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Protein

Reduced viability upon starvation protein 167

Gene

RVS167

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: SGD
  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • endocytosis Source: SGD
  • lipid tube assembly Source: SGD
  • membrane tubulation Source: SGD
  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29936-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Reduced viability upon starvation protein 167
Gene namesi
Name:RVS167
Ordered Locus Names:YDR388W
ORF Names:D9509.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR388W.
SGDiS000002796. RVS167.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • mating projection tip Source: SGD
  • Rvs161p-Rvs167p complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 482481Reduced viability upon starvation protein 167PRO_0000192961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Cross-linki242 – 242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei299 – 2991Phosphoserine; by FUS3 and PHO851 Publication
Modified residuei321 – 3211Phosphoserine; by FUS3 and PHO851 Publication
Modified residuei379 – 3791Phosphoserine; by FUS3 and PHO851 Publication
Cross-linki481 – 481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources1 Publication

Post-translational modificationi

Phosphorylated redundantly by cyclin-dependent kinase PHO85 in association with PCL1,2-type cyclins or by MAP kinase FUS3. Phosphorylation inhibits interaction with complexes involved in actin cytoskeleton function.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP39743.

PTM databases

iPTMnetiP39743.

Interactioni

Subunit structurei

Binds to actin. Interacts with ABP1, GYL1, GYP5, PCL2 and YBR108W.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-14500,EBI-14500
ABP1P158916EBI-14500,EBI-2036
ACF2Q121689EBI-14500,EBI-32973
ACF4P471295EBI-14500,EBI-25556
AIM3P382666EBI-14500,EBI-21584
APP1P539339EBI-14500,EBI-28798
BSP1Q066045EBI-14500,EBI-37047
ERT1P381404EBI-14500,EBI-21048
GTS1P409564EBI-14500,EBI-7968
GYL1Q043228EBI-14500,EBI-27427
GYP5Q123444EBI-14500,EBI-38508
LAS17Q1244612EBI-14500,EBI-10022
MYO5Q044393EBI-14500,EBI-11687
RVS161P2534314EBI-14500,EBI-14490
SEC8P328552EBI-14500,EBI-16896
VRP1P373703EBI-14500,EBI-20502
YDR239CQ037802EBI-14500,EBI-30094
YPR091CQ068333EBI-14500,EBI-37290

GO - Molecular functioni

  • calmodulin binding Source: SGD
  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32449. 553 interactions.
DIPiDIP-770N.
IntActiP39743. 96 interactions.
MINTiMINT-369996.

Structurei

3D structure databases

ProteinModelPortaliP39743.
SMRiP39743. Positions 4-210, 394-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 254238BARPROSITE-ProRule annotationAdd
BLAST
Domaini421 – 48262SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 6434Sequence analysisAdd
BLAST
Coiled coili174 – 20431Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 427136Ala/Gly/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

HOGENOMiHOG000199510.
InParanoidiP39743.
KOiK12562.
OMAiNGMLNHQ.
OrthoDBiEOG092C2RHJ.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKGFTKAV SRAPQSFRQK FKMGEQTEDP VYEDAERRFQ ELEQETKKLS
60 70 80 90 100
EESKRYSTAV NGMLTHQIGF AKSMEEIFKP ISGKMSDPNA TIPEDNPQGI
110 120 130 140 150
EASEQYRAIV AELQETLKPD LALVEEKIVT PCQELLKIIT YIRKMATKRN
160 170 180 190 200
HKKLDLDRHL NTYNKHEKKK EPTAKDEERL YKAQAQVEVA QQEYDYYNDL
210 220 230 240 250
LKTQLPILFS LEAEFVKPLF VSFYFMQLNI FYTLYNRLQD MKIPYFDLNS
260 270 280 290 300
DIVESYIAKK GNVEEQTDAL TITHFKLGYS KAKLEMTRRK YGVATAEGSP
310 320 330 340 350
VSGASSGVGY GAGYDPATAT SPTPTGYGYG AAAPSYAAQP AAQYGTAAAV
360 370 380 390 400
GTAAAVGTAA GAAAGAVPGT YPQYAAAQSP PLTGLGFQQS PQQQQGPPPA
410 420 430 440 450
YSNPLTSPVA GTPAAAVAAA PGVETVTALY DYQAQAAGDL SFPAGAVIEI
460 470 480
VQRTPDVNEW WTGRYNGQQG VFPGNYVQLN KN
Length:482
Mass (Da):52,774
Last modified:February 1, 1995 - v1
Checksum:i3F0AB53EBCC95A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92092 Genomic DNA. Translation: AAA35051.1.
U32274 Genomic DNA. Translation: AAB64830.1.
BK006938 Genomic DNA. Translation: DAA12232.1.
PIRiS40887.
RefSeqiNP_010676.1. NM_001180696.1.

Genome annotation databases

EnsemblFungiiYDR388W; YDR388W; YDR388W.
GeneIDi851996.
KEGGisce:YDR388W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92092 Genomic DNA. Translation: AAA35051.1.
U32274 Genomic DNA. Translation: AAB64830.1.
BK006938 Genomic DNA. Translation: DAA12232.1.
PIRiS40887.
RefSeqiNP_010676.1. NM_001180696.1.

3D structure databases

ProteinModelPortaliP39743.
SMRiP39743. Positions 4-210, 394-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32449. 553 interactions.
DIPiDIP-770N.
IntActiP39743. 96 interactions.
MINTiMINT-369996.

PTM databases

iPTMnetiP39743.

Proteomic databases

MaxQBiP39743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR388W; YDR388W; YDR388W.
GeneIDi851996.
KEGGisce:YDR388W.

Organism-specific databases

EuPathDBiFungiDB:YDR388W.
SGDiS000002796. RVS167.

Phylogenomic databases

HOGENOMiHOG000199510.
InParanoidiP39743.
KOiK12562.
OMAiNGMLNHQ.
OrthoDBiEOG092C2RHJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29936-MONOMER.

Miscellaneous databases

PROiP39743.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRV167_YEAST
AccessioniPrimary (citable) accession number: P39743
Secondary accession number(s): D6VT22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 14600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.