Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P39734

- HPH2_YEAST

UniProt

P39734 - HPH2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein HPH2

Gene

FRT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for growth under high NaCl, alkaline pH and cell wall stress.1 Publication

GO - Biological processi

  1. cellular response to alkaline pH Source: SGD
  2. cellular response to salt stress Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HPH2
Alternative name(s):
Functionally related to TCP1 protein 2
High pH protein 2
Gene namesi
Name:FRT2
Synonyms:HPH2
Ordered Locus Names:YAL028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL028w.
SGDiS000000026. FRT2.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication
Note: Punctate foci at the endoplasmic reticulum membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei505 – 52117HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Protein HPH2PRO_0000202415Add
BLAST

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39734.
PaxDbiP39734.
PeptideAtlasiP39734.

Expressioni

Gene expression databases

GenevestigatoriP39734.

Interactioni

Subunit structurei

Interacts with HPH1/FRT1.1 Publication

Protein-protein interaction databases

BioGridi31738. 72 interactions.
DIPiDIP-1309N.
IntActiP39734. 4 interactions.
MINTiMINT-397872.

Structurei

3D structure databases

ProteinModelPortaliP39734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi308 – 32821Poly-SerAdd
BLAST
Compositional biasi512 – 5176Poly-Ile

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74487.
GeneTreeiENSGT00530000068925.
InParanoidiP39734.
OrthoDBiEOG71VT60.

Family and domain databases

InterProiIPR025752. HPH_family.
[Graphical view]
PfamiPF13694. Hph. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39734-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST
60 70 80 90 100
VETKPNVGWQ ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST
110 120 130 140 150
AMFSDCMFNA APDKVRSLST MKSSGLSPKH PFNVVATFKG PFPQHSVESK
160 170 180 190 200
PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK DNDKYGLKSP SRSFVKDKKR
210 220 230 240 250
LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK RPTHHSHSSD
260 270 280 290 300
GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS
310 320 330 340 350
PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN
360 370 380 390 400
LSLNSDELDY YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK
410 420 430 440 450
IVKELRDLRS RTIGWKELVE EDYLMNLKQD FDKENPESFE ARLSDTINTN
460 470 480 490 500
VAKLQDLEKR MASCKDRLAS RKEVMRKMES LLSLENSLMI SKKNVTFASK
510 520
YRNEALDIVF LIIIIVICYT FKHLVSHK
Length:528
Mass (Da):58,750
Last modified:October 1, 1996 - v2
Checksum:iE5A3CC7C6D60977A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05004.1.
BK006935 Genomic DNA. Translation: DAA06960.1.
PIRiS70295.
RefSeqiNP_009374.1. NM_001178173.1.

Genome annotation databases

EnsemblFungiiYAL028W; YAL028W; YAL028W.
GeneIDi851205.
KEGGisce:YAL028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05004.1 .
BK006935 Genomic DNA. Translation: DAA06960.1 .
PIRi S70295.
RefSeqi NP_009374.1. NM_001178173.1.

3D structure databases

ProteinModelPortali P39734.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31738. 72 interactions.
DIPi DIP-1309N.
IntActi P39734. 4 interactions.
MINTi MINT-397872.

Proteomic databases

MaxQBi P39734.
PaxDbi P39734.
PeptideAtlasi P39734.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL028W ; YAL028W ; YAL028W .
GeneIDi 851205.
KEGGi sce:YAL028W.

Organism-specific databases

CYGDi YAL028w.
SGDi S000000026. FRT2.

Phylogenomic databases

eggNOGi NOG74487.
GeneTreei ENSGT00530000068925.
InParanoidi P39734.
OrthoDBi EOG71VT60.

Enzyme and pathway databases

BioCyci YEAST:G3O-28839-MONOMER.

Miscellaneous databases

NextBioi 968070.

Gene expression databases

Genevestigatori P39734.

Family and domain databases

InterProi IPR025752. HPH_family.
[Graphical view ]
Pfami PF13694. Hph. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Vo D.T.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: PHOSPHORYLATION BY CDC28.
  5. "Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae."
    Heath V.L., Shaw S.L., Roy S., Cyert M.S.
    Eukaryot. Cell 3:695-704(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HPH1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHPH2_YEAST
AccessioniPrimary (citable) accession number: P39734
Secondary accession number(s): D6VPJ0, P39733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3