Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P39880

- CUX1_HUMAN

UniProt

P39880 - CUX1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi542 – 62988CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi934 – 102188CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1117 – 120488CUT 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1244 – 130360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
  4. sequence-specific DNA binding Source: UniProt

GO - Biological processi

  1. auditory receptor cell differentiation Source: Ensembl
  2. kidney development Source: Ensembl
  3. lung development Source: Ensembl
  4. multicellular organismal development Source: ProtInc
  5. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  6. positive regulation of dendrite morphogenesis Source: UniProt
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. retrograde transport, vesicle recycling within Golgi Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 1
Alternative name(s):
CCAAT displacement protein
Short name:
CDP
Homeobox protein cux-1
Gene namesi
Name:CUX1
Synonyms:CUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2557. CUX1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. Golgi membrane Source: Ensembl
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15051505Homeobox protein cut-like 1PRO_0000202393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei763 – 7631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39880.
PRIDEiP39880.

PTM databases

PhosphoSiteiP39880.

Miscellaneous databases

PMAP-CutDBP39880.

Expressioni

Gene expression databases

BgeeiP39880.
CleanExiHS_CUX1.
ExpressionAtlasiP39880. baseline and differential.
GenevestigatoriP39880.

Organism-specific databases

HPAiHPA003277.
HPA003317.

Interactioni

Subunit structurei

Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA By similarity.By similarity

Protein-protein interaction databases

BioGridi107903. 26 interactions.
IntActiP39880. 7 interactions.
MINTiMINT-271237.
STRINGi9606.ENSP00000292535.

Structurei

3D structure databases

ProteinModelPortaliP39880.
SMRiP39880. Positions 547-635, 934-1024, 1116-1296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 407352Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1406 – 143833Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063019.
HOVERGENiHBG051268.
InParanoidiP39880.
KOiK09313.
OMAiMIFPTGP.
PhylomeDBiP39880.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR
60 70 80 90 100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ
110 120 130 140 150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE
160 170 180 190 200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL
210 220 230 240 250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA
260 270 280 290 300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD
360 370 380 390 400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR
410 420 430 440 450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ
460 470 480 490 500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA
510 520 530 540 550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE
560 570 580 590 600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN
660 670 680 690 700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG
710 720 730 740 750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP
760 770 780 790 800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA
810 820 830 840 850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK
860 870 880 890 900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR
960 970 980 990 1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI
1010 1020 1030 1040 1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS
1060 1070 1080 1090 1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS
1110 1120 1130 1140 1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG
1160 1170 1180 1190 1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV
1260 1270 1280 1290 1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR
1310 1320 1330 1340 1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA
1360 1370 1380 1390 1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG
1410 1420 1430 1440 1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP
1460 1470 1480 1490 1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP

IEWEF
Length:1,505
Mass (Da):164,187
Last modified:May 18, 2010 - v3
Checksum:i0F9027E5B8F08D95
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-653: Missing.

Show »
Length:1,483
Mass (Da):161,650
Checksum:i369D44022E3FF3D7
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

Note: No experimental confirmation available.

Show »
Length:1,516
Mass (Da):165,688
Checksum:i13E5E97E8569C5AA
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.

Show »
Length:1,403
Mass (Da):153,364
Checksum:iB10F9B5E864C9D8F
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-687: Missing.

Show »
Length:1,449
Mass (Da):157,895
Checksum:iEC08BD990BA5321C
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
     632-687: Missing.

Show »
Length:1,347
Mass (Da):147,072
Checksum:iD50586280B4D0B81
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.

Note: No experimental confirmation available.

Show »
Length:632
Mass (Da):72,024
Checksum:iA399B4B63B891AA6
GO
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to Basket

Also known as: CASP

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:678
Mass (Da):77,455
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:676
Mass (Da):77,198
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:639
Mass (Da):72,841
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:662
Mass (Da):75,644
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → R in M74099. (PubMed:1301999)Curated
Sequence conflicti145 – 1451K → I in BAG53691. (PubMed:14702039)Curated
Sequence conflicti260 – 2601A → V in BAG53691. (PubMed:14702039)Curated
Sequence conflicti704 – 7052DA → EP in M74099. (PubMed:1301999)Curated
Sequence conflicti844 – 8441E → R in M74099. (PubMed:1301999)Curated
Sequence conflicti1436 – 14361S → T in M74099. (PubMed:1301999)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 PublicationsVSP_015747
Alternative sequencei90 – 13546Missing in isoform 11. 1 PublicationVSP_045924Add
BLAST
Alternative sequencei408 – 509102Missing in isoform 5 and isoform 7. CuratedVSP_017358Add
BLAST
Alternative sequencei409 – 667259SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationVSP_045925Add
BLAST
Alternative sequencei632 – 68756Missing in isoform 6 and isoform 7. CuratedVSP_017359Add
BLAST
Alternative sequencei632 – 65322Missing in isoform 2. 1 PublicationVSP_002310Add
BLAST
Alternative sequencei668 – 1505838Missing in isoform 11. 1 PublicationVSP_045926Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74099 mRNA. No translation available.
AK122726 mRNA. Translation: BAG53691.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
BC066592 mRNA. Translation: AAH66592.1.
AF047825 Genomic DNA. Translation: AAC78778.1.
CCDSiCCDS56498.1. [P39880-3]
CCDS56499.1. [P39880-9]
CCDS5721.1. [P39880-1]
RefSeqiNP_001189472.1. NM_001202543.1. [P39880-3]
NP_001189473.1. NM_001202544.2.
NP_001189474.1. NM_001202545.2. [P39880-9]
NP_852477.1. NM_181500.3.
NP_853530.2. NM_181552.3. [P39880-1]
UniGeneiHs.191482.

Genome annotation databases

EnsembliENST00000292535; ENSP00000292535; ENSG00000257923. [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923. [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923. [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923. [P39880-4]
ENST00000549414; ENSP00000446630; ENSG00000257923. [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923. [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923. [P39880-6]
GeneIDi1523.
KEGGihsa:1523.
UCSCiuc003uys.4. human. [P39880-3]
uc003uyx.4. human. [P39880-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74099 mRNA. No translation available.
AK122726 mRNA. Translation: BAG53691.1 .
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1 .
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1 .
AC005103 Genomic DNA. Translation: AAS07388.1 .
AC092788 Genomic DNA. Translation: AAS07523.1 .
BC066592 mRNA. Translation: AAH66592.1 .
AF047825 Genomic DNA. Translation: AAC78778.1 .
CCDSi CCDS56498.1. [P39880-3 ]
CCDS56499.1. [P39880-9 ]
CCDS5721.1. [P39880-1 ]
RefSeqi NP_001189472.1. NM_001202543.1. [P39880-3 ]
NP_001189473.1. NM_001202544.2.
NP_001189474.1. NM_001202545.2. [P39880-9 ]
NP_852477.1. NM_181500.3.
NP_853530.2. NM_181552.3. [P39880-1 ]
UniGenei Hs.191482.

3D structure databases

ProteinModelPortali P39880.
SMRi P39880. Positions 547-635, 934-1024, 1116-1296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107903. 26 interactions.
IntActi P39880. 7 interactions.
MINTi MINT-271237.
STRINGi 9606.ENSP00000292535.

PTM databases

PhosphoSitei P39880.

Proteomic databases

MaxQBi P39880.
PRIDEi P39880.

Protocols and materials databases

DNASUi 1523.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292535 ; ENSP00000292535 ; ENSG00000257923 . [P39880-1 ]
ENST00000360264 ; ENSP00000353401 ; ENSG00000257923 . [P39880-3 ]
ENST00000425244 ; ENSP00000409745 ; ENSG00000257923 . [P39880-9 ]
ENST00000546411 ; ENSP00000450125 ; ENSG00000257923 . [P39880-4 ]
ENST00000549414 ; ENSP00000446630 ; ENSG00000257923 . [P39880-2 ]
ENST00000550008 ; ENSP00000447373 ; ENSG00000257923 . [P39880-5 ]
ENST00000556210 ; ENSP00000451558 ; ENSG00000257923 . [P39880-6 ]
GeneIDi 1523.
KEGGi hsa:1523.
UCSCi uc003uys.4. human. [P39880-3 ]
uc003uyx.4. human. [P39880-1 ]

Organism-specific databases

CTDi 1523.
GeneCardsi GC07P101459.
HGNCi HGNC:2557. CUX1.
HPAi HPA003277.
HPA003317.
MIMi 116896. gene.
neXtProti NX_P39880.
PharmGKBi PA162382924.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063019.
HOVERGENi HBG051268.
InParanoidi P39880.
KOi K09313.
OMAi MIFPTGP.
PhylomeDBi P39880.
TreeFami TF318206.

Enzyme and pathway databases

Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

Miscellaneous databases

ChiTaRSi CUX1. human.
GeneWikii CUTL1.
GenomeRNAii 1523.
NextBioi 35535424.
PMAP-CutDB P39880.
PROi P39880.
SOURCEi Search...

Gene expression databases

Bgeei P39880.
CleanExi HS_CUX1.
ExpressionAtlasi P39880. baseline and differential.
Genevestigatori P39880.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut."
    Neufeld E.J., Skalnik D.G., Lievens P.M.-J., Orkin S.H.
    Nat. Genet. 1:50-55(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Umbilical vein.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11).
    Tissue: Brain.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Duodenum.
  5. "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
    Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A.
    Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-224 (ISOFORMS 1/2/3).
  6. "Exon/intron structure and alternative transcripts of the CUTL1 gene."
    Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G., Leduy L., Nepveu A.
    Gene 241:75-85(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 6 AND 7).
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCUX1_HUMAN
AccessioniPrimary (citable) accession number: P39880
Secondary accession number(s): B3KV79
, J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3