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P39719 (FLC2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Flavin carrier protein 2
Alternative name(s):
FAD transporter 2
TRP-like ion channel FLC2
Gene names
Name:FLC2
Ordered Locus Names:YAL053W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length783 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be responsible for the transport of FAD into the endoplasmatic reticulum lumen, where it is required for oxidative protein folding. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.5.

Miscellaneous

Present with 414 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the transient receptor potential (TRP) ion channel family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 783761Flavin carrier protein 2
PRO_0000202424

Regions

Topological domain23 – 182160Lumenal Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 2118Cytoplasmic Potential
Transmembrane212 – 23221Helical; Potential
Topological domain233 – 347115Lumenal Potential
Transmembrane348 – 36821Helical; Potential
Topological domain369 – 40234Cytoplasmic Potential
Transmembrane403 – 42321Helical; Potential
Topological domain424 – 4307Lumenal Potential
Transmembrane431 – 45121Helical; Potential
Topological domain452 – 49241Cytoplasmic Potential
Transmembrane493 – 51321Helical; Potential
Topological domain514 – 5218Lumenal Potential
Transmembrane522 – 54221Helical; Potential
Topological domain543 – 5475Cytoplasmic Potential
Transmembrane548 – 56821Helical; Potential
Topological domain569 – 58113Lumenal Potential
Transmembrane582 – 60221Helical; Potential
Topological domain603 – 783181Cytoplasmic Potential

Amino acid modifications

Modified residue6891Phosphoserine Ref.7
Modified residue7441Phosphoserine Ref.7
Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1111C → S in AAC04980. Ref.1
Sequence conflict3121N → D in AAC04980. Ref.1
Sequence conflict641 – 6433NDS → IDP in AAC04980. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39719 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F5944205A7098B89

FASTA78387,469
        10         20         30         40         50         60 
MIFLNTFARC LLTCFVLCSG TARSSDTNDT TPASAKHLQT TSLLTCMDNS QLTASFFDVK 

        70         80         90        100        110        120 
FYPDNNTVIF DIDATTTLNG NVTVKAELLT YGLKVLDKTF DLCSLGQVSL CPLSAGRIDV 

       130        140        150        160        170        180 
MSTQVIESSI TKQFPGIAYT IPDLDAQVRV VAYAQNDTEF ETPLACVQAI LSNGKTVQTK 

       190        200        210        220        230        240 
YAAWPIAAIS GVGVLTSGFV SVIGYSATAA HIASNSISLF IYFQNLAITA MMGVSRVPPI 

       250        260        270        280        290        300 
AAAWTQNFQW SMGIINTNFM QKIFDWYVQA TNGVSNVVVA NKDVLSISVQ KRAISMASSS 

       310        320        330        340        350        360 
DYNFDTILDD SNLYTTSEKD PSNYSAKILV LRGIERVAYL ANIELSNFFL TGIVFFLFFL 

       370        380        390        400        410        420 
FVVVVSLIFF KALLEVLTRA RILKETSNFF QYRKNWGSII KGTLFRLSII AFPQVSLLAI 

       430        440        450        460        470        480 
WEFTQVNSPA IVVDAVVILL IITGLLVYGT IRVFIKGRES LRLYKNPAYL LYSDTYFLNK 

       490        500        510        520        530        540 
FGFLYVQFKA DKFWWLLPLL SYAFLRSLFV AVLQNQGKAQ AMIIFVIELA YFVCLCWIRP 

       550        560        570        580        590        600 
YLDKRTNVFN IAIHLVNLIN AFFFLFFSNL FKQPAVVSSV MAVILFVLNA VFALFLLLFT 

       610        620        630        640        650        660 
IVTCTLALLH RNPDVRYQPM KDDRVSFIPK IQNDFDGKNK NDSELFELRK AVMDTNENEE 

       670        680        690        700        710        720 
EKMFRDDTFG KNLNANTNTA RLFDDETSSS SFKQNSSPFD ASEVTEQPVQ PTSAVMGTGG 

       730        740        750        760        770        780 
SFLSPQYQRA SSASRTNLAP NNTSTSSLMK PESSLYLGNS NKSYSHFNNN GSNENARNNN 


PYL

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 111; 312 AND 641-643.
Strain: ATCC 204508 / S288c.
[3]"Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae."
Kratzer S., Schueller H.-J.
Gene 161:75-79(1995) [PubMed: 7642141] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160.
Strain: GRF78.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum."
Protchenko O., Rodriguez-Suarez R., Androphy R., Bussey H., Philpott C.C.
J. Biol. Chem. 281:21445-21457(2006) [PubMed: 16717099] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-744, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U12980 Genomic DNA. Translation: AAC04980.1.
X76891 Genomic DNA. Translation: CAA54219.1.
BK006935 Genomic DNA. Translation: DAA06935.2.
PIRS51968.
RefSeqNP_009348.2. NM_001178196.2.

3D structure databases

ProteinModelPortalP39719.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6708N.
IntActP39719. 28 interactions.
MINTMINT-613742.
STRINGP39719.

Proteomic databases

PeptideAtlasP39719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID851246.
KEGGsce:YAL053W.
NMPDRfig|4932.3.peg.23.

Organism-specific databases

CYGDYAL053w.
SGDS000000049. FLC2.

Phylogenomic databases

eggNOGfuNOG05784.
GeneTreeEFGT00050000000732.
HOGENOMHBG396900.
OMAHSNTAAH.
OrthoDBEOG4W11ND.

Gene expression databases

ArrayExpressP39719.
GenevestigatorP39719.
GermOnlineYAL053W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR010308. DUF907_fun.
[Graphical view]
PfamPF06011. TRP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968183.

Entry information

Entry nameFLC2_YEAST
AccessionPrimary (citable) accession number: P39719
Secondary accession number(s): D6VPG5, Q05165
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: December 14, 2011
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents