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Protein

Asparagine--tRNA ligase

Gene

asnS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU22360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligaseUniRule annotation (EC:6.1.1.22UniRule annotation)
Alternative name(s):
Asparaginyl-tRNA synthetaseUniRule annotation
Short name:
AsnRSUniRule annotation
Gene namesi
Name:asnSUniRule annotation
Ordered Locus Names:BSU22360
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Asparagine--tRNA ligasePRO_0000176393Add
BLAST

Proteomic databases

PaxDbiP39772.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP39772. 1 interaction.
MINTiMINT-8366105.
STRINGi224308.Bsubs1_010100012296.

Structurei

3D structure databases

ProteinModelPortaliP39772.
SMRiP39772. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5S. Bacteria.
COG0017. LUCA.
HOGENOMiHOG000226034.
InParanoidiP39772.
KOiK01893.
OMAiMEHRHLW.
PhylomeDBiP39772.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTINQVYK HVGEEVTIGA WVANKRSSGK IAFLQLRDGT GFIQGVVVKA
60 70 80 90 100
EVEESIFQTA KSVTQETSLY IKGIVKEDER SPLGYELAVT DIEVIHEATD
110 120 130 140 150
YPITPKEHGT EFLMDHRHLW LRSKRQHAIM KIRNEIIRAT YEFFNNEGFV
160 170 180 190 200
KVDPPILTGS APEGTTELFA TKYFDEDAYL SQSGQLYMEA AAMALGKVFS
210 220 230 240 250
FGPTFRAEKS KTKRHLIEFW MIEPEMAFVE FEENLQVQEN YVSFIVQSVL
260 270 280 290 300
KNCKIELNTL GRDTSKLEQI KAPFPRITYD EAIEFLKEKG FDDIEWGDDF
310 320 330 340 350
GAPHETAIAE HYDKPVFITR YPTSLKPFYM QPASDREDVV LCADLIAPEG
360 370 380 390 400
YGEIIGGSER IHDMELLESR LKEHGLDSDA YKWYAELRKY GSVPHSGFGL
410 420 430
GLERTVAWIS GAPHVRETIP FPRLLNRLYP
Length:430
Mass (Da):49,084
Last modified:October 1, 1996 - v2
Checksum:i62F550E1936B1BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA. Translation: AAB38455.1.
AL009126 Genomic DNA. Translation: CAB14152.1.
U11289 Genomic DNA. Translation: AAA80003.1.
PIRiB69591.
RefSeqiNP_390117.1. NC_000964.3.
WP_004398777.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14152; CAB14152; BSU22360.
GeneIDi939038.
KEGGibsu:BSU22360.
PATRICi18976281. VBIBacSub10457_2331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA. Translation: AAB38455.1.
AL009126 Genomic DNA. Translation: CAB14152.1.
U11289 Genomic DNA. Translation: AAA80003.1.
PIRiB69591.
RefSeqiNP_390117.1. NC_000964.3.
WP_004398777.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP39772.
SMRiP39772. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP39772. 1 interaction.
MINTiMINT-8366105.
STRINGi224308.Bsubs1_010100012296.

Proteomic databases

PaxDbiP39772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14152; CAB14152; BSU22360.
GeneIDi939038.
KEGGibsu:BSU22360.
PATRICi18976281. VBIBacSub10457_2331.

Phylogenomic databases

eggNOGiENOG4105C5S. Bacteria.
COG0017. LUCA.
HOGENOMiHOG000226034.
InParanoidiP39772.
KOiK01893.
OMAiMEHRHLW.
PhylomeDBiP39772.

Enzyme and pathway databases

BioCyciBSUB:BSU22360-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYN_BACSU
AccessioniPrimary (citable) accession number: P39772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.