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Protein

Nucleolar complex protein 2

Gene

NOC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the intranuclear transport of ribosomal precursors.1 Publication

GO - Biological processi

  • ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 2
Gene namesi
Name:NOC2
Ordered Locus Names:YOR206W
ORF Names:YOX001
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR206W.
SGDiS000005732. NOC2.

Subcellular locationi

GO - Cellular componenti

  • Noc1p-Noc2p complex Source: SGD
  • Noc2p-Noc3p complex Source: SGD
  • nucleolus Source: GO_Central
  • nucleoplasm Source: GO_Central
  • nucleus Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210541 – 710Nucleolar complex protein 2Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39744.
PRIDEiP39744.

PTM databases

iPTMnetiP39744.

Interactioni

Subunit structurei

Interacts with MAK21/NOC1 and NOC3. Forms a nucleolar complex with MAK21 that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with NOC3 that binds to 66S pre-ribosomes.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BRX1Q082354EBI-29259,EBI-3775
DBP10Q123895EBI-29259,EBI-5644
EBP2P360493EBI-29259,EBI-6289
ERB1Q046607EBI-29259,EBI-28098
HAS1Q035323EBI-29259,EBI-8170
LOC1P435866EBI-29259,EBI-22906
MAK16P109623EBI-29259,EBI-10937
MAK21Q121769EBI-29259,EBI-10944
NOC3Q078967EBI-29259,EBI-36093
NOP12Q082083EBI-29259,EBI-35895
NOP4P378385EBI-29259,EBI-12122
NOP7P532613EBI-29259,EBI-13145
NSA2P400784EBI-29259,EBI-22681
RLP7P406933EBI-29259,EBI-15415
RPF1P388053EBI-29259,EBI-24614
RPF2P361607EBI-29259,EBI-15881
RRP1P351783EBI-29259,EBI-16002
RRP5Q050223EBI-29259,EBI-16011

Protein-protein interaction databases

BioGridi34601. 104 interactors.
DIPiDIP-4559N.
IntActiP39744. 65 interactors.
MINTiMINT-523291.

Structurei

3D structure databases

ProteinModelPortaliP39744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 104Poly-Ser4
Compositional biasi105 – 108Poly-Glu4

Sequence similaritiesi

Belongs to the NOC2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010057.
HOGENOMiHOG000203797.
InParanoidiP39744.
KOiK14833.
OMAiAPYLLRI.
OrthoDBiEOG092C2OUP.

Family and domain databases

InterProiIPR005343. Noc2.
[Graphical view]
PANTHERiPTHR12687. PTHR12687. 1 hit.
PfamiPF03715. Noc2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVSKSTKK FQSKHLKHTL DQRRKEKIQK KRIQGRRGNK TDQEKADAAG
60 70 80 90 100
TREQQQLKKS AKEEVFKDMS VETFFEKGIE IPKENKKLKK KTTKEQSDED
110 120 130 140 150
SSSSEEEEDM GQSMAKLAEK DPEFYKYLEE NDKDLLDFAG TNPLDGIDSQ
160 170 180 190 200
DEGEDAERNS NIEEKSEQME LEKEKIELSL KLVRKWKKQL HDSPSLKLLR
210 220 230 240 250
NIISAFKVAV NLNKEENIED YKYAITDEKA FHELMFMVLK DVPQAIQKMA
260 270 280 290 300
PYKIVKGART LPNGGNVSRV SSIVKSHAGS LLILLNDITN TETAALVLHS
310 320 330 340 350
VNELMPYLLS YRRILKELIK SIVGVWSTTR ELETQIASFA FLINTTKEFK
360 370 380 390 400
KSMLETTLKT TYSTFIKSCR KTNMRSMPLI NFQKNSAAEL FGIDEVLGYQ
410 420 430 440 450
VGFEYIRQLA IHLRNTMNAT TKKSSKINSA EAYKIVYNWQ FCHSLDFWSR
460 470 480 490 500
VLSFACQPEK ENGSESPLRQ LIYPLVQVTL GVIRLIPTPQ FFPLRFYLIK
510 520 530 540 550
SLIRLSQNSG VFIPIYPLLS EILTSTAFTK APKKSPNLAA FDFEHNIKCT
560 570 580 590 600
QAYLNTKIYQ EGLSEQFVDL LGDYFALYCK NIAFPELVTP VIISLRRYIK
610 620 630 640 650
TSTNVKLNKR LSTVVEKLNQ NSTFIQEKRS DVEFGPTNKS EVSRFLNDVA
660 670 680 690 700
WNKTPLGSYV AVQREVKEEK ARLMRESMEE QDKERETEEA KLLNSLESDD
710
DNEDVEMSDA
Length:710
Mass (Da):81,601
Last modified:May 30, 2000 - v2
Checksum:i48C3B9AE076B9B8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151 – 179DEGED…KIELS → MKVKMLKETVILKKNLNKWS WKRKKLSFL (PubMed:2263475).CuratedAdd BLAST29
Sequence conflicti231 – 232FH → LD in CAA39375 (PubMed:2263475).Curated2
Sequence conflicti333E → Q in CAA39375 (PubMed:2263475).Curated1
Sequence conflicti360 – 362TTY → QRT in CAA39375 (PubMed:2263475).Curated3
Sequence conflicti542D → H in CAA39375 (PubMed:2263475).Curated1
Sequence conflicti707 – 710MSDA → NVRRLTTQQDLIFCLEFNSI VYKCVNKRKVFFKAYISLCS HVLTCEHSKLSLVSWIFLYF GRFMDRKHVKRSMDLIKSND VKQGTKMKEVRFTVIKFSKS FNSLKVPHEIDMIANITENF STRYMISYCWKISSNLNLGA MFMDNNSWNNSFAAYGIVIL IIFSALLQVVHQPL in CAA39375 (PubMed:2263475).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55891 Genomic DNA. Translation: CAA39375.1.
Z75114 Genomic DNA. Translation: CAA99421.1.
BK006948 Genomic DNA. Translation: DAA10978.1.
PIRiS67098.
RefSeqiNP_014849.3. NM_001183625.3.

Genome annotation databases

EnsemblFungiiYOR206W; YOR206W; YOR206W.
GeneIDi854381.
KEGGisce:YOR206W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55891 Genomic DNA. Translation: CAA39375.1.
Z75114 Genomic DNA. Translation: CAA99421.1.
BK006948 Genomic DNA. Translation: DAA10978.1.
PIRiS67098.
RefSeqiNP_014849.3. NM_001183625.3.

3D structure databases

ProteinModelPortaliP39744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34601. 104 interactors.
DIPiDIP-4559N.
IntActiP39744. 65 interactors.
MINTiMINT-523291.

PTM databases

iPTMnetiP39744.

Proteomic databases

MaxQBiP39744.
PRIDEiP39744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR206W; YOR206W; YOR206W.
GeneIDi854381.
KEGGisce:YOR206W.

Organism-specific databases

EuPathDBiFungiDB:YOR206W.
SGDiS000005732. NOC2.

Phylogenomic databases

GeneTreeiENSGT00390000010057.
HOGENOMiHOG000203797.
InParanoidiP39744.
KOiK14833.
OMAiAPYLLRI.
OrthoDBiEOG092C2OUP.

Enzyme and pathway databases

BioCyciYEAST:G3O-33710-MONOMER.

Miscellaneous databases

PROiP39744.

Family and domain databases

InterProiIPR005343. Noc2.
[Graphical view]
PANTHERiPTHR12687. PTHR12687. 1 hit.
PfamiPF03715. Noc2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOC2_YEAST
AccessioniPrimary (citable) accession number: P39744
Secondary accession number(s): D6W2R2, Q08625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 29000 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to be RAD4.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.