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P39880

- CUX1_HUMAN

UniProt

P39880 - CUX1_HUMAN

Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi542 – 62988CUT 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi934 – 102188CUT 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1117 – 120488CUT 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1244 – 130360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
    3. sequence-specific DNA binding Source: UniProt
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. auditory receptor cell differentiation Source: Ensembl
    2. kidney development Source: Ensembl
    3. lung development Source: Ensembl
    4. multicellular organismal development Source: ProtInc
    5. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    6. positive regulation of dendrite morphogenesis Source: UniProt
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. retrograde transport, vesicle recycling within Golgi Source: Ensembl
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein cut-like 1
    Alternative name(s):
    CCAAT displacement protein
    Short name:
    CDP
    Homeobox protein cux-1
    Gene namesi
    Name:CUX1
    Synonyms:CUTL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:2557. CUX1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. Golgi membrane Source: Ensembl
    4. nucleus Source: UniProt

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15051505Homeobox protein cut-like 1PRO_0000202393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei763 – 7631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP39880.
    PRIDEiP39880.

    PTM databases

    PhosphoSiteiP39880.

    Miscellaneous databases

    PMAP-CutDBP39880.

    Expressioni

    Gene expression databases

    ArrayExpressiP39880.
    BgeeiP39880.
    CleanExiHS_CUX1.
    GenevestigatoriP39880.

    Organism-specific databases

    HPAiHPA003277.
    HPA003317.

    Interactioni

    Subunit structurei

    Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107903. 19 interactions.
    IntActiP39880. 7 interactions.
    MINTiMINT-271237.
    STRINGi9606.ENSP00000292535.

    Structurei

    3D structure databases

    ProteinModelPortaliP39880.
    SMRiP39880. Positions 547-635, 934-1024, 1116-1296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili56 – 407352Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1406 – 143833Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Homeobox, Repeat

    Phylogenomic databases

    HOVERGENiHBG051268.
    KOiK09313.
    OMAiMIFPTGP.
    PhylomeDBiP39880.
    TreeFamiTF318206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProiIPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEiPS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR     50
    KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 100
    LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 150
    QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 200
    QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 250
    ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 300
    QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 350
    YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 400
    ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ 450
    FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA 500
    GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE 550
    MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 600
    VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN 650
    GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG 700
    NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP 750
    MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA 800
    DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK 850
    EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA 900
    SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR 950
    QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI 1000
    RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS 1050
    ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS 1100
    QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG 1150
    ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD 1200
    MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV 1250
    LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR 1300
    RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA 1350
    DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG 1400
    PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP 1450
    RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP 1500
    IEWEF 1505
    Length:1,505
    Mass (Da):164,187
    Last modified:May 18, 2010 - v3
    Checksum:i0F9027E5B8F08D95
    GO
    Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         632-653: Missing.

    Show »
    Length:1,483
    Mass (Da):161,650
    Checksum:i369D44022E3FF3D7
    GO
    Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

    Note: No experimental confirmation available.

    Show »
    Length:1,516
    Mass (Da):165,688
    Checksum:i13E5E97E8569C5AA
    GO
    Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         408-509: Missing.

    Show »
    Length:1,403
    Mass (Da):153,364
    Checksum:iB10F9B5E864C9D8F
    GO
    Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         632-687: Missing.

    Show »
    Length:1,449
    Mass (Da):157,895
    Checksum:iEC08BD990BA5321C
    GO
    Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         408-509: Missing.
         632-687: Missing.

    Show »
    Length:1,347
    Mass (Da):147,072
    Checksum:iD50586280B4D0B81
    GO
    Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
         90-135: Missing.
         409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
         668-1505: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:632
    Mass (Da):72,024
    Checksum:iA399B4B63B891AA6
    GO
    Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to Basket

    Also known as: CASP

    The sequence of this isoform can be found in the external entry Q13948.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:678
    Mass (Da):77,455
    GO
    Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q13948.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:676
    Mass (Da):77,198
    GO
    Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q13948.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:639
    Mass (Da):72,841
    GO
    Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q13948.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:662
    Mass (Da):75,644
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51A → R in M74099. (PubMed:1301999)Curated
    Sequence conflicti145 – 1451K → I in BAG53691. (PubMed:14702039)Curated
    Sequence conflicti260 – 2601A → V in BAG53691. (PubMed:14702039)Curated
    Sequence conflicti704 – 7052DA → EP in M74099. (PubMed:1301999)Curated
    Sequence conflicti844 – 8441E → R in M74099. (PubMed:1301999)Curated
    Sequence conflicti1436 – 14361S → T in M74099. (PubMed:1301999)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 PublicationsVSP_015747
    Alternative sequencei90 – 13546Missing in isoform 11. 1 PublicationVSP_045924Add
    BLAST
    Alternative sequencei408 – 509102Missing in isoform 5 and isoform 7. CuratedVSP_017358Add
    BLAST
    Alternative sequencei409 – 667259SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationVSP_045925Add
    BLAST
    Alternative sequencei632 – 68756Missing in isoform 6 and isoform 7. CuratedVSP_017359Add
    BLAST
    Alternative sequencei632 – 65322Missing in isoform 2. 1 PublicationVSP_002310Add
    BLAST
    Alternative sequencei668 – 1505838Missing in isoform 11. 1 PublicationVSP_045926Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74099 mRNA. No translation available.
    AK122726 mRNA. Translation: BAG53691.1.
    AC005072 Genomic DNA. No translation available.
    AC005086 Genomic DNA. Translation: AAP22331.1.
    AC005088 Genomic DNA. No translation available.
    AC005096 Genomic DNA. Translation: AAS07410.1.
    AC005103 Genomic DNA. Translation: AAS07388.1.
    AC092788 Genomic DNA. Translation: AAS07523.1.
    BC066592 mRNA. Translation: AAH66592.1.
    AF047825 Genomic DNA. Translation: AAC78778.1.
    CCDSiCCDS56498.1. [P39880-3]
    CCDS56499.1. [P39880-9]
    CCDS5721.1. [P39880-1]
    RefSeqiNP_001189472.1. NM_001202543.1. [P39880-3]
    NP_001189473.1. NM_001202544.2.
    NP_001189474.1. NM_001202545.2. [P39880-9]
    NP_852477.1. NM_181500.3.
    NP_853530.2. NM_181552.3. [P39880-1]
    UniGeneiHs.191482.

    Genome annotation databases

    EnsembliENST00000292535; ENSP00000292535; ENSG00000257923. [P39880-1]
    ENST00000360264; ENSP00000353401; ENSG00000257923. [P39880-3]
    ENST00000425244; ENSP00000409745; ENSG00000257923. [P39880-9]
    ENST00000546411; ENSP00000450125; ENSG00000257923. [P39880-4]
    ENST00000549414; ENSP00000446630; ENSG00000257923. [P39880-2]
    ENST00000550008; ENSP00000447373; ENSG00000257923. [P39880-5]
    ENST00000556210; ENSP00000451558; ENSG00000257923. [P39880-6]
    GeneIDi1523.
    KEGGihsa:1523.
    UCSCiuc003uys.4. human. [P39880-3]
    uc003uyx.4. human. [P39880-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74099 mRNA. No translation available.
    AK122726 mRNA. Translation: BAG53691.1 .
    AC005072 Genomic DNA. No translation available.
    AC005086 Genomic DNA. Translation: AAP22331.1 .
    AC005088 Genomic DNA. No translation available.
    AC005096 Genomic DNA. Translation: AAS07410.1 .
    AC005103 Genomic DNA. Translation: AAS07388.1 .
    AC092788 Genomic DNA. Translation: AAS07523.1 .
    BC066592 mRNA. Translation: AAH66592.1 .
    AF047825 Genomic DNA. Translation: AAC78778.1 .
    CCDSi CCDS56498.1. [P39880-3 ]
    CCDS56499.1. [P39880-9 ]
    CCDS5721.1. [P39880-1 ]
    RefSeqi NP_001189472.1. NM_001202543.1. [P39880-3 ]
    NP_001189473.1. NM_001202544.2.
    NP_001189474.1. NM_001202545.2. [P39880-9 ]
    NP_852477.1. NM_181500.3.
    NP_853530.2. NM_181552.3. [P39880-1 ]
    UniGenei Hs.191482.

    3D structure databases

    ProteinModelPortali P39880.
    SMRi P39880. Positions 547-635, 934-1024, 1116-1296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107903. 19 interactions.
    IntActi P39880. 7 interactions.
    MINTi MINT-271237.
    STRINGi 9606.ENSP00000292535.

    PTM databases

    PhosphoSitei P39880.

    Proteomic databases

    MaxQBi P39880.
    PRIDEi P39880.

    Protocols and materials databases

    DNASUi 1523.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292535 ; ENSP00000292535 ; ENSG00000257923 . [P39880-1 ]
    ENST00000360264 ; ENSP00000353401 ; ENSG00000257923 . [P39880-3 ]
    ENST00000425244 ; ENSP00000409745 ; ENSG00000257923 . [P39880-9 ]
    ENST00000546411 ; ENSP00000450125 ; ENSG00000257923 . [P39880-4 ]
    ENST00000549414 ; ENSP00000446630 ; ENSG00000257923 . [P39880-2 ]
    ENST00000550008 ; ENSP00000447373 ; ENSG00000257923 . [P39880-5 ]
    ENST00000556210 ; ENSP00000451558 ; ENSG00000257923 . [P39880-6 ]
    GeneIDi 1523.
    KEGGi hsa:1523.
    UCSCi uc003uys.4. human. [P39880-3 ]
    uc003uyx.4. human. [P39880-1 ]

    Organism-specific databases

    CTDi 1523.
    GeneCardsi GC07P101459.
    HGNCi HGNC:2557. CUX1.
    HPAi HPA003277.
    HPA003317.
    MIMi 116896. gene.
    neXtProti NX_P39880.
    PharmGKBi PA162382924.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG051268.
    KOi K09313.
    OMAi MIFPTGP.
    PhylomeDBi P39880.
    TreeFami TF318206.

    Enzyme and pathway databases

    Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

    Miscellaneous databases

    ChiTaRSi CUX1. human.
    GeneWikii CUTL1.
    GenomeRNAii 1523.
    NextBioi 35535424.
    PMAP-CutDB P39880.
    PROi P39880.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P39880.
    Bgeei P39880.
    CleanExi HS_CUX1.
    Genevestigatori P39880.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProi IPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEi PS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut."
      Neufeld E.J., Skalnik D.G., Lievens P.M.-J., Orkin S.H.
      Nat. Genet. 1:50-55(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Umbilical vein.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11).
      Tissue: Brain.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Duodenum.
    5. "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
      Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A.
      Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-224 (ISOFORMS 1/2/3).
    6. "Exon/intron structure and alternative transcripts of the CUTL1 gene."
      Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G., Leduy L., Nepveu A.
      Gene 241:75-85(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 6 AND 7).
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCUX1_HUMAN
    AccessioniPrimary (citable) accession number: P39880
    Secondary accession number(s): B3KV79
    , J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3