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Protein

Profilin

Gene

cdc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.

GO - Molecular functioni

  • actin monomer binding Source: PomBase
  • guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

  • actin cortical patch organization Source: PomBase
  • actin filament polymerization Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • plasma membrane fusion involved in cytogamy Source: PomBase
  • sequestering of actin monomers Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Gene namesi
Name:cdc3
ORF Names:SPAC4A8.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.15c.
PomBaseiSPAC4A8.15c. cdc3.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • actin cytoskeleton Source: PomBase
  • cell cortex of cell tip Source: PomBase
  • cytosol Source: PomBase
  • mating projection Source: PomBase
  • medial cortex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001996071 – 127ProfilinAdd BLAST127

Proteomic databases

MaxQBiP39825.
PRIDEiP39825.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

  • actin monomer binding Source: PomBase

Protein-protein interaction databases

BioGridi279944. 20 interactors.
MINTiMINT-4689399.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 8Combined sources6
Turni9 – 11Combined sources3
Helixi12 – 14Combined sources3
Beta strandi19 – 24Combined sources6
Beta strandi30 – 33Combined sources4
Helixi41 – 52Combined sources12
Helixi56 – 60Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi67 – 74Combined sources8
Beta strandi76 – 83Combined sources8
Beta strandi86 – 92Combined sources7
Beta strandi94 – 102Combined sources9
Helixi108 – 125Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortaliP39825.
SMRiP39825.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39825.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

HOGENOMiHOG000171591.
InParanoidiP39825.
KOiK05759.
OMAiDEMKFIS.
OrthoDBiEOG092C53JE.
PhylomeDBiP39825.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDTS LLGTGKIDRA AIVSRAGDSV WAASAGFNLS PQEIQGLAAG
60 70 80 90 100
FQDPPSMFGT GIILAGQKYI TIRAEGRSIY GKLQKEGIIC VATKLCILVS
110 120
HYPETTLPGE AAKITEALAD YLVGVGY
Length:127
Mass (Da):13,411
Last modified:February 1, 1995 - v1
Checksum:i1D3BE221AAA73594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRiA53952.
RefSeqiNP_593827.1. NM_001019256.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneIDi2543526.
KEGGispo:SPAC4A8.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRiA53952.
RefSeqiNP_593827.1. NM_001019256.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortaliP39825.
SMRiP39825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279944. 20 interactors.
MINTiMINT-4689399.

Proteomic databases

MaxQBiP39825.
PRIDEiP39825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneIDi2543526.
KEGGispo:SPAC4A8.15c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.15c.
PomBaseiSPAC4A8.15c. cdc3.

Phylogenomic databases

HOGENOMiHOG000171591.
InParanoidiP39825.
KOiK05759.
OMAiDEMKFIS.
OrthoDBiEOG092C53JE.
PhylomeDBiP39825.

Miscellaneous databases

EvolutionaryTraceiP39825.
PROiP39825.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROF_SCHPO
AccessioniPrimary (citable) accession number: P39825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.