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Protein

Ribosome-interacting GTPase 1

Gene

RBG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosomal function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 798GTPPROSITE-ProRule annotation
Nucleotide bindingi118 – 1225GTPPROSITE-ProRule annotation
Nucleotide bindingi250 – 2534GTPPROSITE-ProRule annotation

GO - Molecular functioni

  • GTP binding Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • positive regulation of cellular response to amino acid starvation Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-interacting GTPase 1
Alternative name(s):
GTP-binding protein RBG1
Genetically interacts with ribosomal genes protein 1
Gene namesi
Name:RBG1
Synonyms:FUN11
Ordered Locus Names:YAL036C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL036C.
SGDiS000000034. RBG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • polysome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 369368Ribosome-interacting GTPase 1PRO_0000205449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP39729.
PeptideAtlasiP39729.

Interactioni

Subunit structurei

Associates with translating polyribosomes. Interacts with GIR2, TMA46, YAP1 and YGR250C.2 Publications

Protein-protein interaction databases

BioGridi31729. 39 interactions.
DIPiDIP-1750N.
IntActiP39729. 9 interactions.
MINTiMINT-405828.

Structurei

Secondary structure

1
369
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1715Combined sources
Turni22 – 243Combined sources
Helixi25 – 4319Combined sources
Beta strandi47 – 493Combined sources
Turni56 – 583Combined sources
Beta strandi64 – 718Combined sources
Helixi76 – 8611Combined sources
Helixi92 – 943Combined sources
Beta strandi102 – 1098Combined sources
Beta strandi112 – 1187Combined sources
Helixi120 – 1223Combined sources
Helixi132 – 14211Combined sources
Beta strandi144 – 1518Combined sources
Helixi155 – 16814Combined sources
Beta strandi171 – 1733Combined sources
Beta strandi180 – 1845Combined sources
Beta strandi186 – 1883Combined sources
Beta strandi190 – 1967Combined sources
Helixi203 – 21210Combined sources
Beta strandi217 – 2226Combined sources
Helixi228 – 2358Combined sources
Turni236 – 2394Combined sources
Beta strandi241 – 2433Combined sources
Beta strandi245 – 2506Combined sources
Helixi252 – 2543Combined sources
Helixi257 – 2637Combined sources
Beta strandi269 – 2713Combined sources
Turni274 – 2763Combined sources
Helixi280 – 29112Combined sources
Beta strandi294 – 2985Combined sources
Beta strandi301 – 3033Combined sources
Beta strandi307 – 3093Combined sources
Beta strandi311 – 3144Combined sources
Helixi320 – 3278Combined sources
Helixi329 – 3346Combined sources
Beta strandi335 – 3428Combined sources
Beta strandi345 – 3528Combined sources
Beta strandi363 – 3686Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67A/B1-369[»]
ProteinModelPortaliP39729.
SMRiP39729. Positions 2-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 292227OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
InParanoidiP39729.
KOiK06944.
OMAiKATSFHL.
OrthoDBiEOG70S7GB.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVEKIKA IEDEMARTQK NKATSFHLGQ LKAKLAKLRR ELLTSASSGS
60 70 80 90 100
GGGAGIGFDV ARTGVASVGF VGFPSVGKST LLSKLTGTES EAAEYEFTTL
110 120 130 140 150
VTVPGVIRYK GAKIQMLDLP GIIDGAKDGR GRGKQVIAVA RTCNLLFIIL
160 170 180 190 200
DVNKPLHHKQ IIEKELEGVG IRLNKTPPDI LIKKKEKGGI SITNTVPLTH
210 220 230 240 250
LGNDEIRAVM SEYRINSAEI AFRCDATVDD LIDVLEASSR RYMPAIYVLN
260 270 280 290 300
KIDSLSIEEL ELLYRIPNAV PISSGQDWNL DELLQVMWDR LNLVRIYTKP
310 320 330 340 350
KGQIPDFTDP VVLRSDRCSV KDFCNQIHKS LVDDFRNALV YGSSVKHQPQ
360
YVGLSHILED EDVVTILKK
Length:369
Mass (Da):40,701
Last modified:February 1, 1995 - v1
Checksum:iD25C6C732B462A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04995.1.
AY693042 Genomic DNA. Translation: AAT93061.1.
BK006935 Genomic DNA. Translation: DAA06951.1.
PIRiS51983.
RefSeqiNP_009364.1. NM_001178181.1.

Genome annotation databases

EnsemblFungiiYAL036C; YAL036C; YAL036C.
GeneIDi851195.
KEGGisce:YAL036C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04995.1.
AY693042 Genomic DNA. Translation: AAT93061.1.
BK006935 Genomic DNA. Translation: DAA06951.1.
PIRiS51983.
RefSeqiNP_009364.1. NM_001178181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67A/B1-369[»]
ProteinModelPortaliP39729.
SMRiP39729. Positions 2-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31729. 39 interactions.
DIPiDIP-1750N.
IntActiP39729. 9 interactions.
MINTiMINT-405828.

Proteomic databases

MaxQBiP39729.
PeptideAtlasiP39729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL036C; YAL036C; YAL036C.
GeneIDi851195.
KEGGisce:YAL036C.

Organism-specific databases

EuPathDBiFungiDB:YAL036C.
SGDiS000000034. RBG1.

Phylogenomic databases

GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
InParanoidiP39729.
KOiK06944.
OMAiKATSFHL.
OrthoDBiEOG70S7GB.

Enzyme and pathway databases

BioCyciYEAST:G3O-28846-MONOMER.

Miscellaneous databases

NextBioi968043.
PROiP39729.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
    Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
    Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RIBOSOMES AND TMA46.
  7. "Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on polyribosomes with Gcn1."
    Wout P.K., Sattlegger E., Sullivan S.M., Maddock J.R.
    Eukaryot. Cell 8:1061-1071(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH POLYRIBOSOMES, INTERACTION WITH GIR2; TMA46; YAP1 AND YGR250C.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBG1_YEAST
AccessioniPrimary (citable) accession number: P39729
Secondary accession number(s): D6VPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.