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P39727

- ERV46_YEAST

UniProt

P39727 - ERV46_YEAST

Protein

ER-derived vesicles protein ERV46

Gene

ERV46

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Phe-Tyr motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28850-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER-derived vesicles protein ERV46
    Gene namesi
    Name:ERV46
    Ordered Locus Names:YAL042W
    ORF Names:FUN9
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL042w.
    SGDiS000000040. ERV46.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
    Note: Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

    GO - Cellular componenti

    1. ER to Golgi transport vesicle Source: SGD
    2. integral component of endoplasmic reticulum membrane Source: SGD
    3. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415ER-derived vesicles protein ERV46PRO_0000202419Add
    BLAST

    Proteomic databases

    MaxQBiP39727.
    PaxDbiP39727.
    PeptideAtlasiP39727.

    Expressioni

    Gene expression databases

    GenevestigatoriP39727.

    Interactioni

    Subunit structurei

    Interacts with ERV41.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERV41Q046513EBI-20659,EBI-27850

    Protein-protein interaction databases

    BioGridi31785. 74 interactions.
    DIPiDIP-3792N.
    IntActiP39727. 4 interactions.
    MINTiMINT-565838.
    STRINGi4932.YAL042W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39727.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 376331LumenalSequence AnalysisAdd
    BLAST
    Topological domaini398 – 41518CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi402 – 4032Phenylalanine-tyrosine motif

    Sequence similaritiesi

    Belongs to the ERGIC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260258.
    GeneTreeiENSGT00530000063113.
    HOGENOMiHOG000210954.
    OMAiGNYNISH.
    OrthoDBiEOG76HQBV.

    Family and domain databases

    InterProiIPR012936. Erv_C.
    [Graphical view]
    PfamiPF07970. COPIIcoated_ERV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRSTLLSLD AFAKTEEDVR VRTRAGGLIT LSCILTTLFL LVNEWGQFNS    50
    VVTRPQLVVD RDRHAKLELN MDVTFPSMPC DLVNLDIMDD SGEMQLDILD 100
    AGFTMSRLNS EGRPVGDATE LHVGGNGDGT APVNNDPNYC GPCYGAKDQS 150
    QNENLAQEEK VCCQDCDAVR SAYLEAGWAF FDGKNIEQCE REGYVSKINE 200
    HLNEGCRIKG SAQINRIQGN LHFAPGKPYQ NAYGHFHDTS LYDKTSNLNF 250
    NHIINHLSFG KPIQSHSKLL GNDKRHGGAV VATSPLDGRQ VFPDRNTHFH 300
    QFSYFAKIVP TRYEYLDNVV IETAQFSATF HSRPLAGGRD KDHPNTLHVR 350
    GGIPGMFVFF EMSPLKVINK EQHGQTWSGF ILNCITSIGG VLAVGTVMDK 400
    LFYKAQRSIW GKKSQ 415
    Length:415
    Mass (Da):46,235
    Last modified:October 1, 1996 - v2
    Checksum:iFB7BC171B88BB5EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04989.1.
    BK006935 Genomic DNA. Translation: DAA06944.1.
    PIRiS51977.
    RefSeqiNP_009358.1. NM_001178187.1.

    Genome annotation databases

    EnsemblFungiiYAL042W; YAL042W; YAL042W.
    GeneIDi851256.
    KEGGisce:YAL042W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04989.1 .
    BK006935 Genomic DNA. Translation: DAA06944.1 .
    PIRi S51977.
    RefSeqi NP_009358.1. NM_001178187.1.

    3D structure databases

    ProteinModelPortali P39727.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31785. 74 interactions.
    DIPi DIP-3792N.
    IntActi P39727. 4 interactions.
    MINTi MINT-565838.
    STRINGi 4932.YAL042W.

    Proteomic databases

    MaxQBi P39727.
    PaxDbi P39727.
    PeptideAtlasi P39727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL042W ; YAL042W ; YAL042W .
    GeneIDi 851256.
    KEGGi sce:YAL042W.

    Organism-specific databases

    CYGDi YAL042w.
    SGDi S000000040. ERV46.

    Phylogenomic databases

    eggNOGi NOG260258.
    GeneTreei ENSGT00530000063113.
    HOGENOMi HOG000210954.
    OMAi GNYNISH.
    OrthoDBi EOG76HQBV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28850-MONOMER.

    Miscellaneous databases

    NextBioi 968210.
    PROi P39727.

    Gene expression databases

    Genevestigatori P39727.

    Family and domain databases

    InterProi IPR012936. Erv_C.
    [Graphical view ]
    Pfami PF07970. COPIIcoated_ERV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Vo D.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 405.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
      Cho J.-H., Noda Y., Adachi H., Yoda K.
      Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERV41, SUBCELLULAR LOCATION.
    5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
      Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
      J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ERV41, SUBCELLULAR LOCATION.
    6. "The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
      Otte S., Barlowe C.
      EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiERV46_YEAST
    AccessioniPrimary (citable) accession number: P39727
    Secondary accession number(s): D6VPH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3