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Protein

High-affinity zinc uptake system membrane protein ZnuB

Gene

znuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity zinc uptake transport system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciEcoCyc:ZNUB-MONOMER.
ECOL316407:JW1848-MONOMER.
MetaCyc:ZNUB-MONOMER.
RETL1328306-WGS:GSTH-2746-MONOMER.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity zinc uptake system membrane protein ZnuB
Gene namesi
Name:znuB
Synonyms:yebI
Ordered Locus Names:b1859, JW1848
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12368. znuB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77PeriplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 5325CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Topological domaini75 – 839PeriplasmicSequence analysis
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 12117CytoplasmicSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Topological domaini143 – 17735PeriplasmicSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 21315CytoplasmicSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Topological domaini235 – 2351PeriplasmicSequence analysis
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 2615CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261High-affinity zinc uptake system membrane protein ZnuBPRO_0000171161Add
BLAST

Proteomic databases

PaxDbiP39832.

Interactioni

Protein-protein interaction databases

BioGridi4260881. 6 interactions.
STRINGi511145.b1859.

Structurei

3D structure databases

ProteinModelPortaliP39832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105FAV. Bacteria.
COG1108. LUCA.
HOGENOMiHOG000181429.
InParanoidiP39832.
KOiK09816.
OMAiGVFVVWR.
OrthoDBiEOG6K13RC.
PhylomeDBiP39832.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR001626. ABC_3.
IPR029022. ABC_BtuC-like.
[Graphical view]
PfamiPF00950. ABC-3. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P39832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELLFPGWL AGIMLACAAG PLGSFVVWRR MSYFGDTLAH ASLLGVAFGL
60 70 80 90 100
LLDVNPFYAV IAVTLLLAGG LVWLEKRPQL AIDTLLGIMA HSALSLGLVV
110 120 130 140 150
VSLMSNIRVD LMAYLFGDLL AVTPEDLISI AIGVVIVVAI LFWQWRNLLS
160 170 180 190 200
MTISPDLAFV DGVKLQRVKL LLMLVTALTI GVAMKFVGAL IITSLLIIPA
210 220 230 240 250
ATARRFARTP EQMAGVAVLV GMVAVTGGLT FSAVYDTPAG PSVVLCAALL
260
FILSMMKKQA S
Length:261
Mass (Da):27,729
Last modified:November 1, 1997 - v3
Checksum:i78382B2EAECE1490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74929.1.
AP009048 Genomic DNA. Translation: BAA15667.1.
U38702 Genomic DNA. Translation: AAA81031.1.
M21298 Genomic DNA. No translation available.
PIRiC64948.
RefSeqiNP_416373.1. NC_000913.3.
WP_000571480.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74929; AAC74929; b1859.
BAA15667; BAA15667; BAA15667.
GeneIDi946372.
KEGGiecj:JW1848.
eco:b1859.
PATRICi32119041. VBIEscCol129921_1938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74929.1.
AP009048 Genomic DNA. Translation: BAA15667.1.
U38702 Genomic DNA. Translation: AAA81031.1.
M21298 Genomic DNA. No translation available.
PIRiC64948.
RefSeqiNP_416373.1. NC_000913.3.
WP_000571480.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260881. 6 interactions.
STRINGi511145.b1859.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP39832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74929; AAC74929; b1859.
BAA15667; BAA15667; BAA15667.
GeneIDi946372.
KEGGiecj:JW1848.
eco:b1859.
PATRICi32119041. VBIEscCol129921_1938.

Organism-specific databases

EchoBASEiEB2271.
EcoGeneiEG12368. znuB.

Phylogenomic databases

eggNOGiENOG4105FAV. Bacteria.
COG1108. LUCA.
HOGENOMiHOG000181429.
InParanoidiP39832.
KOiK09816.
OMAiGVFVVWR.
OrthoDBiEOG6K13RC.
PhylomeDBiP39832.

Enzyme and pathway databases

BioCyciEcoCyc:ZNUB-MONOMER.
ECOL316407:JW1848-MONOMER.
MetaCyc:ZNUB-MONOMER.
RETL1328306-WGS:GSTH-2746-MONOMER.

Miscellaneous databases

PROiP39832.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR001626. ABC_3.
IPR029022. ABC_BtuC-like.
[Graphical view]
PfamiPF00950. ABC-3. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Robison K., O'Keeffe T., Church G.M.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-92.
    Strain: K12 / EMG2.
  5. "Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination."
    Shinagawa H., Makino K., Amemura M., Kimura S., Iwasaki H., Nakata A.
    J. Bacteriol. 170:4322-4329(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 80-261.
  6. "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome."
    Borodovsky M., Rudd K.E., Koonin E.V.
    Nucleic Acids Res. 22:4756-4767(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli."
    Patzer S.I., Hantke K.
    Mol. Microbiol. 28:1199-1210(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiZNUB_ECOLI
AccessioniPrimary (citable) accession number: P39832
Secondary accession number(s): P76286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.