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P39841

- MANA3_BACSU

UniProt

P39841 - MANA3_BACSU

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Protein

Putative mannose-6-phosphate isomerase YvyI

Gene

yvyI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc1 Publication
Metal bindingi116 – 1161Zinc1 Publication
Metal bindingi173 – 1731Zinc1 Publication
Active sitei193 – 1931By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU35790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mannose-6-phosphate isomerase YvyI (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:yvyI
Synonyms:pmi
Ordered Locus Names:BSU35790
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU35790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Putative mannose-6-phosphate isomerase YvyIPRO_0000194228Add
BLAST

Proteomic databases

PaxDbiP39841.

Interactioni

Protein-protein interaction databases

IntActiP39841. 1 interaction.
STRINGi224308.BSU35790.

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Beta strandi11 – 144
Helixi21 – 266
Beta strandi31 – 4111
Turni55 – 584
Helixi61 – 677
Helixi69 – 724
Beta strandi82 – 9110
Beta strandi95 – 973
Helixi101 – 1077
Turni108 – 1103
Beta strandi116 – 1238
Beta strandi128 – 1336
Helixi138 – 1469
Helixi150 – 1534
Beta strandi154 – 1585
Beta strandi164 – 1674
Beta strandi173 – 1753
Beta strandi177 – 18711
Beta strandi192 – 1954
Helixi211 – 2177
Beta strandi230 – 2345
Beta strandi237 – 2448
Beta strandi249 – 26113
Beta strandi268 – 28114
Beta strandi284 – 2896
Beta strandi293 – 2964
Beta strandi303 – 31513

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QWRX-ray1.80A/B1-316[»]
ProteinModelPortaliP39841.
SMRiP39841. Positions 2-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39841.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
HOGENOMiHOG000054245.
InParanoidiP39841.
KOiK01809.
OMAiIDCKENA.
OrthoDBiEOG66MQQS.
PhylomeDBiP39841.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR014628. Man6P_isomerase_Firm_short.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 2 hits.

Sequencei

Sequence statusi: Complete.

P39841-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSPIFLTP VFKEKIWGGT ALRDRFGYSI PSESTGECWA ISAHPKGPST
60 70 80 90 100
VANGPYKGKT LIELWEEHRE VFGGVEGDRF PLLTKLLDVK EDTSIKVHPD
110 120 130 140 150
DYYAGENEEG ELGKTECWYI IDCKENAEII YGHTARSKTE LVTMINSGDW
160 170 180 190 200
EGLLRRIKIK PGDFYYVPSG TLHALCKGAL VLETQQNSDA TYRVYDYDRL
210 220 230 240 250
DSNGSPRELH FAKAVNAATV PHVDGYIDES TESRKGITIK TFVQGEYFSV
260 270 280 290 300
YKWDINGEAE MAQDESFLIC SVIEGSGLLK YEDKTCPLKK GDHFILPAQM
310
PDFTIKGTCT LIVSHI
Length:316
Mass (Da):35,428
Last modified:February 1, 1995 - v1
Checksum:i21E6FF26E7CF922F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02562 Genomic DNA. Translation: AAA67856.1.
D45048 Genomic DNA. Translation: BAA08088.1.
AL009126 Genomic DNA. Translation: CAB15596.1.
PIRiA69680.
RefSeqiNP_391460.1. NC_000964.3.
WP_003244253.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB15596; CAB15596; BSU35790.
GeneIDi936815.
KEGGibsu:BSU35790.
PATRICi18979174. VBIBacSub10457_3749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02562 Genomic DNA. Translation: AAA67856.1 .
D45048 Genomic DNA. Translation: BAA08088.1 .
AL009126 Genomic DNA. Translation: CAB15596.1 .
PIRi A69680.
RefSeqi NP_391460.1. NC_000964.3.
WP_003244253.1. NZ_CM000487.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QWR X-ray 1.80 A/B 1-316 [» ]
ProteinModelPortali P39841.
SMRi P39841. Positions 2-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P39841. 1 interaction.
STRINGi 224308.BSU35790.

Proteomic databases

PaxDbi P39841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15596 ; CAB15596 ; BSU35790 .
GeneIDi 936815.
KEGGi bsu:BSU35790.
PATRICi 18979174. VBIBacSub10457_3749.

Organism-specific databases

GenoListi BSU35790.

Phylogenomic databases

eggNOGi COG1482.
HOGENOMi HOG000054245.
InParanoidi P39841.
KOi K01809.
OMAi IDCKENA.
OrthoDBi EOG66MQQS.
PhylomeDBi P39841.

Enzyme and pathway databases

BioCyci BSUB:BSU35790-MONOMER.

Miscellaneous databases

EvolutionaryTracei P39841.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR014628. Man6P_isomerase_Firm_short.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF036894. PMI_Firm_short. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene of the N-acetylglucosaminidase, a Bacillus subtilis 168 cell wall hydrolase not involved in vegetative cell autolysis."
    Margot P., Maueel C., Karamata D.
    Mol. Microbiol. 12:535-545(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "Glucosaminidase of Bacillus subtilis: cloning, regulation, primary structure and biochemical characterization."
    Rashid M.H., Mori M., Sekiguchi J.
    Microbiology 141:2391-2404(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / AC327.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Crystal structure analysis of the mannose 6-phosphate isomerase from Bacillus subtilis."
    Midwest center for structural genomics (MCSG)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiMANA3_BACSU
AccessioniPrimary (citable) accession number: P39841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3