P39851 (CAPB_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein kinase CapB
EC=2.7.10.2

Gene names

Name:

capB

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the biosynthesis of type 1 capsular polysaccharide.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the CpsD/CapB family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Biological process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW enzyme regulator activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Putative tyrosine-protein kinase CapB		PRO_0000217234

Sequences

	Sequence		Length	Mass (Da)
	P39851 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 777A4395AA8D7F67	FASTA	228	25,176
	10 20 30 40 50 60 MAKKKSTISP LYVHDKPKST ISEKFRGIRS NIMFSNAENE IKSLLITSEK SASGKSILSA 70 80 90 100 110 120 NIAVTYAQAG YKTLIIDGDM RKPTQHYIFD LPNNSGLSNL IINKTTYSDS IKETRVENLN 130 140 150 160 170 180 VLTAGPTPPN PSELIASSKF ATIFNELLNH YDFIVIDTPP INTVTDAQVY ARIVKNCVLV 190 200 210 220 IDAEKNNKSE VKKAKGLLTK AGGKVLGAVL NKMPIDKNSS YYYYYGED

References

[1]

"Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus." Lin W.S., Cunneen T., Lee C.Y. J. Bacteriol. 176:7005-7016(1994) [PubMed: 7961465] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49951 / M / NCTC 10649.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10927 Genomic DNA. Translation: AAA64641.1.
3D structure databases
ProteinModelPortal	P39851.
SMR	P39851. Positions 1-228.
ModBase	Search...
Protein family/group databases
TCDB	8.A.3.2.1. cytoplasmic membrane-periplasmic auxiliary-1 (MPA1) protein with cytoplasmic (C) domain (MPA1-C or MPA1+C) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002586. CbiA_P_synth. IPR005702. EPS_synthesis. [Graphical view]
Pfam	PF01656. CbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01007. Eps_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAPB_STAAU

Accession

Primary (citable) accession number: P39851

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 31, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program