Reviewed, UniProtKB/Swiss-Prot P39746 (MP2K3_XENLA)

Names and origin

Protein names

Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3
      Short name=MAP kinase kinase 3
      Short name=MAPKK 3
    EC=2.7.12.2
Alternative name(s):
    MAPK-ERK kinase 3

Gene names

Name:	map2k3
Synonyms:	mek3

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	62 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Post-translational modification	Activated by phosphorylation on Ser/Thr catalyzed by MAP kinase kinase kinases.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›62	›62	Dual specificity mitogen-activated protein kinase kinase 3		PRO_0000086380
Regions
	Domain	‹1 – ›62	›62	Protein kinase
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	62	1

Sequences

	Sequence		Length	Mass (Da)
	P39746-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 81A0D7CFF8F5F62D	FASTA	62	6,666
	10 20 30 40 50 60 GKIAVSIVKA LEHLHSKLSV IHRDVKPSNV LINKEGQVNM CDFGISGYLV DSVAKTMDAG CK

References

[1]	"Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis." Yashar B.M., Kelley C., Yee K., Errede B., Zon L.I. Mol. Cell. Biol. 13:5738-5748(1993) [PubMed: 8395011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Embryo.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P39746.
Enzyme and pathway databases
BRENDA	2.7.12.2. 648.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MP2K3_XENLA

Accession

Primary (citable) accession number: P39746

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project