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P39732 (GIP4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GLC7-interacting protein 4
Gene names
Name:GIP4
Synonyms:FUN21
Ordered Locus Names:YAL031C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation. Ref.7

Subunit structure

Interacts with GLC7. Ref.7

Subcellular location

Cytoplasm Ref.5.

Miscellaneous

Present with 227 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the GIP4 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GLC7P325984EBI-20636,EBI-13715

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 760760GLC7-interacting protein 4
PRO_0000202416

Amino acid modifications

Modified residue4971Phosphoserine Ref.8
Modified residue5011Phosphoserine Ref.8
Modified residue6091Phosphoserine Ref.9 Ref.10

Sequences

Sequence LengthMass (Da)Tools
P39732 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 95C5C7DAD4B5D2C8

FASTA76086,636
        10         20         30         40         50         60 
MVDVQKRKKL LAKAAASASI PAIKGSVPLD SYDIKIIQYK NALYKLNELN RLLNVLVPHL 

        70         80         90        100        110        120 
KKKRDNDESY KIIPLVNFIL SLCEGPIFNV SPVLAKRYHL LCRFQLIKLS EVQQRLSTNF 

       130        140        150        160        170        180 
IDVEGWMFPE EVPLDHYKSC IYNNSLQWKI LNSLSCIAQN AIKIYNAKLR QILLERDAYK 

       190        200        210        220        230        240 
ARSLPFDTSI IEDLLNPVEM TLILDLAVLI NDPVRDKSTH SFYKLQWQVM EKLNSCVHSK 

       250        260        270        280        290        300 
IFPILRTYYN QLQKFSETRP TSLSNLQKDL PHWEWTLHRI YTFHLRVFSV LCVIISFSRQ 

       310        320        330        340        350        360 
IFLPNKQHFL DIKTRLSSEN VYHYDLIICE LMALLSPECD DVTALFELQE NLKFWTQTAR 

       370        380        390        400        410        420 
TDNNSSRTPI FHLQPGLVVE LFNNHICKII PKLRSIMGLL SNWMDCWKYI EKNYKTFDET 

       430        440        450        460        470        480 
NDLRENLKEK LERDKALYLE VKNAKSKLKK KPSITKLPAS SSPSPSPTSS ASPSRQASLE 

       490        500        510        520        530        540 
SIRTRARAHL ASNSSRSPSV SPVRTTFNNK NAETKKSVVS PEKRKLINGR RPRSSSLQSY 

       550        560        570        580        590        600 
TNKQQTSYLN STRHPSIAPP SKLNNQRSNS LQSSTMTLNQ KIVQDTVRHL MNKSASTPNP 

       610        620        630        640        650        660 
SASSSLAPSP KVSSINNTSS GKSSSTLIAN SSDTLAIETL TLDPESNSSE LSIKRVRFAG 

       670        680        690        700        710        720 
VPPMTEAENP KPTKVGWYKK PAVLHYPPIP ASAMIKPLQH KSKYNTLRQE EGFTFRKSLR 

       730        740        750        760 
DGLEWENGES GSETTMMPFG IEIKESTGHR IASKIRSKLR 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Vo D.T.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 550-760.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7."
Pinsky B.A., Kotwaliwale C.V., Tatsutani S.Y., Breed C.A., Biggins S.
Mol. Cell. Biol. 26:2648-2660(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GLC7, FUNCTION.
[8]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC05001.1.
X62577 Genomic DNA. No translation available.
BK006935 Genomic DNA. Translation: DAA06957.1.
PIRS70294.
RefSeqNP_009371.1. NM_001178176.1.

3D structure databases

ProteinModelPortalP39732.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31735. 16 interactions.
DIPDIP-6268N.
IntActP39732. 3 interactions.
MINTMINT-597926.
STRING4932.YAL031C.

Proteomic databases

PaxDbP39732.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL031C; YAL031C; YAL031C.
GeneID851202.
KEGGsce:YAL031C.

Organism-specific databases

CYGDYAL031c.
SGDS000000029. GIP4.

Phylogenomic databases

eggNOGNOG45713.
OMAWYKKPAV.
OrthoDBEOG73RBM2.

Enzyme and pathway databases

BioCycYEAST:G3O-28842-MONOMER.

Gene expression databases

GenevestigatorP39732.

Family and domain databases

InterProIPR026241. GIP4.
[Graphical view]
PRINTSPR02082. GLC7IP4.
ProtoNetSearch...

Other

NextBio968061.

Entry information

Entry nameGIP4_YEAST
AccessionPrimary (citable) accession number: P39732
Secondary accession number(s): D6VPI7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families