P39890 (TCMI_STRGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetracenomycin polyketide synthesis protein TcmI

Gene names

Name:

tcmI

Organism

Streptomyces glaucescens

Taxonomic identifier

1907 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for conversion of tetracenomycin F2 to tetracenomycin D3.
Pathway	Antibiotic biosynthesis; tetracenomycin C biosynthesis.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW polyketide biosynthetic process Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 109

109

Tetracenomycin polyketide synthesis protein TcmI

PRO_0000072454

Secondary structure

1

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109

Helix Strand Turn

Details...

Beta strand

3 – 11

9

Helix

13 – 15

3

Helix

16 – 26

11

Helix

31 – 35

5

Beta strand

39 – 45

7

Beta strand

48 – 57

10

Helix

60 – 65

6

Helix

70 – 72

3

Helix

73 – 80

8

Beta strand

83 – 87

5

Helix

93 – 96

4

Sequences

	Sequence		Length	Mass (Da)
	P39890 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 1F9E3EC9E1B90593	FASTA	109	12,861
	10 20 30 40 50 60 MAYRALMVLR MDPADAEHVA AAFAEHDTTE LPLEIGVRRR VLFRFHDLYM HLIEADDDIM 70 80 90 100 ERLYQARSHP LFQEVNERVG QYLTPYAQDW EELKDSKAEV FYSWTAPDS

References

[1]	"Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci." Guilfoile P.G., Hutchinson C.R. J. Bacteriol. 174:3651-3658(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 40716 / ETH 22794 / GLA.0.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M80674 Genomic DNA. Translation: AAA67513.1.

PIR

B53291.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TUW	X-ray	1.90	A	1-109	[»]

ProteinModelPortal

P39890.

SMR

P39890. Positions 2-107.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Enzyme and pathway databases

UniPathway

UPA00174.

Family and domain databases

Gene3D

3.30.70.1090. 1 hit.

InterPro

IPR011008. Dimeric_a/b-barrel.
IPR006765. Polyketide_synth_cyclase.
[Graphical view]

Pfam

PF04673. Cyclase_polyket. 1 hit.
[Graphical view]

ProDom

PD012644. Polyketide_synth_cyclase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF54909. Dimer_A_B_barrel. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P39890.

Entry information

Entry name

TCMI_STRGA

Accession

Primary (citable) accession number: P39890

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program