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P39734 (HPH2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein HPH2
Alternative name(s):
Functionally related to TCP1 protein 2
High pH protein 2
Gene names
Name:FRT2
Synonyms:HPH2
Ordered Locus Names:YAL028W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for growth under high NaCl, alkaline pH and cell wall stress. Ref.5

Subunit structure

Interacts with HPH1/FRT1. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein. Note: Punctate foci at the endoplasmic reticulum membrane. Ref.5

Post-translational modification

Phosphorylated by CDC28. Ref.4

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Protein HPH2
PRO_0000202415

Regions

Transmembrane505 – 52117Helical; Potential
Compositional bias308 – 32821Poly-Ser
Compositional bias512 – 5176Poly-Ile

Sequences

Sequence LengthMass (Da)Tools
P39734 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: E5A3CC7C6D60977A

FASTA52858,750
        10         20         30         40         50         60 
MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST VETKPNVGWQ 

        70         80         90        100        110        120 
ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST AMFSDCMFNA APDKVRSLST 

       130        140        150        160        170        180 
MKSSGLSPKH PFNVVATFKG PFPQHSVESK PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK 

       190        200        210        220        230        240 
DNDKYGLKSP SRSFVKDKKR LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK 

       250        260        270        280        290        300 
RPTHHSHSSD GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS 

       310        320        330        340        350        360 
PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN LSLNSDELDY 

       370        380        390        400        410        420 
YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK IVKELRDLRS RTIGWKELVE 

       430        440        450        460        470        480 
EDYLMNLKQD FDKENPESFE ARLSDTINTN VAKLQDLEKR MASCKDRLAS RKEVMRKMES 

       490        500        510        520 
LLSLENSLMI SKKNVTFASK YRNEALDIVF LIIIIVICYT FKHLVSHK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Vo D.T.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Targets of the cyclin-dependent kinase Cdk1."
Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., Morgan D.O.
Nature 425:859-864(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY CDC28.
[5]"Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae."
Heath V.L., Shaw S.L., Roy S., Cyert M.S.
Eukaryot. Cell 3:695-704(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HPH1, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC05004.1.
BK006935 Genomic DNA. Translation: DAA06960.1.
PIRS70295.
RefSeqNP_009374.1. NM_001178173.1.

3D structure databases

ProteinModelPortalP39734.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31738. 72 interactions.
DIPDIP-1309N.
IntActP39734. 4 interactions.
MINTMINT-397872.

Proteomic databases

MaxQBP39734.
PaxDbP39734.
PeptideAtlasP39734.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL028W; YAL028W; YAL028W.
GeneID851205.
KEGGsce:YAL028W.

Organism-specific databases

CYGDYAL028w.
SGDS000000026. FRT2.

Phylogenomic databases

eggNOGNOG74487.
GeneTreeENSGT00530000068925.
OrthoDBEOG71VT60.

Enzyme and pathway databases

BioCycYEAST:G3O-28839-MONOMER.

Gene expression databases

GenevestigatorP39734.

Family and domain databases

InterProIPR025752. HPH_family.
[Graphical view]
PfamPF13694. Hph. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968070.

Entry information

Entry nameHPH2_YEAST
AccessionPrimary (citable) accession number: P39734
Secondary accession number(s): D6VPJ0, P39733
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD