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P39774

- SPAB_BACIU

UniProt

P39774 - SPAB_BACIU

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Protein
Subtilin biosynthesis protein SpaB
Gene
spaB, spaD, spaE
Organism
Bacillus subtilis
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Involved in the post-translational modification of the lantibiotic subtilin.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Subtilin biosynthesis protein SpaB
Gene namesi
Name:spaB
Synonyms:spaD, spaE
OrganismiBacillus subtilis
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Cell membrane
Note: Possibly associated with, and anchored to, the cytoplasmic side of the membrane.

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10301030Subtilin biosynthesis protein SpaB
PRO_0000072091Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-1521998.

Family & Domainsi

Sequence similaritiesi

To S.epidermidis EpiB and L.lactis NisB.

Family and domain databases

InterProiIPR006827. Lant_deHydtase_C.
IPR006826. Lant_deHydtase_N.
IPR023809. Thiopep_bacteriocin_synth_dom.
[Graphical view]
PfamiPF04738. Lant_dehyd_C. 1 hit.
PF04737. Lant_dehyd_N. 1 hit.
PF14028. SpaB_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03891. thiopep_ocin. 1 hit.

Sequencei

Sequence statusi: Complete.

P39774-1 [UniParc]FASTAAdd to Basket

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MKSLYTPTDY YMIRVPLVHQ DLKNENSQDI DQLLHDLCND SLFREQILVS     50
SRTLYETIHT FLQAPDKLKG KKKRNFQQAI LKYATRRATR TTPFGLFSSV 100
GIGSFSDKNH LSFNQHSFYK KARVDLEWLY QLIRKLENEY TDRLSFTLNS 150
ACYIKGDRAY LLYSTDGKSE EVSVRATSVF YLINELCGES AAYQDIIRCL 200
IDNYPNTPIN KINQYVADLI DKEFLISNLR PPMTVSDQFQ YLIDQAESRH 250
IPNELIQACK DIQYQIDAYN RITIGEGEHQ YLNLIETMNK LIKASSPLQV 300
DAGLADSSIQ LDNETSLAIS ELASMFTYMA SPSANTLDHL EKYHNVFLER 350
YGYEREVPLL EMLCSSTGIG APATYTNPAN EFFEETSFGE QFSPEMKQFF 400
MRKYFESVRK KAPIQLDDET FHRICNSEIA DEEIPLSFEL NFFVKLRNGR 450
VKLYLGPNVG STRAGKTFGR FSHMSDSISE IIKTLHNKEK ELTECNTKVC 500
ELSIVPNQTR SGNVTRNVSY REKEMSLFTN SALHLNDSVK AEDILIGINK 550
DHNFYARHKT TGEILSFESN HMFNPLLMTN AVRFLLEISR DGKRKWNDFP 600
WFSIYSDFKY IPEIKYKEIT LSCEQWLIYK NDLSMHSNAS LEEIKSPFFE 650
FHRTYELPQT FYIVNADNRL LIDIENDCTL DVFFWELKKT NHNQPLQLVA 700
VEHDADALMD RNQNDYSGEI VVPLLRKQPE KPLYLPVLNA IEGSGSDRIK 750
MPFEDWLFIK LYCKQTREEE LIAFEIADFY NQISDQYPVR HFFMRYRDPK 800
PHIRLRFNGK AEVLYSLFPQ LLNWLKSLRE KGLVSESVIT QYEREIERYG 850
GLSLMEAAEQ LFCEDSKVVE MMIRMHRMKD ITISKEIAGM VSVIQFLEQF 900
ELTFEEQLTF LERNSLQNEY RTEFKKDREM YIEICNSDRD WDNLKKTSDG 950
GMLYETLKTR KMAAAHYAFL IKKAFDNKDE VYSRIGSIIH LHCNRLFGTD 1000
RELENKILTL CRHSLYAQRY QKMNGSLAWK 1030
Length:1,030
Mass (Da):120,529
Last modified:November 1, 1997 - v2
Checksum:i89F3B147E02A9DF8
GO

Sequence cautioni

The sequence AAA22774.1 differs from that shown. Reason: Frameshift at position 852.
The sequence AAA22775.1 differs from that shown. Reason: Frameshift at position 852.
The sequence AAA22769.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261L → F in AAA22774. 1 Publication
Sequence conflicti261 – 2611D → N in AAA22774. 1 Publication
Sequence conflicti304 – 3052LA → AG in AAA22774. 1 Publication
Sequence conflicti344 – 3441H → K in AAA22774. 1 Publication
Sequence conflicti553 – 5531N → I in AAA22774. 1 Publication
Sequence conflicti584 – 5841F → L in AAA22774. 1 Publication
Sequence conflicti647 – 6471P → A in AAA22774. 1 Publication
Sequence conflicti730 – 7301E → V in AAA22774. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24075 Genomic DNA. Translation: AAA22779.1.
U09819 Genomic DNA. Translation: AAB91586.1.
M99263 Genomic DNA. Translation: AAA22774.1. Frameshift.
M99263 Genomic DNA. Translation: AAA22775.1. Frameshift.
M86869 Genomic DNA. Translation: AAA22837.1.
M83944 Genomic DNA. Translation: AAA22769.1. Different initiation.
U38418 Genomic DNA. Translation: AAB01536.1.
PIRiI39987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24075 Genomic DNA. Translation: AAA22779.1 .
U09819 Genomic DNA. Translation: AAB91586.1 .
M99263 Genomic DNA. Translation: AAA22774.1 . Frameshift.
M99263 Genomic DNA. Translation: AAA22775.1 . Frameshift.
M86869 Genomic DNA. Translation: AAA22837.1 .
M83944 Genomic DNA. Translation: AAA22769.1 . Different initiation.
U38418 Genomic DNA. Translation: AAB01536.1 .
PIRi I39987.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

MINTi MINT-1521998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR006827. Lant_deHydtase_C.
IPR006826. Lant_deHydtase_N.
IPR023809. Thiopep_bacteriocin_synth_dom.
[Graphical view ]
Pfami PF04738. Lant_dehyd_C. 1 hit.
PF04737. Lant_dehyd_N. 1 hit.
PF14028. SpaB_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03891. thiopep_ocin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Growth phase-dependent regulation and membrane localization of SpaB, a protein involved in biosynthesis of the lantibiotic subtilin."
    Gutowski-Eckel Z., Klein C., Siegers K., Bohm K., Hammelmann M., Entian K.-D.
    Appl. Environ. Microbiol. 60:1-11(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 6633 / PCI 219 / NRS 231.
  2. "Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633."
    Klein C., Entian K.-D.
    Appl. Environ. Microbiol. 60:2793-2801(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 6633 / PCI 219 / NRS 231.
  3. "Determination of the sequence of spaE and identification of a promoter in the subtilin (spa) operon in Bacillus subtilis."
    Chung Y.J., Hansen J.N.
    J. Bacteriol. 174:6699-6702(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 6633 / PCI 219 / NRS 231.
  4. "Analysis of genes involved in biosynthesis of the lantibiotic subtilin."
    Klein C., Kaletta C., Schnell N., Entian K.-D.
    Appl. Environ. Microbiol. 58:132-142(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 641-1030.
    Strain: ATCC 6633 / PCI 219 / NRS 231.
  5. "The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein."
    Chung Y.J., Steen M.T., Hansen J.N.
    J. Bacteriol. 174:1417-1422(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 852-1030.
    Strain: ATCC 6633 / PCI 219 / NRS 231.

Entry informationi

Entry nameiSPAB_BACIU
AccessioniPrimary (citable) accession number: P39774
Secondary accession number(s): P33114, P36360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: May 29, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) proposed to code for two separate adjacent ORFs, SpaE and SpaD.

External Data

Dasty 3

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