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Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi542 – 629CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi934 – 1021CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1117 – 1204CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1244 – 1303HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160967-MONOMER.
ReactomeiR-HSA-1839117. Signaling by cytosolic FGFR1 fusion mutants.
R-HSA-5655302. Signaling by FGFR1 in disease.
SIGNORiP39880.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 1
Alternative name(s):
CCAAT displacement protein
Short name:
CDP
Homeobox protein cux-1
Gene namesi
Name:CUX1
Synonyms:CUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2557. CUX1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: GO_Central
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1523.
OpenTargetsiENSG00000257923.
PharmGKBiPA162382924.

Polymorphism and mutation databases

BioMutaiUGT3A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002023931 – 1505Homeobox protein cut-like 1Add BLAST1505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei763PhosphoserineCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki811Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909PhosphoserineBy similarity1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1069PhosphoserineBy similarity1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1337PhosphoserineBy similarity1
Modified residuei1455PhosphoserineCombined sources1
Modified residuei1486PhosphoserineCombined sources1
Modified residuei1496PhosphoserineBy similarity1
Isoform 11 (identifier: P39880-9)
Modified residuei540PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP39880.
PaxDbiP39880.
PeptideAtlasiP39880.
PRIDEiP39880.

PTM databases

iPTMnetiP39880.
PhosphoSitePlusiP39880.

Miscellaneous databases

PMAP-CutDBP39880.

Expressioni

Gene expression databases

BgeeiENSG00000257923.
CleanExiHS_CUX1.
ExpressionAtlasiP39880. baseline and differential.
GenevisibleiP39880. HS.

Organism-specific databases

HPAiHPA003277.
HPA003317.

Interactioni

Subunit structurei

Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi107903. 50 interactors.
IntActiP39880. 25 interactors.
MINTiMINT-271237.
STRINGi9606.ENSP00000353401.

Structurei

3D structure databases

ProteinModelPortaliP39880.
SMRiP39880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 407Sequence analysisAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1406 – 1438Ala-richAdd BLAST33

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOVERGENiHBG051268.
InParanoidiP39880.
OMAiEYWKDWP.
OrthoDBiEOG091G011E.
PhylomeDBiP39880.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR
60 70 80 90 100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ
110 120 130 140 150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE
160 170 180 190 200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL
210 220 230 240 250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA
260 270 280 290 300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD
360 370 380 390 400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR
410 420 430 440 450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ
460 470 480 490 500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA
510 520 530 540 550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE
560 570 580 590 600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN
660 670 680 690 700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG
710 720 730 740 750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP
760 770 780 790 800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA
810 820 830 840 850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK
860 870 880 890 900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR
960 970 980 990 1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI
1010 1020 1030 1040 1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS
1060 1070 1080 1090 1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS
1110 1120 1130 1140 1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG
1160 1170 1180 1190 1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV
1260 1270 1280 1290 1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR
1310 1320 1330 1340 1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA
1360 1370 1380 1390 1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG
1410 1420 1430 1440 1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP
1460 1470 1480 1490 1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP

IEWEF
Length:1,505
Mass (Da):164,187
Last modified:May 18, 2010 - v3
Checksum:i0F9027E5B8F08D95
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-653: Missing.

Show »
Length:1,483
Mass (Da):161,650
Checksum:i369D44022E3FF3D7
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

Note: No experimental confirmation available.
Show »
Length:1,516
Mass (Da):165,688
Checksum:i13E5E97E8569C5AA
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.

Show »
Length:1,403
Mass (Da):153,364
Checksum:iB10F9B5E864C9D8F
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-687: Missing.

Show »
Length:1,449
Mass (Da):157,895
Checksum:iEC08BD990BA5321C
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
     632-687: Missing.

Show »
Length:1,347
Mass (Da):147,072
Checksum:iD50586280B4D0B81
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:632
Mass (Da):72,024
Checksum:iA399B4B63B891AA6
GO
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:678
Mass (Da):77,455
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:676
Mass (Da):77,198
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:639
Mass (Da):72,841
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:662
Mass (Da):75,644
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti145K → I in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti260A → V in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti704 – 705DA → EP in M74099 (PubMed:1301999).Curated2
Sequence conflicti844E → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti1436S → T in M74099 (PubMed:1301999).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0157471 – 10MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 Publications10
Alternative sequenceiVSP_04592490 – 135Missing in isoform 11. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_017358408 – 509Missing in isoform 5 and isoform 7. CuratedAdd BLAST102
Alternative sequenceiVSP_045925409 – 667SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_017359632 – 687Missing in isoform 6 and isoform 7. CuratedAdd BLAST56
Alternative sequenceiVSP_002310632 – 653Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_045926668 – 1505Missing in isoform 11. 1 PublicationAdd BLAST838

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74099 mRNA. No translation available.
AK122726 mRNA. Translation: BAG53691.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
BC066592 mRNA. Translation: AAH66592.1.
AF047825 Genomic DNA. Translation: AAC78778.1.
CCDSiCCDS56498.1. [P39880-3]
CCDS56499.1. [P39880-9]
CCDS5721.1. [P39880-1]
RefSeqiNP_001189472.1. NM_001202543.1. [P39880-3]
NP_001189473.1. NM_001202544.2.
NP_001189474.1. NM_001202545.2. [P39880-9]
NP_852477.1. NM_181500.3.
NP_853530.2. NM_181552.3. [P39880-1]
UniGeneiHs.191482.

Genome annotation databases

EnsembliENST00000292535; ENSP00000292535; ENSG00000257923. [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923. [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923. [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923. [P39880-4]
ENST00000549414; ENSP00000446630; ENSG00000257923. [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923. [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923. [P39880-6]
GeneIDi1523.
UCSCiuc003uys.5. human. [P39880-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74099 mRNA. No translation available.
AK122726 mRNA. Translation: BAG53691.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
BC066592 mRNA. Translation: AAH66592.1.
AF047825 Genomic DNA. Translation: AAC78778.1.
CCDSiCCDS56498.1. [P39880-3]
CCDS56499.1. [P39880-9]
CCDS5721.1. [P39880-1]
RefSeqiNP_001189472.1. NM_001202543.1. [P39880-3]
NP_001189473.1. NM_001202544.2.
NP_001189474.1. NM_001202545.2. [P39880-9]
NP_852477.1. NM_181500.3.
NP_853530.2. NM_181552.3. [P39880-1]
UniGeneiHs.191482.

3D structure databases

ProteinModelPortaliP39880.
SMRiP39880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107903. 50 interactors.
IntActiP39880. 25 interactors.
MINTiMINT-271237.
STRINGi9606.ENSP00000353401.

PTM databases

iPTMnetiP39880.
PhosphoSitePlusiP39880.

Polymorphism and mutation databases

BioMutaiUGT3A1.

Proteomic databases

EPDiP39880.
PaxDbiP39880.
PeptideAtlasiP39880.
PRIDEiP39880.

Protocols and materials databases

DNASUi1523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292535; ENSP00000292535; ENSG00000257923. [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923. [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923. [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923. [P39880-4]
ENST00000549414; ENSP00000446630; ENSG00000257923. [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923. [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923. [P39880-6]
GeneIDi1523.
UCSCiuc003uys.5. human. [P39880-1]

Organism-specific databases

CTDi1523.
DisGeNETi1523.
GeneCardsiCUX1.
HGNCiHGNC:2557. CUX1.
HPAiHPA003277.
HPA003317.
MIMi116896. gene.
neXtProtiNX_P39880.
OpenTargetsiENSG00000257923.
PharmGKBiPA162382924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOVERGENiHBG051268.
InParanoidiP39880.
OMAiEYWKDWP.
OrthoDBiEOG091G011E.
PhylomeDBiP39880.
TreeFamiTF318206.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160967-MONOMER.
ReactomeiR-HSA-1839117. Signaling by cytosolic FGFR1 fusion mutants.
R-HSA-5655302. Signaling by FGFR1 in disease.
SIGNORiP39880.

Miscellaneous databases

ChiTaRSiCUX1. human.
GeneWikiiCUTL1.
GenomeRNAii1523.
PMAP-CutDBP39880.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257923.
CleanExiHS_CUX1.
ExpressionAtlasiP39880. baseline and differential.
GenevisibleiP39880. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUX1_HUMAN
AccessioniPrimary (citable) accession number: P39880
Secondary accession number(s): B3KV79
, J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.