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Protein

Uracil permease

Gene

pyrP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transport of uracil in the cell.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBSUB:BSU15480-MONOMER.

Protein family/group databases

TCDBi2.A.40.1.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Alternative name(s):
Uracil transporter
Gene namesi
Name:pyrP
Ordered Locus Names:BSU15480
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU15480. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21323HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Uracil permeasePRO_0000165957Add
BLAST

Proteomic databases

PaxDbiP39766.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU15480.

Structurei

3D structure databases

ProteinModelPortaliP39766.
SMRiP39766. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
HOGENOMiHOG000038200.
InParanoidiP39766.
KOiK02824.
OMAiAVMITRC.
OrthoDBiEOG6Z3KKZ.
PhylomeDBiP39766.

Family and domain databases

InterProiIPR029935. Uracil_permease.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF27. PTHR11119:SF27. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39766-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKKVNLGV RDVPTPFSWV SFSLQHLFAM FGSTILVPKL VGMSPAVALV
60 70 80 90 100
TSGIGTLAYL LITKGQIPAY LGSSFAFISP IILVKATGGP GAAMVGAFLA
110 120 130 140 150
GLVYGLIALL IRQLGTGWLM KILPPVVVGP VIIVIGLGLA STAVNMAMYA
160 170 180 190 200
DPNASELVYS LKHFSVAGVT LAITIICAIF LRGFLSLIPV LIGIIGGYLF
210 220 230 240 250
ALTQGIVNFQ PVLDAKWFAV PEFIIPFKDY SPSVTLGIAA AMVPVAFVTM
260 270 280 290 300
SEHIGHQMVL SKVVGQDFIK KPGLHRSIMG DSVATILASL IGGPPTTTYG
310 320 330 340 350
ENIGVLAITR VFSVFVIGGA AVIALCFGFI GKISALISSV PSAVMGGVSF
360 370 380 390 400
LLFGIIASSG LRMLIDNKID YENNRNLIIT SVILVIGVGG AFIQVSQGGF
410 420 430
QVSGMALAAI VGVILNLILP QAKEEQADTS EQHHI
Length:435
Mass (Da):45,452
Last modified:June 16, 2009 - v2
Checksum:i2EB735352A034D33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 26030SPSVT…HQMVL → HRQLRSASQPQWFLSHLSQC QSISATNGAE in AAA21266. (PubMed:1709162)CuratedAdd
BLAST
Sequence conflicti271 – 2722KP → A in AAA21266. (PubMed:1709162)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59757 Genomic DNA. Translation: AAA21266.1.
AL009126 Genomic DNA. Translation: CAB13422.2.
PIRiA38984. A57986.
RefSeqiNP_389431.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13422; CAB13422; BSU15480.
GeneIDi936604.
KEGGibsu:BSU15480.
PATRICi18974903. VBIBacSub10457_1643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59757 Genomic DNA. Translation: AAA21266.1.
AL009126 Genomic DNA. Translation: CAB13422.2.
PIRiA38984. A57986.
RefSeqiNP_389431.2. NC_000964.3.

3D structure databases

ProteinModelPortaliP39766.
SMRiP39766. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU15480.

Protein family/group databases

TCDBi2.A.40.1.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Proteomic databases

PaxDbiP39766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13422; CAB13422; BSU15480.
GeneIDi936604.
KEGGibsu:BSU15480.
PATRICi18974903. VBIBacSub10457_1643.

Organism-specific databases

GenoListiBSU15480. [Micado]

Phylogenomic databases

eggNOGiCOG2233.
HOGENOMiHOG000038200.
InParanoidiP39766.
KOiK02824.
OMAiAVMITRC.
OrthoDBiEOG6Z3KKZ.
PhylomeDBiP39766.

Enzyme and pathway databases

BioCyciBSUB:BSU15480-MONOMER.

Family and domain databases

InterProiIPR029935. Uracil_permease.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF27. PTHR11119:SF27. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional organization and nucleotide sequence of the Bacillus subtilis pyrimidine biosynthetic operon."
    Quinn C.L., Stephenson B.T., Switzer R.L.
    J. Biol. Chem. 266:9113-9127(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism."
    Turner R.J., Lu Y., Switzer R.L.
    J. Bacteriol. 176:3708-3722(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION, CHARACTERIZATION.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 231-260 AND 271-272.

Entry informationi

Entry nameiPYRP_BACSU
AccessioniPrimary (citable) accession number: P39766
Secondary accession number(s): P25982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: January 7, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.