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Protein

High-affinity gluconate transporter

Gene

gntT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate.

Pathwayi: D-gluconate degradation

This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGluconate utilization, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GNTT-MONOMER
MetaCyc:GNTT-MONOMER
UniPathwayiUPA00792

Protein family/group databases

TCDBi2.A.8.1.4 the gluconate:h(+) symporter (gntp) family

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity gluconate transporter
Alternative name(s):
Gluconate permease
Gnt-I system
Gene namesi
Name:gntT
Synonyms:gntM, usgA, yhgC
Ordered Locus Names:b3415, JW5690
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12380 gntT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000619341 – 438High-affinity gluconate transporterAdd BLAST438

Proteomic databases

PaxDbiP39835
PRIDEiP39835

Interactioni

Protein-protein interaction databases

BioGridi4261217, 20 interactors
STRINGi316385.ECDH10B_3590

Structurei

3D structure databases

ProteinModelPortaliP39835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6Z Bacteria
COG2610 LUCA
HOGENOMiHOG000237115
InParanoidiP39835
KOiK06155
OMAiMVLPKGH
PhylomeDBiP39835

Family and domain databases

InterProiView protein in InterPro
IPR003474 Glcn_transporter
PANTHERiPTHR30354 PTHR30354, 1 hit
PfamiView protein in Pfam
PF02447 GntP_permease, 1 hit
PIRSFiPIRSF002746 Gluconate_transporter, 1 hit
TIGRFAMsiTIGR00791 gntP, 1 hit

Sequencei

Sequence statusi: Complete.

P39835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVIVAIGV ILLLLLMIRF KMNGFIALVL VALAVGLMQG MPLDKVIGSI
60 70 80 90 100
KAGVGGTLGS LALIMGFGAM LGKMLADCGG AQRIATTLIA KFGKKHIQWA
110 120 130 140 150
VVLTGFTVGF ALFYEVGFVL MLPLVFTIAA SANIPLLYVG VPMAAALSVT
160 170 180 190 200
HGFLPPHPGP TAIATIFNAD MGKTLLYGTI LAIPTVILAG PVYARVLKGI
210 220 230 240 250
DKPIPEGLYS AKTFSEEEMP SFGVSVWTSL VPVVLMAMRA IAEMILPKGH
260 270 280 290 300
AFLPVAEFLG DPVMATLIAV LIAMFTFGLN RGRSMDQIND TLVSSIKIIA
310 320 330 340 350
MMLLIIGGGG AFKQVLVDSG VDKYIASMMH ETNISPLLMA WSIAAVLRIA
360 370 380 390 400
LGSATVAAIT AGGIAAPLIA TTGVSPELMV IAVGSGSVIF SHVNDPGFWL
410 420 430
FKEYFNLTIG ETIKSWSMLE TIISVCGLVG CLLLNMVI
Length:438
Mass (Da):45,967
Last modified:October 11, 2004 - v3
Checksum:iC142882C557E894C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55 – 58GGTL → ADV in AAA58213 (PubMed:8987614).Curated4
Sequence conflicti385S → A (PubMed:2845225).Curated1
Sequence conflicti420 – 421ET → VS (PubMed:2845225).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58213.1
U00096 Genomic DNA Translation: AAT48179.1
AP009048 Genomic DNA Translation: BAE77876.1
M32793 Genomic DNA No translation available.
PIRiJC4988
RefSeqiWP_001131758.1, NZ_LN832404.1
YP_026217.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48179; AAT48179; b3415
BAE77876; BAE77876; BAE77876
GeneIDi947924
KEGGiecj:JW5690
eco:b3415
PATRICifig|1411691.4.peg.3313

Similar proteinsi

Entry informationi

Entry nameiGNTT_ECOLI
AccessioniPrimary (citable) accession number: P39835
Secondary accession number(s): Q2M780, Q6BF35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health