Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator TreR

Gene

treR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Repressor for the trePA operon. It is able to bind trehalose-6-phosphate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 50H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU07820-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator TreR1 Publication
Alternative name(s):
Trehalose operon repressor1 Publication
Gene namesi
Name:treR
Synonyms:yfxA
Ordered Locus Names:BSU07820
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are constitutive in the expression of the trePA operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506691 – 238HTH-type transcriptional regulator TreRAdd BLAST238

Proteomic databases

PaxDbiP39796.
PRIDEiP39796.

Expressioni

Inductioni

Probably induced by trehalose-6-phosphate.1 Publication

Interactioni

Subunit structurei

Dimer of dimers.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100004353.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi97 – 105Combined sources9
Helixi109 – 115Combined sources7
Beta strandi123 – 132Combined sources10
Beta strandi135 – 145Combined sources11
Turni146 – 148Combined sources3
Helixi154 – 157Combined sources4
Helixi161 – 169Combined sources9
Beta strandi172 – 184Combined sources13
Helixi187 – 192Combined sources6
Beta strandi200 – 210Combined sources11
Beta strandi215 – 224Combined sources10
Helixi225 – 227Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGGX-ray2.50A90-238[»]
ProteinModelPortaliP39796.
SMRiP39796.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39796.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71HTH gntR-typePROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107414. Bacteria.
COG2188. LUCA.
HOGENOMiHOG000228718.
InParanoidiP39796.
KOiK03486.
OMAiSQNGYIQ.
PhylomeDBiP39796.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.1410.10. 1 hit.
InterProiIPR028978. Chorismate_lyase_/UTRA_dom.
IPR012770. TreR.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011663. UTRA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00392. GntR. 1 hit.
PF07702. UTRA. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
SM00866. UTRA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF64288. SSF64288. 1 hit.
TIGRFAMsiTIGR02404. trehalos_R_Bsub. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNKFITIY KDIAQQIEGG RWKAEEILPS EHELTAQYGT SRETVRKALH
60 70 80 90 100
MLAQNGYIQK IRGKGSVVLN REKMQFPVSG LVSFKELAQT LGKETKTTVH
110 120 130 140 150
KFGLEPPSEL IQKQLRANLD DDIWEVIRSR KIDGEHVILD KDYFFRKHVP
160 170 180 190 200
HLTKEICENS IYEYIEGELG LSISYAQKEI VAEPCTDEDR ELLDLRGYDH
210 220 230
MVVVRNYVFL EDTSLFQYTE SRHRLDKFRF VDFARRGK
Length:238
Mass (Da):27,842
Last modified:October 1, 1996 - v2
Checksum:i41715DA057CEA600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54245 Genomic DNA. Translation: CAA91016.1.
D83967 Genomic DNA. Translation: BAA23407.1.
AL009126 Genomic DNA. Translation: CAB12611.1.
X80203 Genomic DNA. Translation: CAA56496.1. Frameshift.
PIRiJC5038.
RefSeqiNP_388663.1. NC_000964.3.
WP_003233679.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12611; CAB12611; BSU07820.
GeneIDi936133.
KEGGibsu:BSU07820.
PATRICi18973212. VBIBacSub10457_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54245 Genomic DNA. Translation: CAA91016.1.
D83967 Genomic DNA. Translation: BAA23407.1.
AL009126 Genomic DNA. Translation: CAB12611.1.
X80203 Genomic DNA. Translation: CAA56496.1. Frameshift.
PIRiJC5038.
RefSeqiNP_388663.1. NC_000964.3.
WP_003233679.1. NZ_JNCM01000032.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGGX-ray2.50A90-238[»]
ProteinModelPortaliP39796.
SMRiP39796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100004353.

Proteomic databases

PaxDbiP39796.
PRIDEiP39796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12611; CAB12611; BSU07820.
GeneIDi936133.
KEGGibsu:BSU07820.
PATRICi18973212. VBIBacSub10457_0820.

Phylogenomic databases

eggNOGiENOG4107414. Bacteria.
COG2188. LUCA.
HOGENOMiHOG000228718.
InParanoidiP39796.
KOiK03486.
OMAiSQNGYIQ.
PhylomeDBiP39796.

Enzyme and pathway databases

BioCyciBSUB:BSU07820-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP39796.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.1410.10. 1 hit.
InterProiIPR028978. Chorismate_lyase_/UTRA_dom.
IPR012770. TreR.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011663. UTRA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00392. GntR. 1 hit.
PF07702. UTRA. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00345. HTH_GNTR. 1 hit.
SM00866. UTRA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF64288. SSF64288. 1 hit.
TIGRFAMsiTIGR02404. trehalos_R_Bsub. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRER_BACSU
AccessioniPrimary (citable) accession number: P39796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.