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Protein

Profilin

Gene

cdc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.

GO - Molecular functioni

  1. actin monomer binding Source: PomBase
  2. guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

  1. actin cortical patch organization Source: PomBase
  2. actin filament polymerization Source: PomBase
  3. mitotic actomyosin contractile ring assembly Source: PomBase
  4. mitotic contractile ring actin filament bundle assembly Source: PomBase
  5. plasma membrane fusion involved in cytogamy Source: PomBase
  6. positive regulation of GTPase activity Source: GOC
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Gene namesi
Name:cdc3
ORF Names:SPAC4A8.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.15c.
PomBaseiSPAC4A8.15c.

Subcellular locationi

GO - Cellular componenti

  1. actin cortical patch Source: PomBase
  2. cell cortex of cell tip Source: PomBase
  3. cytosol Source: PomBase
  4. mating projection Source: PomBase
  5. medial cortex Source: PomBase
  6. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127ProfilinPRO_0000199607Add
BLAST

Proteomic databases

MaxQBiP39825.
PaxDbiP39825.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

BioGridi279944. 20 interactions.
MINTiMINT-4689399.
STRINGi4896.SPAC4A8.15c-1.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 86Combined sources
Turni9 – 113Combined sources
Helixi12 – 143Combined sources
Beta strandi19 – 246Combined sources
Beta strandi30 – 334Combined sources
Helixi41 – 5212Combined sources
Helixi56 – 605Combined sources
Beta strandi62 – 643Combined sources
Beta strandi67 – 748Combined sources
Beta strandi76 – 838Combined sources
Beta strandi86 – 927Combined sources
Beta strandi94 – 1029Combined sources
Helixi108 – 12518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortaliP39825.
SMRiP39825. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39825.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiP39825.
KOiK05759.
OMAiMSWNDII.
OrthoDBiEOG77T1H1.
PhylomeDBiP39825.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDTS LLGTGKIDRA AIVSRAGDSV WAASAGFNLS PQEIQGLAAG
60 70 80 90 100
FQDPPSMFGT GIILAGQKYI TIRAEGRSIY GKLQKEGIIC VATKLCILVS
110 120
HYPETTLPGE AAKITEALAD YLVGVGY
Length:127
Mass (Da):13,411
Last modified:February 1, 1995 - v1
Checksum:i1D3BE221AAA73594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRiA53952.
RefSeqiNP_593827.1. NM_001019256.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneIDi2543526.
KEGGispo:SPAC4A8.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30648 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB38578.1.
PIRiA53952.
RefSeqiNP_593827.1. NM_001019256.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D9YX-ray1.65A/B1-127[»]
3DAVX-ray2.20A/B1-127[»]
ProteinModelPortaliP39825.
SMRiP39825. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279944. 20 interactions.
MINTiMINT-4689399.
STRINGi4896.SPAC4A8.15c-1.

Proteomic databases

MaxQBiP39825.
PaxDbiP39825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4A8.15c.1; SPAC4A8.15c.1:pep; SPAC4A8.15c.
GeneIDi2543526.
KEGGispo:SPAC4A8.15c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.15c.
PomBaseiSPAC4A8.15c.

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiP39825.
KOiK05759.
OMAiMSWNDII.
OrthoDBiEOG77T1H1.
PhylomeDBiP39825.

Miscellaneous databases

EvolutionaryTraceiP39825.
NextBioi20804536.
PROiP39825.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis."
    Balasubramanian M.K., Hirani B.R., Burke J.D., Gould K.L.
    J. Cell Biol. 125:1289-1301(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPROF_SCHPO
AccessioniPrimary (citable) accession number: P39825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.