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Protein

Kinetochore-associated protein MTW1

Gene

MTW1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • kinetochore assembly Source: GO_Central
  • mitotic sister chromatid segregation Source: GO_Central
  • protein localization to kinetochore Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-28844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein MTW1
Alternative name(s):
Mis12-like protein
Gene namesi
Name:MTW1
Synonyms:DSN3, NSL2
Ordered Locus Names:YAL034W-A
ORF Names:YAL034AW
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL034W-A.
SGDiS000000032. MTW1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • nuclear MIS12/MIND complex Source: SGD
  • spindle pole Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Kinetochore-associated protein MTW1PRO_0000096641Add
BLAST

Proteomic databases

MaxQBiP39731.

Interactioni

Subunit structurei

Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NNF1P471496EBI-11606,EBI-12098

Protein-protein interaction databases

BioGridi31731. 103 interactions.
DIPiDIP-1464N.
IntActiP39731. 17 interactions.
MINTiMINT-398205.

Structurei

3D structure databases

ProteinModelPortaliP39731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili105 – 14743Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the mis12 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000001102.
InParanoidiP39731.
KOiK11559.
OMAiFDKLELY.
OrthoDBiEOG092C4HNF.

Family and domain databases

InterProiIPR008685. Centromere_Mis12.
[Graphical view]
PfamiPF05859. Mis12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPTMRSTS ILTEHLGYPP ISLVDDIINA VNEIMYKCTA AMEKYLLSKS
60 70 80 90 100
KIGEEDYGEE IKSGVAKLES LLENSVDKNF DKLELYVLRN VLRIPEEYLD
110 120 130 140 150
ANVFRLENQK DLVIVDENEL KKSEEKLREK VNDVELAFKK NEMLLKRVTK
160 170 180 190 200
VKRLLFTIRG FKQKLNELLK CKDDVQLQKI LESLKPIDDT MTLLTDSLRK
210 220 230 240 250
LYVDSESTSS TEEVEALLQR LKTNGKQNNK DFRTRYIDIR TNNVLRKLGL
260 270 280
LGDKEDEKQS AKPDARTQAG DIVSIDIEEP QLDLLDDVL
Length:289
Mass (Da):33,243
Last modified:October 1, 1996 - v2
Checksum:iD6F94C290106082B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027473 Genomic DNA. Translation: BAA77792.1.
U12980 Genomic DNA. Translation: AAC04997.1.
BK006935 Genomic DNA. Translation: DAA06953.1.
PIRiS70293.
RefSeqiNP_009367.1. NM_001178179.1.

Genome annotation databases

EnsemblFungiiYAL034W-A; YAL034W-A; YAL034W-A.
GeneIDi851197.
KEGGisce:YAL034W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027473 Genomic DNA. Translation: BAA77792.1.
U12980 Genomic DNA. Translation: AAC04997.1.
BK006935 Genomic DNA. Translation: DAA06953.1.
PIRiS70293.
RefSeqiNP_009367.1. NM_001178179.1.

3D structure databases

ProteinModelPortaliP39731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31731. 103 interactions.
DIPiDIP-1464N.
IntActiP39731. 17 interactions.
MINTiMINT-398205.

Proteomic databases

MaxQBiP39731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL034W-A; YAL034W-A; YAL034W-A.
GeneIDi851197.
KEGGisce:YAL034W-A.

Organism-specific databases

EuPathDBiFungiDB:YAL034W-A.
SGDiS000000032. MTW1.

Phylogenomic databases

HOGENOMiHOG000001102.
InParanoidiP39731.
KOiK11559.
OMAiFDKLELY.
OrthoDBiEOG092C4HNF.

Enzyme and pathway databases

BioCyciYEAST:G3O-28844-MONOMER.

Miscellaneous databases

PROiP39731.

Family and domain databases

InterProiIPR008685. Centromere_Mis12.
[Graphical view]
PfamiPF05859. Mis12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTW1_YEAST
AccessioniPrimary (citable) accession number: P39731
Secondary accession number(s): D6VPI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.