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P39841

- MANA3_BACSU

UniProt

P39841 - MANA3_BACSU

Protein

Putative mannose-6-phosphate isomerase YvyI

Gene

yvyI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Zinc1 Publication
    Metal bindingi116 – 1161Zinc1 Publication
    Metal bindingi173 – 1731Zinc1 Publication
    Active sitei193 – 1931By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBSUB:BSU35790-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative mannose-6-phosphate isomerase YvyI (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:yvyI
    Synonyms:pmi
    Ordered Locus Names:BSU35790
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU35790.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Putative mannose-6-phosphate isomerase YvyIPRO_0000194228Add
    BLAST

    Proteomic databases

    PaxDbiP39841.

    Interactioni

    Protein-protein interaction databases

    IntActiP39841. 1 interaction.
    STRINGi224308.BSU35790.

    Structurei

    Secondary structure

    1
    316
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 94
    Beta strandi11 – 144
    Helixi21 – 266
    Beta strandi31 – 4111
    Turni55 – 584
    Helixi61 – 677
    Helixi69 – 724
    Beta strandi82 – 9110
    Beta strandi95 – 973
    Helixi101 – 1077
    Turni108 – 1103
    Beta strandi116 – 1238
    Beta strandi128 – 1336
    Helixi138 – 1469
    Helixi150 – 1534
    Beta strandi154 – 1585
    Beta strandi164 – 1674
    Beta strandi173 – 1753
    Beta strandi177 – 18711
    Beta strandi192 – 1954
    Helixi211 – 2177
    Beta strandi230 – 2345
    Beta strandi237 – 2448
    Beta strandi249 – 26113
    Beta strandi268 – 28114
    Beta strandi284 – 2896
    Beta strandi293 – 2964
    Beta strandi303 – 31513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QWRX-ray1.80A/B1-316[»]
    ProteinModelPortaliP39841.
    SMRiP39841. Positions 2-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP39841.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    HOGENOMiHOG000054245.
    KOiK01809.
    OMAiIDCKENA.
    OrthoDBiEOG66MQQS.
    PhylomeDBiP39841.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P39841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQSPIFLTP VFKEKIWGGT ALRDRFGYSI PSESTGECWA ISAHPKGPST    50
    VANGPYKGKT LIELWEEHRE VFGGVEGDRF PLLTKLLDVK EDTSIKVHPD 100
    DYYAGENEEG ELGKTECWYI IDCKENAEII YGHTARSKTE LVTMINSGDW 150
    EGLLRRIKIK PGDFYYVPSG TLHALCKGAL VLETQQNSDA TYRVYDYDRL 200
    DSNGSPRELH FAKAVNAATV PHVDGYIDES TESRKGITIK TFVQGEYFSV 250
    YKWDINGEAE MAQDESFLIC SVIEGSGLLK YEDKTCPLKK GDHFILPAQM 300
    PDFTIKGTCT LIVSHI 316
    Length:316
    Mass (Da):35,428
    Last modified:February 1, 1995 - v1
    Checksum:i21E6FF26E7CF922F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02562 Genomic DNA. Translation: AAA67856.1.
    D45048 Genomic DNA. Translation: BAA08088.1.
    AL009126 Genomic DNA. Translation: CAB15596.1.
    PIRiA69680.
    RefSeqiNP_391460.1. NC_000964.3.
    WP_003244253.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB15596; CAB15596; BSU35790.
    GeneIDi936815.
    KEGGibsu:BSU35790.
    PATRICi18979174. VBIBacSub10457_3749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02562 Genomic DNA. Translation: AAA67856.1 .
    D45048 Genomic DNA. Translation: BAA08088.1 .
    AL009126 Genomic DNA. Translation: CAB15596.1 .
    PIRi A69680.
    RefSeqi NP_391460.1. NC_000964.3.
    WP_003244253.1. NZ_CM000487.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QWR X-ray 1.80 A/B 1-316 [» ]
    ProteinModelPortali P39841.
    SMRi P39841. Positions 2-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P39841. 1 interaction.
    STRINGi 224308.BSU35790.

    Proteomic databases

    PaxDbi P39841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15596 ; CAB15596 ; BSU35790 .
    GeneIDi 936815.
    KEGGi bsu:BSU35790.
    PATRICi 18979174. VBIBacSub10457_3749.

    Organism-specific databases

    GenoListi BSU35790.

    Phylogenomic databases

    eggNOGi COG1482.
    HOGENOMi HOG000054245.
    KOi K01809.
    OMAi IDCKENA.
    OrthoDBi EOG66MQQS.
    PhylomeDBi P39841.

    Enzyme and pathway databases

    BioCyci BSUB:BSU35790-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P39841.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The gene of the N-acetylglucosaminidase, a Bacillus subtilis 168 cell wall hydrolase not involved in vegetative cell autolysis."
      Margot P., Maueel C., Karamata D.
      Mol. Microbiol. 12:535-545(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "Glucosaminidase of Bacillus subtilis: cloning, regulation, primary structure and biochemical characterization."
      Rashid M.H., Mori M., Sekiguchi J.
      Microbiology 141:2391-2404(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / AC327.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    4. "Crystal structure analysis of the mannose 6-phosphate isomerase from Bacillus subtilis."
      Midwest center for structural genomics (MCSG)
      Submitted (JAN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiMANA3_BACSU
    AccessioniPrimary (citable) accession number: P39841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3