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P39824

- BLAC_BACSU

UniProt

P39824 - BLAC_BACSU

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Protein
Beta-lactamase
Gene
penP, BSU18800
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciBSUB:BSU18800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:penP
Ordered Locus Names:BSU18800
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU18800. [Micado]

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36361 Publication
Add
BLAST
Chaini37 – 306270Beta-lactamase
PRO_0000016975Add
BLAST

Proteomic databases

PaxDbiP39824.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU18800.

Structurei

3D structure databases

ProteinModelPortaliP39824.
SMRiP39824. Positions 53-305.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2367.
HOGENOMiHOG000201073.
KOiK17836.
OMAiMKLIGGP.
OrthoDBiEOG6K9QFS.
PhylomeDBiP39824.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39824-1 [UniParc]FASTAAdd to Basket

« Hide

MKLKTKASIK FGICVGLLCL SITGFTPFFN STHAEAKSIE DTNMASCITN    50
KKFVQLEKKF DARLGVYAID IGSNKTIAYR PNERFAYAST YKVLAAAAVL 100
KKNSIEKLNE VIHYSKDDLV TYSPITEKHL DTGMSLKEIS EAAIRYSDNT 150
AGNILLQQLG GPKGFEKSLK QIGDHVTKAK RFETDLNSAI PGDIRDTSTA 200
KALATDLKAF TLDNTLTTDK RMILTDWMRG NATGDELIRA GAPIGWEVGD 250
KSGAGSYGTR NDIAIVWPPN RAPIVVAILS NRFTKDANYD NALIAEAAKV 300
VLNDLK 306
Length:306
Mass (Da):33,446
Last modified:May 30, 2000 - v2
Checksum:i95BE5644B731500E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511K → N in CAA84711. 1 Publication
Sequence conflicti97 – 993AAV → GGF in CAA84711. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35652 Genomic DNA. Translation: CAA84711.1.
AF027868 Genomic DNA. Translation: AAB84426.1.
AL009126 Genomic DNA. Translation: CAB13772.1.
PIRiG69674.
RefSeqiNP_389761.1. NC_000964.3.
WP_003231385.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13772; CAB13772; BSU18800.
GeneIDi940129.
KEGGibsu:BSU18800.
PATRICi18975601. VBIBacSub10457_1991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35652 Genomic DNA. Translation: CAA84711.1 .
AF027868 Genomic DNA. Translation: AAB84426.1 .
AL009126 Genomic DNA. Translation: CAB13772.1 .
PIRi G69674.
RefSeqi NP_389761.1. NC_000964.3.
WP_003231385.1. NC_000964.3.

3D structure databases

ProteinModelPortali P39824.
SMRi P39824. Positions 53-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU18800.

Proteomic databases

PaxDbi P39824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13772 ; CAB13772 ; BSU18800 .
GeneIDi 940129.
KEGGi bsu:BSU18800.
PATRICi 18975601. VBIBacSub10457_1991.

Organism-specific databases

GenoListi BSU18800. [Micado ]

Phylogenomic databases

eggNOGi COG2367.
HOGENOMi HOG000201073.
KOi K17836.
OMAi MKLIGGP.
OrthoDBi EOG6K9QFS.
PhylomeDBi P39824.

Enzyme and pathway databases

BioCyci BSUB:BSU18800-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of penicillinase-encoding genes of Bacillus amyloliquefaciens and Bacillus subtilis."
    van Dijl J.M., de Jong A., Nauta A., Venema G., Bron S.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / 6GM.
  2. "Sequence analysis of the Bacillus subtilis chromosome region between the terC and odhAB loci cloned in a yeast artificial chromosome."
    Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Proteome analysis of Bacillus subtilis extracellular proteins: a two-dimensional protein electrophoretic study."
    Hirose I., Sano K., Shioda I., Kumano M., Nakamura K., Yamane K.
    Microbiology 146:65-75(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-47, SUBCELLULAR LOCATION.
    Strain: 168.

Entry informationi

Entry nameiBLAC_BACSU
AccessioniPrimary (citable) accession number: P39824
Secondary accession number(s): O34848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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