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Protein

Putative tyrosine-protein kinase CapB

Gene

capB

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the biosynthesis of type 1 capsular polysaccharide.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00934.

Protein family/group databases

TCDBi8.A.3.2.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein kinase CapB (EC:2.7.10.2)
Gene namesi
Name:capB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Putative tyrosine-protein kinase CapBPRO_0000217234Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP39851.
SMRiP39851. Positions 1-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.Curated

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P39851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKKSTISP LYVHDKPKST ISEKFRGIRS NIMFSNAENE IKSLLITSEK
60 70 80 90 100
SASGKSILSA NIAVTYAQAG YKTLIIDGDM RKPTQHYIFD LPNNSGLSNL
110 120 130 140 150
IINKTTYSDS IKETRVENLN VLTAGPTPPN PSELIASSKF ATIFNELLNH
160 170 180 190 200
YDFIVIDTPP INTVTDAQVY ARIVKNCVLV IDAEKNNKSE VKKAKGLLTK
210 220
AGGKVLGAVL NKMPIDKNSS YYYYYGED
Length:228
Mass (Da):25,176
Last modified:February 1, 1995 - v1
Checksum:i777A4395AA8D7F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10927 Genomic DNA. Translation: AAA64641.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10927 Genomic DNA. Translation: AAA64641.1.

3D structure databases

ProteinModelPortaliP39851.
SMRiP39851. Positions 1-228.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.A.3.2.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00934.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus."
    Lin W.S., Cunneen T., Lee C.Y.
    J. Bacteriol. 176:7005-7016(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49951 / M / NCTC 10649.

Entry informationi

Entry nameiCAPB_STAAU
AccessioniPrimary (citable) accession number: P39851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.