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P39825

- PROF_SCHPO

UniProt

P39825 - PROF_SCHPO

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Protein

Profilin

Gene

cdc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.

GO - Molecular functioni

  1. actin monomer binding Source: PomBase
  2. guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

  1. actin cortical patch organization Source: PomBase
  2. actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly Source: PomBase
  3. actin filament polymerization Source: PomBase
  4. actomyosin contractile ring assembly Source: PomBase
  5. plasma membrane fusion involved in cytogamy Source: PomBase
  6. positive regulation of GTPase activity Source: GOC
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Gene namesi
Name:cdc3
ORF Names:SPAC4A8.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC4A8.15c.

Subcellular locationi

GO - Cellular componenti

  1. actin cortical patch Source: PomBase
  2. cell cortex of cell tip Source: PomBase
  3. cytosol Source: PomBase
  4. mating projection Source: PomBase
  5. medial cortex Source: PomBase
  6. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127ProfilinPRO_0000199607Add
BLAST

Proteomic databases

MaxQBiP39825.
PaxDbiP39825.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

BioGridi279944. 20 interactions.
MINTiMINT-4689399.
STRINGi4896.SPAC4A8.15c-1.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 86Combined sources
Turni9 – 113Combined sources
Helixi12 – 143Combined sources
Beta strandi19 – 246Combined sources
Beta strandi30 – 334Combined sources
Helixi41 – 5212Combined sources
Helixi56 – 605Combined sources
Beta strandi62 – 643Combined sources
Beta strandi67 – 748Combined sources
Beta strandi76 – 838Combined sources
Beta strandi86 – 927Combined sources
Beta strandi94 – 1029Combined sources
Helixi108 – 12518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortaliP39825.
SMRiP39825. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39825.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiP39825.
KOiK05759.
OMAiRADKNSI.
OrthoDBiEOG77T1H1.
PhylomeDBiP39825.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39825-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWQAYVDTS LLGTGKIDRA AIVSRAGDSV WAASAGFNLS PQEIQGLAAG
60 70 80 90 100
FQDPPSMFGT GIILAGQKYI TIRAEGRSIY GKLQKEGIIC VATKLCILVS
110 120
HYPETTLPGE AAKITEALAD YLVGVGY
Length:127
Mass (Da):13,411
Last modified:February 1, 1995 - v1
Checksum:i1D3BE221AAA73594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRiA53952.
RefSeqiNP_593827.1. NM_001019256.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneIDi2543526.
KEGGispo:SPAC4A8.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1 .
PIRi A53952.
RefSeqi NP_593827.1. NM_001019256.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3D9Y X-ray 1.65 A/B 1-127 [» ]
3DAV X-ray 2.20 A/B 1-127 [» ]
ProteinModelPortali P39825.
SMRi P39825. Positions 2-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279944. 20 interactions.
MINTi MINT-4689399.
STRINGi 4896.SPAC4A8.15c-1.

Proteomic databases

MaxQBi P39825.
PaxDbi P39825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC4A8.15c.1 ; SPAC4A8.15c.1:pep ; SPAC4A8.15c .
GeneIDi 2543526.
KEGGi spo:SPAC4A8.15c.

Organism-specific databases

PomBasei SPAC4A8.15c.

Phylogenomic databases

eggNOGi NOG277929.
HOGENOMi HOG000171591.
InParanoidi P39825.
KOi K05759.
OMAi RADKNSI.
OrthoDBi EOG77T1H1.
PhylomeDBi P39825.

Miscellaneous databases

EvolutionaryTracei P39825.
NextBioi 20804536.
PROi P39825.

Family and domain databases

InterProi IPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis."
    Balasubramanian M.K., Hirani B.R., Burke J.D., Gould K.L.
    J. Cell Biol. 125:1289-1301(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPROF_SCHPO
AccessioniPrimary (citable) accession number: P39825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3