P39887 (TCMP_STRGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetracenomycin polyketide synthesis O-methyltransferase tcmP
EC=2.1.1.-

Gene names

Name:

tcmP

Organism

Streptomyces glaucescens

Taxonomic identifier

1907 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions: methylation of 8-O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 to 9-carboxymethyl-TCM B3.
Pathway	Antibiotic biosynthesis; tetracenomycin C biosynthesis.
Sequence caution	The sequence AAA67510.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Tetracenomycin polyketide synthesis O-methyltransferase tcmP		PRO_0000072458

Sequences

	Sequence		Length	Mass (Da)
	P39887 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 53D14779B2265F83	FASTA	270	30,886
	10 20 30 40 50 60 MGETIRLTGV HETLLATLQA RALDNRQPRP VLGDATAEEL LRRIDYDFSR IRTATKDMRI 70 80 90 100 110 120 VTFRARKLDE WAGRFLAVHP DAVVLHLACG LDSRAFRMDV PDTVEWIDVD VPDVIELRSR 130 140 150 160 170 180 LYPERDGYRM IGASVTTEDW LDTVPRNRPA LVVAEGLTPY LREADGEEML RRVIRHLPTG 190 200 210 220 230 240 AVMFDAVLPW TLRFAKYSQL LRATGATFGW GIGNPRSLES RVPGLRFQEQ WSMLDSPFLA 250 260 270 DARPVEKWVG AGMRSIPQLR FAHRLLRYTF

References

[1]

"Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens." Decker H., Motamedi H., Hutchinson C.R. J. Bacteriol. 175:3876-3886(1993) [PubMed: 8509339] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 40716 / ETH 22794 / GLA.0.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M80674 Genomic DNA. Translation: AAA67510.1. Different initiation.
PIR	C47127. S27688.
3D structure databases
ProteinModelPortal	P39887.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR016874. Polyketide_Synt_OMeTrfase_TcmP. [Graphical view]
Pfam	PF04072. LCM. 1 hit. [Graphical view]
PIRSF	PIRSF028177. Polyketide_synth_Omtfrase_TcmP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TCMP_STRGA

Accession

Primary (citable) accession number: P39887

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 30, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program