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Protein

Reduced viability upon starvation protein 167

Gene

RVS167

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.1 Publication

Miscellaneous

Present with 14600 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • calmodulin binding Source: SGD
  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • endocytosis Source: SGD
  • lipid tube assembly Source: SGD
  • plasma membrane tubulation Source: SGD
  • vesicle-mediated transport Source: SGD

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29936-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Reduced viability upon starvation protein 167
Gene namesi
Name:RVS167
Ordered Locus Names:YDR388W
ORF Names:D9509.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR388W
SGDiS000002796 RVS167

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001929612 – 482Reduced viability upon starvation protein 167Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei299Phosphoserine; by FUS3 and PHO851 Publication1
Modified residuei321Phosphoserine; by FUS3 and PHO851 Publication1
Modified residuei379Phosphoserine; by FUS3 and PHO851 Publication1
Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Post-translational modificationi

Phosphorylated redundantly by cyclin-dependent kinase PHO85 in association with PCL1,2-type cyclins or by MAP kinase FUS3. Phosphorylation inhibits interaction with complexes involved in actin cytoskeleton function.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP39743
PaxDbiP39743
PRIDEiP39743

PTM databases

iPTMnetiP39743

Interactioni

Subunit structurei

Binds to actin. Interacts with ABP1, GYL1, GYP5, PCL2 and YBR108W.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • calmodulin binding Source: SGD
  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32449, 980 interactors
DIPiDIP-770N
IntActiP39743, 147 interactors
MINTiP39743
STRINGi4932.YDR388W

Structurei

3D structure databases

ProteinModelPortaliP39743
SMRiP39743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 254BARPROSITE-ProRule annotationAdd BLAST238
Domaini421 – 482SH3PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 64Sequence analysisAdd BLAST34
Coiled coili174 – 204Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi292 – 427Ala/Gly/Pro-richAdd BLAST136

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

GeneTreeiENSGT00900000142959
HOGENOMiHOG000199510
InParanoidiP39743
KOiK12562
OMAiRAPQQFK
OrthoDBiEOG092C2RHJ

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKGFTKAV SRAPQSFRQK FKMGEQTEDP VYEDAERRFQ ELEQETKKLS
60 70 80 90 100
EESKRYSTAV NGMLTHQIGF AKSMEEIFKP ISGKMSDPNA TIPEDNPQGI
110 120 130 140 150
EASEQYRAIV AELQETLKPD LALVEEKIVT PCQELLKIIT YIRKMATKRN
160 170 180 190 200
HKKLDLDRHL NTYNKHEKKK EPTAKDEERL YKAQAQVEVA QQEYDYYNDL
210 220 230 240 250
LKTQLPILFS LEAEFVKPLF VSFYFMQLNI FYTLYNRLQD MKIPYFDLNS
260 270 280 290 300
DIVESYIAKK GNVEEQTDAL TITHFKLGYS KAKLEMTRRK YGVATAEGSP
310 320 330 340 350
VSGASSGVGY GAGYDPATAT SPTPTGYGYG AAAPSYAAQP AAQYGTAAAV
360 370 380 390 400
GTAAAVGTAA GAAAGAVPGT YPQYAAAQSP PLTGLGFQQS PQQQQGPPPA
410 420 430 440 450
YSNPLTSPVA GTPAAAVAAA PGVETVTALY DYQAQAAGDL SFPAGAVIEI
460 470 480
VQRTPDVNEW WTGRYNGQQG VFPGNYVQLN KN
Length:482
Mass (Da):52,774
Last modified:February 1, 1995 - v1
Checksum:i3F0AB53EBCC95A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92092 Genomic DNA Translation: AAA35051.1
U32274 Genomic DNA Translation: AAB64830.1
BK006938 Genomic DNA Translation: DAA12232.1
PIRiS40887
RefSeqiNP_010676.1, NM_001180696.1

Genome annotation databases

EnsemblFungiiYDR388W; YDR388W; YDR388W
GeneIDi851996
KEGGisce:YDR388W

Similar proteinsi

Entry informationi

Entry nameiRV167_YEAST
AccessioniPrimary (citable) accession number: P39743
Secondary accession number(s): D6VT22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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