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Protein

60S ribosomal protein L3

Gene

RPL3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3
Gene namesi
Name:RPL3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000772262 – 40360S ribosomal protein L3Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei136N6-acetyllysineBy similarity1
Modified residuei286N6-acetyllysineBy similarity1
Modified residuei294N6-acetyllysine; alternateBy similarity1
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei304PhosphoserineBy similarity1
Modified residuei366N6-acetyllysineBy similarity1
Modified residuei373N6-acetyllysineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP39872.
PeptideAtlasiP39872.
PRIDEiP39872.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003228.

Interactioni

Subunit structurei

Interacts with METTL18.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004188.

Structurei

3D structure databases

ProteinModelPortaliP39872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiP39872.
KOiK02925.
OMAiKVGMTHA.
OrthoDBiEOG091G086T.
TreeFamiTF300555.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDSSKP VHLTAFLGYK
60 70 80 90 100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVIVGIV GYVETPRGLR
110 120 130 140 150
TFKTIFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDA DGKKQLERDF
160 170 180 190 200
SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL MEVQVNGGTV AEKLDWARER
210 220 230 240 250
LEQQVPVSQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK
260 270 280 290 300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
310 320 330 340 350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS
360 370 380 390 400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TVEEKKAFMG PLKKDRIAKE

EGA
Length:403
Mass (Da):46,024
Last modified:January 23, 2007 - v2
Checksum:iBB1FD71F932D224E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362K → E in CAB76199 (PubMed:10684968).Curated1
Sequence conflicti397I → V in CAB76199 (PubMed:10684968).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29555 mRNA. Translation: CAA82654.1.
AJ238851 Genomic DNA. Translation: CAB76199.1.
BT021012 mRNA. Translation: AAX09029.1.
BC102253 mRNA. Translation: AAI02254.1.
PIRiS50221.
RefSeqiNP_777140.1. NM_174715.1.
UniGeneiBt.3467.

Genome annotation databases

EnsembliENSBTAT00000004188; ENSBTAP00000004188; ENSBTAG00000003228.
GeneIDi282688.
KEGGibta:282688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29555 mRNA. Translation: CAA82654.1.
AJ238851 Genomic DNA. Translation: CAB76199.1.
BT021012 mRNA. Translation: AAX09029.1.
BC102253 mRNA. Translation: AAI02254.1.
PIRiS50221.
RefSeqiNP_777140.1. NM_174715.1.
UniGeneiBt.3467.

3D structure databases

ProteinModelPortaliP39872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004188.

Proteomic databases

PaxDbiP39872.
PeptideAtlasiP39872.
PRIDEiP39872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004188; ENSBTAP00000004188; ENSBTAG00000003228.
GeneIDi282688.
KEGGibta:282688.

Organism-specific databases

CTDi6122.

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiP39872.
KOiK02925.
OMAiKVGMTHA.
OrthoDBiEOG091G086T.
TreeFamiTF300555.

Enzyme and pathway databases

ReactomeiR-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

BgeeiENSBTAG00000003228.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL3_BOVIN
AccessioniPrimary (citable) accession number: P39872
Secondary accession number(s): Q5E9A8, Q9N0L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.