Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar complex protein 2

Gene

NOC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the intranuclear transport of ribosomal precursors.1 Publication

Miscellaneous

Present with 29000 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to be RAD4.1 Publication

GO - Biological processi

  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33710-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 2
Gene namesi
Name:NOC2
Ordered Locus Names:YOR206W
ORF Names:YOX001
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR206W
SGDiS000005732 NOC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210541 – 710Nucleolar complex protein 2Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39744
PaxDbiP39744
PRIDEiP39744

PTM databases

iPTMnetiP39744

Interactioni

Subunit structurei

Interacts with MAK21/NOC1 and NOC3. Forms a nucleolar complex with MAK21 that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with NOC3 that binds to 66S pre-ribosomes.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34601, 109 interactors
ComplexPortaliCPX-1733 NOC1-NOC2 complex
CPX-1734 NOC2-NOC3 complex
DIPiDIP-4559N
IntActiP39744, 69 interactors
MINTiP39744
STRINGi4932.YOR206W

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 104Poly-Ser4
Compositional biasi105 – 108Poly-Glu4

Sequence similaritiesi

Belongs to the NOC2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010057
HOGENOMiHOG000203797
InParanoidiP39744
KOiK14833
OMAiLPGINFM
OrthoDBiEOG092C2OUP

Family and domain databases

InterProiView protein in InterPro
IPR005343 Noc2
PANTHERiPTHR12687 PTHR12687, 1 hit
PfamiView protein in Pfam
PF03715 Noc2, 1 hit

Sequencei

Sequence statusi: Complete.

P39744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVSKSTKK FQSKHLKHTL DQRRKEKIQK KRIQGRRGNK TDQEKADAAG
60 70 80 90 100
TREQQQLKKS AKEEVFKDMS VETFFEKGIE IPKENKKLKK KTTKEQSDED
110 120 130 140 150
SSSSEEEEDM GQSMAKLAEK DPEFYKYLEE NDKDLLDFAG TNPLDGIDSQ
160 170 180 190 200
DEGEDAERNS NIEEKSEQME LEKEKIELSL KLVRKWKKQL HDSPSLKLLR
210 220 230 240 250
NIISAFKVAV NLNKEENIED YKYAITDEKA FHELMFMVLK DVPQAIQKMA
260 270 280 290 300
PYKIVKGART LPNGGNVSRV SSIVKSHAGS LLILLNDITN TETAALVLHS
310 320 330 340 350
VNELMPYLLS YRRILKELIK SIVGVWSTTR ELETQIASFA FLINTTKEFK
360 370 380 390 400
KSMLETTLKT TYSTFIKSCR KTNMRSMPLI NFQKNSAAEL FGIDEVLGYQ
410 420 430 440 450
VGFEYIRQLA IHLRNTMNAT TKKSSKINSA EAYKIVYNWQ FCHSLDFWSR
460 470 480 490 500
VLSFACQPEK ENGSESPLRQ LIYPLVQVTL GVIRLIPTPQ FFPLRFYLIK
510 520 530 540 550
SLIRLSQNSG VFIPIYPLLS EILTSTAFTK APKKSPNLAA FDFEHNIKCT
560 570 580 590 600
QAYLNTKIYQ EGLSEQFVDL LGDYFALYCK NIAFPELVTP VIISLRRYIK
610 620 630 640 650
TSTNVKLNKR LSTVVEKLNQ NSTFIQEKRS DVEFGPTNKS EVSRFLNDVA
660 670 680 690 700
WNKTPLGSYV AVQREVKEEK ARLMRESMEE QDKERETEEA KLLNSLESDD
710
DNEDVEMSDA
Length:710
Mass (Da):81,601
Last modified:May 30, 2000 - v2
Checksum:i48C3B9AE076B9B8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151 – 179DEGED…KIELS → MKVKMLKETVILKKNLNKWS WKRKKLSFL (PubMed:2263475).CuratedAdd BLAST29
Sequence conflicti231 – 232FH → LD in CAA39375 (PubMed:2263475).Curated2
Sequence conflicti333E → Q in CAA39375 (PubMed:2263475).Curated1
Sequence conflicti360 – 362TTY → QRT in CAA39375 (PubMed:2263475).Curated3
Sequence conflicti542D → H in CAA39375 (PubMed:2263475).Curated1
Sequence conflicti707 – 710MSDA → NVRRLTTQQDLIFCLEFNSI VYKCVNKRKVFFKAYISLCS HVLTCEHSKLSLVSWIFLYF GRFMDRKHVKRSMDLIKSND VKQGTKMKEVRFTVIKFSKS FNSLKVPHEIDMIANITENF STRYMISYCWKISSNLNLGA MFMDNNSWNNSFAAYGIVIL IIFSALLQVVHQPL in CAA39375 (PubMed:2263475).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55891 Genomic DNA Translation: CAA39375.1
Z75114 Genomic DNA Translation: CAA99421.1
BK006948 Genomic DNA Translation: DAA10978.1
PIRiS67098
RefSeqiNP_014849.3, NM_001183625.3

Genome annotation databases

EnsemblFungiiYOR206W; YOR206W; YOR206W
GeneIDi854381
KEGGisce:YOR206W

Similar proteinsi

Entry informationi

Entry nameiNOC2_YEAST
AccessioniPrimary (citable) accession number: P39744
Secondary accession number(s): D6W2R2, Q08625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health