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P39727 (ERV46_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER-derived vesicles protein ERV46
Gene names
Name:ERV46
Ordered Locus Names:YAL042W
ORF Names:FUN9
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Phe-Tyr motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum. Ref.5 Ref.6

Subunit structure

Interacts with ERV41. Ref.4 Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles. Ref.4 Ref.5 Ref.6 Ref.7

Sequence similarities

Belongs to the ERGIC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ERV41Q046513EBI-20659,EBI-27850

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415ER-derived vesicles protein ERV46
PRO_0000202419

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 376331Lumenal Potential
Transmembrane377 – 39721Helical; Potential
Topological domain398 – 41518Cytoplasmic Potential
Motif402 – 4032Phenylalanine-tyrosine motif

Sequences

Sequence LengthMass (Da)Tools
P39727 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: FB7BC171B88BB5EA

FASTA41546,235
        10         20         30         40         50         60 
MKRSTLLSLD AFAKTEEDVR VRTRAGGLIT LSCILTTLFL LVNEWGQFNS VVTRPQLVVD 

        70         80         90        100        110        120 
RDRHAKLELN MDVTFPSMPC DLVNLDIMDD SGEMQLDILD AGFTMSRLNS EGRPVGDATE 

       130        140        150        160        170        180 
LHVGGNGDGT APVNNDPNYC GPCYGAKDQS QNENLAQEEK VCCQDCDAVR SAYLEAGWAF 

       190        200        210        220        230        240 
FDGKNIEQCE REGYVSKINE HLNEGCRIKG SAQINRIQGN LHFAPGKPYQ NAYGHFHDTS 

       250        260        270        280        290        300 
LYDKTSNLNF NHIINHLSFG KPIQSHSKLL GNDKRHGGAV VATSPLDGRQ VFPDRNTHFH 

       310        320        330        340        350        360 
QFSYFAKIVP TRYEYLDNVV IETAQFSATF HSRPLAGGRD KDHPNTLHVR GGIPGMFVFF 

       370        380        390        400        410 
EMSPLKVINK EQHGQTWSGF ILNCITSIGG VLAVGTVMDK LFYKAQRSIW GKKSQ 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Vo D.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 405.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae."
Cho J.-H., Noda Y., Adachi H., Yoda K.
Biosci. Biotechnol. Biochem. 65:2226-2232(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ERV41, SUBCELLULAR LOCATION.
[5]"Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ERV41, SUBCELLULAR LOCATION.
[6]"The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER."
Otte S., Barlowe C.
EMBO J. 21:6095-6104(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC04989.1.
BK006935 Genomic DNA. Translation: DAA06944.1.
PIRS51977.
RefSeqNP_009358.1. NM_001178187.1.

3D structure databases

ProteinModelPortalP39727.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31785. 74 interactions.
DIPDIP-3792N.
IntActP39727. 4 interactions.
MINTMINT-565838.
STRING4932.YAL042W.

Proteomic databases

MaxQBP39727.
PaxDbP39727.
PeptideAtlasP39727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL042W; YAL042W; YAL042W.
GeneID851256.
KEGGsce:YAL042W.

Organism-specific databases

CYGDYAL042w.
SGDS000000040. ERV46.

Phylogenomic databases

eggNOGNOG260258.
GeneTreeENSGT00530000063113.
HOGENOMHOG000210954.
OMAGNYNISH.
OrthoDBEOG76HQBV.

Enzyme and pathway databases

BioCycYEAST:G3O-28850-MONOMER.

Gene expression databases

GenevestigatorP39727.

Family and domain databases

InterProIPR012936. Erv_C.
[Graphical view]
PfamPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968210.
PROP39727.

Entry information

Entry nameERV46_YEAST
AccessionPrimary (citable) accession number: P39727
Secondary accession number(s): D6VPH4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families