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Protein

GLC7-interacting protein 4

Gene

GIP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.1 Publication

GO - Molecular functioni

  1. protein phosphatase 1 binding Source: SGD
  2. protein phosphatase type 1 regulator activity Source: SGD

GO - Biological processi

  1. chromosome segregation Source: SGD
  2. regulation of phosphoprotein phosphatase activity Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28842-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GLC7-interacting protein 4
Gene namesi
Name:GIP4
Synonyms:FUN21
Ordered Locus Names:YAL031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome I

Organism-specific databases

CYGDiYAL031c.
SGDiS000000029. GIP4.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760GLC7-interacting protein 4PRO_0000202416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei497 – 4971Phosphoserine1 Publication
Modified residuei501 – 5011Phosphoserine1 Publication
Modified residuei609 – 6091Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39732.
PaxDbiP39732.

Expressioni

Gene expression databases

GenevestigatoriP39732.

Interactioni

Subunit structurei

Interacts with GLC7.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GLC7P325984EBI-20636,EBI-13715

Protein-protein interaction databases

BioGridi31735. 16 interactions.
DIPiDIP-6268N.
IntActiP39732. 3 interactions.
MINTiMINT-597926.
STRINGi4932.YAL031C.

Structurei

3D structure databases

ProteinModelPortaliP39732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GIP4 family.Curated

Phylogenomic databases

eggNOGiNOG45713.
InParanoidiP39732.
OMAiWYKKPAV.
OrthoDBiEOG73RBM2.

Family and domain databases

InterProiIPR026241. GIP4.
[Graphical view]
PRINTSiPR02082. GLC7IP4.

Sequencei

Sequence statusi: Complete.

P39732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVQKRKKL LAKAAASASI PAIKGSVPLD SYDIKIIQYK NALYKLNELN
60 70 80 90 100
RLLNVLVPHL KKKRDNDESY KIIPLVNFIL SLCEGPIFNV SPVLAKRYHL
110 120 130 140 150
LCRFQLIKLS EVQQRLSTNF IDVEGWMFPE EVPLDHYKSC IYNNSLQWKI
160 170 180 190 200
LNSLSCIAQN AIKIYNAKLR QILLERDAYK ARSLPFDTSI IEDLLNPVEM
210 220 230 240 250
TLILDLAVLI NDPVRDKSTH SFYKLQWQVM EKLNSCVHSK IFPILRTYYN
260 270 280 290 300
QLQKFSETRP TSLSNLQKDL PHWEWTLHRI YTFHLRVFSV LCVIISFSRQ
310 320 330 340 350
IFLPNKQHFL DIKTRLSSEN VYHYDLIICE LMALLSPECD DVTALFELQE
360 370 380 390 400
NLKFWTQTAR TDNNSSRTPI FHLQPGLVVE LFNNHICKII PKLRSIMGLL
410 420 430 440 450
SNWMDCWKYI EKNYKTFDET NDLRENLKEK LERDKALYLE VKNAKSKLKK
460 470 480 490 500
KPSITKLPAS SSPSPSPTSS ASPSRQASLE SIRTRARAHL ASNSSRSPSV
510 520 530 540 550
SPVRTTFNNK NAETKKSVVS PEKRKLINGR RPRSSSLQSY TNKQQTSYLN
560 570 580 590 600
STRHPSIAPP SKLNNQRSNS LQSSTMTLNQ KIVQDTVRHL MNKSASTPNP
610 620 630 640 650
SASSSLAPSP KVSSINNTSS GKSSSTLIAN SSDTLAIETL TLDPESNSSE
660 670 680 690 700
LSIKRVRFAG VPPMTEAENP KPTKVGWYKK PAVLHYPPIP ASAMIKPLQH
710 720 730 740 750
KSKYNTLRQE EGFTFRKSLR DGLEWENGES GSETTMMPFG IEIKESTGHR
760
IASKIRSKLR
Length:760
Mass (Da):86,636
Last modified:September 30, 1996 - v2
Checksum:i95C5C7DAD4B5D2C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05001.1.
X62577 Genomic DNA. No translation available.
BK006935 Genomic DNA. Translation: DAA06957.1.
PIRiS70294.
RefSeqiNP_009371.1. NM_001178176.1.

Genome annotation databases

EnsemblFungiiYAL031C; YAL031C; YAL031C.
GeneIDi851202.
KEGGisce:YAL031C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC05001.1.
X62577 Genomic DNA. No translation available.
BK006935 Genomic DNA. Translation: DAA06957.1.
PIRiS70294.
RefSeqiNP_009371.1. NM_001178176.1.

3D structure databases

ProteinModelPortaliP39732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31735. 16 interactions.
DIPiDIP-6268N.
IntActiP39732. 3 interactions.
MINTiMINT-597926.
STRINGi4932.YAL031C.

Proteomic databases

MaxQBiP39732.
PaxDbiP39732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL031C; YAL031C; YAL031C.
GeneIDi851202.
KEGGisce:YAL031C.

Organism-specific databases

CYGDiYAL031c.
SGDiS000000029. GIP4.

Phylogenomic databases

eggNOGiNOG45713.
InParanoidiP39732.
OMAiWYKKPAV.
OrthoDBiEOG73RBM2.

Enzyme and pathway databases

BioCyciYEAST:G3O-28842-MONOMER.

Miscellaneous databases

NextBioi968061.

Gene expression databases

GenevestigatoriP39732.

Family and domain databases

InterProiIPR026241. GIP4.
[Graphical view]
PRINTSiPR02082. GLC7IP4.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Vo D.T.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
    Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
    J. Mol. Biol. 225:53-65(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 550-760.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7."
    Pinsky B.A., Kotwaliwale C.V., Tatsutani S.Y., Breed C.A., Biggins S.
    Mol. Cell. Biol. 26:2648-2660(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GLC7, FUNCTION.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIP4_YEAST
AccessioniPrimary (citable) accession number: P39732
Secondary accession number(s): D6VPI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: September 30, 1996
Last modified: January 6, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 227 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.