Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P39905 (GDNF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 148. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glial cell line-derived neurotrophic factor

Short name=hGDNF
Alternative name(s):
Astrocyte-derived trophic factor
Short name=ATF
Gene names
Name:GDNF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Ref.1

Subunit structure

Homodimer; disulfide-linked. Ref.1 Ref.11 Ref.14

Subcellular location

Secreted Ref.10.

Tissue specificity

In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. Ref.2 Ref.12

Induction

By cAMP, 12-O-tetradecanoylphorbol-13-acetate (TPA) and FGF2. Ref.10

Involvement in disease

Hirschsprung disease 3 (HSCR3) [MIM:613711]: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
Note: The disease may be caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.17 Ref.19

Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Hirschsprung disease
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processadult locomotory behavior

Traceable author statement PubMed 12358785. Source: BHF-UCL

axon guidance

Traceable author statement. Source: Reactome

branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

enteric nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA stabilization

Inferred from direct assay PubMed 12358785. Source: BHF-UCL

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

metanephros development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Traceable author statement PubMed 7830769. Source: ProtInc

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from direct assay PubMed 10921886. Source: UniProtKB

negative regulation of neuron apoptotic process

Inferred from direct assay Ref.1. Source: UniProtKB

nervous system development

Traceable author statement PubMed 8637574. Source: ProtInc

neural crest cell migration

Inferred from direct assay PubMed 15242795. Source: MGI

neuron projection development

Inferred from direct assay PubMed 15242795. Source: MGI

organ induction

Inferred from electronic annotation. Source: Ensembl

peristalsis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from direct assay PubMed 17229286PubMed 8657307. Source: UniProtKB

positive regulation of dopamine secretion

Traceable author statement PubMed 12358785. Source: BHF-UCL

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of monooxygenase activity

Inferred from direct assay PubMed 12358785. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12358785. Source: BHF-UCL

positive regulation of ureteric bud formation

Inferred from direct assay PubMed 8657307. Source: UniProtKB

postganglionic parasympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

postsynaptic membrane organization

Inferred from electronic annotation. Source: Ensembl

regulation of dopamine uptake involved in synaptic transmission

Inferred from direct assay Ref.1. Source: UniProtKB

regulation of morphogenesis of a branching structure

Inferred from sequence or structural similarity. Source: UniProtKB

signal transduction

Traceable author statement PubMed 7830769. Source: ProtInc

sympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

ureteric bud formation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from direct assay Ref.10. Source: UniProtKB

   Molecular_functionprotein homodimerization activity

Inferred from direct assay Ref.1Ref.11. Source: UniProtKB

receptor binding

Traceable author statement PubMed 10829012. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P39905-1)

Also known as: Ex1_4L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P39905-2)

Also known as: ATF-1; Ex1_4S; Ex3_4S; HFK2-GDNF;

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: GKRPPEAPAEDRSLGRRRAPFALSSDS → A
Isoform 3 (identifier: P39905-3)

Also known as: Ex2_4L; HFK3-GDNF;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQSLPNSNGAAAGRDFKM
Isoform 4 (identifier: P39905-4)

Also known as: HFK4-GDNF;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQSLPNSNGAAAGRDFKM
     25-51: GKRPPEAPAEDRSLGRRRAPFALSSDS → A
Isoform 5 (identifier: P39905-5)

Also known as: Ex4S_5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 7556 By similarity
PRO_0000034004
Chain78 – 211134Glial cell line-derived neurotrophic factor
PRO_0000034005

Amino acid modifications

Glycosylation1261N-linked (GlcNAc...) Ref.14
Glycosylation1621N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 179 Ref.1 Ref.11 Ref.14
Disulfide bond145 ↔ 208 Ref.1 Ref.11 Ref.14
Disulfide bond149 ↔ 210 Ref.1 Ref.11 Ref.14
Disulfide bond178Interchain Ref.1 Ref.11 Ref.14

Natural variations

Alternative sequence1 – 5252Missing in isoform 5.
VSP_042298
Alternative sequence11M → MQSLPNSNGAAAGRDFKM in isoform 3 and isoform 4.
VSP_026368
Alternative sequence25 – 5127GKRPP…LSSDS → A in isoform 2 and isoform 4.
VSP_006420
Natural variant211P → S in HSCR3; unknown pathological significance. Ref.17
VAR_009494
Natural variant931R → W in HSCR3 and CCHS; associated to a RET mutation; unknown pathological significance. Ref.16 Ref.18
Corresponds to variant rs36119840 [ dbSNP | Ensembl ].
VAR_009495
Natural variant1501D → N in HSCR3; unknown pathological significance. Ref.17
Corresponds to variant rs76466003 [ dbSNP | Ensembl ].
VAR_009496
Natural variant1541T → S in HSCR3; sporadic form. Ref.15
VAR_009497
Natural variant2111I → M in HSCR3. Ref.19
VAR_018152

Secondary structure

................... 211
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Ex1_4L) [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: A0D1EBF77FC82691

FASTA21123,720
        10         20         30         40         50         60 
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ 

        70         80         90        100        110        120 
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL 

       130        140        150        160        170        180 
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR 

       190        200        210 
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I 

« Hide

Isoform 2 (ATF-1) (Ex1_4S) (Ex3_4S) (HFK2-GDNF) [UniParc].

Checksum: 1988C50DA5EA1B10
Show »

FASTA18520,885
Isoform 3 (Ex2_4L) (HFK3-GDNF) [UniParc].

Checksum: 5BAAAC69FEDDBA4C
Show »

FASTA22825,466
Isoform 4 (HFK4-GDNF) [UniParc].

Checksum: 2CAFBC675D40CF2F
Show »

FASTA20222,631
Isoform 5 (Ex4S_5) [UniParc].

Checksum: 97CFDCE97459E34B
Show »

FASTA15918,123

References

« Hide 'large scale' references
[1]"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons."
Lin L.-F.H., Doherty D.H., Lile J.D., Bektesh S., Collins F.
Science 260:1130-1132(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, HOMODIMERIZATION, DISULFIDE BONDS.
[2]"Multiple astrocyte transcripts encode nigral trophic factors in rat and human."
Schaar D.G., Sieber B.-A., Sherwood A.C., Dean D., Mendoza G., Ramakrishnan L., Dreyfus C.F., Black I.B.
Exp. Neurol. 130:387-393(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[3]Zhang B., Feng Z., Zhou Y., Peng X., Yuan J., Qiang B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene."
Baecker P.A., Lee W.H., Verity A.N., Eglen R.M., Johnson R.M.
Brain Res. Mol. Brain Res. 69:209-222(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-187 (ISOFORM 1).
Tissue: Fetal kidney.
[9]"The human GDNF gene promoter."
Suter-Crazzolara C., Baecker P.A., Lee W.H., Johnson R.M., Unsicker K.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-88 (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77, NUCLEOTIDE SEQUENCE [MRNA] OF 1-59 (ISOFORMS 3 AND 4).
Tissue: Brain and Kidney.
[10]"Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products."
Grimm L., Holinski-Feder E., Teodoridis J., Scheffer B., Schindelhauer D., Meitinger T., Ueffing M.
Hum. Mol. Genet. 7:1873-1886(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50, SUBCELLULAR LOCATION, INDUCTION.
[11]"Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure."
Haniu M., Hui J., Young Y., Le J., Katta V., Lee R., Shimamoto G., Rohde M.F.
Biochemistry 35:16799-16805(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 87-122; 141-153; 173-184 AND 196-211, HOMODIMERIZATION, DISULFIDE BONDS.
[12]"Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease."
Airavaara M., Pletnikova O., Doyle M.E., Zhang Y.E., Troncoso J.C., Liu Q.R.
J. Biol. Chem. 286:45093-45102(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3 AND 5), TISSUE SPECIFICITY.
[13]"Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype."
Hofstra R.M.W., Osinga J., Buys C.H.C.M.
Eur. J. Hum. Genet. 5:180-185(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON VARIANTS.
[14]"Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling."
Parkash V., Goldman A.
Acta Crystallogr. F 65:551-558(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 78-211, GLYCOSYLATION AT ASN-126, DISULFIDE BONDS.
[15]"De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease."
Ivanchuk S.M., Myers S.M., Eng C., Mulligan L.M.
Hum. Mol. Genet. 5:2023-2026(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HSCR3 SER-154.
[16]"Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient."
Angrist M., Bolk S., Halushka M., Lapchak P.A., Chakravarti A.
Nat. Genet. 14:341-344(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HSCR3 TRP-93.
[17]"Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease."
Salomon R., Attie T., Pelet A., Bidaud C., Eng C., Amiel J., Sarnacki S., Goulet O., Ricour C., Nihoul-Fekete C., Munnich A., Lyonnet S.
Nat. Genet. 14:345-347(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HSCR3 SER-21 AND ASN-150.
[18]"Mutations of the RET-GDNF signaling pathway in Ondine's curse."
Amiel J., Salomon R., Attie T., Pelet A., Trang H., Mokhtari M., Gaultier C., Munnich A., Lyonnet S.
Am. J. Hum. Genet. 62:715-717(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CCHS TRP-93.
[19]"Pathogenesis of Hirschsprung's disease."
Martucciello G., Ceccherini I., Lerone M., Jasonni V.
J. Pediatr. Surg. 35:1017-1025(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HSCR3 MET-211.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19063, L19062 Genomic DNA. Translation: AAA67910.1.
AY052832 mRNA. Translation: AAL11017.1.
CR541923 mRNA. Translation: CAG46721.1.
AC008869 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55963.1.
BC069119 mRNA. Translation: AAH69119.1.
BC069369 mRNA. Translation: AAH69369.1.
BC128108 mRNA. Translation: AAI28109.1.
BC128109 mRNA. Translation: AAI28110.1.
AF053748 mRNA. Translation: AAD43139.1.
AJ001896 Genomic DNA. Translation: CAA05074.1.
AJ001897 mRNA. Translation: CAA05075.1.
AJ001898 mRNA. Translation: CAA05076.1.
AJ001899 mRNA. Translation: CAA05077.1.
AJ001900 mRNA. Translation: CAA05078.1.
AF063586 Genomic DNA. Translation: AAC98782.1.
PIRB37499.
RefSeqNP_000505.1. NM_000514.3.
NP_001177397.1. NM_001190468.1.
NP_001177398.1. NM_001190469.1.
NP_001265027.1. NM_001278098.1.
NP_954701.1. NM_199231.2.
UniGeneHs.248114.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2V5EX-ray2.35B111-211[»]
3FUBX-ray2.35B/D78-211[»]
ProteinModelPortalP39905.
SMRP39905. Positions 109-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108936. 3 interactions.
DIPDIP-59051N.

Polymorphism databases

DMDM729567.

Proteomic databases

PaxDbP39905.
PRIDEP39905.

Protocols and materials databases

DNASU2668.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326524; ENSP00000317145; ENSG00000168621. [P39905-1]
ENST00000344622; ENSP00000339703; ENSG00000168621. [P39905-2]
ENST00000381826; ENSP00000371248; ENSG00000168621. [P39905-4]
ENST00000427982; ENSP00000409007; ENSG00000168621. [P39905-3]
ENST00000502572; ENSP00000423557; ENSG00000168621.
ENST00000510177; ENSP00000424592; ENSG00000168621.
ENST00000515058; ENSP00000425928; ENSG00000168621. [P39905-2]
GeneID2668.
KEGGhsa:2668.
UCSCuc011cpd.2. human. [P39905-1]
uc011cpe.2. human. [P39905-2]
uc011cpg.2. human. [P39905-3]
uc011cph.2. human. [P39905-4]

Organism-specific databases

CTD2668.
GeneCardsGC05M037812.
HGNCHGNC:4232. GDNF.
HPACAB005210.
MIM209880. phenotype.
600837. gene.
613711. phenotype.
neXtProtNX_P39905.
Orphanet388. Hirschsprung disease.
661. Ondine syndrome.
PharmGKBPA28644.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40754.
HOVERGENHBG106680.
InParanoidP39905.
KOK05452.
OMATMYDKIL.
OrthoDBEOG7BS4BR.
PhylomeDBP39905.
TreeFamTF332366.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
SignaLinkP39905.

Gene expression databases

BgeeP39905.
GenevestigatorP39905.

Family and domain databases

InterProIPR016649. GDNF.
IPR001839. TGF-b_C.
[Graphical view]
PfamPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFPIRSF016238. GDNF. 1 hit.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP39905.
GeneWikiGlial_cell_line-derived_neurotrophic_factor.
GenomeRNAi2668.
NextBio10524.
PROP39905.
SOURCESearch...

Entry information

Entry nameGDNF_HUMAN
AccessionPrimary (citable) accession number: P39905
Secondary accession number(s): B7WPK7 expand/collapse secondary AC list , O95448, O95449, O95986, Q6FH33, Q96L44, Q9UD32, Q9UD33, Q9UMV2, Q9UP67, Q9UP97
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM