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Protein

Flavin carrier protein 2

Gene

FLC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.1 Publication

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD

GO - Biological processi

  • calcium ion homeostasis Source: SGD
  • cellular hypotonic response Source: SGD
  • FAD transport Source: SGD
  • fungal-type cell wall biogenesis Source: SGD
  • protein folding Source: SGD
  • sphingolipid biosynthetic process Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-28858-MONOMER.

Protein family/group databases

TCDBi1.A.4.9.3. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flavin carrier protein 2
Alternative name(s):
FAD transporter 2
TRP-like ion channel FLC2
Gene namesi
Name:FLC2
Ordered Locus Names:YAL053W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL053W.
SGDiS000000049. FLC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 182LumenalSequence analysisAdd BLAST160
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 211CytoplasmicSequence analysis8
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 347LumenalSequence analysisAdd BLAST115
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 402CytoplasmicSequence analysisAdd BLAST34
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 430LumenalSequence analysis7
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 492CytoplasmicSequence analysisAdd BLAST41
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 521LumenalSequence analysis8
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 547CytoplasmicSequence analysis5
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 581LumenalSequence analysisAdd BLAST13
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 783CytoplasmicSequence analysisAdd BLAST181

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000020242423 – 783Flavin carrier protein 2Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP39719.
PRIDEiP39719.

PTM databases

iPTMnetiP39719.

Interactioni

Protein-protein interaction databases

BioGridi31776. 124 interactors.
DIPiDIP-6708N.
IntActiP39719. 27 interactors.
MINTiMINT-613742.
STRINGi4932.YAL053W.

Structurei

3D structure databases

ProteinModelPortaliP39719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065299.
HOGENOMiHOG000168830.
InParanoidiP39719.
OMAiMKDDRVS.
OrthoDBiEOG092C186V.

Family and domain databases

InterProiView protein in InterPro
IPR010308. TRP-like_family.
IPR032800. TRP_N.
PfamiView protein in Pfam
PF06011. TRP. 1 hit.
PF14558. TRP_N. 1 hit.
SMARTiView protein in SMART
SM01320. TRP_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFLNTFARC LLTCFVLCSG TARSSDTNDT TPASAKHLQT TSLLTCMDNS
60 70 80 90 100
QLTASFFDVK FYPDNNTVIF DIDATTTLNG NVTVKAELLT YGLKVLDKTF
110 120 130 140 150
DLCSLGQVSL CPLSAGRIDV MSTQVIESSI TKQFPGIAYT IPDLDAQVRV
160 170 180 190 200
VAYAQNDTEF ETPLACVQAI LSNGKTVQTK YAAWPIAAIS GVGVLTSGFV
210 220 230 240 250
SVIGYSATAA HIASNSISLF IYFQNLAITA MMGVSRVPPI AAAWTQNFQW
260 270 280 290 300
SMGIINTNFM QKIFDWYVQA TNGVSNVVVA NKDVLSISVQ KRAISMASSS
310 320 330 340 350
DYNFDTILDD SNLYTTSEKD PSNYSAKILV LRGIERVAYL ANIELSNFFL
360 370 380 390 400
TGIVFFLFFL FVVVVSLIFF KALLEVLTRA RILKETSNFF QYRKNWGSII
410 420 430 440 450
KGTLFRLSII AFPQVSLLAI WEFTQVNSPA IVVDAVVILL IITGLLVYGT
460 470 480 490 500
IRVFIKGRES LRLYKNPAYL LYSDTYFLNK FGFLYVQFKA DKFWWLLPLL
510 520 530 540 550
SYAFLRSLFV AVLQNQGKAQ AMIIFVIELA YFVCLCWIRP YLDKRTNVFN
560 570 580 590 600
IAIHLVNLIN AFFFLFFSNL FKQPAVVSSV MAVILFVLNA VFALFLLLFT
610 620 630 640 650
IVTCTLALLH RNPDVRYQPM KDDRVSFIPK IQNDFDGKNK NDSELFELRK
660 670 680 690 700
AVMDTNENEE EKMFRDDTFG KNLNANTNTA RLFDDETSSS SFKQNSSPFD
710 720 730 740 750
ASEVTEQPVQ PTSAVMGTGG SFLSPQYQRA SSASRTNLAP NNTSTSSLMK
760 770 780
PESSLYLGNS NKSYSHFNNN GSNENARNNN PYL
Length:783
Mass (Da):87,469
Last modified:July 27, 2011 - v2
Checksum:iF5944205A7098B89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111C → S in AAC04980 (PubMed:7731988).Curated1
Sequence conflicti312N → D in AAC04980 (PubMed:7731988).Curated1
Sequence conflicti641 – 643NDS → IDP in AAC04980 (PubMed:7731988).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04980.1.
X76891 Genomic DNA. Translation: CAA54219.1.
BK006935 Genomic DNA. Translation: DAA06935.2.
PIRiS51968.
RefSeqiNP_009348.2. NM_001178196.2.

Genome annotation databases

EnsemblFungiiYAL053W; YAL053W; YAL053W.
GeneIDi851246.
KEGGisce:YAL053W.

Similar proteinsi

Entry informationi

Entry nameiFLC2_YEAST
AccessioniPrimary (citable) accession number: P39719
Secondary accession number(s): D6VPG5, Q05165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names