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P39800

- XLYA_BACSU

UniProt

P39800 - XLYA_BACSU

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Protein
N-acetylmuramoyl-L-alanine amidase XlyA
Gene
xlyA, BSU12810
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation, Competence, Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU12810-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase XlyA (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:xlyA
Ordered Locus Names:BSU12810
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU12810. [Micado]

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444 Reviewed prediction
Add
BLAST
Chaini45 – 297253N-acetylmuramoyl-L-alanine amidase XlyA
PRO_0000006457Add
BLAST

Proteomic databases

PaxDbiP39800.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU12810.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Beta strandi25 – 306
Helixi40 – 478
Beta strandi57 – 604
Beta strandi65 – 673
Beta strandi78 – 803
Helixi84 – 874
Beta strandi88 – 947
Helixi102 – 11918
Helixi124 – 1263
Beta strandi127 – 1293
Helixi130 – 1345
Turni140 – 1423
Helixi143 – 1453
Helixi146 – 1516

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HMBX-ray2.70A/B/C1-154[»]
3RDRX-ray2.20A1-154[»]
ProteinModelPortaliP39800.
SMRiP39800. Positions 2-154, 223-295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati161 – 20444LysM
Add
BLAST

Sequence similaritiesi

Contains 1 LysM repeat.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3409.
HOGENOMiHOG000273688.
KOiK01447.
OMAiWHAGDGN.
OrthoDBiEOG6XHC2R.
PhylomeDBiP39800.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
3.10.350.10. 1 hit.
3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR018392. LysM_dom.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
PF01476. LysM. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF54106. SSF54106. 1 hit.
SSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39800-1 [UniParc]FASTAAdd to Basket

« Hide

MVNIIQDFIP VGANNRPGYA MTPLYITVHN TANTAVGADA AAHARYLKNP    50
DTTTSWHFTV DDTEIYQHLP LNENGWHAGD GNGSGNRASI GIEICENADG 100
DFAKATANAQ WLIKTLMAEH NISLANVVPH KYWSGKECPR KLLDTWDSFK 150
AGIGGGGSQT YVVKQGDTLT SIARAFGVTV AQLQEWNNIE DPNLIRVGQV 200
LIVSAPSAAE KPELYPLPDG IIQLTTPYTS GEHVFQVQRA LAALYFYPDK 250
GAVNNGIDGV YGPKTADAVA RFQSVNGLTA DGIYGPATKE KIAAQLS 297
Length:297
Mass (Da):31,913
Last modified:February 1, 1995 - v1
Checksum:i33DB710059A3EC72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36941 Genomic DNA. Translation: CAA85403.1.
L25924 Genomic DNA. Translation: AAA22645.1.
Z70177 Genomic DNA. Translation: CAA94049.1.
AL009126 Genomic DNA. Translation: CAB13138.1.
AJ002571 Genomic DNA. Translation: CAA05561.1.
PIRiI39938.
RefSeqiNP_389164.1. NC_000964.3.
WP_003245230.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB13138; CAB13138; BSU12810.
GeneIDi939869.
KEGGibsu:BSU12810.
PATRICi18974313. VBIBacSub10457_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36941 Genomic DNA. Translation: CAA85403.1 .
L25924 Genomic DNA. Translation: AAA22645.1 .
Z70177 Genomic DNA. Translation: CAA94049.1 .
AL009126 Genomic DNA. Translation: CAB13138.1 .
AJ002571 Genomic DNA. Translation: CAA05561.1 .
PIRi I39938.
RefSeqi NP_389164.1. NC_000964.3.
WP_003245230.1. NZ_CM000487.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HMB X-ray 2.70 A/B/C 1-154 [» ]
3RDR X-ray 2.20 A 1-154 [» ]
ProteinModelPortali P39800.
SMRi P39800. Positions 2-154, 223-295.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224308.BSU12810.

Proteomic databases

PaxDbi P39800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13138 ; CAB13138 ; BSU12810 .
GeneIDi 939869.
KEGGi bsu:BSU12810.
PATRICi 18974313. VBIBacSub10457_1349.

Organism-specific databases

GenoListi BSU12810. [Micado ]

Phylogenomic databases

eggNOGi COG3409.
HOGENOMi HOG000273688.
KOi K01447.
OMAi WHAGDGN.
OrthoDBi EOG6XHC2R.
PhylomeDBi P39800.

Enzyme and pathway databases

BioCyci BSUB:BSU12810-MONOMER.

Family and domain databases

Gene3Di 1.10.101.10. 1 hit.
3.10.350.10. 1 hit.
3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR018392. LysM_dom.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
PF01476. LysM. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00257. LysM. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF54106. SSF54106. 1 hit.
SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Krogh S., Joergensen S.T., Diderichsen B., Devine K.M.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / SO113.
  2. "Lytic enzymes associated with defective prophages of Bacillus subtilis: sequencing and characterization of the region comprising the N-acetylmuramoyl-L-alanine amidase gene of prophage PBSX."
    Longchamp P.F., Mauel C., Karamata D.
    Microbiology 140:1855-1867(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "Lysis genes of the Bacillus subtilis defective prophage PBSX."
    Krogh S., Jorgensen S.T., Devine K.M.
    J. Bacteriol. 180:2110-2117(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  5. "Sequence of the Bacillus subtilis genome between xlyA and ykoR."
    Devine K.M.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-297.
    Strain: 168.

Entry informationi

Entry nameiXLYA_BACSU
AccessioniPrimary (citable) accession number: P39800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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