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Protein

Aldose 1-epimerase

Gene

galM

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.1 Publication

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177Proton donorBy similarity1
Binding sitei230SubstrateBy similarity1
Active sitei283Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU18360-MONOMER
UniPathwayiUPA00242

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:galM
Synonyms:yoxA
Ordered Locus Names:BSU18360
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000496662 – 325Aldose 1-epimeraseAdd BLAST324

Proteomic databases

PaxDbiP39840
PRIDEiP39840

Expressioni

Developmental stagei

Expressed at the end of the exponential growth phase.1 Publication

Inductioni

By nitrogen or tryptophan starvation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010116

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Beta strandi13 – 28Combined sources16
Turni29 – 33Combined sources5
Beta strandi34 – 40Combined sources7
Turni41 – 44Combined sources4
Helixi54 – 59Combined sources6
Beta strandi63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi73 – 76Combined sources4
Beta strandi79 – 82Combined sources4
Beta strandi85 – 88Combined sources4
Turni94 – 97Combined sources4
Beta strandi98 – 103Combined sources6
Beta strandi110 – 119Combined sources10
Beta strandi121 – 128Combined sources8
Helixi129 – 131Combined sources3
Helixi133 – 138Combined sources6
Beta strandi143 – 152Combined sources10
Beta strandi155 – 164Combined sources10
Beta strandi166 – 168Combined sources3
Beta strandi170 – 172Combined sources3
Turni184 – 186Combined sources3
Beta strandi187 – 199Combined sources13
Beta strandi205 – 211Combined sources7
Helixi215 – 220Combined sources6
Beta strandi230 – 236Combined sources7
Helixi237 – 240Combined sources4
Beta strandi245 – 250Combined sources6
Turni251 – 254Combined sources4
Beta strandi255 – 261Combined sources7
Beta strandi267 – 271Combined sources5
Beta strandi277 – 287Combined sources11
Helixi291 – 293Combined sources3
Helixi298 – 301Combined sources4
Beta strandi304 – 306Combined sources3
Beta strandi311 – 322Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MWXX-ray1.45A/B1-325[»]
4BZEX-ray2.00A/B1-325[»]
4BZFX-ray1.90A/B2-325[»]
4BZGX-ray2.13A/B2-325[»]
4BZHX-ray2.60A/B2-325[»]
ProteinModelPortaliP39840
SMRiP39840
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39840

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the aldose epimerase family.Curated

Phylogenomic databases

eggNOGiENOG4108N2V Bacteria
COG2017 LUCA
HOGENOMiHOG000008952
InParanoidiP39840
KOiK01785
OMAiPIHGSAW
PhylomeDBiP39840

Family and domain databases

Gene3Di2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR008183 Aldose_1/G6P_1-epimerase
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
PfamiView protein in Pfam
PF01263 Aldose_epim, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFIEKITY LGTPAIKAGN EHLEMIVVPE WGSNVISLVD KTTNVQLLRE
60 70 80 90 100
PETAESFHDT PTLYGIPILF PPNRISDGTF SFRGRTYHFD INEKDKHNHL
110 120 130 140 150
HGFLYHEKWN VVTTKQTDEG VIVETEIDLS ELPHVQKQFP HHAVVRMTYT
160 170 180 190 200
IKENTLFKHA TVMNKGKEAF PWGIGYHTTF IFPAESSLFS LTADQQWELD
210 220 230 240 250
ERLLPTGKLM DVPYKEALHE GMDLRHKQLD DVFLSSYQKR GGENQAVIYH
260 270 280 290 300
QHAHISIIYK ADEQFKHWVV YNADGKQGYL CPEPYTWVTN AVNLDLPSSL
310 320
TGLQVLEPGE ETTAKSSITI ELNHQ
Length:325
Mass (Da):37,228
Last modified:December 15, 1998 - v2
Checksum:iCD80CB777AF4B829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13719.1
Z34883 Genomic DNA Translation: CAA84365.1
PIRiA69930
RefSeqiNP_389718.1, NC_000964.3
WP_004399304.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB13719; CAB13719; BSU18360
GeneIDi938046
KEGGibsu:BSU18360
PATRICifig|224308.179.peg.2003

Similar proteinsi

Entry informationi

Entry nameiGALM_BACSU
AccessioniPrimary (citable) accession number: P39840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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