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Protein

Putative cation/proton antiporter YbaL

Gene

ybaL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei494AMPCombined sources1
Binding sitei514AMPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 428AMPCombined sources2
Nucleotide bindingi447 – 448AMPCombined sources2
Nucleotide bindingi467 – 468AMPCombined sources2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Ion transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YBAL-MONOMER

Protein family/group databases

TCDBi2.A.37.1.5 the monovalent cation:proton antiporter-2 (cpa2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cation/proton antiporter YbaL
Gene namesi
Name:ybaL
Synonyms:ylaA
Ordered Locus Names:b0478, JW0467
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12623 ybaL

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3PeriplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 31CytoplasmicSequence analysis7
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 55PeriplasmicSequence analysis3
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 112PeriplasmicSequence analysis6
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 148CytoplasmicSequence analysisAdd BLAST15
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 185PeriplasmicSequence analysisAdd BLAST16
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 225CytoplasmicSequence analysisAdd BLAST19
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247PeriplasmicSequence analysis1
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 279CytoplasmicSequence analysisAdd BLAST11
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301 – 303PeriplasmicSequence analysis3
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 336CytoplasmicSequence analysisAdd BLAST12
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 367PeriplasmicSequence analysis10
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 558CytoplasmicSequence analysis1 PublicationAdd BLAST170

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001966161 – 558Putative cation/proton antiporter YbaLAdd BLAST558

Proteomic databases

PaxDbiP39830
PRIDEiP39830

Interactioni

Protein-protein interaction databases

BioGridi4262046, 143 interactors
DIPiDIP-11300N
IntActiP39830, 2 interactors
STRINGi316385.ECDH10B_0434

Structurei

Secondary structure

1558
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi420 – 423Combined sources4
Helixi427 – 438Combined sources12
Beta strandi443 – 448Combined sources6
Helixi450 – 458Combined sources9
Beta strandi462 – 466Combined sources5
Helixi471 – 476Combined sources6
Helixi479 – 481Combined sources3
Beta strandi483 – 487Combined sources5
Helixi492 – 505Combined sources14
Beta strandi507 – 517Combined sources11
Helixi518 – 526Combined sources9
Beta strandi530 – 534Combined sources5
Helixi535 – 548Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FWZX-ray1.79A/B414-550[»]
ProteinModelPortaliP39830
SMRiP39830
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39830

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini419 – 541RCK N-terminalPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CKD Bacteria
COG1226 LUCA
COG4651 LUCA
HOGENOMiHOG000179078
InParanoidiP39830
KOiK03455
OMAiTTFSHEG
PhylomeDBiP39830

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR004771 K/H_exchanger
IPR038770 Na+/solute_symporter_sf
IPR036291 NAD(P)-bd_dom_sf
IPR003148 RCK_N
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF02254 TrkA_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00932 2a37, 1 hit
PROSITEiView protein in PROSITE
PS51201 RCK_N, 1 hit

Sequencei

Sequence statusi: Complete.

P39830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHATPLITT IVGGLVLAFI LGMLANKLRI SPLVGYLLAG VLAGPFTPGF
60 70 80 90 100
VADTKLAPEL AELGVILLMF GVGLHFSLKD LMAVKAIAIP GAIAQIAVAT
110 120 130 140 150
LLGMALSAVL GWSLMTGIVF GLCLSTASTV VLLRALEERQ LIDSQRGQIA
160 170 180 190 200
IGWLIVEDLV MVLTLVLLPA VAGMMEQGDV GFATLAVDMG ITIGKVIAFI
210 220 230 240 250
AIMMLVGRRL VPWIMARSAA TGSRELFTLS VLALALGVAF GAVELFDVSF
260 270 280 290 300
ALGAFFAGMV LNESELSHRA AHDTLPLRDA FAVLFFVSVG MLFDPLILIQ
310 320 330 340 350
QPLAVLATLA IILFGKSLAA FFLVRLFGHS QRTALTIAAS LAQIGEFAFI
360 370 380 390 400
LAGLGMALNL LPQAGQNLVL AGAILSIMLN PVLFALLEKY LAKTETLEEQ
410 420 430 440 450
TLEEAIEEEK QIPVDICNHA LLVGYGRVGS LLGEKLLASD IPLVVIETSR
460 470 480 490 500
TRVDELRERG VRAVLGNAAN EEIMQLAHLE CAKWLILTIP NGYEAGEIVA
510 520 530 540 550
SARAKNPDIE IIARAHYDDE VAYITERGAN QVVMGEREIA RTMLELLETP

PAGEVVTG
Length:558
Mass (Da):59,424
Last modified:November 1, 1997 - v2
Checksum:i17DFBAE820B11498
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti553 – 558GEVVTG → VRW in L35149 (PubMed:7721718).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40232.1
U00096 Genomic DNA Translation: AAC73580.1
AP009048 Genomic DNA Translation: BAE76257.1
D73370 Genomic DNA No translation available.
L35149 Genomic DNA No translation available.
PIRiE64778
RefSeqiNP_415011.1, NC_000913.3
WP_000546237.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73580; AAC73580; b0478
BAE76257; BAE76257; BAE76257
GeneIDi946576
KEGGiecj:JW0467
eco:b0478
PATRICifig|1411691.4.peg.1798

Similar proteinsi

Entry informationi

Entry nameiYBAL_ECOLI
AccessioniPrimary (citable) accession number: P39830
Secondary accession number(s): P52068, P77724, Q2MBU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health