di1.20.59.10, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR010954 Chorismate_mutase_GmP-bac
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
IPR006218 DAHP1/KDSA
IPR006268 DAHP_syn_2
PfamiView protein in Pfam
PF01817 CM_2, 1 hit
PF00793 DAHP_synth_1, 1 hit
SMARTiView protein in SMART
SM00830 CM_2, 1 hit
TIGRFAMsiTIGR01801 CM_A, 1 hit
TIGR01361 DAHP_synth_Bsub, 1 hit
PROSITEiView protein in PROSITE
PS51168 CHORISMATE_MUT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTELELLR QKADELNLQI LKLINERGNV VKEIGKAKEA QGVNRFDPVR
60 70 80 90 100
ERTMLNNIIE NNDGPFENST IQHIFKEIFK AGLELQEEDH SKALLVSRKK
110 120 130 140 150
KPEDTIVDIK GEKIGDGQQR FIVGPCAVES YEQVAEVAAA AKKQGIKILR
160 170 180 190 200
GGAFKPRTSP YDFQGLGVEG LQILKRVADE FDLAVISEIV TPAHIEEALD
210 220 230 240 250
YIDVIQIGAR NMQNFELLKA AGAVKKPVLL KRGLAATISE FINAAEYIMS
260 270 280 290 300
QGNDQIILCE RGIRTYETAT RNTLDISAVP ILKQETHLPV FVDVTHSTGR
310 320 330 340 350
RDLLLPTAKA ALAIGADGVM AEVHPDPSVA LSDSAQQMAI PEFEKWLNEL

KPMVKVNA
Length:358
Mass (Da):39,539
Last modified:February 1, 1995 - v1
Checksum:i95D217477A2DE5AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65945 Genomic DNA Translation: CAA46760.1
AF008220 Genomic DNA Translation: AAC00298.1
AL009126 Genomic DNA Translation: CAB14953.1
PIRiS21418
RefSeqiNP_390853.1, NC_000964.3
WP_003223454.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14953; CAB14953; BSU29750
GeneIDi937853
KEGGibsu:BSU29750
PATRICifig|224308.179.peg.3233

Similar proteinsi

Entry informationi

Entry nameiAROG_BACSU
AccessioniPrimary (citable) accession number: P39912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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