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P39734

- HPH2_YEAST

UniProt

P39734 - HPH2_YEAST

Protein

Protein HPH2

Gene

FRT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Required for growth under high NaCl, alkaline pH and cell wall stress.1 Publication

    GO - Biological processi

    1. cellular response to alkaline pH Source: SGD
    2. cellular response to salt stress Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28839-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein HPH2
    Alternative name(s):
    Functionally related to TCP1 protein 2
    High pH protein 2
    Gene namesi
    Name:FRT2
    Synonyms:HPH2
    Ordered Locus Names:YAL028W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL028w.
    SGDiS000000026. FRT2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication
    Note: Punctate foci at the endoplasmic reticulum membrane.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Protein HPH2PRO_0000202415Add
    BLAST

    Post-translational modificationi

    Phosphorylated by CDC28.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP39734.
    PaxDbiP39734.
    PeptideAtlasiP39734.

    Expressioni

    Gene expression databases

    GenevestigatoriP39734.

    Interactioni

    Subunit structurei

    Interacts with HPH1/FRT1.1 Publication

    Protein-protein interaction databases

    BioGridi31738. 72 interactions.
    DIPiDIP-1309N.
    IntActiP39734. 4 interactions.
    MINTiMINT-397872.

    Structurei

    3D structure databases

    ProteinModelPortaliP39734.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei505 – 52117HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi308 – 32821Poly-SerAdd
    BLAST
    Compositional biasi512 – 5176Poly-Ile

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74487.
    GeneTreeiENSGT00530000068925.
    OrthoDBiEOG71VT60.

    Family and domain databases

    InterProiIPR025752. HPH_family.
    [Graphical view]
    PfamiPF13694. Hph. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39734-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST    50
    VETKPNVGWQ ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST 100
    AMFSDCMFNA APDKVRSLST MKSSGLSPKH PFNVVATFKG PFPQHSVESK 150
    PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK DNDKYGLKSP SRSFVKDKKR 200
    LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK RPTHHSHSSD 250
    GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS 300
    PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN 350
    LSLNSDELDY YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK 400
    IVKELRDLRS RTIGWKELVE EDYLMNLKQD FDKENPESFE ARLSDTINTN 450
    VAKLQDLEKR MASCKDRLAS RKEVMRKMES LLSLENSLMI SKKNVTFASK 500
    YRNEALDIVF LIIIIVICYT FKHLVSHK 528
    Length:528
    Mass (Da):58,750
    Last modified:October 1, 1996 - v2
    Checksum:iE5A3CC7C6D60977A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC05004.1.
    BK006935 Genomic DNA. Translation: DAA06960.1.
    PIRiS70295.
    RefSeqiNP_009374.1. NM_001178173.1.

    Genome annotation databases

    EnsemblFungiiYAL028W; YAL028W; YAL028W.
    GeneIDi851205.
    KEGGisce:YAL028W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC05004.1 .
    BK006935 Genomic DNA. Translation: DAA06960.1 .
    PIRi S70295.
    RefSeqi NP_009374.1. NM_001178173.1.

    3D structure databases

    ProteinModelPortali P39734.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31738. 72 interactions.
    DIPi DIP-1309N.
    IntActi P39734. 4 interactions.
    MINTi MINT-397872.

    Proteomic databases

    MaxQBi P39734.
    PaxDbi P39734.
    PeptideAtlasi P39734.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL028W ; YAL028W ; YAL028W .
    GeneIDi 851205.
    KEGGi sce:YAL028W.

    Organism-specific databases

    CYGDi YAL028w.
    SGDi S000000026. FRT2.

    Phylogenomic databases

    eggNOGi NOG74487.
    GeneTreei ENSGT00530000068925.
    OrthoDBi EOG71VT60.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28839-MONOMER.

    Miscellaneous databases

    NextBioi 968070.

    Gene expression databases

    Genevestigatori P39734.

    Family and domain databases

    InterProi IPR025752. HPH_family.
    [Graphical view ]
    Pfami PF13694. Hph. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Vo D.T.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: PHOSPHORYLATION BY CDC28.
    5. "Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae."
      Heath V.L., Shaw S.L., Roy S., Cyert M.S.
      Eukaryot. Cell 3:695-704(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HPH1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiHPH2_YEAST
    AccessioniPrimary (citable) accession number: P39734
    Secondary accession number(s): D6VPJ0, P39733
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3