Skip Header

Contribute Send feedback
Read comments (?) or add your own

P39766 (PYRP_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil permease
Alternative name(s):
Uracil transporter
Gene names
Name:pyrP
Ordered Locus Names:BSU15480
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transport of uracil in the cell.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Uracil permease
PRO_0000165957

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane191 – 21323Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane376 – 39621Helical; Potential
Transmembrane399 – 41921Helical; Potential

Experimental info

Sequence conflict231 – 26030SPSVT…HQMVL → HRQLRSASQPQWFLSHLSQC QSISATNGAE in AAA21266. Ref.1
Sequence conflict271 – 2722KP → A in AAA21266. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39766 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 2EB735352A034D33

FASTA43545,452
        10         20         30         40         50         60 
MSKKKVNLGV RDVPTPFSWV SFSLQHLFAM FGSTILVPKL VGMSPAVALV TSGIGTLAYL 

        70         80         90        100        110        120 
LITKGQIPAY LGSSFAFISP IILVKATGGP GAAMVGAFLA GLVYGLIALL IRQLGTGWLM 

       130        140        150        160        170        180 
KILPPVVVGP VIIVIGLGLA STAVNMAMYA DPNASELVYS LKHFSVAGVT LAITIICAIF 

       190        200        210        220        230        240 
LRGFLSLIPV LIGIIGGYLF ALTQGIVNFQ PVLDAKWFAV PEFIIPFKDY SPSVTLGIAA 

       250        260        270        280        290        300 
AMVPVAFVTM SEHIGHQMVL SKVVGQDFIK KPGLHRSIMG DSVATILASL IGGPPTTTYG 

       310        320        330        340        350        360 
ENIGVLAITR VFSVFVIGGA AVIALCFGFI GKISALISSV PSAVMGGVSF LLFGIIASSG 

       370        380        390        400        410        420 
LRMLIDNKID YENNRNLIIT SVILVIGVGG AFIQVSQGGF QVSGMALAAI VGVILNLILP 

       430 
QAKEEQADTS EQHHI

« Hide

References

« Hide 'large scale' references
[1]"Functional organization and nucleotide sequence of the Bacillus subtilis pyrimidine biosynthetic operon."
Quinn C.L., Stephenson B.T., Switzer R.L.
J. Biol. Chem. 266:9113-9127(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism."
Turner R.J., Lu Y., Switzer R.L.
J. Bacteriol. 176:3708-3722(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION, CHARACTERIZATION.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 231-260 AND 271-272.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M59757 Genomic DNA. Translation: AAA21266.1.
AL009126 Genomic DNA. Translation: CAB13422.2.
PIRA57986. A38984.
RefSeqNP_389431.2. NC_000964.3.

3D structure databases

ProteinModelPortalP39766.
SMRP39766. Positions 7-421.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU15480.

Proteomic databases

PaxDbP39766.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13422; CAB13422; BSU15480.
GeneID936604.
KEGGbsu:BSU15480.
PATRIC18974903. VBIBacSub10457_1643.

Organism-specific databases

GenoListBSU15480. [Micado]

Phylogenomic databases

eggNOGCOG2233.
HOGENOMHOG000038200.
KOK02824.
ProtClustDBCLSK887278.

Enzyme and pathway databases

BioCycBSUB:BSU15480-MONOMER.

Family and domain databases

InterProIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERPTHR11119. PTHR11119. 1 hit.
PfamPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsTIGR00801. ncs2. 1 hit.
PROSITEPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRP_BACSU
AccessionPrimary (citable) accession number: P39766
Secondary accession number(s): P25982
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents