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Protein

Protein HPH2

Gene

FRT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for growth under high NaCl, alkaline pH and cell wall stress.1 Publication

GO - Biological processi

  1. cellular response to alkaline pH Source: SGD
  2. cellular response to salt stress Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HPH2
Alternative name(s):
Functionally related to TCP1 protein 2
High pH protein 2
Gene namesi
Name:FRT2
Synonyms:HPH2
Ordered Locus Names:YAL028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome I

Organism-specific databases

CYGDiYAL028w.
SGDiS000000026. FRT2.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication
Note: Punctate foci at the endoplasmic reticulum membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei505 – 52117HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Protein HPH2PRO_0000202415Add
BLAST

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39734.
PaxDbiP39734.
PeptideAtlasiP39734.

Expressioni

Gene expression databases

GenevestigatoriP39734.

Interactioni

Subunit structurei

Interacts with HPH1/FRT1.1 Publication

Protein-protein interaction databases

BioGridi31738. 72 interactions.
DIPiDIP-1309N.
IntActiP39734. 4 interactions.
MINTiMINT-397872.

Structurei

3D structure databases

ProteinModelPortaliP39734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi308 – 32821Poly-SerAdd
BLAST
Compositional biasi512 – 5176Poly-Ile

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74487.
GeneTreeiENSGT00530000068925.
InParanoidiP39734.
OrthoDBiEOG71VT60.

Family and domain databases

InterProiIPR025752. HPH_family.
[Graphical view]
PfamiPF13694. Hph. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST
60 70 80 90 100
VETKPNVGWQ ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST
110 120 130 140 150
AMFSDCMFNA APDKVRSLST MKSSGLSPKH PFNVVATFKG PFPQHSVESK
160 170 180 190 200
PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK DNDKYGLKSP SRSFVKDKKR
210 220 230 240 250
LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK RPTHHSHSSD
260 270 280 290 300
GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS
310 320 330 340 350
PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN
360 370 380 390 400
LSLNSDELDY YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK
410 420 430 440 450
IVKELRDLRS RTIGWKELVE EDYLMNLKQD FDKENPESFE ARLSDTINTN
460 470 480 490 500
VAKLQDLEKR MASCKDRLAS RKEVMRKMES LLSLENSLMI SKKNVTFASK
510 520
YRNEALDIVF LIIIIVICYT FKHLVSHK
Length:528
Mass (Da):58,750
Last modified:October 1, 1996 - v2
Checksum:iE5A3CC7C6D60977A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05004.1.
BK006935 Genomic DNA. Translation: DAA06960.1.
PIRiS70295.
RefSeqiNP_009374.1. NM_001178173.1.

Genome annotation databases

EnsemblFungiiYAL028W; YAL028W; YAL028W.
GeneIDi851205.
KEGGisce:YAL028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05004.1.
BK006935 Genomic DNA. Translation: DAA06960.1.
PIRiS70295.
RefSeqiNP_009374.1. NM_001178173.1.

3D structure databases

ProteinModelPortaliP39734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31738. 72 interactions.
DIPiDIP-1309N.
IntActiP39734. 4 interactions.
MINTiMINT-397872.

Proteomic databases

MaxQBiP39734.
PaxDbiP39734.
PeptideAtlasiP39734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL028W; YAL028W; YAL028W.
GeneIDi851205.
KEGGisce:YAL028W.

Organism-specific databases

CYGDiYAL028w.
SGDiS000000026. FRT2.

Phylogenomic databases

eggNOGiNOG74487.
GeneTreeiENSGT00530000068925.
InParanoidiP39734.
OrthoDBiEOG71VT60.

Enzyme and pathway databases

BioCyciYEAST:G3O-28839-MONOMER.

Miscellaneous databases

NextBioi968070.

Gene expression databases

GenevestigatoriP39734.

Family and domain databases

InterProiIPR025752. HPH_family.
[Graphical view]
PfamiPF13694. Hph. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Vo D.T.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: PHOSPHORYLATION BY CDC28.
  5. "Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae."
    Heath V.L., Shaw S.L., Roy S., Cyert M.S.
    Eukaryot. Cell 3:695-704(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HPH1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHPH2_YEAST
AccessioniPrimary (citable) accession number: P39734
Secondary accession number(s): D6VPJ0, P39733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.