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P39880 (CUX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein cut-like 1
Alternative name(s):
CCAAT displacement protein
Short name=CDP
Homeobox protein cux-1
Gene names
Name:CUX1
Synonyms:CUTL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer By similarity.

Subunit structure

Interacts with BANP By similarity.

Subcellular location

Nucleus.

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 3 CUT DNA-binding domains.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Homeobox
Repeat
   LigandDNA-binding
   Molecular functionDevelopmental protein
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauditory receptor cell differentiation

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Traceable author statement Ref.1. Source: ProtInc

negative regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

retrograde transport, vesicle recycling within Golgi

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionchromatin binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P39880-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P39880-2)

The sequence of this isoform differs from the canonical sequence as follows:
     632-653: Missing.
Isoform 3 (identifier: P39880-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
Note: No experimental confirmation available.
Isoform 5 (identifier: P39880-4)

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
Isoform 6 (identifier: P39880-5)

The sequence of this isoform differs from the canonical sequence as follows:
     632-687: Missing.
Isoform 7 (identifier: P39880-6)

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
     632-687: Missing.
Isoform 11 (identifier: P39880-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q13948-1)

Also known as: CASP;

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform 8 (identifier: Q13948-2)

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Isoform 9 (identifier: Q13948-9)

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Isoform 10 (identifier: Q13948-10)

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15051505Homeobox protein cut-like 1
PRO_0000202393

Regions

DNA binding542 – 62988CUT 1
DNA binding934 – 102188CUT 2
DNA binding1117 – 120488CUT 3
DNA binding1244 – 130360Homeobox
Coiled coil7 – 363357 Potential
Coiled coil669 – 72557 Potential

Amino acid modifications

Modified residue7631Phosphoserine Ref.11

Natural variations

Alternative sequence1 – 1010MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11.
VSP_015747
Alternative sequence90 – 13546Missing in isoform 11.
VSP_045924
Alternative sequence408 – 509102Missing in isoform 5 and isoform 7.
VSP_017358
Alternative sequence409 – 667259SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11.
VSP_045925
Alternative sequence632 – 68756Missing in isoform 6 and isoform 7.
VSP_017359
Alternative sequence632 – 65322Missing in isoform 2.
VSP_002310
Alternative sequence668 – 1505838Missing in isoform 11.
VSP_045926

Experimental info

Sequence conflict51A → R in M74099. Ref.1
Sequence conflict1451K → I in BAG53691. Ref.2
Sequence conflict2601A → V in BAG53691. Ref.2
Sequence conflict704 – 7052DA → EP in M74099. Ref.1
Sequence conflict8441E → R in M74099. Ref.1
Sequence conflict14361S → T in M74099. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 0F9027E5B8F08D95

FASTA1,505164,187
        10         20         30         40         50         60 
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF 

        70         80         90        100        110        120 
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE 

       130        140        150        160        170        180 
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ 

       190        200        210        220        230        240 
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN 

       250        260        270        280        290        300 
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 

       310        320        330        340        350        360 
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI 

       370        380        390        400        410        420 
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES 

       430        440        450        460        470        480 
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL 

       490        500        510        520        530        540 
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE 

       550        560        570        580        590        600 
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 

       610        620        630        640        650        660 
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI 

       670        680        690        700        710        720 
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ 

       730        740        750        760        770        780 
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN 

       790        800        810        820        830        840 
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE 

       850        860        870        880        890        900 
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA 

       910        920        930        940        950        960 
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG 

       970        980        990       1000       1010       1020 
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ 

      1030       1040       1050       1060       1070       1080 
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP 

      1090       1100       1110       1120       1130       1140 
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT 

      1150       1160       1170       1180       1190       1200 
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD 

      1210       1220       1230       1240       1250       1260 
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK 

      1270       1280       1290       1300       1310       1320 
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD 

      1330       1340       1350       1360       1370       1380 
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT 

      1390       1400       1410       1420       1430       1440 
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP 

      1450       1460       1470       1480       1490       1500 
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP 


IEWEF 

« Hide

Isoform 2 [UniParc].

Checksum: 369D44022E3FF3D7
Show »

FASTA1,483161,650
Isoform 3 [UniParc].

Checksum: 13E5E97E8569C5AA
Show »

FASTA1,516165,688
Isoform 5 [UniParc].

Checksum: B10F9B5E864C9D8F
Show »

FASTA1,403153,364
Isoform 6 [UniParc].

Checksum: EC08BD990BA5321C
Show »

FASTA1,449157,895
Isoform 7 [UniParc].

Checksum: D50586280B4D0B81
Show »

FASTA1,347147,072
Isoform 11 [UniParc].

Checksum: A399B4B63B891AA6
Show »

FASTA63272,024
Isoform 4 (CASP) [UniParc].

See Q13948.

Isoform 8 [UniParc].

See Q13948.

Isoform 9 [UniParc].

See Q13948.

Isoform 10 [UniParc].

See Q13948.

References

« Hide 'large scale' references
[1]"Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut."
Neufeld E.J., Skalnik D.G., Lievens P.M.-J., Orkin S.H.
Nat. Genet. 1:50-55(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Umbilical vein.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11).
Tissue: Brain.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Duodenum.
[5]"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A.
Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-224 (ISOFORMS 1/2/3).
[6]"Exon/intron structure and alternative transcripts of the CUTL1 gene."
Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G., Leduy L., Nepveu A.
Gene 241:75-85(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 6 AND 7).
[7]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74099 mRNA. No translation available.
AK122726 mRNA. Translation: BAG53691.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
BC066592 mRNA. Translation: AAH66592.1.
AF047825 Genomic DNA. Translation: AAC78778.1.
RefSeqNP_001189472.1. NM_001202543.1.
NP_001189474.1. NM_001202545.2.
NP_853530.2. NM_181552.3.
UniGeneHs.191482.

3D structure databases

ProteinModelPortalP39880.
SMRP39880. Positions 547-635, 934-1024, 1116-1296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107903. 19 interactions.
IntActP39880. 7 interactions.
MINTMINT-271237.
STRING9606.ENSP00000292535.

PTM databases

PhosphoSiteP39880.

Proteomic databases

PRIDEP39880.

Protocols and materials databases

DNASU1523.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292535; ENSP00000292535; ENSG00000257923. [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923. [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923. [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923. [P39880-4]
ENST00000549414; ENSP00000446630; ENSG00000257923. [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923. [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923. [P39880-6]
ENST00000562419; ENSP00000456964; ENSG00000259938. [P39880-6]
ENST00000562858; ENSP00000456303; ENSG00000259938. [P39880-9]
ENST00000565244; ENSP00000456251; ENSG00000259938. [P39880-2]
ENST00000566988; ENSP00000455160; ENSG00000259938. [P39880-5]
ENST00000568052; ENSP00000458017; ENSG00000259938. [P39880-4]
ENST00000568166; ENSP00000456980; ENSG00000259938. [P39880-1]
ENST00000569498; ENSP00000455398; ENSG00000259938. [P39880-3]
GeneID1523.
KEGGhsa:1523.
UCSCuc003uys.4. human. [P39880-3]
uc003uyx.4. human. [P39880-1]

Organism-specific databases

CTD1523.
GeneCardsGC07P101459.
HGNCHGNC:2557. CUX1.
HPAHPA003277.
HPA003317.
MIM116896. gene.
neXtProtNX_P39880.
PharmGKBPA162382924.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG051268.
KOK09313.
OMAEYWKDWP.
PhylomeDBP39880.
TreeFamTF318206.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.

Gene expression databases

ArrayExpressP39880.
BgeeP39880.
CleanExHS_CUX1.
GenevestigatorP39880.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
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ChiTaRSCUX1. human.
GeneWikiCUTL1.
GenomeRNAi1523.
NextBio35535424.
PMAP-CutDBP39880.
PROP39880.
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Entry information

Entry nameCUX1_HUMAN
AccessionPrimary (citable) accession number: P39880
Secondary accession number(s): B3KV79 expand/collapse secondary AC list , J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM