P39721 (AIM2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein AIM2

Alternative name(s):
Altered inheritance rate of mitochondria protein 2

Gene names

Name:	AIM2
Ordered Locus Names:	YAL049C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.4.
Miscellaneous	Present with 1800 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the AIM2 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.4. Source: SGD
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-20689,EBI-20689
APP1	P53933	2	EBI-20689,EBI-28798

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Protein AIM2		PRO_0000202423

Sequences

	Sequence		Length	Mass (Da)
	P39721 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 607298D79EECEF5B	FASTA	246	27,089
	10 20 30 40 50 60 MASNQPGKCC FEGVCHDGTP KGRREEIFGL DTYAAGSTSP KEKVIVILTD VYGNKFNNVL 70 80 90 100 110 120 LTADKFASAG YMVFVPDILF GDAISSDKPI DRDAWFQRHS PEVTKKIVDG FMKLLKLEYD 130 140 150 160 170 180 PKFIGVVGYC FGAKFAVQHI SGDGGLANAA AIAHPSFVSI EEIEAIDSKK PILISAAEED 190 200 210 220 230 240 HIFPANLRHL TEEKLKDNHA TYQLDLFSGV AHGFAARGDI SIPAVKYAKE KVLLDQIYWF NHFSNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12980 Genomic DNA. Translation: AAC04982.1. AY692654 Genomic DNA. Translation: AAT92673.1. BK006935 Genomic DNA. Translation: DAA06937.1.
PIR	S51970.
RefSeq	NP_009350.1. NM_001178194.1.
3D structure databases
ProteinModelPortal	P39721.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2008N.
IntAct	P39721. 3 interactions.
MINT	MINT-402861.
STRING	4932.YAL049C.
Proteomic databases
PaxDb	P39721.
PeptideAtlas	P39721.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAL049C; YAL049C; YAL049C.
GeneID	851248.
KEGG	sce:YAL049C.
Organism-specific databases
CYGD	YAL049c.
SGD	S000000047. YAL049C.
Phylogenomic databases
eggNOG	COG0412.
GeneTree	ENSGT00390000000183.
HOGENOM	HOG000216630.
OMA	NPPGACC.
OrthoDB	EOG42592W.
Gene expression databases
Genevestigator	P39721.
GermOnline	YAL049C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002925. Dienelactn_hydro. [Graphical view]
Pfam	PF01738. DLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968189.

Entry information

Entry name

AIM2_YEAST

Accession

Primary (citable) accession number: P39721
Secondary accession number(s): D6VPG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program