P39853 (CAPD_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsular polysaccharide biosynthesis protein CapD

Gene names

Name:

capD

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the biosynthesis of type 1 capsular polysaccharide.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the polysaccharide synthase family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Capsular polysaccharide biosynthesis protein CapD		PRO_0000166445
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P39853 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 11ECBB26D729E6DB	FASTA	599	67,562
	10 20 30 40 50 60 MTSISAKLRF LILIIIDSFI VTFSVFLGYA ILEPYFKGYS IDLLVLSSVI LLVSHHIFAY 70 80 90 100 110 120 VFNLYHRAWE YASVSELMSV LKAVTSSIVV TLLLVSLLIS ESPFLRLYFI TWMMHLLLIG 130 140 150 160 170 180 GSRLFWRVYR RYFIDNAVEK KATLVVGAGQ GGSVLIREML RSQDMRMQPV LAVDDDKNKQ 190 200 210 220 230 240 KMTITERVKV QGYVEDIPEL VKKFRIKKII IAIPTLSQKR LNEINKICNI EGVELFKMPN 250 260 270 280 290 300 IEDVLSGELE VNNLKKVEVE DLLGRDPVEL DMALISRELT NKTILVTGAG GSIGSEICRQ 310 320 330 340 350 360 VSKFDPQKII LLGHGENSIY SIHQELSKTY GNRIEFVPVI ADVQNKTRIL EVMNEFKPYA 370 380 390 400 410 420 VYHAAAHKHV PLMEYNPHEA IRNNILGTKN VAESAKEGEV SKFVMISTDK AVNPSNVMGA 430 440 450 460 470 480 TKRIAEMVIQ SLNEDNSKTS FVAVRFGNVL GSRGSVIPLF KNQIESGGPV TVTHPEMTRY 490 500 510 520 530 540 FMTIPEASRL VLQAGALAQG GEVFVLDMGK PVKIVDLAKN LIRLSGKKEE DIGIEFSGIR 550 560 570 580 590 PGEKLYEELL NKNEIHPQQV YEKIYRGKVD HYIKTEVDLI VEDLINNFSK EKLLKIANR

References

[1]

"Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus." Lin W.S., Cunneen T., Lee C.Y. J. Bacteriol. 176:7005-7016(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49951 / M / NCTC 10649.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10927 Genomic DNA. Translation: AAA64643.1.
3D structure databases
ProteinModelPortal	P39853.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00934.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR016040. NAD(P)-bd_dom. IPR003869. Polysac_CapD-like. [Graphical view]
Pfam	PF02719. Polysacc_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPD_STAAU

Accession

Primary (citable) accession number: P39853

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program