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P39825

- PROF_SCHPO

UniProt

P39825 - PROF_SCHPO

Protein

Profilin

Gene

cdc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.

    GO - Molecular functioni

    1. actin monomer binding Source: PomBase
    2. guanyl-nucleotide exchange factor activity Source: PomBase

    GO - Biological processi

    1. actin cortical patch organization Source: PomBase
    2. actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly Source: PomBase
    3. actin filament polymerization Source: PomBase
    4. actomyosin contractile ring assembly Source: PomBase
    5. plasma membrane fusion involved in cytogamy Source: PomBase
    6. positive regulation of GTPase activity Source: GOC

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin
    Gene namesi
    Name:cdc3
    ORF Names:SPAC4A8.15c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC4A8.15c.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cortical patch Source: PomBase
    2. cell cortex of cell tip Source: PomBase
    3. cytosol Source: PomBase
    4. mating projection Source: PomBase
    5. medial cortex Source: PomBase
    6. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127ProfilinPRO_0000199607Add
    BLAST

    Proteomic databases

    MaxQBiP39825.
    PaxDbiP39825.

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Protein-protein interaction databases

    BioGridi279944. 20 interactions.
    MINTiMINT-4689399.
    STRINGi4896.SPAC4A8.15c-1.

    Structurei

    Secondary structure

    1
    127
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 86
    Turni9 – 113
    Helixi12 – 143
    Beta strandi19 – 246
    Beta strandi30 – 334
    Helixi41 – 5212
    Helixi56 – 605
    Beta strandi62 – 643
    Beta strandi67 – 748
    Beta strandi76 – 838
    Beta strandi86 – 927
    Beta strandi94 – 1029
    Helixi108 – 12518

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3D9YX-ray1.65A/B1-127[»]
    3DAVX-ray2.20A/B1-127[»]
    ProteinModelPortaliP39825.
    SMRiP39825. Positions 2-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP39825.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Phylogenomic databases

    eggNOGiNOG277929.
    HOGENOMiHOG000171591.
    KOiK05759.
    OMAiRADKNSI.
    OrthoDBiEOG77T1H1.
    PhylomeDBiP39825.

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDTS LLGTGKIDRA AIVSRAGDSV WAASAGFNLS PQEIQGLAAG    50
    FQDPPSMFGT GIILAGQKYI TIRAEGRSIY GKLQKEGIIC VATKLCILVS 100
    HYPETTLPGE AAKITEALAD YLVGVGY 127
    Length:127
    Mass (Da):13,411
    Last modified:February 1, 1995 - v1
    Checksum:i1D3BE221AAA73594
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30648 Genomic DNA. No translation available.
    CU329670 Genomic DNA. Translation: CAB38578.1.
    PIRiA53952.
    RefSeqiNP_593827.1. NM_001019256.2.

    Genome annotation databases

    EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
    GeneIDi2543526.
    KEGGispo:SPAC4A8.15c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30648 Genomic DNA. No translation available.
    CU329670 Genomic DNA. Translation: CAB38578.1 .
    PIRi A53952.
    RefSeqi NP_593827.1. NM_001019256.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3D9Y X-ray 1.65 A/B 1-127 [» ]
    3DAV X-ray 2.20 A/B 1-127 [» ]
    ProteinModelPortali P39825.
    SMRi P39825. Positions 2-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279944. 20 interactions.
    MINTi MINT-4689399.
    STRINGi 4896.SPAC4A8.15c-1.

    Proteomic databases

    MaxQBi P39825.
    PaxDbi P39825.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC4A8.15c.1 ; SPAC4A8.15c.1:pep ; SPAC4A8.15c .
    GeneIDi 2543526.
    KEGGi spo:SPAC4A8.15c.

    Organism-specific databases

    PomBasei SPAC4A8.15c.

    Phylogenomic databases

    eggNOGi NOG277929.
    HOGENOMi HOG000171591.
    KOi K05759.
    OMAi RADKNSI.
    OrthoDBi EOG77T1H1.
    PhylomeDBi P39825.

    Miscellaneous databases

    EvolutionaryTracei P39825.
    NextBioi 20804536.
    PROi P39825.

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis."
      Balasubramanian M.K., Hirani B.R., Burke J.D., Gould K.L.
      J. Cell Biol. 125:1289-1301(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPROF_SCHPO
    AccessioniPrimary (citable) accession number: P39825
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3