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P39851

- CAPB_STAAU

UniProt

P39851 - CAPB_STAAU

Protein

Putative tyrosine-protein kinase CapB

Gene

capB

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    • Comment

    Functioni

    Required for the biosynthesis of type 1 capsular polysaccharide.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme regulator activity Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00934.

    Protein family/group databases

    TCDBi8.A.3.2.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tyrosine-protein kinase CapB (EC:2.7.10.2)
    Gene namesi
    Name:capB
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Putative tyrosine-protein kinase CapBPRO_0000217234Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP39851.
    SMRiP39851. Positions 1-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsD/CapB family.Curated

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13614. AAA_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01007. eps_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P39851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKKSTISP LYVHDKPKST ISEKFRGIRS NIMFSNAENE IKSLLITSEK    50
    SASGKSILSA NIAVTYAQAG YKTLIIDGDM RKPTQHYIFD LPNNSGLSNL 100
    IINKTTYSDS IKETRVENLN VLTAGPTPPN PSELIASSKF ATIFNELLNH 150
    YDFIVIDTPP INTVTDAQVY ARIVKNCVLV IDAEKNNKSE VKKAKGLLTK 200
    AGGKVLGAVL NKMPIDKNSS YYYYYGED 228
    Length:228
    Mass (Da):25,176
    Last modified:February 1, 1995 - v1
    Checksum:i777A4395AA8D7F67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10927 Genomic DNA. Translation: AAA64641.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10927 Genomic DNA. Translation: AAA64641.1 .

    3D structure databases

    ProteinModelPortali P39851.
    SMRi P39851. Positions 1-228.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.A.3.2.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00934 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13614. AAA_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01007. eps_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus."
      Lin W.S., Cunneen T., Lee C.Y.
      J. Bacteriol. 176:7005-7016(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 49951 / M / NCTC 10649.

    Entry informationi

    Entry nameiCAPB_STAAU
    AccessioniPrimary (citable) accession number: P39851
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3