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Reviewed, UniProtKB/Swiss-Prot P39719 (FLC2_YEAST)

Last modified November 24, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Flavin carrier protein 2
Alternative name(s):
    FAD transporter 2
    TRP-like ion channel FLC2
Gene names
Name: FLC2
Ordered Locus Names: YAL053W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length783 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be responsable for the transport of FAD into the endoplasmatic reticulum lumen, where it is required for oxidative protein folding. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Miscellaneous

Present with 414 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the transient receptor potential (TRP) ion channel family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 783761Flavin carrier protein 2
PRO_0000202424

Regions

Topological domain23 – 182160Lumenal Potential
Transmembrane183 – 20321 Potential
Topological domain204 – 2118Cytoplasmic Potential
Transmembrane212 – 23221 Potential
Topological domain233 – 347115Lumenal Potential
Transmembrane348 – 36821 Potential
Topological domain369 – 40234Cytoplasmic Potential
Transmembrane403 – 42321 Potential
Topological domain424 – 4307Lumenal Potential
Transmembrane431 – 45121 Potential
Topological domain452 – 49241Cytoplasmic Potential
Transmembrane493 – 51321 Potential
Topological domain514 – 5218Lumenal Potential
Transmembrane522 – 54221 Potential
Topological domain543 – 5475Cytoplasmic Potential
Transmembrane548 – 56821 Potential
Topological domain569 – 58113Lumenal Potential
Transmembrane582 – 60221 Potential
Topological domain603 – 783181Cytoplasmic Potential

Amino acid modifications

Modified residue6891Phosphoserine Ref.6
Modified residue7441Phosphoserine Ref.6
Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1111S → C in CAA54219. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P39719-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F721F6A03850B194

FASTA78387,463
        10         20         30         40         50         60 
MIFLNTFARC LLTCFVLCSG TARSSDTNDT TPASAKHLQT TSLLTCMDNS QLTASFFDVK 

        70         80         90        100        110        120 
FYPDNNTVIF DIDATTTLNG NVTVKAELLT YGLKVLDKTF DLCSLGQVSL SPLSAGRIDV 

       130        140        150        160        170        180 
MSTQVIESSI TKQFPGIAYT IPDLDAQVRV VAYAQNDTEF ETPLACVQAI LSNGKTVQTK 

       190        200        210        220        230        240 
YAAWPIAAIS GVGVLTSGFV SVIGYSATAA HIASNSISLF IYFQNLAITA MMGVSRVPPI 

       250        260        270        280        290        300 
AAAWTQNFQW SMGIINTNFM QKIFDWYVQA TNGVSNVVVA NKDVLSISVQ KRAISMASSS 

       310        320        330        340        350        360 
DYNFDTILDD SDLYTTSEKD PSNYSAKILV LRGIERVAYL ANIELSNFFL TGIVFFLFFL 

       370        380        390        400        410        420 
FVVVVSLIFF KALLEVLTRA RILKETSNFF QYRKNWGSII KGTLFRLSII AFPQVSLLAI 

       430        440        450        460        470        480 
WEFTQVNSPA IVVDAVVILL IITGLLVYGT IRVFIKGRES LRLYKNPAYL LYSDTYFLNK 

       490        500        510        520        530        540 
FGFLYVQFKA DKFWWLLPLL SYAFLRSLFV AVLQNQGKAQ AMIIFVIELA YFVCLCWIRP 

       550        560        570        580        590        600 
YLDKRTNVFN IAIHLVNLIN AFFFLFFSNL FKQPAVVSSV MAVILFVLNA VFALFLLLFT 

       610        620        630        640        650        660 
IVTCTLALLH RNPDVRYQPM KDDRVSFIPK IQNDFDGKNK IDPELFELRK AVMDTNENEE 

       670        680        690        700        710        720 
EKMFRDDTFG KNLNANTNTA RLFDDETSSS SFKQNSSPFD ASEVTEQPVQ PTSAVMGTGG 

       730        740        750        760        770        780 
SFLSPQYQRA SSASRTNLAP NNTSTSSLMK PESSLYLGNS NKSYSHFNNN GSNENARNNN 


PYL

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae."
Kratzer S., Schueller H.-J.
Gene 161:75-79(1995) [PubMed: 7642141] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160.
Strain: GRF78.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum."
Protchenko O., Rodriguez-Suarez R., Androphy R., Bussey H., Philpott C.C.
J. Biol. Chem. 281:21445-21457(2006) [PubMed: 16717099] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-744, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U12980 Genomic DNA. Translation: AAC04980.1.
X76891 Genomic DNA. Translation: CAA54219.1.
PIRS51968.
RefSeqNP_009348.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6708N.
IntActP39719. 34 interactions.
STRINGP39719.

Proteomic databases

PeptideAtlasP39719.
PRIDEP39719.

Genome annotation databases

EnsemblYAL053W; YAL053W; YAL053W; Saccharomyces cerevisiae. [Genome view]
GeneID851246.
KEGGsce:YAL053W.
NMPDRfig|4932.3.peg.23.

Organism-specific databases

CYGDYAL053w.
SGDS000000049. FLC2.

Phylogenomic databases

HOGENOMP39719.
OMAMKDDRVS
OrthoDBEOG90S1XV

Gene expression databases

ArrayExpressP39719.
GenevestigatorP39719.
GermOnlineYAL053W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR010308. DUF907_fun.
IPR011071. Lyase_8-like_C.
[Graphical view]
PfamPF06011. TRP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio968183.

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Entry information

Entry nameFLC2_YEAST
AccessionPrimary (citable) accession number: P39719
Secondary accession number(s): Q05165
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 24, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents