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Protein

ER-derived vesicles protein ERV46

Gene

ERV46

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Phe-Tyr motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.2 Publications

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV46
Gene namesi
Name:ERV46
Ordered Locus Names:YAL042W
ORF Names:FUN9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL042W.
SGDiS000000040. ERV46.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 376LumenalSequence analysisAdd BLAST331
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 415CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • ER to Golgi transport vesicle Source: SGD
  • integral component of endoplasmic reticulum membrane Source: SGD
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024191 – 415ER-derived vesicles protein ERV46Add BLAST415

Proteomic databases

MaxQBiP39727.
PRIDEiP39727.

Interactioni

Subunit structurei

Interacts with ERV41.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV41Q046513EBI-20659,EBI-27850

Protein-protein interaction databases

BioGridi31785. 82 interactors.
DIPiDIP-3792N.
IntActiP39727. 4 interactors.
MINTiMINT-565838.

Structurei

3D structure databases

ProteinModelPortaliP39727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi402 – 403Phenylalanine-tyrosine motif2

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
InParanoidiP39727.
KOiK20367.
OMAiNINMTHI.
OrthoDBiEOG092C3TSE.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSTLLSLD AFAKTEEDVR VRTRAGGLIT LSCILTTLFL LVNEWGQFNS
60 70 80 90 100
VVTRPQLVVD RDRHAKLELN MDVTFPSMPC DLVNLDIMDD SGEMQLDILD
110 120 130 140 150
AGFTMSRLNS EGRPVGDATE LHVGGNGDGT APVNNDPNYC GPCYGAKDQS
160 170 180 190 200
QNENLAQEEK VCCQDCDAVR SAYLEAGWAF FDGKNIEQCE REGYVSKINE
210 220 230 240 250
HLNEGCRIKG SAQINRIQGN LHFAPGKPYQ NAYGHFHDTS LYDKTSNLNF
260 270 280 290 300
NHIINHLSFG KPIQSHSKLL GNDKRHGGAV VATSPLDGRQ VFPDRNTHFH
310 320 330 340 350
QFSYFAKIVP TRYEYLDNVV IETAQFSATF HSRPLAGGRD KDHPNTLHVR
360 370 380 390 400
GGIPGMFVFF EMSPLKVINK EQHGQTWSGF ILNCITSIGG VLAVGTVMDK
410
LFYKAQRSIW GKKSQ
Length:415
Mass (Da):46,235
Last modified:October 1, 1996 - v2
Checksum:iFB7BC171B88BB5EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04989.1.
BK006935 Genomic DNA. Translation: DAA06944.1.
PIRiS51977.
RefSeqiNP_009358.1. NM_001178187.1.

Genome annotation databases

EnsemblFungiiYAL042W; YAL042W; YAL042W.
GeneIDi851256.
KEGGisce:YAL042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04989.1.
BK006935 Genomic DNA. Translation: DAA06944.1.
PIRiS51977.
RefSeqiNP_009358.1. NM_001178187.1.

3D structure databases

ProteinModelPortaliP39727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31785. 82 interactors.
DIPiDIP-3792N.
IntActiP39727. 4 interactors.
MINTiMINT-565838.

Proteomic databases

MaxQBiP39727.
PRIDEiP39727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL042W; YAL042W; YAL042W.
GeneIDi851256.
KEGGisce:YAL042W.

Organism-specific databases

EuPathDBiFungiDB:YAL042W.
SGDiS000000040. ERV46.

Phylogenomic databases

GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
InParanoidiP39727.
KOiK20367.
OMAiNINMTHI.
OrthoDBiEOG092C3TSE.

Enzyme and pathway databases

BioCyciYEAST:G3O-28850-MONOMER.

Miscellaneous databases

PROiP39727.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERV46_YEAST
AccessioniPrimary (citable) accession number: P39727
Secondary accession number(s): D6VPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.