P39746 (MP2K3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity mitogen-activated protein kinase kinase 3
Short name=MAP kinase kinase 3
Short name=MAPKK 3
EC=2.7.12.2

Alternative name(s):
MAPK-ERK kinase 3

Gene names

Name:	map2k3
Synonyms:	mek3

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	62 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Post-translational modification	Activated by phosphorylation on Ser/Thr catalyzed by MAP kinase kinase kinases.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›62	›62	Dual specificity mitogen-activated protein kinase kinase 3		PRO_0000086380
Regions
	Domain	‹1 – ›62	›62	Protein kinase
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	62	1

Sequences

	Sequence		Length	Mass (Da)
	P39746 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 81A0D7CFF8F5F62D	FASTA	62	6,666
	10 20 30 40 50 60 GKIAVSIVKA LEHLHSKLSV IHRDVKPSNV LINKEGQVNM CDFGISGYLV DSVAKTMDAG CK

References

[1]	"Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis." Yashar B.M., Kelley C., Yee K., Errede B., Zon L.I. Mol. Cell. Biol. 13:5738-5748(1993) [PubMed: 8395011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Embryo.

Cross-references

3D structure databases
ProteinModelPortal	P39746.
SMR	P39746. Positions 1-46.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MP2K3_XENLA

Accession

Primary (citable) accession number: P39746

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	July 27, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program