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P39732

- GIP4_YEAST

UniProt

P39732 - GIP4_YEAST

Protein

GLC7-interacting protein 4

Gene

GIP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein phosphatase 1 binding Source: SGD
    3. protein phosphatase type 1 regulator activity Source: SGD

    GO - Biological processi

    1. chromosome segregation Source: SGD
    2. regulation of phosphoprotein phosphatase activity Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28842-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GLC7-interacting protein 4
    Gene namesi
    Name:GIP4
    Synonyms:FUN21
    Ordered Locus Names:YAL031C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL031c.
    SGDiS000000029. GIP4.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760GLC7-interacting protein 4PRO_0000202416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei497 – 4971Phosphoserine1 Publication
    Modified residuei501 – 5011Phosphoserine1 Publication
    Modified residuei609 – 6091Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP39732.
    PaxDbiP39732.

    Expressioni

    Gene expression databases

    GenevestigatoriP39732.

    Interactioni

    Subunit structurei

    Interacts with GLC7.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GLC7P325984EBI-20636,EBI-13715

    Protein-protein interaction databases

    BioGridi31735. 16 interactions.
    DIPiDIP-6268N.
    IntActiP39732. 3 interactions.
    MINTiMINT-597926.
    STRINGi4932.YAL031C.

    Structurei

    3D structure databases

    ProteinModelPortaliP39732.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GIP4 family.Curated

    Phylogenomic databases

    eggNOGiNOG45713.
    OMAiMTEAENP.
    OrthoDBiEOG73RBM2.

    Family and domain databases

    InterProiIPR026241. GIP4.
    [Graphical view]
    PRINTSiPR02082. GLC7IP4.

    Sequencei

    Sequence statusi: Complete.

    P39732-1 [UniParc]FASTAAdd to Basket

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    MVDVQKRKKL LAKAAASASI PAIKGSVPLD SYDIKIIQYK NALYKLNELN    50
    RLLNVLVPHL KKKRDNDESY KIIPLVNFIL SLCEGPIFNV SPVLAKRYHL 100
    LCRFQLIKLS EVQQRLSTNF IDVEGWMFPE EVPLDHYKSC IYNNSLQWKI 150
    LNSLSCIAQN AIKIYNAKLR QILLERDAYK ARSLPFDTSI IEDLLNPVEM 200
    TLILDLAVLI NDPVRDKSTH SFYKLQWQVM EKLNSCVHSK IFPILRTYYN 250
    QLQKFSETRP TSLSNLQKDL PHWEWTLHRI YTFHLRVFSV LCVIISFSRQ 300
    IFLPNKQHFL DIKTRLSSEN VYHYDLIICE LMALLSPECD DVTALFELQE 350
    NLKFWTQTAR TDNNSSRTPI FHLQPGLVVE LFNNHICKII PKLRSIMGLL 400
    SNWMDCWKYI EKNYKTFDET NDLRENLKEK LERDKALYLE VKNAKSKLKK 450
    KPSITKLPAS SSPSPSPTSS ASPSRQASLE SIRTRARAHL ASNSSRSPSV 500
    SPVRTTFNNK NAETKKSVVS PEKRKLINGR RPRSSSLQSY TNKQQTSYLN 550
    STRHPSIAPP SKLNNQRSNS LQSSTMTLNQ KIVQDTVRHL MNKSASTPNP 600
    SASSSLAPSP KVSSINNTSS GKSSSTLIAN SSDTLAIETL TLDPESNSSE 650
    LSIKRVRFAG VPPMTEAENP KPTKVGWYKK PAVLHYPPIP ASAMIKPLQH 700
    KSKYNTLRQE EGFTFRKSLR DGLEWENGES GSETTMMPFG IEIKESTGHR 750
    IASKIRSKLR 760
    Length:760
    Mass (Da):86,636
    Last modified:October 1, 1996 - v2
    Checksum:i95C5C7DAD4B5D2C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC05001.1.
    X62577 Genomic DNA. No translation available.
    BK006935 Genomic DNA. Translation: DAA06957.1.
    PIRiS70294.
    RefSeqiNP_009371.1. NM_001178176.1.

    Genome annotation databases

    EnsemblFungiiYAL031C; YAL031C; YAL031C.
    GeneIDi851202.
    KEGGisce:YAL031C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC05001.1 .
    X62577 Genomic DNA. No translation available.
    BK006935 Genomic DNA. Translation: DAA06957.1 .
    PIRi S70294.
    RefSeqi NP_009371.1. NM_001178176.1.

    3D structure databases

    ProteinModelPortali P39732.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31735. 16 interactions.
    DIPi DIP-6268N.
    IntActi P39732. 3 interactions.
    MINTi MINT-597926.
    STRINGi 4932.YAL031C.

    Proteomic databases

    MaxQBi P39732.
    PaxDbi P39732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL031C ; YAL031C ; YAL031C .
    GeneIDi 851202.
    KEGGi sce:YAL031C.

    Organism-specific databases

    CYGDi YAL031c.
    SGDi S000000029. GIP4.

    Phylogenomic databases

    eggNOGi NOG45713.
    OMAi MTEAENP.
    OrthoDBi EOG73RBM2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28842-MONOMER.

    Miscellaneous databases

    NextBioi 968061.

    Gene expression databases

    Genevestigatori P39732.

    Family and domain databases

    InterProi IPR026241. GIP4.
    [Graphical view ]
    PRINTSi PR02082. GLC7IP4.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Vo D.T.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
      Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
      J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 550-760.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7."
      Pinsky B.A., Kotwaliwale C.V., Tatsutani S.Y., Breed C.A., Biggins S.
      Mol. Cell. Biol. 26:2648-2660(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GLC7, FUNCTION.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIP4_YEAST
    AccessioniPrimary (citable) accession number: P39732
    Secondary accession number(s): D6VPI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 227 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3