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P39825 (PROF_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton.

Sequence similarities

Belongs to the profilin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Profilin
PRO_0000199607

Secondary structure

......................... 127
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P39825 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1D3BE221AAA73594

FASTA12713,411
        10         20         30         40         50         60 
MSWQAYVDTS LLGTGKIDRA AIVSRAGDSV WAASAGFNLS PQEIQGLAAG FQDPPSMFGT 

        70         80         90        100        110        120 
GIILAGQKYI TIRAEGRSIY GKLQKEGIIC VATKLCILVS HYPETTLPGE AAKITEALAD 


YLVGVGY 

« Hide

References

« Hide 'large scale' references
[1]"The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis."
Balasubramanian M.K., Hirani B.R., Burke J.D., Gould K.L.
J. Cell Biol. 125:1289-1301(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRA53952.
RefSeqNP_593827.1. NM_001019256.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortalP39825.
SMRP39825. Positions 2-127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279944. 18 interactions.
MINTMINT-4689399.
STRING4896.SPAC4A8.15c-1.

Proteomic databases

PaxDbP39825.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneID2543526.
KEGGspo:SPAC4A8.15c.

Organism-specific databases

PomBaseSPAC4A8.15c.

Phylogenomic databases

eggNOGNOG277929.
HOGENOMHOG000171591.
KOK05759.
OMAQLLASQC.
OrthoDBEOG77T1H1.
PhylomeDBP39825.

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP39825.
NextBio20804536.
PROP39825.

Entry information

Entry namePROF_SCHPO
AccessionPrimary (citable) accession number: P39825
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references