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Protein

Ribosome-interacting GTPase 1

Gene

RBG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosomal function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 79GTPPROSITE-ProRule annotation8
Nucleotide bindingi118 – 122GTPPROSITE-ProRule annotation5
Nucleotide bindingi250 – 253GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTP binding Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • positive regulation of cellular response to amino acid starvation Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-interacting GTPase 1
Alternative name(s):
GTP-binding protein RBG1
Genetically interacts with ribosomal genes protein 1
Gene namesi
Name:RBG1
Synonyms:FUN11
Ordered Locus Names:YAL036C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL036C.
SGDiS000000034. RBG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic stress granule Source: SGD
  • polysome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002054492 – 369Ribosome-interacting GTPase 1Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP39729.
PRIDEiP39729.

Interactioni

Subunit structurei

Associates with translating polyribosomes. Interacts with GIR2, TMA46, YAP1 and YGR250C.2 Publications

Protein-protein interaction databases

BioGridi31729. 39 interactors.
DIPiDIP-1750N.
IntActiP39729. 9 interactors.
MINTiMINT-405828.

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 17Combined sources15
Turni22 – 24Combined sources3
Helixi25 – 43Combined sources19
Beta strandi47 – 49Combined sources3
Turni56 – 58Combined sources3
Beta strandi64 – 71Combined sources8
Helixi76 – 86Combined sources11
Helixi92 – 94Combined sources3
Beta strandi102 – 109Combined sources8
Beta strandi112 – 118Combined sources7
Helixi120 – 122Combined sources3
Helixi132 – 142Combined sources11
Beta strandi144 – 151Combined sources8
Helixi155 – 168Combined sources14
Beta strandi171 – 173Combined sources3
Beta strandi180 – 184Combined sources5
Beta strandi186 – 188Combined sources3
Beta strandi190 – 196Combined sources7
Helixi203 – 212Combined sources10
Beta strandi217 – 222Combined sources6
Helixi228 – 235Combined sources8
Turni236 – 239Combined sources4
Beta strandi241 – 243Combined sources3
Beta strandi245 – 250Combined sources6
Helixi252 – 254Combined sources3
Helixi257 – 263Combined sources7
Beta strandi269 – 271Combined sources3
Turni274 – 276Combined sources3
Helixi280 – 291Combined sources12
Beta strandi294 – 298Combined sources5
Beta strandi301 – 303Combined sources3
Beta strandi307 – 309Combined sources3
Beta strandi311 – 314Combined sources4
Helixi320 – 327Combined sources8
Helixi329 – 334Combined sources6
Beta strandi335 – 342Combined sources8
Beta strandi345 – 352Combined sources8
Beta strandi363 – 368Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67A/B1-369[»]
ProteinModelPortaliP39729.
SMRiP39729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 292OBG-type GPROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
InParanoidiP39729.
KOiK06944.
OMAiEAKSRSY.
OrthoDBiEOG092C332H.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVEKIKA IEDEMARTQK NKATSFHLGQ LKAKLAKLRR ELLTSASSGS
60 70 80 90 100
GGGAGIGFDV ARTGVASVGF VGFPSVGKST LLSKLTGTES EAAEYEFTTL
110 120 130 140 150
VTVPGVIRYK GAKIQMLDLP GIIDGAKDGR GRGKQVIAVA RTCNLLFIIL
160 170 180 190 200
DVNKPLHHKQ IIEKELEGVG IRLNKTPPDI LIKKKEKGGI SITNTVPLTH
210 220 230 240 250
LGNDEIRAVM SEYRINSAEI AFRCDATVDD LIDVLEASSR RYMPAIYVLN
260 270 280 290 300
KIDSLSIEEL ELLYRIPNAV PISSGQDWNL DELLQVMWDR LNLVRIYTKP
310 320 330 340 350
KGQIPDFTDP VVLRSDRCSV KDFCNQIHKS LVDDFRNALV YGSSVKHQPQ
360
YVGLSHILED EDVVTILKK
Length:369
Mass (Da):40,701
Last modified:February 1, 1995 - v1
Checksum:iD25C6C732B462A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04995.1.
AY693042 Genomic DNA. Translation: AAT93061.1.
BK006935 Genomic DNA. Translation: DAA06951.1.
PIRiS51983.
RefSeqiNP_009364.1. NM_001178181.1.

Genome annotation databases

EnsemblFungiiYAL036C; YAL036C; YAL036C.
GeneIDi851195.
KEGGisce:YAL036C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04995.1.
AY693042 Genomic DNA. Translation: AAT93061.1.
BK006935 Genomic DNA. Translation: DAA06951.1.
PIRiS51983.
RefSeqiNP_009364.1. NM_001178181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67A/B1-369[»]
ProteinModelPortaliP39729.
SMRiP39729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31729. 39 interactors.
DIPiDIP-1750N.
IntActiP39729. 9 interactors.
MINTiMINT-405828.

Proteomic databases

MaxQBiP39729.
PRIDEiP39729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL036C; YAL036C; YAL036C.
GeneIDi851195.
KEGGisce:YAL036C.

Organism-specific databases

EuPathDBiFungiDB:YAL036C.
SGDiS000000034. RBG1.

Phylogenomic databases

GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
InParanoidiP39729.
KOiK06944.
OMAiEAKSRSY.
OrthoDBiEOG092C332H.

Enzyme and pathway databases

BioCyciYEAST:G3O-28846-MONOMER.

Miscellaneous databases

PROiP39729.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBG1_YEAST
AccessioniPrimary (citable) accession number: P39729
Secondary accession number(s): D6VPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.