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Protein

Inner membrane protein YbaL

Gene

ybaL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YBAL-MONOMER.
ECOL316407:JW0467-MONOMER.

Protein family/group databases

TCDBi2.A.37.1.5. the monovalent cation:proton antiporter-2 (cpa2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein YbaL
Gene namesi
Name:ybaL
Synonyms:ylaA
Ordered Locus Names:b0478, JW0467
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12623. ybaL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33PeriplasmicSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 317CytoplasmicSequence analysis
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Topological domaini53 – 553PeriplasmicSequence analysis
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Topological domaini77 – 859CytoplasmicSequence analysis
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 1126PeriplasmicSequence analysis
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 14815CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 18516PeriplasmicSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST
Topological domaini207 – 22519CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 2471PeriplasmicSequence analysis
Transmembranei248 – 26821HelicalSequence analysisAdd
BLAST
Topological domaini269 – 27911CytoplasmicSequence analysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST
Topological domaini301 – 3033PeriplasmicSequence analysis
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 33612CytoplasmicSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Topological domaini358 – 36710PeriplasmicSequence analysis
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Inner membrane protein YbaLPRO_0000196616Add
BLAST

Proteomic databases

PaxDbiP39830.
PRIDEiP39830.

Interactioni

Protein-protein interaction databases

BioGridi4262046. 99 interactions.
DIPiDIP-11300N.
IntActiP39830. 2 interactions.
MINTiMINT-1293198.
STRINGi511145.b0478.

Structurei

Secondary structure

1
558
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi420 – 4234Combined sources
Helixi427 – 43812Combined sources
Beta strandi443 – 4486Combined sources
Helixi450 – 4589Combined sources
Beta strandi462 – 4665Combined sources
Helixi471 – 4766Combined sources
Helixi479 – 4813Combined sources
Beta strandi483 – 4875Combined sources
Helixi492 – 50514Combined sources
Beta strandi507 – 51711Combined sources
Helixi518 – 5269Combined sources
Beta strandi530 – 5345Combined sources
Helixi535 – 54814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FWZX-ray1.79A/B414-550[»]
ProteinModelPortaliP39830.
SMRiP39830. Positions 414-550.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39830.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini419 – 541123RCK N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RCK N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CKD. Bacteria.
COG1226. LUCA.
COG4651. LUCA.
HOGENOMiHOG000179078.
InParanoidiP39830.
KOiK03455.
OMAiFGHSRRT.
OrthoDBiEOG6XDGX2.
PhylomeDBiP39830.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
IPR016040. NAD(P)-bd_dom.
IPR003148. RCK_N.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00932. 2a37. 1 hit.
PROSITEiPS51201. RCK_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHATPLITT IVGGLVLAFI LGMLANKLRI SPLVGYLLAG VLAGPFTPGF
60 70 80 90 100
VADTKLAPEL AELGVILLMF GVGLHFSLKD LMAVKAIAIP GAIAQIAVAT
110 120 130 140 150
LLGMALSAVL GWSLMTGIVF GLCLSTASTV VLLRALEERQ LIDSQRGQIA
160 170 180 190 200
IGWLIVEDLV MVLTLVLLPA VAGMMEQGDV GFATLAVDMG ITIGKVIAFI
210 220 230 240 250
AIMMLVGRRL VPWIMARSAA TGSRELFTLS VLALALGVAF GAVELFDVSF
260 270 280 290 300
ALGAFFAGMV LNESELSHRA AHDTLPLRDA FAVLFFVSVG MLFDPLILIQ
310 320 330 340 350
QPLAVLATLA IILFGKSLAA FFLVRLFGHS QRTALTIAAS LAQIGEFAFI
360 370 380 390 400
LAGLGMALNL LPQAGQNLVL AGAILSIMLN PVLFALLEKY LAKTETLEEQ
410 420 430 440 450
TLEEAIEEEK QIPVDICNHA LLVGYGRVGS LLGEKLLASD IPLVVIETSR
460 470 480 490 500
TRVDELRERG VRAVLGNAAN EEIMQLAHLE CAKWLILTIP NGYEAGEIVA
510 520 530 540 550
SARAKNPDIE IIARAHYDDE VAYITERGAN QVVMGEREIA RTMLELLETP

PAGEVVTG
Length:558
Mass (Da):59,424
Last modified:November 1, 1997 - v2
Checksum:i17DFBAE820B11498
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti553 – 5586GEVVTG → VRW (PubMed:7721718).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40232.1.
U00096 Genomic DNA. Translation: AAC73580.1.
AP009048 Genomic DNA. Translation: BAE76257.1.
D73370 Genomic DNA. No translation available.
L35149 Genomic DNA. No translation available.
PIRiE64778.
RefSeqiNP_415011.1. NC_000913.3.
WP_000546237.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73580; AAC73580; b0478.
BAE76257; BAE76257; BAE76257.
GeneIDi946576.
KEGGiecj:JW0467.
eco:b0478.
PATRICi32116113. VBIEscCol129921_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40232.1.
U00096 Genomic DNA. Translation: AAC73580.1.
AP009048 Genomic DNA. Translation: BAE76257.1.
D73370 Genomic DNA. No translation available.
L35149 Genomic DNA. No translation available.
PIRiE64778.
RefSeqiNP_415011.1. NC_000913.3.
WP_000546237.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FWZX-ray1.79A/B414-550[»]
ProteinModelPortaliP39830.
SMRiP39830. Positions 414-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262046. 99 interactions.
DIPiDIP-11300N.
IntActiP39830. 2 interactions.
MINTiMINT-1293198.
STRINGi511145.b0478.

Protein family/group databases

TCDBi2.A.37.1.5. the monovalent cation:proton antiporter-2 (cpa2) family.

Proteomic databases

PaxDbiP39830.
PRIDEiP39830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73580; AAC73580; b0478.
BAE76257; BAE76257; BAE76257.
GeneIDi946576.
KEGGiecj:JW0467.
eco:b0478.
PATRICi32116113. VBIEscCol129921_0498.

Organism-specific databases

EchoBASEiEB2507.
EcoGeneiEG12623. ybaL.

Phylogenomic databases

eggNOGiENOG4105CKD. Bacteria.
COG1226. LUCA.
COG4651. LUCA.
HOGENOMiHOG000179078.
InParanoidiP39830.
KOiK03455.
OMAiFGHSRRT.
OrthoDBiEOG6XDGX2.
PhylomeDBiP39830.

Enzyme and pathway databases

BioCyciEcoCyc:YBAL-MONOMER.
ECOL316407:JW0467-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP39830.
PROiP39830.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
IPR016040. NAD(P)-bd_dom.
IPR003148. RCK_N.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00932. 2a37. 1 hit.
PROSITEiPS51201. RCK_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Fujisaki S., Ohnuma S., Horiuchi T., Takahashi I., Tsukui S., Nishimura Y., Nishino T., Inokuchi H.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    Strain: K12 / DH5-alpha.
  5. "Cloning and characterization of the gsk gene encoding guanosine kinase of Escherichia coli."
    Harlow K.W., Nygaard P., Hove-Jensen B.
    J. Bacteriol. 177:2236-2240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 486-558.
    Strain: K12.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYBAL_ECOLI
AccessioniPrimary (citable) accession number: P39830
Secondary accession number(s): P52068, P77724, Q2MBU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.